The only members of Hellsing alive after the Valentine brothers attack are Walter, Integra, and whoever was on vacation that day (Victoria and Alucard don't count). The next assault on Hellsing leaves only two alive (not counting Victoria).
Berserk: At the end of the anime, almost the entire Band of the Hawk gets brutally slaughtered by demons in a manner that exemplifies numerous primal fears. The only ones to make it out of the Eclipse alive are Guts and Casca, and neither of them make it out whole, if you knowwhat we're talking about. Enjoy knowing the endearing, Badass Normal minor characters while you can.
Played as a joke/Shout-Out to Red Dwarf in CLANNAD. When Sunohara wakes up after falling asleep in class, Okazaki plays a prank and tells him that the world has ended; He is actually a hologram and Sunohara is the only person left on Earth. Naturally, Sunohara freaks out and asks whether this is true. Okazaki then admits he's lying; he's actually a cyborg. This serves to freak Sunohara out even more.
Vexille does this soon after The Squad infiltrates hostile territory, with only the titular Action Girl apparently surviving the slaughter. It is later revealed that her lover The Captain also survives but he doesn't reappear until the end of the movie.
JoJo's Bizarre Adventure is infamous for frequently killing off protagonists near the end of each arc. It's especially prevalent at the end of the sixth arc where everyone on the entire planet, including all but one of the protagonists, who wasn't even the main focus of the story, and the Big Bad, have been killed off. Thankfully most of them get better.
In Saikano, the main character is the only one left on the desolated Earth at the end.
Code Geass seems to start like this: Before the first episode is even finished, it seems that everyone who could have been a supporting character in the story is dead, and only in the subsequent episodes do you find out that C.C. and Suzaku both survived getting shot.
This is the situation near the end of Sailor Moon, but (fast) everybody gets better at the end
In Alien of Darkness, there is only one survivor.
In the most recent arc of Katekyo Hitman Reborn! Tsuna and Co. are transported 10 years into the future where they are told many major supporting characters have been killed by a rival mafia group. Including all the arcobalenos (including Reborn), Yamamoto's father and even Tsuna himselfnote Though this is later revealed to be false. Tsuna's parents, Vongola 9th boss, Shamal and Naito Longchamp are still MIA.
In Higurashi no Naku Koro ni, Tatarigoroshi-hen and Yakusamashi-hen end like this. In both instances, the point-of-view character (Keiichi in the former and Satoko in the latter) is the sole survivor, and for similar reasons; they both fall off the same bridge into a river that carries them out of Hinamizawa. Although they survive it, they eventually die shortly thereafter.
Also occurs at the start of the second series, subverting the happy ending of the first series with Rena being talked down by Keiichi. Turns out everyone was killed in a "gas leak" (yeah right) except for Rena, who happened to be out of town at the time. Unlike the previous example however, Rena really does survive the incident, and presumably leads the rest of her life out.
Actually, in the sound novels, it's revealed in one of the TIPS that Keiichi survives, but he's completely mentally broken, thinking that he was the one who had caused the disaster. He spends the rest of his life in a mental asylum, until he died of a heart attack.
In Fullmetal Alchemist, Scar initially believes himself to be the only survivor of the Ishval genocide.
In later chapters of the manga it is revealed that Hohenheim was originally a slave in Xerxes, and when Father tricked the king into using the entire population of the country to create a philosopher's stone only the two of them survived.
And in an even later chapter Father kills everyone in Amestris besides Ed, Al, Hohenheim, Izumi, Roy, May, Pride and Greedling. Of course, it happens at the end of a chapter in a series known for cliff-hangers, so not all of them stay dead.
Kakashi's Back Story is like this too. In relatively rapid succession, his mother, father, best friend, mentor, mentor's wife, and other teammate all die. It's apparently for this reason that he joined ANBU at age fourteen. Much later, when Sasuke half-threatens to kill someone important to Kakashi to make him feel his pain, Kakashi simply replies that everyone he cares about is already dead.
The Saiyans. The entire population, likely to be in the single-digit billions, is reduced to four eight, if you're going by the movies and specials in a matter of minutes. Going against Dragon Ball's usual 'death has no consequence' vibe, the Saiyans are Killed Off for Real.
After lots of building up to the moment, in chapter 352 of Mahou Sensei Negima!, it is apparent that, while Asuna has been asleep protecting the Magic World, everyone she knew has died - even Negi, who supposedly has an immortal body, and Ayaka, who lived to the age of 115 to try to meet Asuna at the time she was supposed to wake up. However, it's sort of subverted a little bit, since Evangeline and Chao, of all people, appear to still be alive.
There is the first episode of Ga-Rei Zero- in which everyone who gets introduced promptly drops dead before the credits begins to roll.
The first The Transformers comic book starts its Un-Cancelled run (pictured above) with the bad guys victorious and the good guys reduced to one pacifistic medic and a bunch of scrap.
Note that the above image has endlessly been parodied and imitated both within the official materials and fan-made works since.
In Robert Kirkman's The Walking Dead, the main character wakes in a hospital after being shot in a firefight — he's a cop — only to find the hospital apparently empty. Then he finds the zombies. The city is in much the same state. He does find survivors though, including his wife and son. Although it's not good news for the survivors either. It's a Zombie Apocalypse, so that's expected.
Near the end of Maus, Art asks his father Vladek what happened to Art's paternal family after the war. Vladek then explains briefly what happened to each of them as far as he knows. All except one brother who now lives in Israel died in the Holocaust.
Thorn, Gran'ma, and the Bones react as if they are in an Everybody's Dead situation after the Locust's volcano erupts about two thirds of the way through Bone, because they can't detect any other survivors. Lucius, the villagers, and the Veni-yan monks did survive, as well as most of the city of Athiea, and most everyone else who died came back when the ghost circles were destroyed at the end.
In The Punisher MAX miniseries Born, Frank Castle's last Vietnam deployment ends with him as the sole survivor of Firebase Valley Forge, surrounded by the corpses of all his comrades and the hundreds of Vietcong who overran the base. The Vietcong directly around him have all been beaten to death with the butt of his gun. None of the soldiers who show up to "rescue" him are particularly surprised at what he eventually becomes.
In The DCU mini-series Kingdom Come, viewpoint character Norman McKay has prophetic visions telling him that this will happen to Superman. In the end it happens exactly like that. Except instead of redshirts, it's an entire battlefield filled with most of the superhuman characters in the DC universe which gets hit with a nuke. There are survivors, thanks to Captain Marvel's Heroic Sacrifice, but most of them are dead, with Superman kneeling in the ashes, more or less unharmed but exceptionally angry. Kingdom Come is worth reading just for this — it's about the only time we've ever seen Supes in a true, unhindered, out-and-out homicidal rage.
The premise of the original batch of Marvel Zombies stories. The intermittently intelligent zombies don't know what to do since they ate everyone. Then, in the sequel, they have the same problem AGAIN, after eating nearly everyone in the entire KNOWN UNIVERSE. Hank Pym: "I can't believe we ate the whole thing.".
In the related Army of Darkness Versus Marvel Zombies, Ash fights through the zombie invasion from first bite to apocalyptic showdown. He's allowed access to Doctor Doom's dimension spanning machine and waits too long to make a choice of what dimensions. He ends up right back in a similar world of everyone's dead, except the super-powered zombies are now also werewolves.
