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Big Nate has been around for over 20 years. So, it's expected that it gets in some hilarious stuff.
In one strip, Nate and Francis are binder-shopping. Francis spends the majority of the strip raving about the awesomeness of binders he finds. He then asks Nate which binder he'll take. Nate takes a binder, whacks Francis in the head, and then buys it.
Nate is explaining comic gags to Chad. He says that in comics, you can have the gag happen in the second-to-last panel and then have the last panel be a reaction. Cue a monkey run past them.
Nate: Now, Where was I?
Prank Day, 2008.
Francis: Somebody let a flying squirrel loose in the computer room.
Nate: Yeah, that was me.
Teddy: A squirrel? Isn't that kind of tame for the guy who calls himself "Mr. Prank Day?"