- Humans taste really good, so enslaving us en-masse is in their interest.
- They see us as a threat to their empire or race.
- They are Fantastic Racists who consider us inferior and weak, fit only to be wiped out.
- They need slaves for the ice mines on Chiron Beta Prime.
- Humans have exhibited Fantastic Racism on them, potentially trying to wipe them out or enslave them.
- Humans treat them as delicious/worth enslaving, so preventive genocide is on the table.
- They've observed or otherwise learned human history from afar, and are appropriately horrified or terrified.
- They were once human and want to lord it over the rest.
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Anime & Manga
- Done by Optimus Prime/Megatron expies in Panty & Stocking with Garterbelt — the eponymous characters kill them when they arrive on Earth, and they merge into a single powerful Ghost that wants to wipe out all humanity (after making peace with each other).
- In Rosario + Vampire the monsters (at least several, if not dozens of species) have united to create a monster world separate from Earth, and exterminate humans who sneak into the monster world. Much to his chagrin, Token Human Tsukune finds himself mistaken for a monster and gains a Cute Monster Girl Unwanted Harem, at least some of whom believe Humans Are the Real Monsters. His True Companions choose to stand by him when his cover is blown in the anime, fending off a small army of their classmates.
- The final arc of the manga involves Tsukune and his True Companions trying to take down one of these.
- In Drifters, the Black Cloaked Man is gathering such an army, comprised of all non-human races except Elves and Dwarves (who have already formed the beginnings of their own version of The Federation).
- In Tokyo Ghoul, Ghouls are not known for their cooperation, primarily due to being extremely territorial and naturally competitive. That is what makes Aogiri Tree so significant, with hundreds of Blood Knights brought together under the banner of Ghoul Supremacy. Humans and peaceful Ghouls alike are targeted by them, and their criminal dealings combine them with The Syndicate.
- In DC Comic's Crisis Crossover Invasion!, various alien races are convinced by The Dominators to help them invade Earth, out of fear of its superbeings — and disgust over our genetic variety. Of course, The Dominators all along planned to capture the superhumans and use them to conquer the universe.
- Marvel Comics had a similar crossover in which Earth was sealed off from the rest of the universe for having intervened in the affairs of other civilizations too often (nevermind that it was often to save them). They even dumped their alien criminals on our world! (As in Invasion! this turned to be part of a plan by one race to then turn on the rest.)
- Speaking of Marvel, um, the Brotherhood of Mutants? Though to be fair, humans started it.
- The Superman arc that reintroduced the "retroboot" Legion of Super-heroes features the United Planets going to war with the xenophobic Earth.
Films — Animation
Films — Live-Action
- In the backstory to Hellboy II: The Golden Army, humans are at war with elves and the other magical races, nearly driving them to extinction. This prompted the elves to create the Golden Army, which decimated the humans so badly that the elven king was horrified and negotiated a peace.
- Star Wars Legends
- In Young Jedi Knights, there's the Diversity Alliance. Who plan on killing humans with a bio-weapon that only targets humans.
- Far earlier, there were several anti-human resistance movements on Coruscant, mostly in reaction to the oppressively human-centrist government.
- In the X-Wing Series these tendencies are exploited by Director of Imperial Intelligence turned de facto Empress Ysanne Isard after the Imperial capital falls to the New Republic... soon after a biological weapon whose symptoms make Ebola look good by comparison that targets almost every species except humans is deliberately set loose on the surface, leaving the arriving New Republic forces with a huge public health crisis and the human and nonhuman populations at each other's throats.
- Sergey Volnov's Army of the Sun is set after a galaxy-wide rebellion of alien races against the EarthStella Empire, which had formerly conquered all of them. All the aliens join together to wipe out the human threat. Of course, no side is in the right here. This is a Crapsack Universe, after all.
- In The Stainless Steel Rat Wants You, humanity is attacked by a coalition of alien races hell-bent on wiping out all humans simply for looking ugly. Their only similarities are that they're all slimy, ugly (from a human point of view), and reptilian/amphibian.
- The vampires of the Red Court in The Dresden Files were gunning for one of these for most of their war against the White Council. Unusually, they didn't have much luck, partially because the White Council actively took steps against it and partially because nobody really liked the Reds either.
