Astro City: A guy who is depressed because of overwork, homesickness and lack of romance, a ten year old girl who doesn't know what hopscotch is, a guy who beats people up while dressed as a clown, a metallic former crook, a teenager who dresses as an altar boy because he's annoyed at his dead father and other inhabitants of the same city have adventures and are psychoanalyzed.
Aquaman: The adventures of the mutant bastard child of a sailor and a mermaid.
Batgirl: Abused and learning-disabled runaway girl finds a constructive outlet for her death wish.
Batman And Robin: An acrobat and his Tyke Bomb stepbrother fight the mentally ill, estranged family members, and sometimes a mentally ill estranged family member.
Battle For The Cowl: Brothers fight over their apparently dead step-father's stuff.
Birds of Prey: A paraplegic, a screamer, and a crossbow-enthusiast develop a social club.
Blacksad: A feline detective in a world of furries must solve cases of murder, racism, and the rather gritty realities of life, while dealing with a hygiene-challenged sidekick. Originally in French.
Bloom County: A naive talking penguin and his woodland creature friends hang out with a boy in glasses, another boy who wants to be a ballerina, and a Vietnam Vet.
Blue Beetle: A high school kid who wants to be a dentist teams up with a homicidal alien superweapon, and fights an array of Genre Savvy villains with the assistance of his family and friends.
Ted Kord: Batman without the psychological problems.
Bone: A slacker, a corrupt politician, and a literature buff are chased into the desert and plunge into a valley, where they meet a queen and princess who specialize in cows and fight a crazy old woman who spits out bugs.
Buck Godot: Zap Gun for Hire: On a lawless world, a man protects a woman from religious fanatics, prevents a kidnapping, stops a hijacking, and works to save the population of a doomed world. It's a comedy.
Buck Godot, zap gun for hire: Psmith: Love blossoms amidst assassination attempts by a stubborn drunk.
Buck Godot, zap gun for hire: The Gallimaufry: Tax law causes a man to visit a brothel.
Cable & Deadpool: Cyborg Mutie Jesus and a brain-damaged, motormouthed mercenary have morally questionable adventures that involve one of them turning into goo and the other eating him, then vomiting him back up. Hijinx ensue!
The Beano Calamity James: A bucktoothed youth is subjected to the most painful and humiliating situations imaginable. His talking pet lemming finds this hilarious.
Calvin and Hobbes: A boy and his talking stuffed animal travel through time and discuss politics.
Captain America: Scrawny shrimp is rejected from the army, takes drugs and becomes icon of America.
Captain Atom: A Vietnam veteran tries to reconnect with his now-adult children after having been absent from their lives since they were babies, and also tries to get over his dead wife. He falls in love with and eventually marries a terrorist..
Catwoman: A crazy cat lady goes running around the city waving a whip.
Cerebus the Aardvark: A funny animal sets out on an adventure that is really just a thinly-veiled way for the author to work through his beliefs. Then the author goes apewire and everything gets really, really weird.
Children's Crusade: Gay mutie loses control of his powers and finds out his mom is marrying a supervillain.
Civil War: Concerned citizens protest government legislation. Things go out of hand. YouTube and MySpace are somehow involved.
Close To Home: Everyday life is really, really weird
Concrete: A man gets his brain transplanted into a stone body by aliens.
Cosmic Odyssey: The god-like ruler of an alternate universe made of anti-matter wants to destroy the main DC universe, so a powerful, mysterious being who up until that time had been known as an antagonist or villain gathers a bunch of DC superheroes to fight said god-like anti-matter being. It is revealed in the course of the story that the anti-matter being had attempted to destroy the positive-matter universe once before, but had been locked away, but that, at some point before the beginning of the story, a brilliant scientist had inadvertently released said anti-matter being, an event which did serious psychological damage to said brilliant scientist. The heroes successfully team up to defeat the threat, although they take some fatalities in the process, and, in the end, the good guys only prevail with the help of Darkseid, who is instrumental in defeating the anti-matter being in the final confrontation within his anti-matter universe. Is notCrisis on Infinite Earths.