In Miracleman the eponymous character discovers that his nemesis has killed virtually every single person in London. During the fight to stop the carnage from spreading they kill everyone else in the city. The issue ends with Miracleman crying over the body of his enemy's innocent alternate personality and sitting on a pile of corpses.
All of three or five characters survive in the end of 100 Bullets. Three if you count the ones who get away, five if you count Graves and Dizzy, both of whom are bleeding out, holding a gun to each other, and stuck in a burning building.
The end of the Wildstorm series Stormwatch has almost the entire team of superheroes killed by Aliens
The Magical Girl Lyrical Nanoha fanfic "Toward the World's End" invokes this. In fact, if you'll believe the author, it's based around it. In the first fic, "Lifetime Destiny" what may be the entire population of earth is wiped out. The only known survivors, under a eerie green sky, are the series protagonist Nanoha herself, and the fic's OC Protagonist, Arthur Kingston. Arthur manages to take Nanoha and himself to a deserted island, to spare Nanoha from having to see death and dead bodies everywhere as well, completely cutting them off.
This happens again when Nanoha, Arthur and the others return in fic number 3: Mission Fail.
According to the Author, the whole idea for the fic came from a dream that was this trope.
In A.I.: Artificial Intelligence, the boy robot is frozen in stasis while the world wastes away and humanity becomes extinct. Eventually, highly advanced robots come and put the boy in an alternate reality, also giving him back his mother for a day before permanently shutting him down and storing his mind as a historical archive.
Three Days Of The Condor plays this trope straight at the very beginning: the protagonist goes out of the office to get lunch and upon returning minutes later finds all of his co-workers, friends and love interest brutally murdered.
The Battle of Yavin in A New Hope ended with all the on-screen rebel pilots except Han, Luke, Wedge and a Y-wing pilot dead, with all of the dead pilots having only been introduced so they could fight in the battle. However, the Expanded Universe continues to write more and more just-off-screen characters into the battle.
Only two students out of the forty-two who make up the cast of Battle Royale survive the Program. And that's precisely one student more than was meant to survive and "win the game".
In the original book the "winner" was not one of the two survivors.
Sunshine : the movie's old website gushed about having each of the principle characters die.
Robin Hood: Blinkin, listen to me. They've taken the castle! Blinkin: I thought it felt a bit drafty. Cor, this never would have happened if your father was alive. Robin Hood: He's dead? Blinkin: Yes. Robin Hood: And my mother? Blinkin: She died of pneumonia while... oh, you were away... Robin Hood: My brothers? Blinkin: They were all killed by the plague. Robin Hood: My dog, Pogo? Blinkin: Run over by a carriage. Robin Hood: My goldfish, Goldie? Blinkin: Eaten by the cat. Robin Hood: (on the verge of tears) My cat? Blinkin: Choked on the goldfish. Oh, it's good to be home, ain't it, Master Robin?
Army of Darkness originally ended with Ash starting taking his magic potion, which he must take one drop of for each of the four centuries that he wishes to sleep, pauses to glance at a noise, and accidentally overdoses by one drop. When he wakes up, he's the last man on Earth looking over an apocalyptic wasteland screaming "No! I slept too long!". The Hollywood studio demanded a more kickass ending.
Another Russian film, The Dawns Here Are Quiet (1972), takes place during World War II and follows an army sergeant in command of an Amazon Brigade made up of utterly incompetent volunteers. They try to stop a German diversion group and succeed at the cost of all of girls' lives (while the sergeant survives until twenty years after the war),
In, Aliens, Ripley, Newt, Cpl. Hicks and Bishop survive. The aliens completely demolish the squad of marines. At the beginning of Alien 3, we learn that Newt and Hicks are killed while in hypersleep, leaving only Ripley and Bishop.
In Alien³, Morse is the only survivor. Ripley, impregnated by a facehugger in hypersleep, kills herself.
Prometheus Only Dr. Shaw and David the android (who was never truly alive anyway) survive out of a crew of seventeen.
The Quiet Earth: the quote says it all.
Zac Hobson, July 5th. One: there has been a malfunction in Project Flashlight with devastating results. Two: it seems I am the only person left on Earth.
The Mexican Standoff in Reservoir Dogs ends up with everyone in the room dead or near dead except for heavily wounded Mr White, mortally wounded Mr Orange, and Mr. Pink who promptly makes off with the diamonds (and gets arrested). Immediately after, Mr. White shoots Mr. Orange through the head and is shot dead by the police. NOW everybody's dead, Mr. Pink.
Ethan Hunt after the Prague mission in the first Mission: Impossible film. ("My team! My team is DEAD!")
Grig: Death is a primitive concept. I prefer to think of them as battling evil. In another dimension. Alex: Another dimension? How many are left? Grig: Including yourself? Alex: Yeah! Grig: One.
Gettysburg has a memorable exchange between General Lee and Pickett after the famous charge by Pickett's division resulted in said division being massacred. (Note that it's also believed to have happened in Real Life).
Lee: General Pickett, sir. You must look to your division.
Pickett: General Lee... I have no division.
There is a similar scene in When Trumpets Fade, a movie about the Battle of Hurtgen Forest in late 1944. A commanding officer asks his lieutenant, "What is the status of your platoon?" In reply, the shell-shocked lieutenant mutely hands his superior a pile of bloodied dog tags.
In Revenge of the Sith, all of the (appearing onscreen) Jedi are killed except for Yoda and Obi-Wan.
In The Incredibles, Mr. Incredible hacks into Syndrome's computer to discover that variations of the giant robot have killed off many former superheroes— perhaps all former superheroes except for Frozone, Elastigirl, and Mr. Incredible himself. Genocide makes for a fairly bleak subject in a family-friendly movie.
In Disney's Mulan, the protagonists are journeying through a mountain pass to unite with the rest of the Chinese army, only to find that the army and the villagers they were protecting have all been slaughtered, including Lee Shang's father. Later, the same thing happens to the antagonists after a devastating avalanche kills all but six of the Huns.
In Serenity, when the crew figures out that "Miranda" is a planet, the crew makes a perilous journey through reaver territory, to try to find out why Miranda is so important. When they finally land planet-side, they discover the long dead corpses of an entire planet's population. Of course there were once survivors, but they all turned into reavers.
Earlier, in the same film, after The Operative has been outwitted by the crew of Serenity one more time, he proceeds to have everyone who has ever provided shelter to the crew killed, en masse, including any inconvenient bystanders and Shepard Book. This is what pushes Mal into going to Miranda to find out just what the Alliance is trying to hide.
The Brest Fortress is a Russian film depicting the siege of the titular fortress. In the end, almost every character is dead, even Anya is told to be Executed by Germans, along with all other women and children, with the sole exception of the main character, who somehow escapes.
The fate of the entire "Odyssey" crew except for Julia. Bonus whammy points for this information being given to her by a clone of her own husband in Oblivion (2013).
Both versions of The Ladykillers end with a sort of inversion of the title; the entire gang ends up dead while the old lady survives.
