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- In One Piece, Fishmen inherently have 10 times the strength of normal humans, but they are constantly getting captured and placed into slavery, where they are bought for extremely high prices by the fabulously wealthy. People confirmed to have Devil Fruit powers also fetch very high prices at the slave auctions.
- Witch Hunter Robin had the inquisition out to mostly kill witches, but the Japanese branch wasn't averse to recruiting witches... in order to use them to hunt down their own kind. The ones they captured were then enslaved (or processed, it's not clear) to produce "orbo," an Anti-Magic material.
- Darker Than Black Contractors were treated like dangerous, though useful monsters and either used as expendable killers or experimented upon at will — at least, until U.N. intervened... to demand that countries share this research and form PANDORA. Dolls who got a shorter straw were treated like corpses with still living brains — if normal humans don't take cyborgization well, try to cut off a Doll's legs and "program" him to test the replacement. Just like that, it's equipment. Or sometimes a pretty one get "programmed" and sold as a Sex Bot — illegal, but behind the masquerade there's very little difference.
- The manga series +Anima is about young people who develop the ability to transform into Petting Zoo People, with the ability to grow wings, claws, tails, and more. Discrimination against the +Anima occurs in many places, but in Sailand, enslaving them is legal and there is an active business. It's implied that they're usually sold to people who can make the most use of their abilities, (such as a fisherman who wants to use a swimming +Anima for his work) though attractive +Anima may be sold to rich people and artists for the purpose of standing around and looking pretty.
- Gangsta features a split-off of humanity called Twilights, all of whom have Super Strength, Super Speed, etc. but constantly face Fantastic Racism and were legal to enslave until just a few years before the main story starts. The only reason normals got away with this sort of treatment is because Twilights are a very small minority of the population and all of them are hopelessly addicted to the pricey drug Célèbre, which many slave masters used to control them. For example, one of the main reasons Nicolas never ran away from his highly abusive owners as a child was because they provided him with just enough Célèbre to keep him barely lucid.
- May or may not happen frequently with the more monstrous monster girls of Daily Life with Monster Girl. A shown example would be Rachnera Arachnera, whose host family was expecting a girl of the softer variety.
- In one of the more recent chapters, during a flashback we see several monster children being rescued from a group of kidnappers.
- World Trigger: The Neighbors' motive for coming to earth is essentially this. Drones are sent to earth to harvest humans for their Trion. Humans with low Trion merely have their Trion Glands removed (which is, naturally, fatal). Humans with sufficiently high Trion, however, are taken alive and used as Slaves Soldiers back in The Neighborhood.
- Tokyo ESP: The reason the protagonists from Part 1 are missing is because they've gone undercover to break up an ESPer trafficking ring.
- The Ancient Magus' Bride starts with Elias buying Chise from an auction for that deals in magical creatures.
- The 1970s alien version of Starman spent years as a drugged slave being bought and sold by various "collectors".
- At one point, Fantastic Four foe the Puppet Master attempted to sell a number of Marvel Comics superheroines under his Mind Control as Sex Slaves to various nasty sorts.
- 1980s Justice League of America villainess the (human) Queen Bee was introduced running an auction to sell off a brainwashed superhero from another world.
- Justice Society of America enemy Roulette engages in this so that she can profit from betting on superhuman blood sports.
- The Cyborg-Superman and Mongul have both tried to do this to the members of the Green Lantern Corps.
- The X-Men are basically the Trope Codifiers. Among the groups out to enslave them are: The Weapon X project, the U-Men (although in this case, they were specifically trafficking mutant body parts, blood and whatever else carried the mutations) and the island nation of Genosha, which built its prosperity on mutant slavery until Magneto stepped in and took over.
- X-Men villain Mojo's entire existence is practically to televise Differently Powered Individuals doing awesome things for the benefits of higher ratings. Their consent, is of course, purely optional.
- We once did see the Hellfire Club having an actual superhuman auction. This isn't as suicidally dumb as it sounds, as the Marvel Universe has always had a population of lower-level superhumans—not always visible, but there. The club wasn't selling anyone who could kill you with their brain. Not to mention, the Hellfire Club is run by an Inner Circle of powerful superhumans in their own right. Natch, the X-Men had to break it up.