Infinite Crisis: The few people who did remember that fight are pissed off by the fact that no one else does and that they are all too Darker and Edgier than they used to be. A teenage boy becomes one of the most dangerous threats to all of existence, but is very whiny.
Final Crisis: Turns out the original man and his counterpart weren't exactly who we thought they were. The real man is now a threat to that thing that hadn't existed for over twenty years and more. Only one or two (relatively) small group(s) of people know about this; everyone else is distracted by the more immediate, yet equally serious threat of an old man destroying everything by sitting in a chair, who eventually kills Batman. Needs to be read a few times to be understood completely.
Final Crisis: Legion of 3 Worlds: The teenage boy discovers that people don't think to highly of him in the future and decides that just being whiny about this won't do much, so he decides to make people respect him. Two previously dead characters are brought back by three versions of the same team (who have never met prior) to stop the teenage boy. The teenage boy manages to get back to home, but wants to go back since people think he's a psycho.
Ultraheroes: Various superheroes and supervillains from the main universe (and some guys that usually don't have superpowers but now they do because yes) fight eachother for the pieces of a Weapon of Mass Destruction.
Wizards Of Mickey: A good wizard, a wizard with late-effect spells and a wizard who wants to do something different than being a wizard try to collect magic diamonds. In season 2, the good wizard becomes an evil tyrant, then snaps back and builds a Humongous Mech to fight dragons. In Season 3, a giant worm drains the magic away from the diamonds, and the worm is later defeated from a lich by making it cry. In season 4, they discover that the diamonds are actually eggs for giant bugs (which are referred from everyone as spiders even when they're clearly not).
DMZ: A photographer goes to New York City, turns out it's not such a great place.
Doctor Strange: Surgeon attempts to get his hands treated and ends up becoming the most powerful sorcerer on the planet.
Doom Patrol: People with unfortunate medical/metaphysical conditions save the world repeatedly, but people mostly don't notice.
Dork Tower: A bunch of nerds bicker with each other and play role-playing games with a muskrat. One of them has the hots for a Perky Goth.
Earth X: Everybody gains superpowers, but are powerless to stop an egg from hatching.
ElfQuest: Elves go on a quest. Um, did I make that one too easy?
Magitek aliens go looking for their old spaceship and otherwise adventure.
Empowered: An artist best known for his print adaptations of a Japanese cartoon decides to base an ongoing superhero series on a set of soft-porn bondage sketches he did on commission. The titular heroine is aware of this and not really thrilled by it. The art of the final, published comic is uninked, uncolored pencil sketches.
The Eternal Smile: A fantasy hero's life falls apart because of an anachronism, an Uncle Scroogeknock-off discovers his life is a lie, and a shy office worker gains self-confidence after falling for a classic Internet scam.
Fantastic Four: A Nerd, his girlfriend, her brother and the nerd's best friend live together and spend their time bickering and fighting the Nerd's insecure college rival, who really doesn't know how to let go of a grudge.
The Far Side: Weird things happen to animals and fat people with glasses.
Fell: A good cop tries to make a difference in a bad city. He doesn't.
Fish Police: An alcoholic fish, who may have once been a human, has to solve crimes.
The Flash: One habitually late forensic scientist has lab accident in thunderstorm, starts running faster.
Wally West: kid with hero complex gets struck by lightning and chemicals and goes real fast, then real slow, (relatively speaking) then real fast, then REALLY fast, then has a suit made out of "goes fast".
Jay Garrick: A man breaths in hard water vapors, then starts to run really fast.
Professor Zoom: man blames hard life on historical figure, sets out to murder him.
Forever Evil: Villains from another universe take over the world, and can only be stopped by villains from the main universe.
Foxtrot: A nerd, his siblings, and his pet reptile discuss current things.
Frazz: An elementary school janitor ex-musician philosophises with the students.
If you want people to actually give it a try, tell them it's when Calvingrows up gets older and becomes a school employee.
Gordon Yamamoto and the King of the Geeks: A bully gets a spaceship stuck up his nose, and teams up with a geek to get it out. He pays the geek back by using animal crackers and a donut to help the geek deal with his daddy issues.
Gotham Central: Police officers fight crime while dealing with the interference of an obsessed billionaire.