- In Out of the Dark, a group of aliens scheme to make another race come and kill all humans because the prospect of having a second warlike, omnivore race as neighbors is terrifying for them. In a lovely case of Nice Job Fixing It, Villain!, while humans might've wanted to coexist peacefully before this little stunt, they're hell-bent on revenge now.
- Star Trek
- The Alliance in the Mirror Universe in Star Trek: Deep Space Nine is a coalition of races that rose to power in the vacuum created by the Terran Empire's decay into a more democratic and peaceful organization after Kirk made some convincing arguments about mercy and compassion to Mirror-Spock.
- Before that (in-universe chronology), there was the Anti-Imperial Alliance in Star Trek: Enterprise.
- According to the non-canon Shatnerverse novels, it was Tiberius himself who manages to convince the Cardassians and the Klingons (who hate each other) to join against the weakened Empire, after Spock ousts him. Then they pull an You Have Outlived Your Usefulness on him.
- There are also the Xindi, who are hell-bent on eliminating humanity. While they're all originally from the same planet, they are five (formerly six) distinct species (Xindi-Primates/Humanoids, Xindi-Arboreals/Sloths, Xindi-Reptilians, Xindi-Insectoids, Xindi-Aquatics, and the extinct Xindi-Avians).
- The Votanis Collective in Defiance is a joint government representing each of the several alien races that live on earth, and regularly engages in covert actions against the all Human Earth Republic. The Cult that abducted Irisa as a child is made of many Votans and plans to wipe out Humanity and turn Earth into a paradise for the Votan. In Season 3, a Votanis Collective Doom Troops regiment shows up outside Defiance and plans to kill all humans, but it turns out they were rogue and the VC proper shows up to apologize; they may work against the Earth Republic, but they aren't butchers.
- In Anima: Beyond Fantasy, where Fantastic Racism is almost rampant, we've Samael, an organization that encompasses sentient, non-human races. While some members of it just want to live in peace again with mankind, others want to destroy it.
- Warhammer 40,000: The Tau Empire is made up of several races which would be horrifying Scary Dogmatic Aliens or Starfish Aliens in any other work. They'd be perfectly content to make allies of humanity (in fact, many human "heretics" do join up with them) but humanity is so xenophobic that they're more this trope. The Tau are often considered the closest thing to "good guys" in this setting, but bear in mind that a lot of their recruitment strategy is flat out brainwashing... unless that's just propaganda...
- Artemis Spaceship Bridge Simulator has four species of sentient alien. Three, the Kraliens, Argonians, and Torgoth, are members of an anti-human "Hegemony," per the Word of God canon. The fourth race, the Skaraan, aren't part of this hegemony but have a mutual nonagression pact.
- Halo: While the multi-species theocracy known as the Covenant had already existed for millennia before they ever encountered humans, their main goal in the games is to wipe humanity from the face of the universe because they're unholy. Well, that's what the Prophets are telling their followers anyways. Nonetheless, many Covenant members harbor doubts about the validity of their campaign against humanity, and this trope eventually becomes subverted by the end of Halo 3: during the Great Schism, many former Covenant soldiers who were betrayed by the Prophets or simply disagree with the Covenant religion ally with the humans against those still loyal to the Prophets.
- After the Covenant falls apart, a number of remnant factions still wish to finish the job against humanity. Ironically, the leaders of the most powerful of these factions (which we fight in Halo 4 and Halo 5: Guardians) were among those who were betrayed by the Prophets. They just happen to really hate humans that much.
- That said, the motivations of the soldiers in both the Covenant and its remnants vary widely; while some are true believers, many are simply coerced slaves or mercenaries Only in It for the Money.
- This is the plot of Icewind Dale II. The two Big Bads gather all the monster races bullied by the six towns in the north for their savage behavior (the monsters', that is) and put them under one banner. Hypocritically, the villains also take advantage of their connections to the Host Tower of the Arcane Brotherhood of Luskan, an organization of evil human wizards.
- World of Warcraft
- Two of the races in the Horde fit. The orcs were once enslaved by humans, and most Forsaken were once human themselves. Many humans in the Alliance would very much like to see both of these groups destroyed because of what others of their race have done.
- The blood elves are another example. They used to be part of the Alliance, but a racist human leader decided to betray them before they could betray him. This set off a series of events that led to them being new members of the Horde.