Kainan's backstory in Outlander involves two separate instances of this trope. Kainan is a human warrior from a highly advanced civilisation far from Earth whose military colonised a planet after wiping out the indigenous population of Moorwen. One Moorwen survived and wiped out the entire colony, after which Kainan captured the dragon-like creature, only to crash land on Earth circa 709AD, setting it free amongst the Vikings.
In The Odyssey, Odysseus's ship sank, and only he survived to spend seven years with Calypso.
Eiji Yoshikawa's Musashi opens with one of these, the two main characters literally the only ones left after a battle. They even wake up to find themselves as such, too.
Markus Zusak's The Book Thief ends with the entire street where Liesel lives with her foster family being bombed to rubble by the American planes. Everybody dies, except for Liesel, who happened to be lurking in the basement, reading a book; Alex Steiner, who was working for the German Army as a tailor; and Max, who was in a concentration camp at the time. The only things keeping this from being a Diabolus ex Machina are that 1. The narrator is Death himself ("I do not wear a cloak with a hood unless it is chilly"), and 2. Since the prologue, the narrator has been informing the audience of how everyone is going to die. ("A fact about Rudy Steiner: he did not deserve to die the way that he did.") and 3. The bombings were plenty foreshadowed themselves. Saves this book from being thrown at the wall of many a reader's corner.
In Catch-22- by the end of the book, nearly all of the Loads and Loads of Characters are dead. But because they only died one at a time and each chapter only focused on a few characters, this realization doesn't really hit the reader until the last chapter, where there's hardly any left.
In Catch-22's sequel Closing Time, Yossarian and the chaplain are the sole survivors of a nuclear war that killed everybody on Earth. They then decide to commit passive suicide by leaving the bunker.
The ending of Sometime Never: A Fable for Supermen is similar to Closing Time mentioned above, as the world gets nuke-washed and all the humans are dead, the Gremlins move to the surface but found out when there's no human alive, there is no imagination to keep them existing. They fade out.
Happens three times in Terry Pratchett's Nation. A tidal wave kills everyone in Mau's village, leaving him sole survivor. A ship destroyed by the same wave leaves Daphne the one survivor (two, if you like parrots). Meanwhile, a plague has decimated England and wiped out (among others) the 137 people standing between Daphne's father and the crown.
The Day of the Triffids is a classic post-apocalyptic novel by John Wyndham in which the narrator wakes up on a hospital bed, and realizes that a freak space phenomenon (later implied to have been a malfunctioning orbital weapon) has caused everyone to go blind. The only people unaffected are those like him who were asleep, sedated, or otherwise unable to look at the sky. The resulting collapse of civilization causes most of mankind to die like flies, and that's when the killer mutant plants show up.
To be fair, the mutant killer plants were always there, just kept locked up and their dangerous stingers regularly docked.
In the movie, this scene happens as well, and it comes across almost like 28 Days Later... except after that he finds one other person, and then they do find some other survivors. Unfortunately, they happen to be on board a plane, and, due to panic and a blind pilot, they go down in a fiery crash, children included. It's extremely disturbing compared to the rest of the fairly goofy film.
John Wyndham books in general start with the end of the world (except Dave), and work their way up to a climax.
The book The Road by Cormac McCarthy is about a father and son as they travel south during what is suspected to be a nuclear winter. The father and son are all they have left.
Except not quite. The book is full of references to death-cults, sightings of and interactions with cannibals and their victims, an old man they share a meal and a fire with on the road, and a family of four who'd apparently been shadowing them, preparing to take the Boy in when the Father died from his illness.
Z for Zachariah - the only survivor initially is the young girl in the mysteriously unaffected valley, writing her diary.
Dragonlance has this. When Caramon goes forward in time, he find the entire world dead.
In "The Yarn of the 'Nancy Bell'" (the first of the Bab Ballads by W. S. Gilbert), the sole survivor of the Nancy Bell's crew describes what happened to the others.
Nevil Shute's On the Beach describes the reactions of the remaining survivors of an all-out nuclear war that has already destroyed most of the population of Earth. The characters are mostly Australians who are waiting for the fallout to reach them, but they know that they're already doomed.
At the end of The Chronicles of Narnia, Susan is the only character left alive. This isn't really a happy ending for her though if you think about it, since it ends focusing on the fact that her family and all friends of the family are now in heaven and she is, frankly, not.
King's Under the Dome. Only a handful survivors out of more than a thousand people trapped.
In his short novel The Long Walk, only one out of the original one hundred contestants in the titular endurance competition survives. The others were all killed when they couldn't keep up the pace.
The Star Trek: Deep Space Nine novel Fallen Heroes. Odo and Quark accidentally shoot themselves three days into the future with an alien artefact to find the station in ruins and everyone dead. There are then a series of flashbacks showing just what happened - aliens attacked the station looking for the artefact, which wasn't there as it had been sent into the future...they end up putting everything right by figuring out how to time travel back into the past again.
This is part of Willis Corto/ Armitage's backstory in Neuromancer. He was part of Operation Screaming Fist, a special-forces raid on a Russian base during The War. After being shot down, he and a few others managed to steal a helicopter and escape to Finland, only to be shot to pieces by the Finnish defense forces while they were trying to land. Corto was the only one to survive the escape. Automatic Jack, a central character in the short story Burning Chrome, was the only other survivor of the operation as a whole.
The Brief History of the Dead starts with this for the entire world, as one last survivor is stranded somewhere in Antarctica. The world of the dead is a bit more crowded—they don't fade until everyone who remembers them is dead, so she's preserving her friends, her family, and even the checkout worker at the grocery store she used to shop at. Then she dies, and away they go.
The Commander's Daughter by Y. Jakovlev is set during the siege of Brest Fortress. At the end, every named character is dead, except the heroine's mother (imprisoned by enemy) and the heroine herself, who makes an Unexplained Recovery, somehow surviving the whole mess (her prototypes also survived, but in-story this less explainable than in Real Life).
Olaf Stapledon's Last and First Men has almost the entire human race being wiped out in a nuclear holocaust with just 35 survivors. Their descendants eventually evolve into a new species of humans, which is promptly wiped out a bit later. This trend carries on, including the extinction of all life on Earth and then Venus (twice) until the 18th species of "men" is completely destroyed, along with the entire solar system, by a supernova a couple of billion years later.
The post-apocalyptic adolescent novel The Lake at the End of the World subverts the trope at the beginning when a teenage boy shows up at a farm and claims to be from an underground settlement of a few hundred people. The family that takes him in assumes he's gone insane with loneliness, but naturally it turns out he's telling the truth.
Terry Pratchett's Johnny and the Bomb explores the Real Life example of the pal's battalions in World War I, which were special units of the British Army consisting of men from a single town. In theory, this increased camaraderie, as people were fighting alongside friends and work colleagues. In practice, they were a fearsomely efficient way to wipe out the entire young male population of a town in a single stroke.
This is the way The Secret Gardenopens, oddly enough. Mary Lennox wakes up to find that her house is completely empty and silent. She is found a few minutes later by two soldiers, who proceed to tell her that her parents and everyone else in the household has died of cholera.
Isabelle, Alec, and Clary do this in City of Ashes when they realize that all the silent brothers are dead.
Margaret Atwood's Oryx and Crake is mostly flashbacks from the point of view of apparently the only human survivor of a global pandemic. The last chapters — and the sequels — reveal that there are rather more survivors than he thinks.
