"I will not attempt to pick our son's wife based on whether or not she can feel a pea through a stack of mattresses. Any woman dainty enough to feel a single dried pea through one mattress much less dozens of them, is far too dainty to ever give me grandchildren."
So, you've grown up and flown the nest. When you look in the mirror, you see a confident, sassy young woman (usually) with a great career, and everything to be proud of.
Well. Not quite. See, your parents know that the only way you'll truly make them proud is to pop out a few kids of your own, allowing them to live their dream of being grandparents.
The reasons for this can differ from parent to parent. Maybe they really do think the only way for their child to be happy is to have children. Maybe they think the only reason you exist is to give them what they want. Maybe they just want some cute kids to dandle on their knee and show photos of them to strangers. Maybe they need someone to carry on the family name. Maybe they want all the joy of children with none of the responsibility of raising them. Or maybe they just want to watch you endure all the torture you gave them. Or, if you want to go by evolutionary psychology on this, the entire point of life (as much as life can be said to have a point) is to produce healthy—and fertile—grandkids, as it means that your genes have passed the test of natural selection.
Either way, you can bet they'll be taking every opportunity to remind their children that their biological clock is ticking, and they should hop to it and make some kids. If the children resist, they can expect to be treated to Not Wanting Kids Is Weird.
Expect things to be awkward if these parents get introduced to a new love interest, or even an opposite sex friend.
If the child is bereaved, this may be one reason why they urge them to seek out a new partner, telling them You Have Waited Long Enough.
This can be Truth in Television, to a rather extreme extent.
Compare Siblings Wanted, where it's the characters' own children who demand from them to get busy (again) rather than their parents.
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Anime & Manga
Present in Kage Kara Mamoru!. Since the line of Kagemori ninja needs to continue, Mamoru's parents are very pushy when it comes to these matters. For example, when he was possibly going on a date with Hotaru, he comes home to find that his parents have already named his and Hotaru's child.
One reason why Grandma Godai uses her funeral savings to pay for Godai and Kyoko's wedding is that she wants to see her great-grandkids.
Kyoko's mother is constantly pushing Kyoko at Mitaka, but when she discovers that Kyoko is fighting with Godai, she immediately begins asking about him, and encouraging Kyoko to forgive him for whatever it was that made her mad (accidentally proposing to another woman) and hurry up and get married. It greatly annoys Kyoko.
Used along with a subversion of Virgin Power in Devil Hunter Yohko: Yohko's grandmother impresses on her that a Devil Hunter must be a virgin to take on the power — but once they've acquired their powers, they can go ahead and have sex! In fact, guess who wants great-grandkids...
Similarly, her Mother wanted her to go out and get laid as soon as possible, presumably to avoid the whole Virgin Power thing.
Kei's mother in the manga Houou Gakuen Misoragumi is so worried about the possibility that her daughter won't end up giving her grandchildren that she tricked her into going to an All Boys School; while this would be a secret fantasy for most girls, it's a nightmare for Kei due to a number of reasons. First, the Principal has threatened to erase her if she tries to expose herself as a girl (thus runing the school's reputation); second, she is allergic to guys which makes her throw up a lot; and lastly, she is a lesbian (it is this fact that the mother is trying to cure).
The grandmother in Otome no Iroha came back to life due her concerns that her two grandchildren, Iroha, a masculine girl, and Hifumi, a feminine boy, won't be able to get married and continue the family line due to their gender dissonance. Her solution: magically Gender Bend them.
In the Mai-Otome Arashi manga, Lena Sayers hopes for this.
Japan Inc: Ueda's mom comments that Miss Amamiya (his boss!) has the right shape to get many children, hint hint. When the latter can hear it.
Lady Ramia expresses this desire in the Vampire Game epilogue.
"Vord! Baby! Now!"
Mentioned in a Naruto flashback, when the Konoha children and tenagers are banned from joining the adults in fighting the Kyuubi on the loose. The one leading the operation is Kurenai's father, who tells the trope almost word by word to not just his daughter but to the boys he's taking to safety as well.
Notable in that this was more a case of More Expendable Than You than pressuring his child to have children. He's in no rush to be a grandfather; he just wants his kid to live long enough to have kids.
In Rosario + Vampire, both Mizore and Kurumu's mothers tell them that they expect Tsukune to pop out some kids with them, much to his chagrin. Highly justified in Mizore's case, as her people hit menopause in their mid twenties, leaving them a very narrow window in which to produce the next generation.