Great Lakes Avengers: A guy discovers he's immortal and teams up with a mute dinosaur, a 2-dimensional man, the grim reaper and a bulimic fat chick to fight crime. There are lots of squirrels and murders. They Fight Crime, and a guy in bondage gear who likes to dress up as the leader of a small European country.
Green Arrow: An aging hunter gets involved in political situations and cheats on his girlfriend.
The team is a lady who wears fishnets to work, a (former?) Buddhist, an AIDS patient, and a LIBERAL! Cool huh?
Green Lantern: The adventures of various humans who serve as troopers of a stateless police force wearing the ultimate in functional jewelry and use their imagination to fight crime.
Alan Scott: A railroad engineer finds a magic rock the stateless police force threw away.
Green Lantern: Rebirth: The most famous human (who had been dead for years) comes back in a way that retcons his Face-Heel Turn so his character assassination could be reversed. This does not get rid of any of the other humans (especially his replacement) and helps the police force get rebuilt.
Green Lantern: Sinestro Corps War: The police force is attacked by newly formed counterpart group with robots whose leaders are a disgruntled ex-cop, a cyborg, a whiny teenage boy and some dead guy's newly reborn evil counterpart (see entries above for latter two). Many asses are kicked in the process.
Blackest Night: Death is tired of being cheated by superheroes and decides to destroy all life in the universe with the aid of a necrophiliac and the power of some dead guy's evil counterpart. Everyone decides to stop fighting each other to prevent this from occurring.
Guardians of the Galaxy: After the galaxy survives a pair of wars, a spaceman puts together a team consisting of a living tree, a talking raccoon, a space madonna, a mass murderer, a femme fatale, and a resurrected space wizard with the intent of preemptively keeping the peace. They run the operation out of a base with a psychic cosmonaut dog as the head of security.
Hack Slash: Goth girl with a troubled past involving an overbearing mother and her gas mask wearing sidekick raised by a butcher travel around the country fighting dead people.
Hellboy: A demonic pancake-enthusiast fights Nazis and magic things.
This troper once had to explain to a friend what Hellboy: The Conqueror Worm is about. "Well.. it's about a demon working for a secret agency, that fights space-nazis who are trying to summon an ancient god/s by using the dead to communicate with space-ghost-aliens. It's WAY better than it sounds." Also in this few pages he fights a cyborg gorilla, undead, a floating head in a jar, frog-people and a giant space-worm with the help of a pyrokinetic psychic, a homunculus and an alien disguised as a soldier.
This troper once fell asleep on the couch in his sharehouse, and woke up to find his housemates halfway through the sequel, where a demon and a fish-man are singing Barry Manilow, asking 'what the f—k are we watching?' came with hilarious results as the group realised at that moment they were in an extreme example of this trope.
The Infinity Crusade: Alien's OTHER doppelganger tries to make utopia.
Invincible: A teenager fights his dad after finding out that he's been living a double-life. The dad skips town, and his son has to take over the family business. The fate of the universe hangs in the balance.
It's A Bird...: Comic artist contemplates turning down plum job because of personal issues.
Johnny the Homicidal Maniac: A skinny goth philosophizes about the human condition while killing people and drawing comics about a crazy, foul-mouthed stick figure. Also there might or might not be a monster in his basement, and his best friend is a dead rabbit.
Judge Dredd: A complete fascist rides around on a motorbike beating the snot out of half the criminals he encounters and executing the rest with a massive gun.
Justice League of America: A journalist who sometimes feels alienated in human society, an obsessive planner who has probably like five different mental illnesses, a woman from a society with (presumably) rampant lesbianism, a member of an organisation of space cops, a lightning strike victim, a man with a paralyzing fear of fire, and a winged man/a winged woman/an aquatic man save the world.
Justice League: Cry for Justice: In the wake of a disaster which claimed the lives of two oftheir colleagues, a number of people decide they want justice, but end up looking for vengeance. A supervillain who'd been confused for his incompetent ward decides to go on a rampage, resulting in major casualties. And in the end, a man avenging his adoptive son and his granddaughter permanently stops said supervillain.
Justice League International: A wealthy businessman establishes by means of political intrigue an international law-enforcement agency under United Nations sanction. The members of said agency frequently have difficulty getting along, and some of them behave immaturely.