A rare midplot invocation in Idlewild as the characters suddenly realize how many of their friends/family are virtual and how empty the world actually is.
Three million years after a nuclear reactor leak killed the crew of an interstellar mining ship, the only survivors of the pilot episode's disaster are the main characters. Well, one survivor (who was in Stasis during the leak). The other three protagonists are the ship's AI computer, an evolved, humanoid descendant of the main character's pet cat (and, therefore, not actually born at the time of the disaster) and a holographic simulation of the main character's roommate. Why a hologram? Because he's dead, Dave. Being a comedy, the page quote (where Holly breaks the news and names the trope) quickly spirals into an Overly-Long Gag - and the book adaptation's take ends with Holly ranting every possible grammatical combination of the words, "everyone", "is", "dead" and "Dave".
Lister: Rimmer? Holly: He's dead, Dave. Everybody's dead. Everybody. Is. Dead. Dave. beat Lister: ...Wait. Are you trying to tell me everybody's dead? Holly: I should have never let him out in the first place.
At the start of the second series the crew give a similar speech to Kryten, who hadn't realized his masters had been dead for centuries. And even after they tell him, it still takes a few minutes for it to register.
"The Horror of Fang Rock": Everybody on the island except the Doctor and his companion, dead.
"Warriors of the Deep": Every named character but one is killed (and that one is a fairly minor one). Famous because the Doctor figures out how to destroy the alien invaders quite early in the story, but can't bring himself to kill them until it's too late for all the people he might have saved.
"Pyramids of Mars": Once again, everyone dies but the Doctor and Sarah Jane.
"The Caves of Androzani": Everybody on the (sparsely populated) planet of Androzani Minor except the Doctor's companion, dead (at least every named character — we are not told explicitly that all of the soldiers were involved in the failed attack in the caves died, but we are not told that anybody survived, either). And yes, that includes the Doctor. He gets better. Bonus points for also killing off all but one of the characters who appear in scenes on Androzani Major, although the off-screen population survives intact.
Let us not forget "Resurrection of the Daleks." - The only survivors besides the Doctor, Tegan, and Turlough are Davros and the Mercenary Commander (who gets killed off in a later episode).
Happened offscreen during the Time War, when the Time Lord and Daleks were wiped out (in a manner of speaking) and only the Doctor seems to have survived. The Ninth Doctor's epic Survivor Guilt over this was arguably his main character trait.
Both lampshaded and joyously averted in "The Doctor Dances", in the process naming a contrasting trope:
"The Parting of the Ways": Everybody not evacuated from the Game Station except companion Rose Tyler, dead. (Including the Doctor again. And his other companion, Jack Harkness, although he gets brought back by Applied Phlebotinum (permanently, it turns out.) Plus a considerable percentage of Earth's population.)
In "The Waters of Mars", it is flat-out stated by the Doctor himself near the beginning of the episode that every single character except himself dies. When he tries to saves them, the leader, Adelaide, commits suicide anyway, knowing that she was meant to die, although two of her subordinates do remain alive.
"The Pandorica Opens" takes this to the absolute extreme. Auton Rory kills Amy, River Song gets trapped in the TARDIS as it explodes, and every single person on every single planet is wiped out of existence as the entire universe collapses.
In "The Time of the Angels" and "Flesh and Stone" everybody but the Doctor, Amy, and River Song are dead by the end of it. Several of the clerics are even erased from time, remembered only by the TARDIS veterans.
Supernatural has a few of these, most notably in the episode "Croatoan" where an entire town's population except the brothers and one doctor (not counting one kid who turns out to be working for the Big Bad) are wiped out.
Another memorial episode is "Jus In Bello" where the brothers could easily have stopped any more deaths just by allowing Ruby to sacrifice one virgin girl, who was prepared to be the sacrifice. Even for Supernatural, this episode has a Downer Ending...
Season 5 has the episode "The End". 5 years into the future, Dean witnesses a zombie apocalypse where Bobby is dead, Lucifer possesses Sam's body, and possibly every other hunter he's ever known dead as well. All that's left is him, Castiel (who is self-destructing fast), and Chuck. At the end of the ep, future-Dean leads a suicide run at Lucifer wherein he sacrifices Castiel and everybody else he brought along with him except past-Dean. Lucifer kills him without effort and so, in the future, the only main character left is Chuck. This episode was put-a-gun-in-your-mouth-and-pull-the-trigger depressing.
At the end of Season 7 Bobby is dead, as is the entire angelic garrison, Kevin and Meg have both been kidnapped by Crowley, Dean and Castiel have been zapped to purgatory, and this is on top of the high character attrition of the previous seasons. The last scene is of Sam standing alone in the wreck of the Big Bad's office.
Crowley: Looks like you are well and truly on your own.
Babylon 5 gets two, actually. In the episode Confessions and Lamentations, members of one of the minor species on the station ( the Markab start coming down with an unknown illness, which eventually begins to kill them off. Rather than looking at it scientifically, they get whipped into a religious fervor and decide that it's the judgment of God killing the immoral, and all they need to do to be saved is to come together to pray and perform sacred rituals. As they lock themselves away, Delenn and Lennier (two regular cast members, immune to the plague because of the species difference) go in with them to offer help. At the end of the episode, the doctor on the station figures out a cure and races down with it to save everyone . . . and they're all dead. The two regular cast members are the only ones left alive, to the point where Delenn is holding the corpse of the obligatory cute child that had been dancing around earlier in the episode. In fact, news reports at the end of the episode state that the plague was severe enough that it effectively killed off the entire species, and they never appeared on the show again. It was shocking and utterly depressing, but amazingly well done.
The end of the Farscape episode "Different Destinations". What's worse, it's the heroes' fault due to changing history, and just to twist the knife, the "everybody" in question was a monastery-full of NUNS. Nurse-nuns. With children.
Star Trek: Deep Space Nine episode The Siege of AR-558 ends with the main characters in addition to 10 or so soldiers alive - out of a 150-strong unit.
In earlier episode "Valiant", the titular ship, sister ship of "Defiant", is destroyed and the only survivors are Nog, Jake, and one girl - the rest of Red Squad dies.
In Star Trek: Voyager episode Dragon's Teeth, The Vaadwaur, once 6 billion strong and a major power, are reduced to less then 600 - but are no less dangerous...
Both the new and oldBattlestar Galactica series begins with a devastating Cylon attack on the Colonies, leaving only the Galactica and a number of civilian ships. There Is Another.
Both versions of Survivors have Abby Grant waking up halfway through the first episode to find that her husband and all her neighbours are dead, issuing the famous plea "Please don't let me be the only one."
In the ending of the Japanese toku Pretty Guardian Sailor Moon, Princess Sailor Moon, in a fit of angsty rage, literally ended all life on Earth, turning the whole into a desert. This was, naturally, complete with shots of her friends and family disappearing in a white light. Just for the emotional kick. Things got better.
24: Jack's backstory involves a mission by a Special Forces team to take out Victor Drazen, a genocidal Milosevic lieutenant. An emotionally scarred Jack is presumed to be the only one who makes it out alive...until team member Stephen Saunders surfaces as the Big Bad in Season 3.
