It's a bad old time for Humanity in general. The human Empire is presided over by Empress Lionstone, aka the Iron Bitch, a ruler who makes Josef Stalin look like Gandhi. Everywhere in the Empire, rebellions are popping up and popping heads as fast as one can blink, and are slaughtered with utmost efficiency. Espers, clones, degenerates, and slaves are ubiquitous, treated as third-class citizens when they're not being tortured, experimented on, or simply shot. And, for once in the Empire's history, nobody is truly safe - be it noble, commoner, or servant.
That's not the worst of it, though. From the borders of the Empire, a number of threats have arisen: a group of formerly subservient AIs which broke free of their programming and formed the planet Shub, driven to exterminate their old masters; the Sleepers, a group of aliens genetically engineered as weapons, intended to destroy all in their path... and other horrors from beyond the Darkvoid, a multiple-light-year-wide sphere of death which the Empire created hundreds of years ago. Oh, and that's still nothing compared to the court intrigues, only kept at bay by the terror the Empress bestows upon her subjects.
The eight-book Deathstalker series, written by Simon R. Green, drops the reader right into the midst of this, beginning with the outlawing of one Owen Deathstalker, an aristocratic historian who just wanted to relax in comfort on his idyllic, pastoral homeworld. That changes fast, and he's forced to take up arms with the smuggler Hazel D'Ark, the bounty hunter Ruby Journey, the hero of the rebellion Jack Random, and the former Hadenman Tobias Moon... as well as a host of other unsavory characters, all of whom are out for themselves as much as anything.
In short, the Deathstalker series is a Fantasy Kitchen SinkSpace Opera, soft as warm butter on the Mohs scale, and is sliced up into hundred- or two-hundred-page sections which could generally stand as stories on their own right. One can expect quite a lot of HSQ and similar moments when explaining any given segment, particularly as one reads further on. Finally, outside of the series itself, there are a handful of other stories written by Simon R. Green in the same universe, including the compilation Twilight of the Empire.
Body Horror: Shub does this to some folks. ... well, okay, everyone they find. Also, Half-A-Man.
Simon Green seems to really like this trope. Wormboy, a giant tub of goo which literally fills an auditorium, the Maids, young girls converted into mindless cybernetic monsters, marines in the Madness Maze, hell, even the Empress gets her moment of this.
Bury Your Gays / Hide Your Lesbians: Averted in one case, with the Stevie Blues; played straight as an arrow in another case, with David Deathstalker and Kit Summerisle.
Chekhov's Boomerang: The Madness Maze after it was supposedly destroyed by Captain Silence.
Complete Monster: The Blood Runners, who kill people for body parts in their quest to find immortality. Additionally, Lionstone herself. By the end of the fourth book, Valentine Wolfe can claim this title, too.
Cool, but Inefficient: Disruptor cannons can fire through most armor - once, every two minutes. Beyond that, swords come into play. The only reason projectile weapons aren't still around is because they were systematically banned.
Disruptor weapons get a little better in the last three books. It just takes 30 sec. to recharge. Just long enough to get run though if you miss, or fighting more than one enemy and have only one gun. which lead to Badass Bandolier.
Cool Old Guy: Jack Random. Thanks to the Madness Maze, he gets younger as the books go on. But he stays cool.
Door Stopper: The books clock in at a decent 500 pages apiece, in general - which doesn't seem horribly long until you remember that there are (at last count) nine of them.
A drug dealer/chemist in the later books is exposed to the Madness Maze, he starts producing drugs that cause specific effects, like killing off the left, or right, side of the body leaving the user as a half-dead junkie, and thats not even the limit of Doctor Happy...
Fantasy Kitchen Sink: In the first chapter of the book, we have gravity sleds, assassin concubines, Turing-class AIs, massive starships, hyperspace-compatible yachts, regeneration machines, organ smugglers, and a corrupt empire. It gets more convoluted from there.
Genius Loci: the Red Brain: a giant, sentient forest, that may or may not be an entire planet. There is also another, literal living planet, and then at least one other world that was effectively a Genius Locus after a Big Gray Goo scenario. The A Is of Shub may also count, being three sentient computers the size of a planet.
Me's a Crowd: Hazel D'Ark eventually learns how to summon clones of herself. Unfortunately, when she gets experimented on, her captors start killing them, one by one.
The Mole: Loads of them. Oz, the Lord High Dram (as Hood), Alexander Storm, and Young Jack Random, to name some. The poor rebels.
In the later books Saturday for all the six lines of dialog or so he/she gets
Moral Event Horizon: For many citizens and people in the series, it had to take Lionstone ordering mass murder in Virimonde for them to conclude that she had gone batshit insane. Why they didn't realize that she had already passed the Moral Event Horizon long ago might be a mystery.
Musical Assassin: There's a type of esper called "Sirens," who can use their own voices as sonic weaponry.
Names to Run Away From Really Fast: "Golgotha," the capital world of the Empire, is also the name of the place where Christ was crucified. Also "Haceldama" is where Judas hanged himself.
They Would Cut You Up: Silence and Frost's reasoning for not telling anyone about their abilities.
Touched by Vorlons: The people who went through the Madness Maze; and to a lesser extent (they already had powers), the espers touched by the Mater Mundi.
Unresolved Sexual Tension: Silence and Frost, cut short by Frost's death. To be fair, Silence admitted that even if Frost lived, their relationship would always be in this state, since Frost is an investigator.