Justice Society of America: Octogenarian superheroes and a bunch of their legacies (including at least three teenage girls) fight Nazis and the legacies of supervillains.
Phonogram: Rue Britannia: Indie music snob with magical powers attempts to stop Disco Dans from rewriting his musical tastes.
Planetary: A hero from the Thirties discovers that a hero from the Sixties is secretly a villain from the Fifties. The hero joins up with a dude with ADD and a woman with ADHD. They Fight Crime by digging things up.
Spider-Man Loves Mary Jane: A teenage girl nurses a crush on a boy whose name she doesn't know (although maybe she does) whilst having to deal with high school and the complicated relationships she has with her best friends.
Superman Versus Muhammed Ali: Aliens force Superman and Muhammad Ali to box in the ring under a red sun to decide who will face their champion in another red-sun boxing ring. The fate of the world depends on this.
Squee: The story of a little boy who is the neighbor of a homicidal maniac, has neglectful parents, and his only friends are a talking teddy bear that is a "Trauma sponge" and the son of Satan.
Teen Titans: Young vigilantes gather in an elaborate clubhouse.
Teenage Mutant Ninja Turtles Mirage: Four unusual looking teenagers live in the sewers of New York City with their adoptive dad. This dad teaches his kids how to take revenge on a guy who wronged him several years ago.
The Thanos Imperative: A team of cosmic superheroes try to stop their counterparts from an alternate universe from making it so that everybody gets to live forever.
Therefore Repent: A couple survives the Rapture only to discover that all the Christians that thought they were being bodily taken up to heaven have suffocated to death and now form an orbital ring of corpses.
The Tick: The adventures of an escapee from a mental institution and a bored accountant.
Tintin: Freakishly talented, seemingly ageless guy goes everywhere with a hairy old drunk and a dog.
The Calculus Affair: An entire nation conspires against a reporter and a deaf old man and loses.
Transmetropolitan: A drug addict attempts to make the world a better place by swearing a lot and shooting people. The president is not pleased.
Trinity War: A manipulative Evil Brit and his social club trick three groups of heroes into fighting over a woman's box.
Uncle Scrooge: An obscenely rich old man pays his nephew and his nephew's nephews an absurdly small wage to, alternately, guard his house or accompany him around the world on bizarre adventures. Occasionally they battle a gang of identical masked idiots who have numbers instead of names.
Witchblade: NYC cop destroys crime and clothing with help from her magical bling, then is knocked up by a supernatural mafioso.
Wolverine (series): Amnesiac from Canada travels the world, admires the sights and sounds, and has a drink with his Cajun friend every once in a while.
Wonder Woman: A bondage enthusiast hailing from a society composed entirely of (presumably) lesbians attempts to bring peace to the world by beating people up and subjecting them to her slightly kinky tie-up games.
X-Men: A bald old man in a wheelchair who likes watching teenagers sweat founds a school for people with genetic abnormalities. They fly everywhere in a supersonic jet and fight giant robots, a fat guy with a big appetite, and a magnetic Holocaust survivor.
Or: A bald young man with functional legs fights a metal-associated survivor of a holocaust (who is sometimes a jerk).
Or: a school principal tells his minority students they can improve their reputations by beating up others in their ethnic group.
New X-Men: A vomiting woman, a self-loathing birdman, a Chinese immigrant with a helmet, and a French assassin all help a legitimate school fight crime.
Y: The Last Man: The only guy in town and his monkey are dragged all the way around the world by a cloning expert and a secret agent so secret she doesn't have a name.
Young Avengers: An angry black super soldier, a sassy archer, a gay reality warper, his alien boyfriend, a robot with emotions, and a superhero's daughter cause chaos (often unintentionally).
Young Justice: A geeky ninja, a KidAnova clone, a boy with the world's shortest attention span, an amnesiac ghost, a girl with super strength, an archer with an overbearing mom, and a robot hang out in a mountain and have wacky adventures.
Zerogirl: An outcast teenager has a crush on her school counselor and fights square people with circles and blue slime that leaks from her feet.
Zits: Perpetual teenager whines intermittently on how it sucks to be 15.