They failed to kill Victor Drazen and his sons as well
In the 1-2 P.M. episode, Pillar hears this from a wounded Russian bodyguard who answers a manipulative Russian diplomat's cell phone right after Jack slaughtered the entire detail.
The AU movie for Kamen Rider Faiz, Paradise Lost. The number of humans alive doesn't even get close to the five-digit mark. At the start.
In the miniseries The Stand, the CDC office where Stu was imprisoned while The Plague was decimating the general population was adorned with the uplifting grafitti "All Dead Here"
In LOST, only a handful of Flight 815 survivors and Others make it to the end of the series following the fire arrow attack in season 5 and the Monster's purge of the Temple in season 6, and the only known survivors of the Kahana are Miles and Lapidus.
The first person the 815 survivors meet who was already on the island besides Ethan didn't come alone. She killed all of her companions for reasons we don't understand at first.
And Ben, acting on behalf of the Others, kills nearly all of the Dharma Initiative folks in "the Purge," using poisonous gas to wipe them out. It's a pretty chilling image.
The season six episode "Ab Aeterno" shows us what happened when the Black Rock crashed on the island. All concerned except that episode's POV character ended up dead within a few weeks.
Everyone in the flash sideways who wasn't already dead died after living out the remainder of their lives offscreen.
In Andromeda, the titular ship ends up fully crewed in Season 4. However, during the Magog attack at the end of the season, everyone aboard the ship is slaughtered other than Dylan and Trance (the other main characters being conveniently off-ship). Dylan even uses this as a tactical advantage, as with no crew left there's nothing to stop him removing all the oxygen (except in the section he and Trance are in) to kill all the Magog still aboard.
In the Stargate SG-1 episode 2010 we find ourselves in a future where Earth has been manipulated by a seemingly friendly alien race who have shared their technology to improve human life. In reality, they have secretly plotted to take over the Earth by reducing the human popluation. Finding this out, SG-1 try to escape into the past through the stargate to warn the SGC...none survives the attempt, although O'Neill does manage to toss a note through just before he dies and the warning makes it.
An episode of Stargate Atlantis involved Sheppard being propelled tens of thousands of years into the future to find Atlantis long abandoned. An AI hologram of McKay tells him that the Wraith eventually forced them out of the Pegasus galaxy and that he must go back to his own time (no easy task) armed with foreknowledge of how to stop this chain of events from occurring.
Similar to the SG-1 example above, another Alternate Universe gives us this. In the well-received Star Trek: Enterprise "Twilight" we see an alternate timeline in which the Xindi have succeeded in destroying the Earth and nearly every other Earth colony or human outpost. When the episode proper takes place, the retired Captain Archer is a resident of a small human colony of barely 20,000 and the Enterprise herself is the last true capital ship humanity has. They do manage to undo this bleak turn of events, but they narrowly succeed as the Xindi lay siege to the last of humanity's ships, including nearly completely destroying the Enterprise.
An The X-Files episode saw Mulder have a fever dream which ended with him lying in bed as an old man and Cancer Man explaining that they're the only ones left - everyone else he knew is dead. Mulder looked out the window and saw a burning city that resembled Hell.
Boyd Crowder from Justified gets a big dose of this when he returns to his camp to find all of his followers murdered by his father.
"Come Away Melinda" (various versions). Probably the closest thing to a Crowning Moment of Heartwarming you can get in a song about the last two survivors of nuclear armageddon.
Happens to the main character of the French song "La tribu de Dana". He's a celtic warrior fighting alongside his brothers against an invader. When the enemy troops retreat, he can't figure out why until he looks down and sees that he's the only one of his tribe left standing.
Galloglass's song Burden of Grief is told from the point of view of a knight who is awakening from a state of battle-enduced rage/insanity and realising that he's now alone on the battlefield.
"Nautical Disaster" by The Tragically Hip recounts the disastrous Dieppe Raid of World War II where almost 4500 men, mostly Canadian infantry, die and only 10 survive.
This is how the punk band The Exploding Hearts came to an end. Three out of the four band members were killed in an auto accident.
The Dutch novelty song Dodenrit (roughly, "Sleigh ride of death") by Drs. P, about a Russian family (two adults, four children) in a troika on their way to Omsk, singing to pass the time as a pack of wolves begins to close in on them. One by one, the children are sacrificed to the wolves, then the wife, all of which is Played for Laughs ("How about Natasha?" "But she's doing so well in school!"). The final lines of the song have the narrator himself, while celebrating that he can see Omsk, slip and be devoured, observing that "Omsk is a lovely town, but just a little too remote."
The Les Savy Fav songs "Reformat" and "Reformat(Dramatic Reading), the latter a spoken piece in the style of a radio play, are about the captain of a diesel-powered submarine who pushes it beyond its capability and decides to use the crew's oxygen to power the sub long enough to surface. He kills anyone who tries to stop him and the rest die when the plan goes horribly wrong, leaving him the sole survivor. He is then executed by guillotine on live TV thanks to an obscure maritime law.
Mythology and Religion
In Homer's The Odyssey, Odysseus survives a shipwreck while the entire crew dies, courtesy of divine retribution.
The Indian epic Mahabharata has its final showdown in a massive battle involving almost 4 million warriors. At the end of the eighteenth day, the battle ends with only the five Pandava brothers and three of their warriors surviving, as well as the three last members of the opposing Kaurava army.
In Peter Brook's theatrical (and later, television) adaptation; the sole survivor is Arjuna's son Abhimanyu's pregnant wife, Uttarā.
The Bible, Genesis, Chapters 6 - 9: God kills all but Noah's family in a world-wide deluge:
Genesis, Chapter 19: God destroys Sodom and Gomorrah; only Lot and his daughters are spared.
Technically Lot's wife was spared for about five minutes, but when God says "don't look" and you look anyway, no one's going to have a lot of sympathy for you.
Okay, if you really want to get technical here:
Gen 19:17 (NRSV): "When they had brought them outside, theynote 'he' in Septuagint/Syriac/Vulgate said 'Flee for your life; do not look back or stop anywhere in the Plain; flee to the hills, or else you will be consumed.'" End quote. The speaker is an angel of the Lord.
Ragnarök, the Norse equivalent of Armageddon, ends with all but six (or fewer) of the Norse pantheon dead, and with upwards of half the human population of the world massacred to boot. Everyone's dead, Baldr, indeed.
In some versions all but two humans are killed.
Older Than Dirt: In the Old Kingdom Egyptian Tale of the Shipwrecked Sailor, the protagonist was the only survivor of his ship after a storm on the Red Sea. This is the oldest story about getting shipwrecked alone on an island.
The legends related to King Arthur. Only 1-7 knights (it varies between various accounts) survive Arthur's final battle at Camlann. There are no survivors on the opposing side.
Used in the print comic Garfield, in a Halloween storyline starting on October 23, 1989 where Garfield wakes up to find that Jon and Odie are gone. And his home has been abandoned for some time. Which can only mean...
Spoofed in a Peanuts strip where Peppermint Patty, after napping in class, wakes up to find the room empty except for Marcie, who tells her the world came to an end and they are the only survivors. Patty looks out the window and asks "So why is the playground full of kids?" Marcy replies "Sorry, sir. When I saw you got an A on that quiz, I thought the world had come to an end." (Schulz said he intended the strip to make fun of preachers predicting the end of the world, and was surprised when no one wrote him to complain about it.)