In High School D×D, Issei's parents are happy when they see him genuinely interacting with girls. They expressed a fear that they would never have grandchildren because Issei is a perverted idiot who spends most of his time ogling girls or his Porn Stash instead of actually talking to them.
In Circles, Marty's grandmother wants grandkids, even after she finds out her grandson is gay.
Even Wonder Woman gets this from her mother, Queen Hippolyta, when she introduces new love interest Tom Tresser. Is no-one safe? Granted, this was during a time when Diana and Hippolyta were the only two Amazons left which strongly influenced how they were thinking.
And of course, Hippolyta was so desperate for a daughter that she moved the gods into miraculously creating Diana. She just really seems to like kids.
She's not alone either. One Amazon lead the others into revolt mostly out of envy that Hippolyta got to be a mother and she didn't.
In one MAD parody of Cathy, the titular character's mother decides to prevent her from getting an abortion by burning down the local abortion clinics and having two pro-lifers move in with her, even though she was date-raped. Even though she justifies it by saying that she doesn't want Cathy to violate God's laws, she admits after hanging up that "The need to be a grandmother overrides all else."
Not that Mad Magazine was exaggerating much. In the strip, her mother constantly nagged Cathy to marry so she can give her grandkids, to the point that she sent cards to Cathy's ex-boyfriends. The nagging only increased when Cathy did get married, to the point when Cathy and Irving even suggested the idea of kids at their age, she came storming in with material to help them out. When Cathy announced she was pregnant in the final strip, her mother fell to her knees in jubilation.
In Sin City, Senator Roark has his son undergo unorthodox (putting it mildly) methods to regrow his shot-off genitalia, which have unfortunate side-effects, so Senator Roark can have a grandchild to carry on his legacy.
This might be one of the reasons Galactusstops his estranged daughter Galacta's attempt to destroy the "Tapeworm Cosmic" (actually the larval form of Power Cosmic entities like Galactus and Galacta) near the end of her one-shot. He doesn't want her or his unborn grandkid to be destroyed.
Ninjette's parents from Empowered had this plan for her, but it's even worse than most examples and not played for laughs: They plan on cutting off her limbs and basically turning her into a Baby Factory. Another ninja basically let herself be sterilized to avoid this same fate.
Vandal Savage wants his daughter Scandal now formerly of the Secret Six to have kids. This is not going to happen with Scandal's consent for a few reasons: 1) Scandal hates her father, 2) she is a lesbian with absolutely no interest in the opposite sex, and 3) she is convinced (with good reason) that the only reason Vandal wants grandchildren is so that he can harvest them for organs to sustain his immortality.
A hilariously pragmatical example can be found in chapter ten of Don Rosa's The Life and Times of Scrooge McDuck, where Beagle Boys conclude that four of them against Scrooge is not enough anymore, so Blackheart Beagle tells his sons that "You boys need to start raising families. We need more Beagle Boys", which prompts one of them to make an Aside Glance.
In Empire State, the protagonist's mom sets him up on a blind date, and explains:
Mom: I'm fifty-five already. I just want to see the face of my grandson before I die. Jimmy: Geez, Ma.
A short Hellboy story has Kate Corrigan dealing with this. From her mother's ghost.
In Garfield, when Jon's parents were introduced, one of the first things we hear Jon's mother say (besides "Eat, eat, eat!") is "You meet some nice girl. Settle down. Start a family." She never touched on the issue again… that is until Jon and Liz started dating.
Ranma ½Fanon traditionally has this as a major motivation for Ranma's mother, Nodoka. This probably arose as a way to justify her concern with Ranma's "manliness" with the opposite sex, especially since he spent most of his life away from her during his training trip. Canonically, both of the fathers want Ranma to "carry on the School of Anything-Goes martial arts", which would involve grandchildren.
This pops in so manyDragon Ball Z fanfics, it's not even funny anymore. Chichi is the usual culprit, despite the fact that she's usually nagging her sixteen-year-old son while she still has a seven-year-old at home.
In the Oneiroi Series, the only reason Redcloak'smother is willing to give Vaarsuvius, an elf, a chance with her son is because of this trope. That, and they already have a kid with each other and a second on the way.
In Child Of The Storm Frigga is a mild version of this: she really wants to meet her grandson, and more grandbabies would be nice. She's teasing her son. Mostly.
Nobody Dies: Lilith, progenator of humanity. Simply being in her presence compels humans (of opposite gender) to think of one thing and one thing only. Babies.
Kyoko invokes the trope by name after Shinji and Asuka's first time.
