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- In Justice League International #5, Guy Gardner challenges Batman for leadership of the League. Bats ends◊ the fight with one punch!
- DC Comics:
- Thanks to Superman's near-unstoppable Super Strength, anytime he's serious or enraged almost all his confrontations becomes this. The What If? scenarios with Supes fighting Batman, tend to end quickly◊ unless Batman is crazy prepared prior to facing Superman. There's also Joker's death in Injustice aka the "Superman high five". However, if it's a reversal and it's Superman going down in one attack, it's usually a Did You Just Punch Out Cthulhu? moment or at worst The Worf Effect. Though Kryptonite is more often used to this effect.
- The Flash's introduction in the New 52, invoked this, since Supes was previously mopping the floor with Batman and Green Lantern and Barry Allen instantly turns the tables◊ with his Super Speed. However it's reversed again with Superman's Finger Poke of Doom sending Flash flying.
- Done in Superman and Wonder Woman "Power Couple", where Superman meets Apollo the Sun God and in response for Clark threatening Apollo after he insulted Diana, the god effortlessly bitchslaps Superman across the room. Apollo might've won that if didn't also use his solar powers on Superman... which was a very bad idea.
- A straight example comes from He-Man of all people who takes out◊ a possessed Superman with one stab of The Power Sword in a crossover. By the power of gray skull people.
- Thor knocked out◊ Namor with one punch in Invaders #33.
- Marv from Sin City never seems to have to hit a person a second time (although sometimes he does anyway).
- Despite being touted as "Street-level" Spider-Man has done this alot, likely due to Spidey has the necessary strength to knock the Incredible Hulk around the more average (or higher) foes don't stand a chance when Peter Parker gets serious.
- Early example with Flash Thompson who made the dear mistake of challenging Peter to a boxing match, Peter tried using just a fraction of his strength to end bout before Flash got hurt. But even a love tap from Peter sent Flash flying◊.
- Grey Hulk had a memorial "encounter" Cosmic Spider-Man, aka punched into space.
- The poor T-rex◊ who met Spidey in the Savage Land.
- Happens in Dark Reign where Norman Osborn who had long since gone off the deep end, was ranting madly and was quickly◊ silenced by his Arch-Enemy.
- In The Death of Spider-Man, the Human Torch does this to the Green Goblin. Keep in mind, that in this universe, the Goblin is a nigh-invincible hulking beast with the ability to throw fireballs and not a guy in a suit as he is in most media. Though this then shifts into Broke Your Arm Punching Out Cthulhu, when Goblin - who's fire powered in the Ultimate universe - comes back from this bigger and stronger than ever, allowing him to fulfill the name of the arc. Later in that same arc, Peter Parker shows up, bleeding from a gunshot wound, and takes the Vulture out for a while with one web.
- It's revealed in Superior Spider-Man, that Peter is holding back all the time as Doc-Ock discovered when took over Peter's body and punched Scorpion in the face tearing his jaw off◊.
- The finale of X-Men: Age of Apocalypse has Magneto (who's the closest thing this Crapsack World has to a Big Good) going one on one with Apocalypse, who's pounding on Magneto and asks why he doesn't fight back. Magneto responds that he can't, because he's concentrating. Apocalypse doesn't even have time to wonder what Magneto means before getting ripped in half.
- In Uncanny Avengers, Rogue accidentally does this to Grim Reaper after absorbing Wonder Man's strength. She was unprepared for just how much more powerful she'd become, and ended up snapping the villain's neck with one punch.
- La Quête de l'Oiseau du Temps, this is a favorite of legendary warrior Le Rige, who tends to kill his prey with just one swift and powerful blow of his axe.
- In Amulet, the Amulet spirit kills Chronos the Mountain Giant by crushing him under a massive boulder. Keep in mind Chronos is a giant winged half-spider, half-beast creature, providing a horrifying demonstration of how strong the Amulet spirit is.
- Judge Dredd: Dredd was confronted by one of the "Dark Judges"- Judge Fear, one look at whose face will usually kill; Fear opened the visor on his helmet and invited Dredd to "Gaze into the face of FEAR!" Dredd responded by PUNCHING RIGHT THROUGH FEAR'S HEAD, killing him, while bellowing, "GAZE INTO THE FIST OF DREDD!"
