People going mad from the revelation in movies.
- In Big Hero 6, Hiro discovers that Professor Callahan is alive and was Yokai the whole time, and that his brother Tadashi died for nothing, prompting him to reprogram Baymax into a killing machine to destroy him.
- In Frozen, Elsa fled her kingdom Arendelle and built her own ice palace on a distant mountain, mistakenly believing that Arendelle would be safe from her dangerous power. When Anna delivers the news that Elsa in fact unleashed an eternal winter, Elsa is sent into a flurry of panic that leads her to freeze Anna's heart.
- Toy Story — Buzz Lightyear ends up doing this after discovering he is indeed only a toy and not a Space Ranger as he previously believed. He snaps out of it later, though.
- The entire point of the movie π is that this happens when you try to find the ratio that rationalizes pi, predicts the stock market, and is also the true name of God.
- Jack Nicholson's Joker loses his mind the instant he sees his new perma-grin in Batman (1989), stumbling into the street giggling insanely.
- In Batman v Superman: Dawn of Justice, while Lex Luthor was already psychotic, what he learns from the Kryptonian ship sends him completely off the deep end.
- Bird Box: Seeing the creatures causes humans and animals to kill themselves (or in the case of the deranged, force others who haven't looked into doing so).
- Bram Stoker's Dracula: Keanu Reeves' Jon Harker seems to have an episode of this when Dracula feeds his brides. He gets better.
- Contact has a more benign and temporary version, when Ellie Arroway travels through the wormhole and perceives a celestial event so beautiful and magnificent that she is rendered a babbling, weeping mess."No words... No words... They should have sent a poet..."
- Creepshow. After watching two people get eaten by the thing in "The Crate", Dex Stanley raves and giggles when he appears at Henry's house. He gets better.
- Dark Angel: The Ascent: One of the two detectives investigating the vigilante killer has the bad luck of finding out Veronica's true nature in a frightful vision the demon girl projects in his mind. He's a shivering wreck for the rest of the film and promptly calls off the investigation.
- In Dark City, detective Eddie Walenski is driven mad by the revelation that the City and everyone's identity is being mercilessly torn apart and remade by aliens, repeatedly. He compulsively draws spiral shapes on the walls of his room, refuses to acknowledge his wife's identity, and rounds off the evening by jumping in front of a train.
- This trope, mixed with Hyperspace Is a Scary Place, is essentially the plot of Event Horizon. The test run of the titular ship's hyperdrive sent it beyond the edge of the universe where the crew experienced something that can only be described as Hell. When the rescue crew watches the video logs on the now deserted ship after it returned from the journey they see the former crew engaging in various deranged acts of graphic self-mutilation after the madness of the place took them over.
- In Indiana Jones and the Kingdom of the Crystal Skull, the Crystal Skull itself contains immense psychic power and knowledge, which turns Harold Oxley into a gibbering lunatic and almost Indiana Jones as well. Though he regains his sanity once the skull is returned to Akator.
- The Aliens at the climax also have incredible knowledge, which reduces the knowledge-hungry Soviet agent, Irina Spalko, to madness and then dust.
- During the ending of In the Mouth of Madness, after witnessing the collapse of human civilization in a rising tide of madness and mutation, John Trent cracks when he discovers that the nightmarish book that did the deed was just a novelisation of everything he did in the last few days. He finds this out by watching the film adaptation.
- In I Shot Jesse James, Robert Ford completely loses it when he learns that his Love Interest Cynthy is leaving him for his rival John Kelley.
- This happens to Makoto Fukami after finding out his true origins in Kamen Rider Specter Re:birth. Saying that he didn't take it well would be an understatement.
- In The Matrix, Morpheus suggested that adults freed from the Matrix have an exceptionally hard time adjusting to the real world, which is why they normally don't free people after they reach a certain age. A character remarked "We're gonna kill him. You understand that?" and "He's gonna pop!" on two different occasions regarding Neo reeling from The Reveal.
- When the mummified corpse of Imhotep comes back to life in original The Mummy (1932), the archeologist who saw it went insane."He went for a little walk! You should have seen his face! HAHAHAHA!"
- Parodied in National Lampoon's Class Reunion, in which the Axe-Crazy Walter got that way when he was set up for a masked tryst by his classmates, only to discover that the girl they'd recruited to hook up with him was his own twin sister.
- In Oldboy (2003) Oh Dae-su discovers the girl he had sex with was his daughter, madness and cutting out his tongue followed.
- Implied with Father Brennan in The Omen (1976). It turns out he was a former follower of Satan who freaked after witnessing Damien's birth. When Robert Thorn and Keith Jennings go to Brennan's residence, they find the walls plastered with crucifixes, pages of the Bible and other religious artifacts.
- The Fourth Mistress in the movie Raise the Red Lantern was pushed over the edge when she saw the dead body of the Third Mistress after her execution.
- Implied to be the case in RoboCop 2, with the two Robocop II prototypes note which both graphically killed themselves during their demonstrations. The given explanation by Dr. Faxx is that Murphy's past psychological profile - Irish-Catholic work ethic, intense devotion to duty and willingness to sacrifice himself for the good of others, lets him face the nature of his existence as a cyborg without putting a bullet through his head.
- In the Slasher Movie Terror Train, poor Kenny finds out his designated "date" for the evening sitting in the bed is actually a corpse set there by his med schooler "friends". It drives him insane, leading him to get institutionalized and returning after couple of years to exact revenge upon everyone involved.
- Loki from Thor after discovering he is a Frost Giant. While he was already a bit unstable to start with having allowed a few Frost Giants into Asgard for "a bit of fun" (and to discredit Thor), this was what truly tips him over the edge.