- The Scoia'tael in The Witcher is an alliance formed between elves, dwarves and a few other fantasy races, who commit acts of terrorism against humans in retaliation for the Fantastic Racism humans subject them to. Like all things in the Witcher-verse, its not quite that clear-cut. Many, humans and non-humans alike, sympathize with their goals, if not their methods. Some non-humans consider the atrocities the Scoia'tael perform to be more likely to incite racial riots than address the injustices non-humans are submitted to. At least one Elven ruler has sworn fealty to a human overlord, and is doing very well out of that deal. Elves are clearly over-represented among the Scoia'tael, and the Dryads, who are suffering most from human expansion, want nothing to do with them. The Dwarves feelings about the Scoia'tael seem to be "Ach ye pointy-eared bastards, noo, when the humans are everywhere, noo we're all "Elder races" and best chums, aye?!", and no-one even bothers to ask the aboriginal species, the gnomes, what they think about the whole mess.
- The Fomors in Mabinogi and its prequel Vindictus see humans as a menace to the world (all that chopping and building and domesticating — such greed and hubris!) and want to exterminate or at least ruin humanity. The Fomors accept anyone who wishes the end the human threat, even disillusioned human renegades.
- In The Elder Scrolls series, both before Tiber Septim's rise to power and after the fall of the Septim Dynasty and the beginning of the Fourth Era, the Summerset Isles (the Altmer) and Valenwood (the Bosmer) were a unified nation known as the Aldmeri Dominion (which is decidedly anti-human in its overall stance). Before, Tiber Septim used a massive golem to conquer it. After, as of the books, which are set 160 years before Skyrim, the Dominion is in direct conflict with Titus Mede's reborn Empire. Given the lore of the Altmer (who are the dominant partner in the Dominion), it would stand to reason that they are quite decidedly anti-human in stance, even if the two power blocs are powerful enough to discourage open war.
- The alliance bit is a bit, er, questionable when it comes to the Dominion's thirdnote iteration (the new Dominion is very, very clearly dominated by the Thalmor, Altmer who believe in Elven supremacy). The anti-human bit very much is not: part of the Thalmor agenda is erasing the possibility of man existing from reality. The first Dominion, however, plays this trope perfectly straight.
- In The Elder Scrolls Online, the (mostly) elven Aldmeri Dominion is explicitly opposed to a human-dominated Tamriel, which is why they oppose the Imperials and the other two factions.
- Individual elves may not hate humans, but their governments have, in unison, proclaimed that human lifespans are too short to possibly do a fair and even-handed job of governing the entire continent. The fact that their Khajit members barely outlive humans is carefully ignored, as is the fact that the other factions include the Hist, the Dunmer, and the Orsimer, who live as long as the other Elves.
- If you played the Renegade path in Mass Effect, the Citadel species become a lesser version of this in 2: they aren't openly hostile to humanity, but they resent humanity's quick rise to power and offer the implication that Shepard deliberately threw the Battle of the Citadel in order to kill the Council. Depending on dialogue choices, they may be completely right.
- Subverted in the Winds of War expansion of Heroes of Might and Magic 4 — The other factions have specific and very different reasons for fighting the humans, and are fighting each other over which one will eventually conquer them.
- In Genesis Rising the Defiance is an alliance of the remnants of several species that humanity conquered or exterminated. They have also reverse-engineered the Human Empire's Organic Technology to fight them.
- In Drowtales, the multi-species adventuring party takes on the human kingdom after the king orders all beings of elven descent arrested. However, Lady Ariel is fighting only to rescue Faen and her companions are mostly just trying to keep her from getting herself killed.
- In Goblins, there's a generalized conflict between the humans and their allies (dwarves and elves), and creatures such as goblins, orcs, ogres, etc. The main reason for the conflict seems to be Fantastic Racism on part of the humans, most of whom aren't very bright.
- In The Order of the Stick, Redcloak's goblins & hobgoblins fight alongside Xykon's undead against the mostly-human Azure City. Redcloak is Lawful Evil and freely admits it, but he and his forces are also fighting for their right to not exist only to be killed for Experience Points by the player races. On the other hand, Xykon's fighting to accomplish his current Evil Plan and For the Evulz.