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The title character. Nate is a sixth grade straight-F student, self-proclaimed ladies' man and Renaissance Man, and quite short (4'6" to be exact). His crush is Jenny, who hates him, and his sworn enemies are Gina and Mrs. Godfrey.
- Abhorrent Admirer: Believes that he and Jenny are destined together and uses every possible opportunity to pursue her. Jenny, for her part,does not like him back, but she does tolerate him to some extent.
- Adorkable: He may be a jerk, but all he wants is to be respected by the kids in his school. Awww.
- Anime Hair: At one point, his friends try to make fun of him by making an ice cream cone with ice cream that looks like his hair. Nate admits that while he's not happy with it, it is a creative use of "Hershey's Kisses."
- Arch-Enemy: He has a few for different reasons:
- Gina: Him being a slacker and her a kiss-up straight-A student, they clash very frequently. Nate's friends see it as a Love Hate Relationship though.
- Mrs. Godfrey: His social studies teacher. Somewhat one-sided, he does not like her at all and they clash the most frequently. While most of it is Nate's doing, there are times where she also shows her frustration with him. Her favoritism to his older sister may have been a part of it.
- Randy Betancourt: The school's Top Jerkass. He tends to mess or screw with people For the Lulz. Nate usually steps in to put a stop to Randy's Jerkass deeds and Randy doesn't take stuff lying down.
- The chapter book Big Nate Blasts Off has this intensify when Nate actually moves on from Jenny and likes a new girl... the same one Randy does. Furthermore, the only times Nate has ever gotten into a physical altercation was with Randy, and this has happened twice so far (the first time being in a prior book where Randy teases Francis and Nate just goes nuts on him.)
- Anime Hair: Has very spiky hair. Lampshaded by other characters on various occasions.
- Butt-Monkey: Gets scared by cats, hurt in sports, fails to impress Jenny, and other things.
- Berserk Button: Notably, mentioning school during the summer or bringing up the possibility that he can be outdone.
- Also messing with his friends. Despite not being on speaking terms (due to a fight) with Francis, when Randy bullies him, Nate proceeds to go berserk and physically fight him (he even mentions it's the first time he ever fought someone).
- Brilliant, but Lazy: Nate is amazing with random trivia (basketball, Peanuts, etc.), yet earns horrible grades because he lacks the motivation to study properly. He's also a chess prodigy (even going to the occasional state tournament), and only earns horrible grades in Ms. Godfrey's history class. Every other class hovers around a grade of C. He is also shown to be a master prankster and creating some of the largest pranks pulled on Prank Day. From letting a flying squirrel and a moose into the school (Rocky and Bullwinkle theme) to setting up a dating profile with Ms. Godfrey and setting her up on a date with a desperate rodeo clown (evening showing up to school with flowers), Nate shows off a commendable amount of planning and logistics for these pranks.
- Casanova Wannabe: Nate frequently tries to chat up any pretty girl he encounters (but especially Jenny, whom he believes is his soulmate), but are almost never successful with his endeavours. There are some aversions, however:
- He had a girlfriend named Angie in the summer of 1997, who he met at Summer School. She broke up with him six months later, on Valentines' Day.
- During the summer of 2001, he got a girlfriend named Kelly. Unfortunately, he broke up with her the following year, (they met in soccer camp and was seldom seen, going to a different school).
- In 2015, he found another girl named Trudy, a seventh-grader whom he met on a carnival ride. However, he broke up with her the following year as he was often forced to be around her friend group of seventh-graders while she never wanted to be around his friends.
- Catch-Phrase: "Spitsy, you idiot" and "Oh, how I hate her."
- Cosmic Plaything: Oh so much. While he may deserve his misfortune from time to time, usually, the fates are flatout mean to the kid. Especially when he tries to do something nice for Jenny.
- Deadpan Snarker: What'd you expect from the Yo Mama King/Nickname Czar/King of the Trash Talk?
- Dirty Kid: He's somewhat obsessed with a racy Superheroine called "Femme Fatality", which got him in trouble when he lend one of her comics to his 1st grade reading buddy, Peter.
- Everyone Has Standards: In the strip in which Jenny asks Artur out, she gives Nate the fateful note. He considers disposing it, before realizing it was a sleazeball move... and then goes to deliver it to Artur, chastising himself for not being a sleaseball.
