The "Legendary Heroes" filler arc in Yu-Gi-Oh! features an evil virtual-reality RPG created by the Big Five to trap Kaiba and keep him from firing them. Then Yugi, Joey, and Mokuba go in the game to free him.
The virtual-reality game Greed Island in Hunter × Hunter really physically transports players to a real gameworld (a small, uncharted island) and only lets the player leave at certain Save Points... which means you can be trapped in the game if you can't get that Last Lousy Point, and if you die you're really dead.
It's also an MMO, which means not only do players have to contend with monsters in the game, but also with literal player-killers who try to take care of the game's item scarcity problem by wiping out the competition so their spellcards and MacGuffins are dumped back into the game world.
The game in Angel Sanctuary allows an angel to steal the body of the player.
In the first Story Arc of Sword Art Online, ten thousand players can't log off from the Sword Art Online game and must Win to Exit. Your Mind Makes It Real where death in the game makes the NerveGear game interface destroy your brain. The game and interface creator's simply wanted to play God in his virtual world. Two thousand die in the first month, with four thousand gone by the time the game is beaten. Thankfully, towns are safe, and many players chose to find a city and stay there, rather than work on beating the game.
Towns stop being completely safe when player killers discover that they can challenge sleeping players to a Duel to the Death. The whole process from sending the duel request to killing the target takes 2-3 minutes, longer if the victim is significantly stronger than the attacker. Here's hoping you wake up before that happens.
The Hack/Slash miniseries My First Maniac featured an old arcade game called Bludbus, which urban legends state was banned due to causing things like suicidal and homicidal thoughts (undoubtedly inspired by the real-life urban legend of the Polybius cabinets). The slasher of the story, Grinface, was a normal boy who was either possessed by the game after his death, or was so obsessed with it he simply decided to adopt the identity of the Villain Protagonist.
A weird Venom story (intended to tie into the Maximum Carnage game) had Carnage sending pieces of his symbiote through electronics in order to kill people playing a game based on him called Carnage Unleashed. The story ended with a cyberspace showdown between Carnage and Venom.
In Layer Game, japanese actress and gravure idol Ayaka Komatsu, as herself, is playing a fight game in which her avatar fights various adversaries while wearing a different cosplay for each level (There's even one where she's dressed as a kangaroo!)◊. Each level ends with her avatar being victorious or getting killed by her oponents. After completing every levels, she discovers the game features an hidden level. When she chooses to play it, ninjas enter her room and murders her offscreen◊. We only hear her screaming while her computer's screen reads "game over".
The game in Spy Kids 3D traps the player and keeps them playing.
One of the four segments from the film Nightmares is about JJ Cooney, a video game whiz obsessed with beating an arcade game named The Bishop of Battle - a game so unfairly difficult, not even the best players could make it past the twelfth stage. When Cooney finally succeeds (after having snuck into the arcade in the middle of the night), he realizes that beating the game causes the threats and enemies from within to come alive.
The game in Stay Alive summons the spirit of the Blood Countess in its intro sequence. If your character in the game dies, she hunts you down and kills you in the same way.Not only that, but if you turn the game off or pause for too long, it will take control of your avatar itself—it... isn't very good at playing itself.
This trope has been used often in terrible straight-to-rental movies, particularly in the 90's. Specific examples are difficult to pinpoint because they are all equally forgettable.
In Brainscan, a kid tries a product that supposedly uses hypnosis to make the in-game experiences more realistic, before discovering that he is affecting the real world by playing the game.
Another was called Arcade; about its only memorable feature was the villain played by John de Lancie, who also portrayed Q on Star Trek.
De Lancie also played the scientist/creator in Evolver, another mid-90's flick about a Robot Buddy that takes VR combat way too seriously.
Of course, said Robot Buddy was originally a military Killer Robot prototype. The project was shut down when the robot broke its programming and proved impossible to control. The natural alternative is to make it a toy.
How to Make a Monster had a video game coming to life after a lightning strike. It then starts killing its developers by animating an animatronic suit based off the game. It's only stopped when one junior developer dons a virtual reality suit of her own, which somehow allows her to destroy it in the real world too.
