Da Chief: He occasionally loses his patience with Gadget Boy's bumbling.
Mr. Exposition: Like Chief Quimby before him, his main role is to explain to Gadget Boy what Spydra is up to.
Voiced by: Maurice LaMarche
All Love Is Unrequited: He has a crush on Agent Heather, but she is either unaware of his affections or is blatantly annoyed by them.
Child Prodigy: He once mentioned that he graduated from college when he was seven years old.
Funny Foreigner: Subverted. He at first appears to be a Swiss inventor, but the episode "Back to the Vulture" revealed that he was born in Cleveland and that he talks with a Swiss accent because he moved to the Swiss Alps when he was young.
Mad Scientist: He's not exactly insane, but his inventions can be pretty odd.
Ambiguously Human: With her six arms and concealed hideous face, one has to wonder what she really is.
Bad Boss: She constantly abuses Boris the Vulture and her henchmen Mulch and Hummus. She doesn't even bother to try telling Mulch and Hummus apart in spite of both of them having slight differences in appearance and having completely different voices.
Bald of Evil / Bald Women: She is seen maskless from behind in "Gadget Boy and the Great Race", during which she has no hair visible.
Enfant Terrible: She wasn't any better when she was younger. A flashback in "A Gadget Boy Christmas All Around the World" shows that she was mean to Boris even when they were kids and footage of her when she was a baby shown in "Pirate of the Airwaves" shows her stealing the other babies' bottles.
Evil Laugh: She constantly cackles and even does so in the show's opening.
The Faceless: Spydra's face is always concealed by a facemask. The reason is because her face is so hideous that seeing it will turn you into stone. Her face is always obscured by foreground objects or a Discretion Shot, but if "Gadget Boy and the Great Race" is anything to go by, she apparently has pale skin and is bald.
The Grinch: The Christmas Episode of Adventures in History had her attempt to alter the histories of major Christmas traditions in order to eliminate the holiday entirely.
Jerkass: She constantly insults her goons and is rude to every civilian she encounters.
Large Ham: She always speaks loudly and dramatically.
Paper-Thin Disguise: They would wear one in almost every episode. In the Adventures in History season, their disguises became more blatantly conspicuous because they had a tendency to wear costumes that were not appropriate for the time and place.