- Follow Your Nose: Nate's sense of smell is so keen that at several points he identifies several things to crazy specifics (blindfolded) just by smelling them.
- The Friend Nobody Likes: Teddy and Francis put up with him more than they hang out him. Lampshaded in one strip, where Nate loudly wonders why one would hang out with people they don't like, and, in the next panel, Francis and Teddy had disappeared.
- Genius Ditz: Is able to plan out complex pranks with precision, but is unable to name a Chinese emperor.
- Hopeless Suitor: Continuously tries to win Jenny's affection despite the fact that she and Artur are Sickeningly Sweethearts. However, as of the novel Big Nate Blasts Off, he has moved on from her. He has also mvoed on from her in the comic strips it seems since she moved back.
- Jerk with a Heart of Gold: Nate is often seen sticking up for those needing it and will give a helping hand in his own way (such as when a student is dealing with someone annoying or that's a jerk, Nate lures them to his locker and opens it, blasting them away with the crammed junk.) His reasons for not being nice more often could be due to his status as a Cosmic Plaything.
- Luminescent Blush: Whenever he gets embarrassed or angry. Extends to his ears.
- Missing Mom: His mother divorced his father when he was young, and he doesn't really know her all that well.
- The Nicknamer: He's a master nicknamer who has come up with at least a dozen of insulting nick names for the teachers (especially Mrs. Godfrey).
- The Nose Knows: He's able to pinpoint exactly what something is based on its scent, though he has been fooled on occasion-for example, he assumes that a smell of rose-scented soap is coming from a female teacher, when the source is actually his (male) math teacher.Mr. Staples might want to consider using soap that's a bit more macho.
- The Pig Pen: : He's a slob who practically keeps a junkyard in his locker, and the homework he submitted is always in a mess (crumpled up, stained with various food scraps, etc)
- The Prankster: The best prankster in school, and had always pulled the craziest stunts during Prank Day.
- Prince Charming Wannabe: His attempts to court Jenny frequently involves writing her (lame) poetries, calling her "milady", and generally trying and failing to be chivalrous around her.
- Selective Obliviousness: No matter how many times, ways, or just flat-out statements of hate for him he gets, Nate still believes that deep down, Jenny likes him.
- The chapter novel Big Nate Blasts Off actually has him move on from this and realizes she never really liked him (romantically, anyway.) It also seems to have happened in the strip after his breakup with Trudy.
- Small Name, Big Ego: Frequently boasts of his own greatness, even though he rarely achieve anything.
- Stalker With a Crush: It is mentioned that he once played a "Love You Like a Love Song"-esque song in order to impress Jenny.
- The Napoleon: Originally mentioned to be "the shortest kid in school" (before people like Chad came along) and definitely bigheaded enough. Heck, he even mentioned once that Napoleon would make a good middle name.
- Trademark Favourite Food: Cheez Doodlez, which he uses as his #1 subject for poetry writing (when he's not trying to write stupid love poems for Jenny, of course).
- Unsympathetic Comedy Protagonist: Often becomes one, such as when he treats Jenny's breakups with a smile and basically grinds her feelings to powder.
- Why Can't I Hate You?: To Artur. Interesting example of being a romantic version and nonromantic version. Nate's dislike of Artur stems from Artur being with Jenny, being better at chess and being Born Lucky compared to Nate's Butt-Monkey status. Despite this, he can't bring himself to hate him and is friends with him. He even admits that he finds Artur okay, but is annoyed how nothing bad tends to happen to him.
- Why Did It Have to Be Snakes?: Nate has a fear of cats. Often Played for Laughs.
Francis Butthurst Pope
Nate's best friend, a bookish, school-loving, at times borderline butt-kisser. He's, among other things, a Neat Freak, Nice Guy, and Deadpan Snarker.
- Berserk Button: He does not take nicely to having his Book of Facts taken away.
- Deadpan Snarker: Does this frequently to Nate.
- Embarrassing Middle Name: His middle name is Butthurst.
- Insufferable Genius: He's smarter than his peers and doesn't hesitate to show it off, leading to several Unsympathetic Comedy Protagonist moments.
- Momma's Boy: Is definitely the wussiest of the group, having My Beloved Smother tendencies at times, using a roller backpack, and being Jimmylike at times.
- Neat Freak: Maakes a good Foil to Nate being such a mess.