In Maximum Overdrive a man is mesmerized by an arcade cabinet, which fatally electrocutes him when he touches it.
In a sense, TRON was one of the earlier movies to pull this off. It wasn't the game itself sucking you in, but the MCP used several "game programs" (disc battles, the jai-alai looking arena, Space Paranoids, Light Cycles, the tanks) to help keep control over still-semi-free programs. The MCP simply zapped Flynn into the computer world and stuck him in the deadly games. TRON: Legacy took it a step further, in that CLU became just a dick that enjoyed making others fight to the death, program, user or otherwise.
WarGames has a variation. Global Thermonuclear War is itself just a simulator, but the computer JOSHUA can't tell the difference between simulations and real life, and is not inclined for NORAD to tell the difference either. Thus, what should have been just a game nearly causes a real nuclear war.
Another variation in Gamer. Everyone knows that the characters they're controlling in Societies and Slayers are actually real people injected with Mind Control nanites (in the first case, they're highly-paid volunteers, while the second game uses life-sentence prison inmates who volunteer for a chance at freedom). It's just that no one cares
A Spanish children's book called La aventura de los chips biológicos (Adventure of the Biological Chips) is about an evil, addictive computer game that drains the life of the children that play it.
One of Robert Rankin's Brentford Trilogy books features a Space Invaders machine at the Flying Swan that causes its only player to become possessed by actual space invaders.
What kicks off the story of Otherland. A number of kids who access the future-Internet fall into comas.
Comes with the implication that all games are like this; at one point they pass by the wreckage of a Space Invaders fleet.
The Shivers novel The Animal Rebellion had a cursed (...or something, it's never really explained) computer game that caused all animals in the immediate vicinity to go violently insane. In order to reverse the effects of the game (which was purposely Unwinnable, being the kind where you just have try and survive for as long as possible) the main characters had to wipe it from the hard drive and destroy the physical copy.
Gillian Rubinstein's Space Demons trilogy featured three of these (each one a sequel to the previous): Space Demons, Skymaze and Shinkei.
In The Reality Bug this happens with an alternate reality as opposed to a game.
Twisted in Heir Apparent. Loosing the game doesn't kill in itself, but if the game is not won, gamers will eventually die.
In The California Voodoo Game, a game arcade becomes possessed by the loa Oggun, who conjures up a horde of holographic game avatars to attack the Gamers and some dogs they're protecting.
In Joseph Locke's Game OverHades Video Arcade was full of nothing but violent games - violent games where some of the enemies took on the features of the player's worst bully. Enough time spent playing and the victim would eventually commit real-life violence against the person(s) depicted.
A Doctor Who novel involves a new game taking the world by a storm involving a brave human fighter sent to battle the evil praying mantis-like aliens by the benevolent porcupine-like aliens (the intro shows that the two alien races can't kill one another due to their natural defenses). In reality, the porcupine aliens are kidnapping homeless people and using them as Player Characters. One of the notable "bugs" in the game is the fact that the single save game is sometimes deleted, forcing the player to start anew. The real reason is more horrifying: the Player Character is left standing when his or her player logs off and becomes an easy prey for the mantises. Oh, and Rose ends up becoming one of the PCs, the Doctor being forced to "play" her to the end.
Sergey Lukyanenko's Labyrinth of Reflections has a variation. There are a number of games in Deeptown, the most popular being the Labyrinth of Death. While there's no chance of physical harm coming to players, there is a very real chance of people dying from dehydration if they neglect their Real Life bodily needs (which happens a lot). There's also the fact that the nature of the Deep makes it impossible for most people to break the illusion without certain so-called "exit" points. This is one of the jobs of the Divers, people who have the ability to break the illusion at any point. They help rescue people who forgot to set a log-off timer and are in danger of dying. In the backstory, the first person to ever undergo a Deep-psychosis did so while playing Doom. Suddenly finding himself completely immersed in the game and being unable to exit until he beat it in one sitting.