- Gambit was stolen from a hospital shortly after birth and given to a slave trafficking sorceror as a gift because of his demonic-looking eyes.
- In the DCAU, Superman, Batman and Wonder Woman were once captured and auctioned off to the highest bidder. All the major villains of the DCAU were invited to the auction. It turned out to be a trap by the Justice League to lure out of hiding and arrest as many villains as possible.
- In the original Escape to Witch Mountain Tony & Tia are chased by a Corrupt Corporate Executive who wants to use their powers for his personal gain and a mob of people on a literal Witch Hunt. Not that they know what they'll do with them once they catch them.
- The Marvel Cinematic Universe has a solitary example: The Incredible Hulk, whom General Thunderbolt Ross says, in no uncertain terms "is property of the US Government". Specifically, since Banner tested an attempt to reverse-engineer a super-soldier serum on himself, the power of the resultant Hulk Out is seen by Ross as useful to the government as study. He's prepared to capture Banner and use him as a guinea pig/monster on a leash for the rest of his life.
- This is the premise of Push, all the world's superpowers hunt down... people with actual superpowers, killing, brainwashing, and experimenting on them.
FrancisAjax runs a lab that creates brings latent superpowers in people, under the pretense of making superheroes out of them, then sells them off as super-slaves to various criminal organizations.
- In Crest of the Stars, the Abh were originally created to be slaves. Now that they have an empire of their own, they're hated.
- In Dragon Bones there is Oreg, who was turned into some highly supernatural Genius Loci ghost-thingy in order to create a castle that would take care of itself. He is also a shapeshifting dragon, so he was supernatural to being with. There is also the skeleton of a dragon in chains somewhere in the caves under the castle. Dragons are sapient beings in that world, so this not better than having a human skeleton in the basement. Rather worse.
- In The Dresden Files short story Aftermath, Murphy has to disguise herself as a kidnapper selling a couple of werewolves in order to track down and destroy a Fomor group operating in Chicago. Formors are a group of aquatic supernaturals snatching up humans possessing varying degrees of magical talent. It's mentioned that werewolf blood has several useful properties, and presumably other kinds of magic-users would have unique traits.
- The Damane in The Wheel of Time.
- In the Honor Harrington series, Manpower Incorporated of Mesa. Whatever sort of genetically engineered slave you need, from pleasure units engineered with stunning good looks and thoroughly trained to please any man or woman's desires, through to the heavy labour lines engineered for size and strength and nothing else, Manpower Incorporated has you covered.
- Library of Souls: Peculiars enslave and pimp other peculiars in Devil's Acre.
Live Action TV
- This is the ambition of the Doctor Who villain Henry van Statten. Pity his first attempt involves a Dalek.
- In the Classic story "Warrior's Gate", the Tharils are enslaved for their time-sensitivity, forced to work as navigators for human vessels by being strapped into mechanisms that can damage their minds from prolonged use.
- Heroes had a mix of both options by the same organization, which both hunted, exterminated, recruited and blackmailed people with abilities.
- In Firefly, a government facility known as "The Academy" exists to experiment on young people who show signs of psychic abilities and turn them into Super Soldiers. Among other things, the process vastly amplifies their Psychic Powers, but it frequently drives the subjects insane. The Academy recruits their 'students' by posing as a prestigious school; while there's no evidence of them using force to obtain new subjects, it's very difficult to get out again once you've signed on. Any escapees are hunted by "Hands of Blue" agents.
- This was the premise of The Immortal, a standard episodic drama from 1969 to 1971. Ben Richards was a race car driver whose blood contains every immunity and antibody possible, making him effectively immortal. A very rich and old man discovers this by receiving a transfusion from Richards and instantly feeling much younger and healthier. This prompts him to want to capture and imprison and effectively enslave Richards to ensure a constant supply of this (literally) life-giving substance. They even covered the point about paying Richards to frequently donate some blood, and the old man refusing by postulating that serious injury could kill Richards, thereby cutting off the supply of blood.
- In one Angel episode, Lorne is being forced to use his ability to read people's destinies so that they can be sold on the black market.
