- Crosses the Line Twice: Zoe poking Wanda in the eye with a tongue depressor, trying to amputate her, and giving her a shot in the butt while playing Doctor? Terrible. Zoe commenting it means she wins? Hysterical!
- Enfant Terrible: All of the kids have their moments but middle child and only boy Hammie really sticks out. He intentionally seeks out destructive activities, goes out of the way to prank Zoe (though she dishes it right back at him), grosses out anyone in range of him, pesters people constantly, and doesn't think twice about the consequences. Zoe is starting to branch out of this stage and Wren is still too young to settle firmly into it.
- Harsher in Hindsight: In a couple early strips, Wanda was shown to be a fan of Mel Gibson (or rather, his buns). Obviously, this was before Gibson's first anti-Semetic rant incident.
- Hilarious in Hindsight: One strip that took place early in Bunny's second pregnancy had her pointing out how big her stomach was getting, and exclaiming "I think it might be twins!" (the joke being that her stomach still looked relatively flat). A few months later, Bunny revealed that she actually was having twins (and then her stomach really did get a lot bigger, much to Wanda and Yolanda's amusement).
- The title of the comic's eighth book, "One More and We're Outnumbered!", has become this with the introduction of Wren.
- One early strip had Darryl bringing home a large box of crayons and coloring books, only for Wanda to scold him because Zoe (then still a baby) was too young for crayons; the joke being Darryl responding "Who said they were for her?" Nowadays, coloring books marketed specifically for adults are very much a thing.
- Periphery Demographic: The strip is popular even among those who aren't parents — including, apparently, teenage girls.
- Audience-Alienating Premise: Unlike the strip, the show was fused with crass humor and language aimed squarely at older audiences, but this seemed to turn off fans of the actual comic, and the show didn't have much of an audience to grab outside of that fanbase.
- Broken Base: Some people who weren't familiar with the strip thought it was a decent show in its own right, while others that grew up with the strip disliked it for how much it changed the story to the point where it barely even resembled the original strip.