Live Action Television
The infamous Touched by an Angel episode "Virtual Reality" reveals that all violent video games are apparently tools of hatred and of Satan that make children evil bastards with little regard for human life.
The show Level Up revolves around a group of teens working with the creator of an MMO to defeat monsters from the game that have escaped into reality. The monsters keep escaping even after they initially defeat the game's Big Bad in the 90-minute pilot.
In The X-Files episode "First Person Shooter", co-written by William Gibson, a virtual reality game becomes haunted by an AI that kills players in real life. The episode gets virtually nothing right about programming or gaming.
Though not deadly by itself, a virtual reality game in the Star Trek: The Next Generation episode "The Game" caused its users to become highly addicted, to the point of not wanting to do anything else, and also become extremely open to suggestion at the same time. It was planted by a woman seeking to gain control of the Enterprise by controlling her entire crew, and spread through the ship due to peer pressure and, eventually, crewmembers forcing it on the few individuals who refused to participate.
The Star Trek: Deep Space Nine season one episode "Move Along Home" seems to feature one of these, a game called Chula, belonging to a race of aliens from the Gamma Quadrant obsessed with games called the Wadi. Sisko, Bashir, Dax, and Kyra find themselves transported into the game world to serve as pieces while back on the station, Quark is forced by the Wadi to play to get them back (The Wadi had been winning too much at dabo, so Quark had ordered the games fixed, which the Wadi discovered). It certainly seems like a dangerous game; one of the challenges Sisko and the others are subjected to involves poison gas, for example, and when Quark makes a desperate gamble to end the game quickly and get the crew back, he loses, and Sisko and his crew seemingly die...only to reappear back in Quark's, no worse for the wear, because, as the Wadi leader Falow points out "It's just a game!"
Polybius, an (thought to be fictional) arcade game of American youth and urban lore that's become ubiquitous thanks to the Internet. The game, so the story goes, is a Tempest knock-off that appeared in Portland arcades in 1981. The children who played it suffered from all three of the symptoms detailed above before killing themselves in the middle of the night. The game disappeared shortly afterward, as suddenly as it had come - in some tellings, wheeled away by mysterious men in black. Someone actually decided to make a Polybius game, purposely simulating elements found in the mythology (subliminal messages, supernatural things, and so on). Of course, they can be toggled on and off. See it here.
There's the Lavender Town Syndrome story, which has plain old Pokemon Red and Green/Blue being a dangerous video game, and talking about how various things (Lavender Town's music, fake stuff supposedly from the tower and haunted video games) led to mass suicide. There are actually two stories tied to this one, one haunted and one having various in-game stuff causing illness and death.
There's actually a grain of truth to this; the Lavender Town theme in the original Japanese Red/Green has a brief but incredibly obnoxious high-pitched, screechy sound pop up at some point during the chorus, which can supposedly cause distress to very young children, whose ears are very sensitive. This was fixed in (Japanese) Blue and the international versions, much to the relief of eardrums everywhere.
The nameless game in Nanashi no Game. Completing it reveals the game's name — Road to Sunrise.
In Kid Chameleon, the new Virtual Reality arcade game on the block turns deadly, and actively tries to kill the players. Kid Chameleon tries to beat the game at its own game, presumably to save the people the game has already beaten. It won't be easy.
Also used as the Excuse Plot for the Wayne's World video game; it's not quite clear if Wayne and Garth were sucked into the game or if the baddies came out, but the levels are 90's platformer versions of a few places from the movie; Wayne must use his laser-shooting guitar to rescue Garth, who has been consumed by the purple gelatinous cube from that game in Noah's Arcade in the movie.
The premise of the Adventure GameOmikron: The Nomad Soul is that the player character is you, the person sitting in front of the computer, and that the game is a trap that sucks the souls of players into the game world, where they have to fight to save the world and escape back to reality or be eaten by demons.
.hack: "The World" is a perfectly benign MMO to the vast majority of its users, but there are a number who get caught up in the series shenanigans that have... interesting things happen to them, such as getting their mind trapped within the game or having data from the game transfer to their brain and affect their real life behavior. It's not usually the game itself being malignant, but some entity within the game (often an AI) using its hidden functions in malicious ways.