Used to bleak effect in a couple of scenarios from a Champions supplement dealing with alternate dimensions. In particular, in one the player characters arrive in their home city's counterpart in a world where Germany won WW2, developed nuclear weapons before anybody else did, and conquered the US. They run into and fight power armored patrols, get in touch with the local resistance, get sent to another city to speak with the real leaders there...then the Nazis, alarmed that there are still superpowered individuals despite all their heretofore effective-seeming efforts to exterminate them, drop a nuke on the city they just left. And then threaten to repeat that performance as necessary until the resistance surrenders for keeps...
In William Shakespeare's Hamlet, all of the main characters die in the end except Horatio, who maybe contemplates suicide (peer pressure is powerful, you know), and Fortinbras, who arrives to pay his respects after returning from fighting the Poles.
In William Shakespeare's Macbeth, the character Macduff, the only man who can oppose the titular Macbeth Because Destiny Says So, has just had his entire family and everyone else in his castle killed, unbeknownst to him. While in England to raise a rebel army, a Thane (Noble) by the name of Ross is telling him of these merciless killings. Macduff asks Ross for confirmation about his wife, children, and servants at least twice.
"Did you say all? O hell-kite! All? What, all my pretty chickens and their dam at one fell swoop?"
Then there's Titus Andronicus, by the end of which 14 of the 17 named characters are dead. The only characters left standing at the end are Lucius, Marcus and Aaron, and the latter is about to be executed.
In the one-act play At The Bottom Of Lake Missoula, the protagonist Pam is told by the dean of her school that a tornado has stuck her family's home.
Pam: "Who is it? Who's dead?!"
Dean: "All of them." [beat] "All of them."
Quite possible in several ending combinations in Heavy Rain: Not saving Shaun alone kills Ethan AND Norman in their epilogues if they hadn't died already.
This is one of the worst endings you can get in the third game of Splatterhouse.
Technically all of the endings aside from the True Ending are this. No matter who the killer is in the ending, they will be unable to unlock the final door.
The sequel does this no less than three times. In Luna's path, Sigma and Phi find everyone dead, except for Quark, who's missing. In Clover's ending, Sigma finds everybody's (except for, once again, Quark's) dead bodies. And in Phi's route, Tenmyouji reveals that most of the human population of Earth has been killed by the Radical-6 pandemic.
At the end of the first Sakura Taisen, as your party marches through the Seimajou, they are killed off one by one, until only Ogami and your chosen love interest remain. The player then either has to kill the traitor (Ayame) or watch her sacrifice herself to save you. Then, after you beat the Big Bad, he reveals himself to be the devil. Ogami despairs that he can't go on without the rest of the party, then Ayame as an angel shows up and they get revived.
Twice in Halo: Combat Evolved. Before the game even starts, the human military capital of Reach is bombed into molten glass, with the Pillar of Autumn being one of the few ships to escape. By the end of the game, the titular ring-world is blown up, and pretty much everyone on it dies; the only surviving humans are the Master Chief, his trusty AI Cortana, Sergeant Johnson, and a handful of other stragglers. Only the first three make it back to human-controlled space.
By the end of the original trilogy, Earth's population is reduced to a few hundred million, its fleet is all but gone, and a good chunk of Africa has been rendered uninhabitable. Fortunately, as shown in Halo 4, humanity as a whole still has enough planets and people left that it takes less than four years for humans to reestablish themselves as a major power.
Both System Shock and System Shock 2 kill almost every single NPC aboard the station/ship besides the nameless player. There's a group of survivors in the first game, but they are wiped out before the player can reach them. In the sequel, the ending cutscene shows SHODAN taking control of Rebecca Siddons and menacing Tommy Suarez (presumably killing him).
It's particularly annoying in the second game: you actually see quite a number of survivors, only they die before you can meet them, sometimes while you watch haplessly through the window. Tommy and Rebecca example is even worse. You run to escape pods bay only to find they're just boarding a pod as the glass door you are behind opens slowly enough, so you can't reach them before they leave.
In System Shock's Spiritual SuccessorBioShock, the main character is the only survivor of a plane wreck that he caused in the opening sequence. Rapture itself may qualify, as nearly everyone you encounter is either dead, homicidally insane (and killed by the main character during the game), or no longer truly human. The sequel reveals that there were a few others who survived, and that even the splicers went on to be partially rehabilitated... before joining a sinister cult, whose leader happens to want the protagonist dead.
Dead Space follows the tradition with a massive ship drifting in space and its crew turned into monsters. The few survivors you see either kill themselves, or murder each other in truly disturbing ways.
Plus the ones who bleed to death in from of you or the one who is actually killed by accident.
Subverted in Dead Space 2. We can see massive evacuation at the beginning of the game. It's highly probable that many people made it, they were just gone before Isaac woke up.
This is the fate of the "God of Destruction" Alex in one of the Multiple Endings of Nippon Ichi's Makai Kingdom. He wants to destroy everything; he succeeds. And is left alone in an empty universe, too powerful to kill himself.
A very similar thing happens in the Demon Path of Soul Nomad & the World Eaters. Except you're the one who destroys everything, and when the fabric of the world is undone, you go along with it.
Many of the NPCs in Treasure of the Rudra die out around day 10 Due to Sodom's Moonlight. The ones who are smart enough stay inside, away from getting fried by it. The Residents of the Netherworld are completely safe aside from the wandering souls who return to Gafu.
Call of Duty 4:Modern Warfare does this twice; first, when the nuclear warhead in Al-Asad's capital detonates, killing Lieutenant Vasquez, most of his squad, the Cobra pilot they were rescuing seconds earlier, and, a few minutes later, Sergeant Paul Jackson, the player character. Later on, "Soap" MacTavish is disabled by a gas tanker explosion, and forced to watch helplessly as Griggs is shot in the throat, Gaz is executed in the forehead by the Big Bad, and the rest of his surviving SAS/Marine unit is gunned down in cold blood by the Ultranationalists, right before Price slides him his Colt M1911 and lets Soap rip the badguys a new one. Talk about your Downer Ending. Soap and Price manage to survive, though their status in the first Modern Warfare was left up in the air prior to the sequel.
In Modern Warfare 2, everyone in Task Force 141 except for Soap and Price are dead by the end.
Price is the only main character to survive the entire trilogy.
This is your character's backstory if you select the "Sole Survivor" and "Colonist" backgrounds in Mass Effect. For bonus points, your character can have BOTH. And then BioWare had a lot of fun with this trope in the sequel:
Inverted: In the beginning of the game, Shepard and 21 crew members on the Normandy are killed, though most escaped.
Subverted: In the worst ending of the game, Shepard's entire team and crew dies but it looks like Shepard him/herself will survive... and then s/he falls to his death...thus, leaving Joker the sole (organic) survivor of the Suicide Mission.
When the Collectors kidnap the crew, this is definitely the feeling when you walk around the empty Normandy. Yeoman Kelly telling you about the messages at your private terminal, the officers in the crew quarters concerned about their families, the cook, the doctor, Those Two Guys down in Engineering... All part of the ship's atmosphere and suddenly gone. And depending on how fast you head through the Omega 4 relay, they could really become dead.