Eakins Hard Reset: Twilight's mother feels this way. The fact that Twilight's a lesbian only means she expects both her and her future girlfriend to churn 'em out.
Nyx's Family: Twilight Sparkle's mother has been standoffish and fearful ever since Twilight adopted Nyx, the filly version of Nightmare Moon... till the moment she sets eyes on the filly.
That instant, she realized that nagging fearful voice had a competitor. The moment she clapped eyes on the tiny, wide eyed little black filly, a second voice had come roaring up behind the first, chased it down a back alley of her mind, and gleefully stomped it into the mud: "I'm a Grandmama!"
The Mixed Up Life Of Brad: Celestia playfully asks this of Cadence (who is her protege and thus the closest thing she has to a daughter.) Cadence responds by revealing to her "auntie" that she is, indeed, pregnant.
A justified gender-inverted example in Empath: The Luckiest Smurf, in that since there's only one adult female Smurf among them who's about the same age physically if not chronologically as her fellow adult male Smurfs, Papa Smurf is hoping that one of his little Smurfs would marry her and have children so that their people would not die off. The only problem with that idea was that Papa Smurfwas also in love with Smurfette, and in an alternate timeline even marries her.
In Bride and Prejudice, the Bollywood version of Pride and Prejudice, this is a great concern of the Mrs. Bennett equivalent. The original Mrs. Bennett was more concerned about impending homelessness.
The last line of the adorable Chinese film Saving Face involves Wilhelmina's mother asking when she can expect grandkids from Wil and her girlfriend. This prompts a Spit Take. What makes it funnier is that Wil's mother has just had a kid with her boyfriend, so it's not like she needs a baby right then.
The King from Cinderella has this bad, to the point where he takes the prince's comment about how he'd marry the girl Cinderella's slipper belongs to (not knowing her name) literally, and tries to find any girl that will fit the slipper, regardless of if it's the same one. Justified, since producing heirs (and having his heirs produce heirs) is the only way a royal dynasty can survive. This, however, averts Heir Club for Men when the King actually dreams about doing 'grandfatherly' things like playing horsie with a grandson and granddaugher
Present in Toy Story 3 in sentiment though not literally (in light of the toys-as-parents metaphor) when Woody mentions, "Someday, if we're lucky, Andy may have kids of his own."
Kevin Flynn's smile at his son Sam and Quorra's growing interest in each other in TRON: Legacy suggests this.
Apocalypto: Poor Blunted is apparently impotent. His hunting buddies find ways to tease him about this when on a hunt, and he returns to find his mother-in-law completely uninterested in the meat he's caught, but hollering out this trope to no end. Mother in law grabs her daughter and all but pitches the two of them into the tent with orders to get busy. Poor, poor Blunted. This is the day the old huntmaster also chose to pull a practical joke on him regarding his ineffectual genitals. Think, son, why would Gramps be carrying Jungle Viagra on him during a hunt? No good reason. But Jungle Heat Rub?
Imagine Me And You: One of the reasons why Tessa tries to talk her daughter Rachel out of the whole "being gay"-thing.
Jehana to her son Kelson before he leaves for Torenth in King Kelson's Bride: "All apart from Gwynedd's need for an heir, I would have grandchildren to dandle on my knee."
Honor Harrington's mother is obsessed with getting her daughter knocked up and drops hints about bring vials when she meets her boyfriend. Since they can raise the babies in tubes, it's not even a problem that she's an active duty navy officer. In some ways not having grandchildren actually creates huge problems when Honor is believed dead due to inheritance laws being complicated.
In Agatha H. and the Clockwork Princess, one Jager is a nuisance to his great-great-grandson owing to his wanting great-great-great-grandchildren. It is noted that many Jagers have hobbies trying to reconnect with the humanity they left behind him, and preoccupation with his family is his, and has nearly wiped out his descendents.
In The Decline of the West, Oswald Spengler gives the justification for this trope: "He does not entirely die who lives on in sons and nephews."
In Seanan McGuire's October Daye novel Rosemary and Rue, Toby suggests that the message Luna is trying to send Connor is that she wants him, and her daughter, to give her grandchildren. Connor points out what would Luna do with a grandchild?
Live Action TV
In Frasier, Daphne has a dream in which her mother shows up to do just this. And when Gertrude moves to Seattle, that dream becomes a constant reality.
Don and Charlie's father in NUMB3RS isn't too pushy about it, but he does give his sons the occasional nudge.