Ben Drowned (sometimes called simply Majora), an Internet meme / alternate reality game about a blogger named "jadusable" who gradually loses his grip on reality as he is tormented by a haunted Majora's Mask cartridge. The whole thing can be found here.
That site now redirects to the forum for the 3rd arc of the BEN Drowned ARG. Right now, you'll have to view that story here.
Pokémon is a very frequent subject of these sorts of stories. Examples include Tarnished Silver and its sequel Audible, which use Missing No., the Unown, and events from the protagonist's past to screw with his life and/or health.
Sonic R has the myth of Tails Doll. Tails Doll was an unlockable character with an appearance that many considered to be creepy (though some just find him cute). According to a number of Creepypastas, upon meeting certain conditions (usually tagging Super Sonic with Tails Doll on a specific track), Tails Doll would break into the real world and violently murder the player.
It gets worse from there. Sburb is necessary for the creation of other universes - meaning the players are forced to sacrifice their civilization to bring about a new universe. IF their game is not a "null session," meaning it is predetermined to fail, making the sacrifice completely senseless. And unfortunately, null sessions are much more numerous than the successful ones.
Averted with a void session, which cannot cause an apocalypse.
In the Batman: The Animated Series episode "What is Reality?" the Riddler traps Commissioner Gordon in a deathtrap-themed virtual reality game, forcing Batman to enter to rescue him. (Of course, the Riddler seems fond of video games in general in this continuity, having become a villain in the first place after being cheated out of the royalties for one he invented, as revealed in his first appearance. That game was harmless, but the amusement park that was based on it sure wasn't.)
The entire plot of Code Lyoko is an inversion of the Trope. While the VR world is deadly, the Big Bad would rather the heroes stay out of it; they have to go there to stop him every time he launches an attack.
Megas XLR: Coop comes into possession of what appears to be an old video game cartridge, but it's actually an intergalactic prison housing many dangerous alien criminals. When Coop finally finds a game console that it fits into (or rather one that he can hit it hard enough to fit into), he accidentally releases them and spends the episode putting them back in.
SinisteRRR from We Are the Strange is an evil arcade game that (possibly) acts as a watchdog and alarm for the Big Bad and later transforms into a Humongous Mecha who proceeds to kill off all but 3 of the main cast.
In The Fairly OddParents episode "Power Mad", Timmy wishes for a VR game that he can't wish out of. Timmy, Chester, and AJ then have to finish the game without losing all three of their lives otherwise they'll be destroyed.
In The Powerpuff Girls special "Dance Pantsed", when the girls get a parody of Dance Dance Revolution Mojo Jojo sends them a fake sequel that turns them into evil cyborgs. This being Mojo, he also outlined his plan on the back, which is how the Professor finds out what happened when the Girls are gone.
An episode of Darkwing Duck involves the titular character end up digitized into a popular game. Gossalyn has to control him using VR gloves to beat the game in order to return him to the real world.
The first recorded death while playing a video game was with Berzerk - a man got a heart attack while playing it.
There are many media accounts of gamers dying after playing for absurdly long periods without rest, especially in Asia. The deaths were mostly caused by the physical stress of such a long continuous session rather than any property of the games themselves. This goes back to 1981-82, when two teenagers died very shortly after posting high scores in the arcade game Berzerk. Even more common are reports of health issues stemming from the same practices, which have prompted game companies and service providers to institute Anti-Poop Socking changes.
There have been cases of online game players fighting or killing each other in real life over virtual property, though the players themselves were usually as much to blame as the service providers.
The case of a Korean family leaving their infant daughter alone to play World of Warcraft, only to come back and find that she'd rolled over and suffocated. MMORPGs in general seem to attract these kinds of stories.
Imscared is a real-life version of this. The game can open itself, interfere with your browser, put files on your computer, has several fake endings to make you paranoid about if the game is over or not, and pretends that the villain is a monster that turned itself into a computer virus.