The main family:
Darryl MacPhersonA well-meaning, long-suffering father. Occasionally does something ill-advised but means well. More intelligent than the typical example, but has his foolish moments. Works in a typical office job.
Wanda MacPherson (née Wizowski)Darryl's wife, the mother of the strip's main family. Down to earth to the point of being a bit cynical, she nevertheless cares about her family and does her best to work with them. A stay at home mom, and heaven help you if you tell her that it's not enough work by itself.
Zoe MacPhersonThe eldest child and older daughter. Though about 10 years old, she acts like a spoiled teenager. Frequently bratty and self-absorbed, but less likely to actually make a mess these days than her brother, preferring whining and mocking to actual destruction.
Hamish "Hammie" MacPhersonZoe's younger brother, the middle child, and the MacPhersons' only boy. A typical young boy, goes through the world like a hurricane, leaving broken glass and dirty fingerprints in his wake. Hammie is fond of rude noises and gross things. He enjoys annoying Zoe, but will team up with her on occasion.
Wren MacPhersonThe youngest MacPherson, she is still an infant. May be the sanest of the bunch.Other characters include:
BunnySomwhat of a cross between Martha Stewart and Barbie, she and her rarely-mentioned husband, Butch, are the overly-perfect young couple down the street. Their children include one of Zoe's playmates, named Bogart, and infant twins, both named Wendell.
Yolanda, Mike, and familyYolanda, Mike, and their daughters Keesha and Dziko (commonly called "Dizzy") provide a Black Best Friend for each of the MacPhersons, except Hammie. They don't have big personality traits or provide any role bigger than being the MacPhersons' neighbors and friends.