- Nice Guy: He is definitely the nicest of the trio, although his know-it-all tendencies can get annoying.
- Only Sane Man: Whenever it's just him and Nate. Otherwise Teddy is usually the only sane man.
- Professional Butt-Kisser: It is mentioned that he has Mrs. Godfrey's birthday in his planner. Also, in the Jefferson saga, upon learning that they're going to Jefferson, Francis shows up in Jefferson garb.
- Running Gag: His obsession with The Book of Facts.
- Sensitive Guy and Manly Man: The sensitive guy to Nate's manly man.
- Smart People Wear Glasses: Francis wears glasses and plays the role of the stereotypical Smart Guy in Nate's group, as he enjoys reading Trivia books, studies for leisure and is excited about school.
- Teacher's Pet: Is definitely in far better graces with teachers than Teddy and Nate.
- Unsympathetic Comedy Protagonist: Frequently acts as a know-it-all spoilsports, which earned him wedgies from his peers.
Nate's other best friend, who matches Nate in prankster tendencies. On the rare occasions that anyone agrees with Nate, it will most likely be Teddy. His parents are mathematicians, as evidenced by his middle name being the square root symbol.
- Deadpan Snarker: He enjoys making wisecracks.
- Embarrassing Middle Name: The square root symbol (it's mentioned that his parents are math majors).
- Nightmare Fetishist: He can be rather gross, as Nate first opened up to him when he played around with a squid's leg to pretend they were boogers during a science class. He has also more than once disgusted his friends when he started to discuss about his eating habits, such as how he "ate so many gummy bears that one of them came out from [his] nose".
- Only Sane Man: He's the most normal of the trio — he's not as wacky or stupidly reckless as Nate, but is far more socially adept then Francis.
- The Prankster: Which is one of the reasons why Nate got along with him so quickly.
- Shout-Out: In terms of looks, Teddy is essentially Franklin.
Nate's dad. The epitome of a Bumbling Dad, who is divorced, sucks at sports, and on the occasions that Nate is not the Butt-Monkey, expect Dad to be.
- Berserk Button: It's not a good idea to mention college money to him. He's also rather volatile while working his taxes.
- Bumbling Dad: Hits pretty much every single note, and seems to have "Epic Fail" written on his attempts to do anything.
- Butt-Monkey: If Nate isn't the one getting the Butt-Monkey treatment, it's usually his father who takes up the role.
- Dirty Old Man: Enjoys Nate's "Femme Fatality" comics, and has an Anna Kournikova screen saver.
- Fan Disservice: He's a balding, middle-aged guy with a port belly and has the tendency to walk around shirtless or in shorts.
- Hollywood Genetics: Guy with ambiguous hair color gets a raven-haired kid and a blonde kid.
- Hypocritical Humor: Quite a bit. Examples include: Confiscating Femme Fatality when he's a Dirty Old Man himself, telling Nate to eat healthy when in fact he has a rather decent-sized sweet stash, etc.
Nate's older sister, who drives Nate crazy. While originally one of the main characters, she has grown to less significance as the strip goes on.
- Art Shift: Goes from this to this.
- Big Sister Bully: At times. One of the books showed a photo of her and Nate as toddlers, and Ellen is dragging the screaming Nate by the foot.
- Bratty Teenage Daughter: Is Marty's daughter and a jerk to Nate.
- Ditzy Genius: She may be absentminded but she was an amazing student to Mrs. Godfrey.
- Dumb Blonde: Inverted. Nate considers her dumb and annoying, but she's very smart and was a Teacher's Pet of Mrs. Godfrey, Nate's current Social Studies teacher.
- Sibling Yin-Yang: To Nate. She is a Ditzy Genius and Crazy Cat Lady to Nate's lazy intelligence and dog love.
- Sickeningly Sweethearts: Although it is not shown very often, she can get very lovey-dovey with her boyfriend Gordie.
Nate's teacher and Arch-Enemy. While not as evil as Nate often describes her (because only Umbridge could be that evil), often shows blatant favoritism.
- Arch-Enemy: She is one of Nate's least favorite teachers (after Coach John). Mrs. Godfrey, on her part, detests Nate for his lack of effort and disrespectfulness, and is shown to be very pleased when Nate is assigned to another teacher during the school's temporary "visit" to Jefferson.