- Ace Combat: Wings of Unity has Fluttershy of all ponies get this in the third chapter: when the villains launch a "burst missle" that destroys a fleet of Equestrian ships, she enters a Freak Out! and knocks an enemy Pegasus out of the sky to his doom with one punch, screaming in rage the whole time. Even her friends are startled, with Firefly remarking on how she'll avoid making Fluttershy angry at all costs.
- Gather features this as Taylor's ultimate attack. As part of her AU powerset, she can instantly kill any parahuman she makes skin contact with, stealing their powers and turning them into a nearly indestructable minion.
- Naruto gets to deal one of these out to Sasuke in the Alternate History fic Team 8 during the Chuunin Exam preliminary battles (it's a knockout instead of a kill). It's fully explained in author's notes later on, given the context of the fight — Sasuke was still recovering from Orochimaru's seal being applied (and then removed), Naruto just watched Neji beat Hinata half to death in their preliminary battle and was understandably pissed off, and Sasuke crossed a line he should not have crossed:
Sasuke: (as Naruto stumbles after vaulting off the balcony to the battlefield) Can't you do anything right, Dead-last?
(Naruto ignores this remark. But...)
Sasuke: (scoff) I hope you put up a better fight than your pathetic teammate.
(Naruto gawks at Sasuke, then glares a hole through him.)
Test proctor Hayate: Begin!
(Flash Step, "Fuck You" Punch, broken jaw, ragdolls away. KO.)
(Beat) [Exit Naruto.]
Hayate: ...winner, Uzumaki Naruto.
- In the Tamers Forever Series, Chaos easily kills Doumon by crushing her skull in his hand.
- "Days of Futures Past What Does That Mean It Kinda Sounds Sexy", Naruto knocks out Superboy by throwing a cake laced with Kryptonite at his face.
- In Sugar Plums this is how most of Ume's fights end. It's noted this is because she's weaker than most shinobi by default, thus unlike other shinobi who will prod and test opponents to conserve energy in case they have to run away or fight other opponents she will go all out immediately. It's only because of this trait she's able to kill objectively stronger opponents at all and even then it'll usually come at a cost.
- Any number of Kung Fu B-movies, which often featured characters (usually villains) who knew a special technique that could kill people (or otherwise take them out of a fight) instantly.
- This happens to Bill in Kill Bill: Volume 2, when the Bride does a special move that explodes the heart of the victim after the victim takes 5 steps.
- Bruce Willis pulls off a one-hit kill in The Last Boy Scout.
"I'm gonna need a light. You touch me again, I'll kill ya."
- The Duel to the Death in Seven Samurai comes down to this.
- Likely the Trope Codifier in Raiders of the Lost Ark when Indy is searching for Marion the crowd parts to reveal a black swordsmen with scimitar showing off his skill ready to fight, but Indy casually pulls out his gun and blows him away... making it's place in movie history. Hilarious practicality aside, this scene originally was gonna have Indy face the swordsmen for real in choreographed fight scene which would've taken three days to film and blown the studio over budget. Until Harrison Ford wisely suggested to Spielberg that he just "Just shoot the sucker".
- In Star Wars:
Kenobi: (throwing the blaster away) So uncivilized.
- The Death Star plays this both ways. One shot from the superlaser at a target planet creates the planetary equivalent of the Chunky Salsa Rule. Whereas a single proton torpedo to the thermal exhaust port, and the Death Star — the size of a moon with a crew numbering in the millions — turns itself into a planet-sized firework.
- This is how the famous "who shot first" is resolved. Han shoots and kills Greedo with a single shot before Greedo can react.
- Despite how badass and unique Darth Maul is in the otherwise lame Phantom Menace many forget he is the only major film antagonist to be taken out (sliced in half) in one slash by Obi-Wan. Kylo Ren (Big Bad Wannabe) in The Force Awakens in contrast got up again after taking a slash to face from Rey's Lightsaber strike.