Black Books: When Manny's parents believe he's dating Fran:
Manny's mother: People are leaving it too late these days, and I don't think that's wise. Fran: Leaving what late? Manny's mother: Babies.
Both Ross and Emily's parents in Friends seem to be keen on the idea, since Ross threatens them with "No Grandkids!" when they are squabbling at his wedding. Ross' parents already have a grandson prior to that event, but they frequently forget about Ben, as well as about their own daughter Monica.
In the CBC adaptation of Douglas Coupland's jPod, Carol is continually pressuring Ethan for grandchildren.
In The Nanny, Fran's mother was very obsessed with having grandchildren from Fran, despite the fact that her other daughter has several children. It's stated several times that Yetta nagged Sylvia about giving her grandchildren years ago.
Discussed in an episode of Designing Women. Mary Jo tells the story of the first time she visited her parents after being married. They told her they weren't comfortable with her and her husband having sex under their roof, then spent the entire trip pestering them for grandchildren.
Living Single has Laverne Hunter who finds a way to work in the need for her daughter Regine to 'settle down and put some beans in that oven'.
In 30 Rock, this is a major source of tension in Liz Lemon's otherwise ideal relationship with her parents.
Marie in Everybody Loves Raymond, to the point of making a "love nest" for her son Robert and his wife in their house complete with Barry White CDs. Robert moans "I can't breed in captivity!". What makes this an interesting case is that she already has three grandchildren but because they are no longer excited to see her when she comes over (due to both growing out of it and, as Debora pointed out, simply by virtue of her spending more time at their house than her own) and simply wants new ones so she can "be grandma" again. Marie is generally considered one of, if not THE, most selfish, self centered characters on the show because of actions like these.
Variation occurs in the "Look at the Princess" trilogy of Farscape. A Sebacean princess can only become Empress if she marries a man who can provide her with viable offspring and thanks to DNA poisoning by her brother, only John can "put the sword IN the stone" as he puts it. For good measure, on their first meeting, the current Empress tells John "I expect sturdy grandchildren from you."
A particularly obnoxious (and, thanks to the Imagine Spot inserts that were a motif of the programme, hilarious) incarnation of this kind of parent was added to the BBC's 2009 sitcom Reggie Perrin. This was a new addition for the remake- in the original, The Fall and Rise of Reginald Perrin, Reg hated his mother-in-law and had two independent adult(ish) children. Possibly it was felt that, as the actors were very slightly younger and middle-class people like the Perrins now have children rather later, they would be unlikely to have children that old, and the dynamic would be different if their children were still young.
Full House. Despite having three granddaughters, throughout the second season Jesse's parents pestered him to marry Becky so they could have more grandkids.
In an early episode of The Cosby Show, Claire's mother explains the trope:
Claire's Mother: "You know, when you and Cliff got married, what did I say?"
Claire: "You wanted me to have a child."
Claire's Mother: "You know why?"
Claire's Mother: "If you want the joy of a child without the bother, There's a perfectly simple answer."
Claire's Mother: "They're perfect. If you don't like them, you go home."
In Game of Thrones, Lord Walder Frey constantly expresses this. Although for him, it's less about the grandkids and more he wants his many, many children to finally get married and move out of his house.
The Bible has this in Genesis, as the first thing God tells his living creations is to "Go forth and multiply". By extension, He also expects this from the animals. To drive the point home, after Adam and Eve sin and become mortal, God promises to multiply Eve's "conceptions," though this is possibly so there would be saints to replace the souls who would be damned.
In the story of Apollo and Daphne in Ovid's Metamorphoses (making this trope Older Than Feudalism): "Saepe pater dixit 'Generum mihi, filia, debes.' Saepe pater dixit 'Debes mihi, nata, nepotes'". "Often [Daphne's] father said, 'You must [give] me a son-in law, daughter.' Often her father said, 'You must [give] me grandchildren, daughter'".
Since Garfield's owner Jon is regularly dating Liz the veterinarian, his mother comes right out and says she wants to see grandchildren before she dies.
Garfield: Moms are not masters of subtlety.
Shows up a lot in Cathy. It's to show the differences between the attitudes and aspirations of Cathy and her mother; Cathy wants to further her career; marriage and children were not high on her priority list. Although, much to her mother's delight, both eventually happened. Meanwhile, her mother was raised with the idea that a woman's purpose in life is to get married and produce Babies Ever After.
In Baby Blues Wanda's sister has a rather strained relationship with their mother due to constant badgering for grandkids. Wanda already has kids so she doesn't get ragged on as badly.
