- Take a drink every time Teddy and Francis make a tag-team burn on Nate.
- Take a drink every time Nate says, "Oh, how I hate her."
- Take a drink every time Dad's the butt of a joke. Take two if the joke's about his flab. Take three if it's about his baldness. Guzzle if it's about anything else.
- Take a drink every time Nate tries to flirt with Jenny.
- Take a drink if anyone (Nate included) says "Cripes" or "Behold the power of Chad!"
- Take a drink every time Nate makes an insulting comic about Ellen.
- Take a drink whenever Nate's locker explodes. Take two if Nate is unaffected.
Drinking Game / Big Nate
With its fair share of Running Gags, expect liver failure if you play this drinking game.