- The Hangman's Daughter being an artist with a unibrow may be a reference to Frida Kahlo.
- There are plenty of shout-outs towards other DC heroes, mainly Aquaman, Flash, Superman and Batman.
- Robotman almost always wears rock band shirts, including Bad Brains, The Germs, Dead Kennedys, Motörhead and Black Flag
Doom Patrol Patrol
- One of the trophies Mento has in his collection is Wonderwoman's Godkiller sword.
- Larry makes a reference to The Shining when he comments on how the academy turned into a literal haunted house.
- Admiral Whiskers obliquely quotes The Princess Bride before enacting his revenge on Cliff.
- Karen going back to Doug and recreating the scene from The Notebook.
- The way Karen is begin dragged back into the Underground looks similar to the famous "sunken place" scene in Get Out!.
- Dolly getting killed via dusting will likely remind many of what happened to a lot of characters in Avengers: Infinity War and Avengers: Endgame.
- The poster used to advertise the show (as seen on the main page) is directly based on the cover of The Doom Patrol Omnibus, the collected edition of Grant Morrison's run, from which the series takes heavy inspiration.