And then again in Doom II where the hero is the last man on earth (sans a lone escaping spaceship).
At the conclusion of Doom 3, the nameless protagonist is the only survivor. Every single NPC he has met over the course of the game has met their end through one way or another.
In Max Payne 2 The Fall Of Max Payne, the only non-Max character of any import to live through to the end of the game is Jim Bravura, who happened to take a few bullets to the torso first. Though, if the player completes the game on the hardest difficulty setting, Mona survives too.
the white chamber, regardless of the three main endings, drives the point home that Sarah murdered the entire crew, and she is the only one still alive, everything that seemed to be alive that she had encountered was a complete illusion.
In Penny Arcade: On the Rain-Slick Precipice of Darkness: Episode Two, near the end of the game, the Big Bad comes in and kills everybody at the robotics convention off... even the beloved characters from the first game... even the characters you had JUST finished side-questing for. As Gabe and Tycho would probably say, "Shit just got real."
Knights of the Old Republic II opens with the player character awakening in a mining facility with everybody else dead except for an old woman who had been in a hibernation trance and a man who was forgotten in the detention area.
You were supposed to be responsible for the deaths of nearly everyone in your party, but it was cut due to time restraints. If you go evil, you almost kill everyone in the galaxy.
And let's not forget that the Jedi have been driven to extinction with just three remaining in hiding. None of those three survive the game, meaning if you go Dark Side, the Jedi are completely extinct by the end.
In Left 4 Dead, the four survivors are some of the only people not turned into zombies. The only other people that appear in-game are a man locked up in a church (who quickly turns into a zombie himself), and the people that come to rescue the survivors at the end of each campaign.
And even their rescuers often come to bad ends in the first game. The survivors are truly fortunate to be immune to both infection and helicopter crashes.
Used in Super Paper Mario when a rather cute samurai-Japan gets sucked into The Void. You survive, but upon going back to the world you find this blank white space, with the occasional piece of broken building or debris.
Most of the first Resident Evil has Jill or Chris wandering a zombie-infested mansion with only one person to aid them depending on which one, finding out that everyone they went in to look for in the first place is dead or dying except Rebecca.
HUNK is notorious in-universe for being the only person to survive his missions. One of the bonus ending screens in Resident Evil 3: Nemesis has a chopper pilot getting sarcastic about it: "Once again, only you survive, Mr. Death." Chronicles shows that he prefers it that way.
During the course of Final Fantasy II, the towns around Fynn are subject to various hardships, from the initial assault of Imperial soldiers to aerial bombardment by the airship Dreadnought; after each, the party listens to shellshocked townspeople lament the death of their loved ones. Except after the Cyclone. After that, every town but Fynn and a few far-distant places is literally wiped off of the map. A grey patch remains in the place the town once stood, but the party can't enter it because there is nothing left to enter and no survivors.
In Final Fantasy VI, after The End of the World as We Know It (which is roughly the midway point of the game; yeah, it's that kind of story), Celes wakes a year later to find herself and Cid on a tiny godforsaken spit of land. There are no other humans, all the animals are dead or slowly dying, and there is nothing visible to suggest that any other land survived the apocalypse. Truly the end of the world. Cid explains that all of the other survivors committed suicide in despair before too long. If Cid dies, Celes, seemingly the last human alive, jumps from the cliff like all the others. However, she survives, and a dove with a familiar bandanna tied to it gives her enough hope to try and find other survivors and other continents. Turns out that not everyone was dead after all. It's still close to that level of despair, though. If the player manages to save Cid, this doesn't happen, and instead he convinces Celes that she ought to take the raft he's made and check if there are any survivors on the mainland.
In Final Fantasy Crystal Chronicles Ecoes Of Time, your Player Character eventually finds that this is the backstory of the village. Larkeicus' Mooks slaughtered all of its inhabitants a thousand years ago because the village was the pathway to the world's last crystal. The people you were raised by were created by the villagers' spirits so that you could have a normal life; you eventually find the original village, which is a burnt-out ruin. After you learn the truth and start fighting Larkeicus, they allow themselves to fade away.
In Mortal Kombat 3, Stryker is the lone survivor of the destruction of an unspecified major city.
In Arcanum: Of Steamworks and Magick Obscura, you start out as the only surviving passenger of a zeppelin after it's untimely crash. And depending on how you play and which options you pick during the endgame, you will end up the only living being in the entirety of Arcanum AND the Void.
In Dead Rising, if you follow the plot missions, just before the finale the Special Forces will have killed every single survivor and zombie in the mall except you and Isabella. You make your final run to the helipad alone with the mall completely lifeless.
In Dead Rising 2, the clock initially counts down to when the military arrives. Once they do, they're slaughtered by souped up zombies. The only survivor is Sgt. Boykin, who goes insane and believes his squad is still alive. The second clock counts down to a firebombing by the military which presumably kills every living and undead thing in the area, possibly including the player character depending on the player's actions beforehand.
Theresia is, in essence, a Beautiful Void without the beauty. There are an a lot of rotting corpses, but if anyone else is still living (and setting those traps that keep targetting you), they're awfully good at keeping out of sight.
In 7 Days A Skeptic, near the end, all of the characters are dead except for the player, and the homicidal frankenstein monster that killed the rest.
Something like this happens in Dragon Age: Origins in the beginning with the Grey Wardens at Ostagar. Although most of the order join the King and his army on the battlefield against the darkspawn, two have been selected for a separate mission away from the fighting: the player character and another junior Warden named Alistair. The battle is a complete massacre because the King's father-in-law, Loghain, ordered his troops to retreat instead of coming to help, and the player and Alistair are only saved due to intervention by a sort-of supernatural ally. They awaken a few days after the battle and are greeted with the news that they are the only surviving Grey Wardens in the entire country, and the responsibility for stopping the darkspawn is entirely on their shoulders.
This is also seen earlier in the game if you choose the Human Noble origin. During the backstory, the family castle is invaded and everyone inside is slaughtered. Only the player character and his/her dog escape.
Shin Megami Tensei III: Nocturne. The End of the World as We Know It takes place within the first ten to fifteen minutes (depending on how fast you read.) On the entire planet, only the five humans at the Shinjuku Hospital (and one Intrepid Reporter) escape the horror of the Conception, an apocalyptic event which destroyed the world outside Tokyo and turned the city into the Vortex World. All other humans, everywhere have died, and they have either become helpless ghosts who can only hope demons don't eat them, or their souls have been reduced to raw emotional energy called "Magatsuhi"... which demons crave to enhance their own powers. By the end of the game, not one true human exists anymore.
The Orion Conspiracy starts off with 20 characters on a space station. By the end of the game, Devlin, Meyer, and LaPaz are the only characters still alive.
In Final Fantasy Tactics every character in the game who had a name and was ever slightly important winds up dead, with maybe a half a dozen exceptions. Considering the population in this game, that's an impressive genocide. Notable exceptions are the main character and his sister, who are shown surviving the final battle.
When you arrive aboard the station in Metroid: Fusion, every member of the station's crew is already dead or is infested with X parasites.
BattleZone II ends this way if you side with General Braddock. You murder your former commanding officer, wipe out a rebellion opposing Braddock's plans for dictatorship - killing Braddocks' former right-hand man, then you go on to commit genocide on an entire species. By the end, Braddock and you are the only named characters left alive.