- In an Alternate History episode of Misfits, a Holocaust survivor travels back in time to kill Hitler, but inadvertently causes the Nazis to have a technological advantage and take over Europe. In the alternate present, the Nazis are rounding up superpowered individuals and using Seth, who has a combination of Power Parasite and Super Empowering, to give them to high ranking Nazi officials. The superpowered individuals are then killed.
- In Babylon 5, human telepaths (except the very weakest) are required to join the Psi Corps, or take psi-dampening drugs that include suicidal depression as side effects.
- In the Aberrant role-playing, some novas (superpowered individuals) are hunted by criminal syndicates who kidnap them and harvest their organs to make superpowered drugs.
- Champions. The organization PSI (Parapsychological Studies Institute) hunts down and captures people with psionic abilities and brainwashes them into becoming villains and slaves of PSI. PSI plans to use them to take control of the world.
- In the New World of Darkness gameline Hunter: The Vigil, the Cheiron corporation does this to any being with powers, dissecting them to make medicine. Interestingly their strategy is stated to be very successful at curing the sick. They also harvest organs to give their agents superpowers.
- In Mummy: The Curse, Last Dynasty, Incorporated harvests mummies for their Sekhem, which they use for a variety of drugs, from an AIDS cure to a longevity treatment.
- Shadowrun. Drakes are creatures which appear to be human but can shapeshift into the form of small dragons, with appropriate powers. Once they started to appear, powerful entities such as Great Dragons and MegaCorps immediately started to hunt them down and capture them.
- In general, awakened magic users tend to fetch a premium in human trafficking rings.
- In the Dungeons & Dragons Dark Sun setting, muls (crossbreeds between humans and dwarves) have incredible endurance, being able to work three days straight without rest, but are rare due to sterility. Their endurance makes them great slaves, and large numbers are made into gladiators. Slave-hunters will generally put more effort into capturing muls than slaves of other races, and will probably have to because muls sprinting for freedom tend to be Bad Ass.
- The Imperium of Man from Warhammer 40,000 counts psykers as part of their planetary tithes. The Imperium uses psykers for faster-than-light communication (astro-telepathy) and as military assets (sanctioned wyrdvane psykers) and the Navigator Houses (in)breed their own unique psychic mutants that are required for faster-than-light travel. Psykers who fail whatever tests are fed to the Golden Throne, where they fuel the Astronomican, the Emperor's massive psychic lighthouse, which allegedly burns through a thousand psykers a day. Untrained psykers are incredibly dangerous to Imperial citizens, as the powers of the Warp can use an unsuspecting psyker as a gateway into the real world and wreak havoc until they dissipate back whence they came.
- The Little Sisters in Bioshock are little girls who have been kidnapped and augmented with a parasitic slug that makes them effectively immortal until they're ripped apart for Applied Phlebotinum (or reach puberty, which turns them into feral teenagers with superpowers). There was a market for harvesting the stomachs of little girls until the civil war turned Rapture into a ruined nightmare, at which point the little girls are paired with giant, hulking cyborgs dedicated to killing anyone who harms their bow-wrapped drug factories. You can either save them or get in on the action.
- The Harvester gang in Deus Ex: Human Revolution likes to kidnap people with augmentations and cut them out to either sell or install in themselves. Not a very nice group of people, all things considered.
- Biotics (especially untrained children) in the Mass Effect universe are very sought after by illegal groups, particularly if they're powerful for their species. In a more benign variant, biotics are also rare enough among humans that there are monetary incentives offered for them join the armed forces; the discrimination they face is so omnipresent that a very large percentage of them do indeed sign up just to escape it.
- The Blackwatch of [PROTOTYPE] once infected the entire population of a town with an experimental bioweapon. Every subject died after the town had to be shelled except for two, a woman and her newborn baby, who both exhibited odd capabilities. They were seized and designated "military assets" to spend the next forty years imprisoned and subject to all kinds of tests to develop tactics for fighting (and creating) new bioweapons.
- The titular organization in X-COM does this a lot to aliens - both by selling their corpses, which is pretty profitable in the beginning, and capturing living ones for interrogation and conducting research.