Eli Vance in Half-Life doesn't take it to extremes, but he does tease his daughter Alyx about her affection for the hero because, "can you blame an old man for wanting grandkids?". This comment was particularly significant because it was made shortly after the destruction of a device that the occupying alien force had set up the to make human reproduction impossible.
If you marry Nera in Dragon Quest V, Nera's mother will pressure Nera to have grandchildren right after you're married. She eventually does, giving you twin children, a son and a daughter. Strangely, she doesn't say this to Debora, her other daughter. Though she gets the two grandkids either way.
If you spared Teryn Loghain and married Anora (only possible as a male Human Noble) in Dragon Age: Origins, Loghain will reappear in Awakening and remind you that you have a duty to produce an heir. Ostensibly it's because the Ferelden throne needs a clear line of succession, but this trope is probably in play as well. However, the game implies that having children can be difficult for Grey Wardens.
The opening of King's Quest VII: The Princeless Bride opens with Valanice attempting to marry Rosella off and listing who she thinks are suitable candidates. Rosella is less than thrilled with the idea. Yes, it's justified by the fact that Alex took up ruling the Green Isles, leaving her as Daventry's only heir. Still, she's no more eager to be "up for auction" than her dad was in King's Quest II: Romancing The Throne.
Older Family-oriented parents in The Sims 2 will often have a want to get grandchildren sometimes as soon as their oldest child progresses to adulthood.
This returns in The Sims 3, where Sims will often roll the "Become a Grandparent" wish as soon as their grown child gets married. (If said wish is fulfilled, the new grandparents may then wish for five grandkids altogether)
If you get Fayt's ending with Adray in Star Ocean: Till the End of Time, Adray makes it clear that he intends for Fayt and his daughter Clair to get together for this purpose. Clair is not quite as supportive of this (she calls her father into the other room, then beats the crap out of him). It's a bit more subtle in his solo ending where he has Clair's subordinates in a push-up competition for the right to marry her.
Tales of Graces: Lady Kerri Lhant makes it abundantly clear that she wants Asbel to settle down and have a child. Much to Asbel's chagrin, she already has marriage proposals ready.
The plot of True Love Junai Monogatari is tied to this, in a way. The PC's father is desperate to see his son married with kids, so he forces the PC to live on his own in a family-owned apartment so he will look more independent anf attractive to any prospect girlfriend...
When Roy leaves the Heavenly Mountain, his mother Sara instructs him to marry his girlfriend and get her pregnant. Celia isn't the same species or even from the same plane of existence as Roy, although the strip takes place in a RPG Mechanics Verse where Half-Human Hybrids of every sort are possible.
Apparently, Roy's mother would get along well with Celia's.
Oggie, despite not being human anymore, is very concerned about the continuation of his family line. His great-great-grandson is currently in hiding to avoid being pestered about when he'll settle down and father some great-great-great grandchildren. Oggie's great-great-grandson also made the mistake of telling his ancestor he'd "get married when you find a Heterodyne!" As he shortly discovers, that's not as far-fetched as he'd thought. Oggie's response? "Iz going to be great-great-GREAT grandpapa!"
Castle Heterodyne has a bit of this, what with pestering Agatha to get busy making the next generation of Heterodynes and pointing out that she has two healthy available young men around.
In Schlock Mercenary Kaff Tagon's father berates him about his life in general, and not producing grandchildren. Eventually he steps it up a notch.
Kathryn: So instead of nagging your son about producing grandchildren, you nag women who may or may not be remotely interested in him? General Tagon: This is a new tactic. I guess I do both. Kathryn: For as stupid as your selfish DNA is, I'm surprised you were able to reproduce at all. General Tagon: The boy's mother used to say the same thing.
Drowtales contains one of the most horrific instances of his trope in fiction with the relationship between Quain'tana and her daughter Mel'arnach. Basically, she couldn't have children anymore but needed an heir, so she wanted to get one from her daughter — by force. And to rub salt in the wound once the child (Ariel, who was actually born from a consensual relationship with another elf turned giant spider) was born, she was taken away from her real mother and raised without knowing her true lineage or even seeing her real mother for 10 years, did not know their real relationship for over 30 chapters. Minus a single, non-canon and very spoilerific chibi page (which indulge in Black Comedy anyway) this is not played for laughs at all, and many fans consider it a Moral Event Horizon crossing for Quain'tana. After a 10 year timeskip it's also shown that in exchange for not killing Mel after she came back after running away (again) Quain has gotten her wish and Mel already had two more children with a third on the way, and though her circumstances are better Mel still lives in a Gilded Cage and the two young children are being raised elsewhere.
