During a Let's Play of The Walking Dead, the Chilean player Xoda had the option of killing - by himself - one of the characters of the game, and decided to call his mom to ask her what to do. Her answer? "Kill him, then".
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Another one from Xoda, during a Let's Play Slender: The Arrival, just when the Slenderman appear to him, his light turned off at the same time! He got scared even more during that moment.
The vision Lanayru gives Link in The Legend of Zelda: Twilight Princess is pretty trippy-weird, right? Well, in the The Straw Hat NO Let's Play, the commentary track is pitched down for much of it, making said commentary incomprehensible and kind of unsettling.