In Strike Suit Zero, pretty much the entire Earth fleet has been wiped out, without the single loss of an enemy ship.
Asura's Wrath: Mithra is the only character with a name left alive by the end of the game.
Bastion has only four surviving Caelondians trying to undo The Calamity. until Zulf finds out exactly what the Calamity was supposed to do...
Fire Emblem: Radiant Dawn has this at the end of Part 3. The Big Bad's judgement has turned about 99% of the world's population to stone. The major characters note how the battlefield they were in the middle of has turned eerily quiet, and Ike runs outside, screaming for someone to reply to him.
Implied by the ending of the bonus chapter (only found in the collector's edition of the game) of Dark Tales: Edgar Allan Poe's The Fall of the House of Usher. Taking the entirety of the story into account, it is very heavily suggested that the only survivors of the events are the player character and his/her partner, Dupin.
Something similar happens to the unfortunate Rina in The Dragon Doctors. The young lady is turned to stone for two thousand years and is devastated to learn everyone she's ever known is dead. Kili the shaman also went through a similar experience; as a kid, everyone but Kili in Kili's town was killed by a tsunami, leaving Kili to wander the beach looking for survivors and screaming at the sky when none were found.
This is the likely ending of Homestuck - since four kids and their guardians are the only (presumed) living humans left.
Also during the Bad Future, where John and Jade have been killed. Considering that the only two people left are Rose and Dave, it is likely that this particular line was actually uttered, off-screen.
And what happens to the Troll race, leaving only their Empress (plus the players) alive.
Uttered almost word-for-word by Dirk's auto-responder - so precisely that it's almost definitely a Shout-Out.
In the first arc of The Order of the Stick, when Celia is turned back to normal (having been turned to stone by the villains), Nale (the leader of said villains, now captured by the heroes) informs her that she's been stone for a thousand years, and everyone she's known and loved are long dead! She blasts him when she finds out he's lying, but he still thinks it was "Worth It".
In Episode 4 of Halo 4: Forward Unto Dawn, after Master Chief saves a quartet of cadets at a Covenant-besieged military academy, they ask him why he came for them. He responds that they are the only survivors. When one of them says "Of the school?", the Chief corrects him with "On the planet."
Parodied on The Simpsons when Homer and Bart watch a movie entitled The Thing that Ate Everybody, which contains the following exchange;
Woman: "You mean, it ate Patrick?" Man: "It ate everybody." Woman: "What about Erika?" Man, Homer and Bart: "It ate everybody!" Homer: "Stupid!"
In the pilot episode of Futurama, Fry awakens in the future and realizes that his family, his co-workers and his girlfriend are all long since gone. After a moment of reflection... he lets out a jubilant "Yahoo!" Softened considerably by the fact that they weren't, so far as Fry knows, Killed Horribly; they're dead because of the natural human tendency not to live 1000+ years.
And in the last movie, "Into the Wild Green Yonder", after yet another mass-death on Zapp Brannigan's ship, which only he and Kif survive.
Zapp: "How many men did we lose?" Kif: "...All of them." "Well, at least they won't have to mourn each other!"
"The Late Philip J. Fry", when Fry, Bender and Farnsworth travel to a future where everyone is dead. They pass a couple of less total apocalypses on their way to the end of the world, and eventually go onward past the recreation of the Universe and the birth and death of everyone in it. Twice.
Prof. Farnsworth: Everyone we ever knew died hundreds of years ago. Bender: Everyone we ever knew? Eh, I never liked those guys.
In the Beast With A Billion Backs movie, every living being in the Universe goes to a parallel dimension which is totally not exactly like Heaven, leaving only Bender and his fellow robots in the "living" world.
The Teenage Mutant Ninja Turtles episode "Same As It Never Was" a Bad Future tale set thirty years in the future, features the final battle between the turtles (and their surviving allies) and the Shredder, who has conquered the world. In the end, the only surviving cast members are resistance leader April O' Neil and present-day Donatello, who soon after is whisked away to another era.
This is the situation Aang finds himself in when he wakes up from his 100-year sleep. All of his people, the Air Nomads, have been completely wiped out by the Fire Nation, and almost all of the friends he had in other nations died, if nothing else, of old age.
Jake: Finn! Oh, my Glob, man, everyone's dead, man! They're all burned! There's barbecue'd bods EVERYWHERE! Finn: WHAT??!!! Jake: I was just kidding. I saved them. Everyone's fine, see? *points to group of alive and well Goblins*
Similar to the Men in Tights parody, one story (framed as a country song setting in The Big Book of Urban Legends) starts with a sheriff telling his friend who just returned from a trip that his dog had died... because of eating too much horse flesh... due to the barn burning... because of the house fire... because of the candles at his mother-in-law's funeral... who died due to seeing his wife run off with another man...
Farmer: So I'm going to have to raise three children without their mother?! Sheriff: Heck no, your kids all died in the fire!
In 150 years, everyone you've ever known will be dead. So will you.
Around 550 BC, Sparta got into a conflict with Argos which they decided to settle in the so-called Battle of the 300 Champions. Each side sent only its 300 finest soldiers to the fight, and the outcome was meant to decide the whole war. Only one Spartan and two Argive soldiers survived. The requirements of the fight called for one side to be entirely destroyed, and the fact that the one spartan lived came from one of the biggest Faileda Spot Check in Greek history. The Spartans loopholed their way out of that embarrassment and won the war anyways.
The Battle of Little Bighorn. The five companies of the 7th Calvary led by Custer were so severely wiped out that the only American survivor of the battle was a horse.
Pickett's Charge from Gettysburg, (as under films, above). The Confederates moved in on the Union position assuming the Union had stopped firing their cannons because they were overheated. They weren't. It was such a slaughter that the creek ran red with blood. For some units only a small handful of people showed up for roll call the next morning.
When Pickett himself was ordered to reform his division after the charge, he responded with "There is no Division."
The Battle of Stalingrad: 230,000 soldiers of the German 6th Army were trapped in the pocket of Stalingrad. Only 6,000 survived the battle and the labour camps to return to Germany after the war.
The retreat from Kabul in 1842 is a strong contender for the worst military disaster in the history of the British Army. 4,500 troops and 12,000 civilians left the city on the 6th of January, intending to regroup with the garrison at Jalalabad. A week later, surgeon William Brydon rode into Jalalabad alone, suffering from a severe head wound. When asked about the rest of the army, Brydon replied, "I am the army." A few dozen captives and stragglers trickled in over the next days, but the vast majority of the column was annihilated by the Afghans.
Archeology seems to suggest that there was a period around the last Ice Age where the entire human population got whittled down to only a few thousand people. You can just imagine the number of deaths involved.note Less than you think, as the number of homo sapiens sapiens is thought to have peaked at no more than a few hundred thousand beforehand
On the morning of May 8, 1902, the city of Saint-Pierre on the French island of Martinique had a population of around 30,000 people. Then the nearby volcano Mount Pelée erupted and sent a pyroclastic flow into the city. When it was over, only two (possibly three) people survived. Interestingly, one of the survivors later survived two other instances in which pyroclastic flows from Mount Pelée killed nearly everyone but him; he died in 1936, from a fall.