- Legalized example in Dragon Age: Origins: all individuals, human or elf, with magical talent can be taken away by the Templars and placed inside a glorified prison with others of the like (ostensibly for their own and everyone else's protection) to toil away for the Chantry and whomever the Templars deem suitable clients.
- The situation is made complicated by the fact that mages are so because of their connection to the Fade, which includes a significant population of malevolent demons ready to use the mage as a tunnel to wreak havoc in the mortal world. A mage who loses control and gets possessed is generally accompanied by a massive body count. The Chantry sees its practices as a reasonable compromise: Mages are taken away from the public population for the safety of all, but the mages themselves aren't killed outright, but confined amongst their kind in relative comfort where they can study their art, use them for the better, and be warned not to give into the demons. As is with most complicated matters, there is ferocious IC and OOC debate on this, and lots of room for abuse on both sides.
- The Qunari, though, treat their mages as dangerous beasts. All mages are called Saarebas, which literally means "dangerous thing" in Qunari. They are forced to wear special collars that nullify their abilities and can be used to cause them great pain. Many also have their mouths sewn shut, so that they can't speak the words of a spell. In Dragon Age II, if a certain Qunari mage hunter finds out that you or anyone in your party is a free mage, he will go berserk and attack you immediately (of course, he would still attack you anyway for attempting to free a Saarebas). They have only recently started to grudgingly use Saarebas in warfare, once their attempt to fight the Tevinter Imperium (a magocracy) with only conventional means (including gunpowder) was met with devastating magic.
- In StarCraft, telepaths are deceptively (if possible) or forcibly (if not) recruited into the Ghost Program by wranglers. They are then trained The Spartan Way and mind-wiped.
- Golden Sun: Dark Dawn specifically says that the beastmen of old were enslaved for their great strength, and were hunted again for the same purpose when they re-emerged after the return of Alchemy to Weyard.
- In Drowtales, while "Goblin" races (humans, orcs, etc.) are terrified of Fae races (elves, faeries), one kingdom has offered a reward for captives of elven blood for use as Human Sacrifice in hopes of obtaining the power of immortality.
- In Blue Yonder, the Davenports have been targeted. Their parents were taken in the Back Story, and Maiden Flight sacrificed herself to buy Blue Yonder time — and the reasons why are as yet unknown.
- One Global Guardians PBEM Universe story saw the heroes shutting down a slaver ring who were selling female Pelkons (a race of very human-like alien refugees who had been stranded on Earth during the Xorn invasion of 1985) into sexual slavery. A partial subversion in that the Pelkons have no "superhuman" abilities to speak of.
- Although the superhumans are the upper class in Arcadia, the primary setting for Destine Enormity, the Minos Corporation was found to be shipping Arcadian citizens out to be enslaved in the outside would. Both the Elite and the Messiah Complex were pissed when they found out.
- Not uncommon in Brennus. People with the Adonis trait (especially if it comes with little or nothing else in the way of superpowers) are targets for sex slavery. Other powers tend to vary depending upon the risk-versus-reward scenario, but the Califate pays top-dollar for Contrivers, and everyone wants a Gadgeteer.
- DC Comics villainess Roulette turns up with this M.O. on Justice League as well (see comic books above).
- In Young Justice, the "genomorphs" are this: genetically-engineered/cloned superbeings that are kept under mental control until ordered with a task. In fact, the pilot was a carefully-crafted revolt by the genomorphs to supplant the control of The Light (the Omniscient Council of Vagueness which created them) and allow the most human-looking of them (Superboy) to escape and act as their advocate to the outside world.
- Unfortunately, the Light is still in control, just more subtly, and Superboy has trouble even advocating for himself. Also, they left the same guy who was brainwashed into being head of security for the evil version as head of the reformed version, instead of getting him some damn therapy.
- As of season 2, both of them have been cured of this. On the other hand, the Light have started making deals with evil alien forces after advertising humanities potential for superpowers, which means lots of homeless people getting kidnapped and shipped off for human experiments to keep invoking this trope anyway.
- In The Fairly OddParents, Fairies are often hunted, almost always Mr. Crocker going after Timmy's fairies. In The Movie, Abracatastrophe, he succeeds
- A plotline in season 3 of The Legend of Korra involves new airbenders being forcibly conscripted into the Earth Kingdom army.