In Kevin & Kell, Desdemona Fuscus is seen asking Kell which of them should be the first to bring the topic of grandchildren up to the recently married Fenton and Lindesfarne.
Faye once became depressed that Davan didn't seem like he would ever settle down and Dahlia was on the record that she didn't want kids. She briefly considered finding a way to trick Davan and his girlfriend Branwen into getting pregnant (to Fred's surprise, since she's usually the sane one in the family).
Chirag is gay. His parents know he's gay, but they don't know that he knows that. His brother and sister are also gay, and once they came out of the closet their parents immediately started bugging them about settling down and having kids. To avoid this, he still pretends to be in the closet when they visit him, begging his female friends to play The Beard.
Takeru Oyama in Ménage à 3demonstrates the trope within seconds of meeting his daughter Yuki's new boyfriend Gary. Faintly creepy, or at least Freudian, in that his relationship with Yuki has previously been difficult, and that's largely because childhood exposure to the tentacle-pornHentai which he created damaged her psychologically.
In Evil Inc. Lightning Lady's mother starts off discussing her daughter's scandalous wardrobe (LL dresses like a typical comic book supervillainess), but when her daughter protests she mentions grandchildren. Lightning Lady goes back to the conversation about her costume .
In Fans!, when Rikk and his wife Aly formed a polyamorous union with Rumy, Rikk's conservative mother did not take it well and nearly stopped speaking to her son. Later, at dinner with Rikk's parents, Rumy accidentally let it slip that she was preparing to act as a surrogate mother for Rikk and Aly (Aly wanted a baby but due to a disease that nearly killed her before she did not have viable ovaries, and Rumy was too active as a member of AEGIS to carry a baby to term, so Rumy conceived the child with Rikk, and then doctors used alien-tech to transplant the fetus into Aly's still-functioning womb). Rikk's mom then approached Rumy, hugged her fiercely and declared, "You're my new favorite daughter-in-law!" Her desire to be an active part of her grandchild's life won out over any objections to her son's unconventional lifestyle.
Adam: Her parents were very presumptuous about grandkids.
The Lizzie Bennet Diaries: Mrs. Bennet's only goal in life is to have her three daughters married. According to Lizzie, she once cried hysterically: "It's your fault if I die without graaandbabiiieees!"
Not Always Right has this story, where an older woman freaks out about her age and mentions trying to pressure her 30-year-old daughter into dating for this purpose.
Amy's Mom: We met a nice boy in the cabin next to ours. Amy's Dad:He's not very ugly. Amy's Mom: You should marry him. Or at least use him to conceive a grandchild for us. Amy:I already have a boyfriend. Amy's mom: Really? Then where is he? Amy's dad: And why isn't he here right now, fathering our grandchild?
Amy: Mom, Dad, I know this is weird but— Mrs. Wong: Yeah, yeah. We don't care how squishy alien get pregnant. All we care is that we have grandchild now! Kif: You're very open-minded, Mrs. Wong. Mr. Wong: Hey! You call her "Grandma" now! Mrs. Wong: Call me Grandma like crazy! All the time!
In a later episode, they bug Amy again. Possibly they were disappointed that their grandkids are tadpoles who have about a decade or two until they metamorph into children.
There's the episode where the crew (including Amy) are all reverted to their early teenage years:
Mrs. Wong: This is like a mother's dream! (beat) Bad dream that is - at this rate I'm never going to get a grandchild!
The episode "The Burns and the Bees": When Marge is asked what her greatest fear is, she instantly replies: "Never being a grandmother."
Another episode Marge was despairing that she wouldn't see her children grow up and start their own families, etc.
In King of the Hill when Bobby has joined a cult of geeks — after he got sent to the Principal's office for what they think is witchcraft — when Hank and Peggy are called over; Bobby does this dance to provide a positive vibe. Peggy says:
"I may be a mother, but I am also a woman, and I know a girl repellent when I see it. I. Want. Grandchildren, will you fix this!?"
On Daria, the title character writes about a story about her family's ideal future. Quinn already has five kids, but Helen still prods Daria and her unseen husband to start a family of their own.
On Scooby-Doo! Mystery Incorporated, Mayor Jones and the Sheriff are having lunch when they spot Fred completely fumbling his date with Daphne. The Mayor groans and says that at the rate Fred is going, he's never going to have grandchildren.