- Does Not Like Spam: As stated below, she hates jelly beans.
- Evil Smells Bad: According to Nate, her breath stinks of dead fish.
- Fat Bastard: She's a Sadist Teacher who is fat.
- Jerkass Has a Point: Her favoring of Gina and clear dislike of Nate may seem unfair, but Gina's obviously a very good student, while Nate is lazy and clearly doesn't care about school at all.
- Parental Favoritism: Quite blatantly favors Gina over Nate. A recurring gag is that Gina will answer a question (without raising her hand and usually with a loud "OOH!", but when Nate does the same thing, she shoots him down.
- Sadist Teacher: While Nate does bring a lot of it on himself, Ms. Godfrey is usually unfair to him. For example, when Gina complains about Nate's loud breathing, Mrs. Godfrey immediately ordered Nate to stop breathing, even though he's not really doing anything wrong.
- Skewed Priorities: At one point, Nate sneaks into her desk to see if he can find his research paper topic. Mrs. Godfrey catches him, but the thing she notices is that Nate ate her Skittles.
- Sweet Tooth: Loves candy (but can't stand jelly beans), and has been mentioned to have Skittles and Junior Mints hidden in her desk.
Nate's long-running crush who is often annoyed and angered by him. Despite this, she manages to have something of a friendship with him. Is currently dating Artur. Moved to Seattle for awhile in 2013, but ended up returning. Nate also seems to have gotten over her after his breakup with Trudy.
- Alliterative Name: Jenny Jenkins.
- Berserk Button: Can get rather violent when Nate makes advancements or accidentally messes her up when trying to do something.
- Deadpan Snarker: When dealing with Nate.
- Everyone Loves Blondes: She's blonde, popular and is Nate's biggest crush.
- Hair Decorations: She wears a black hairband.
- Lysistrata Gambit: Uses a (toned down) version of this technique to beat Nate at Monopoly.
- Odd Friendship: Although Jenny frequently shoots down Nate's advances with either violence or harsh words, she frequently hangs out with him and the rest of his friends for swimming or Monopoly. She also appeared more often early in the strip as just one of Nate's friends whom he had a crush on.
- Nate's Odd Friendship with her boyfriend Artur may be a reason. In a chapter book, she goes to Nate when Artur is an uncharacteristically bad mood (inadvertently caused by Nate, though only he knows that) and when he asks why she came to him, she mentions that Artur trusts and respects Nate.
A transfer student from Belarus, who is Nate's Foil. While he is probably the nicest character in the strip, he has a one-sided rivalry with Nate (from Nate's point of view). Very blind to sarcasm.
- Always Someone Better: He is better at drawing and chess than Nate, two skills that Nate values the most about himself. However, while Nate has no problem with Artur being a better artist, Artur's superiority in chess bothers him to no end.
- Born Lucky: One of his traits that bothers Nate's, contrasting with his Butt-Monkey status.
- Foil: To Nate. While Nate is a Casanova Wannabe, Butt-Monkey, and Deadpan Snarker, Artur is probably the nicest person in the strip, a Chick Magnet, Born Lucky, and seriously Sarcasm-Blind.
- Foreign Exchange Student: He's an exchange student from Belarus.
- Funny Foreigner: He is from Belarus.
- Innocently Insensitive: Due to his somewhat poor English skills, he occasionally says offensive stuffs without actually understanding what they mean.
- When asked if he wants to play table football, he jumps on a table.
- When asked if he had ever played soccer, Artur responded that no, he hadn't... because he isn't from America, and it was called football there.
- Metaphorgotten: See Literal-Minded.
- Nice Guy: Negative emotions are practically nonexistent to Artur, though Nate annoyed him once or twice.
- Odd Friendship: With Nate. Despite Nate's one-sided rivalry, Nate means a great deal to Artur. In fact, when Artur was upset (accidently due to Nate and known only by Nate, Teddy and Francis), Jenny says she went to Nate because of how much Artur trusts him.
- Sarcasm-Blind: Partly due to being a foreign student and serves as a good Foil to Deadpan Snarker Nate.
- Unknown Rival: Nate has a massive grudge against Artur for being better than him in several things (particularly, chess and drawing, two skills Nate prides himself on, though the latter is never addressed). To make matters worse, Artur is not only better at them than him, he's so darn modest about it!
