- Take a drink every time Teddy and Francis make a tag-team burn on Nate.
- Take a drink every time Nate says, "Oh, how I hate her."
- Take a drink every time Dad's the butt of a joke. Take two if the joke's about his flab. Take three if it's about his baldness. Guzzle if it's about anything else.
- Take a drink every time Nate says, "Jenny, m'lady!"
- Take a drink if anyone (Nate included) would say "Cripes."
Drinking Game / Big Nate
With its fair share of Running Gags, expect liver failure if you play this drinking game.