Nate's other arch-enemy, Gina is the polar opposite of Nate, getting straight A's and never letting him forget it. Basically, she's Ellen all over again, just a whole lot less ditzy.
- Academic Alpha Bitch: Takes pride in her academic achievements, and generally treats other people like shit.
- Insufferable Genius: She likes to show-off her knowledge by trying to answer any and every question Mrs. Godfrey asks in class. She once had a knowledge show-down with Francis to determine which of them is smarter.
- Kick the Dog: Nate's not a nice person, but tattling on Nate for the way he breathes is just weird.
- Not So Above It All: Gina was quite annoyed by Nate's weird habit of hitting his head with a plastic bottle as stress relief. He then had the moxie to hit her head with it... which prompted her to do it and it relaxed her as well.
- The Smart Guy: One of the smartest kids in the school.
- Smart People Wear Glasses: She wears glasses and, along with Francis, is one of the smartest students in Nate's year.
- Teacher's Pet: She's one of Mrs. Godfrey's favorite students (the other being Ellen) and appears to enjoy being in her company. Once, an unusually friendly Gina meets Nate & co. in the beach and asks if she can hang around with them. Nate drove her away by pointing out that Mrs. Godfrey is also in the beach, and wouldn't Gina want to be with her instead? It worked.
Dee Dee Dorcas Holloway
A Canon Immigrant from the books who eventually became a character in the comic strip. She's a member of the drama club and a fellow cartoonist.
- Drama Queen: Part of the drama club, so it is a given.
- Embarrassing Middle Name: Her middle name is Dorcas, though she doesn't seem to be very embarrassed about it when mentioning it to Nate.
- Large Ham: Deliberately, as she take her drama club activities very seriously.
- Meganekko: She wears glasses.
- Nice Girl: One of Nate's best friends, and for good reasons.
- Only Sane Man: Is the best one of Nate's friends to talk to if you need to resolve something, and she's good at figuring out relationships. Also sees herself as this—she's the one who rolls her eyes the most in response to the other characters.
A dog belonging to Nate's neighbor and is probably the closest thing to a pet Nate could ever have.
- Big, Friendly Dog: Often greets Nate by glomping and licking him. Nate regards this gesture as either touching or annoying (usually the latter, though).
- Cone of Shame: Spitsy is never actually seen without his collar, and it enhances his goofy appearance. Fitting, for a dumb dog as him.
- Dogs Are Dumb: Nate constantly calls him an idiot for getting beat up by squirrels and going out for parties with Francis's cat.
- Glomp: His preferred way of greeting people, especially Nate.
- Interspecies Romance: Is dating Francis's cat, Pickles. Don't think on that one too hard.
Nate's lazy uncle who still lives with Nate's grandparents.
- Basement-Dweller: He lives with his parents and spends most of his time watching "Battlestar Galactica".
- Casanova Wannabe: Has shades of this, such as when he tried to flirt with one of Nate's neighbors when she was visiting. She didn't really catch on, and Uncle Ted was disappointed when it turned out she was married.
- Lame Excuse: He's the king of lame excuses, and managed to completely get out of helping Nate paint his grandparent's house with such excuses as "I feel a touch of malaria coming on" and "I probably wouldn't even know what to do with a paintbrush".
- Lazy Bum: Hoo boy. As if "still lives with his parents" wasn't enough of a hint.
Breckenridge Puffington III
A new kid introduced in "Big Nate Lives It Up".
- Adorkable: Taken Up to Eleven, with his extensive knowledge about plants and flowers making him annoying at times, but remains a positive person.
- The Bully: Used to be this.
- Karma Houdini: Breckenridge was a bully to Nate as a toddler, but he always got away with it. Later, though, Nate forgives him and they remain friends.
- Nice Guy: He is like this now, but as a toddler, on the other hand...
- The Smart Guy: He knows everything about flowers.
- Smart People Wear Glasses
ShermanNate's class hamster who spends his days snarking at the class' antics.
- Deadpan Snarker: His only "lines" consist of him making snide commentaries about Nate and his classmates, especially when they start fussing about him. Here's one of his gems:Nate: It's a cheesy trinket! Sherman deserves something more dignified!Sherman: At this point, the dignity ship has sailed.
- Silent Snarker: Well, he isn't a Talking Animal, so nobody in-universe can actually hear his snark.