- General Grievous from Revenge of the Sith survived mutiple Lightsaber strikes and having his arms sliced off thanks to being a Cyborg. But thanks to his heart being left vulnerable Obi-Wan just shoots him dead with common blaster.
- Snatch. has "One Punch Mickey", Gypsy bare-knuckle boxing champion. Bonus points for doing it when he shouldn't.
- Godzilla possesses the "Spiral Ray" in a few of his later incarnations, a supercharged, red/orange-colored variant of his normal light-blue atomic Breath Weapon. It proved capable of annihilating some of Godzilla's most powerful foes ever (such as Super Mechagodzilla, Spacegodzilla, and Kaiser Ghidorah) within seconds. The one and only time it did not provide an immediate victory was when used against Destoroyah — and that was when it was being used for the duration of the entire climactic battle — which demonstrated how amazingly dangerous Destoroyah really was.
- The Hobbit: The Battle of the Five Armies: as you may know after reading the book, the dragon Smaug gets instantly killed by Bard after being pierced by the Black Arrow on the scaleless skin spot of its chest.
- Kiryu (AKA "Mechagodzilla 3") possessed a weapon called the Absolute-Zero Cannon which could instantly freeze anything it hit down to absolute zero. The devastating effects of the weapon are seen when Kiryu accidentally freezes several skyscrapers during a battle with Godzilla. Said skyscrapers collapsed into dust almost immediately after freezing. The lethality of the weapon is subverted when used against Godzilla himself twice. The first time, Kiryu had gone berserk from hearing Godzilla's roar and was rampaging across Tokyo before they could fire the weapon. And, the second time, the Absolute-Zero Cannon was badly damaged and could only very temporarily trap Godzilla in ice.
- Ong-Bak contains a kick-to-the-face that is possibly the best example ever.
- In Diggstown, "Honey" Roy Palmer gets pissed off and knocks out an opponent with a single punch immediately after the round starts.
Roy: (to the ref) Get the next one in here now.
- All but the tiniest phantoms in Final Fantasy: The Spirits Within, since they're an Intangible Man that does Collision Damage by ripping the soul from your body like walking through a cloud of smoke.
- In Punisher: War Zone, Frank kills a man with a single punch that penetrates his skull.
- Alex Kinchen gives us the Godkiller. A unique gun that can kill anything shot by its bullets in one shot, and even banishes them from existence.
- In the I Spy film, Eddie Murphy's character is a boxing champion known for one-hit KOs. Not exactly a "kill", but it would definitely end your career if you went down from one punch.
- Transformers: The Movie: Galvatron kills Starscream with one shot.
- In Godzilla (2014), Godzilla performs one on the male MUTO, by way of a Tail Slap into a skyscraper. Amusingly, the way Godzilla turns around to deliver said attack looks almost casual.
- In Kingsman: The Secret Service, Gazelle does this to Lancelot, cutting him in half lengthwise.
- In Jason Bourne, Bourne is shown knocking an opponent out in a single hit during a illegal fight.
- A staple of Choose Your Own Adventure books are the no-escape dead ends, though gamebooks (e.g. Lone Wolf) fit the trope best with instant death if you're lacking the right skill/item or just plain unlucky — being not only accepted, but expected.
- In Lone Wolf, the bow and arrow, far from being just annoying, often allows a one-hit kill for the hero, if he chooses the right target and is enough of a good shot (though some monsters are utterly immune to this).
- The best Choose Your Own Adventures were better known for their creatively gory endings to your life than for their successful endings.
- Ditto Star Challenge. You and/or your robot are as common to be the one(s) on the receiving side as your enemies.
- Harry Potter:
- The Killing Curse, Avada Kedavra, works like this. In nearly all circumstances, the only way to survive it is to not be hit. The fact that the title character survived it as a child is what made him a legend ("The Boy Who Lived") in the wizarding world. Quirrell in A Very Potter Musical all but uses the trope name when he describes it as Boring, but Practical.
- Direct eye contact with a basilisk will instantly kill the victim. Indirect eye contact, such as through a camera lens or a reflective surface, merely petrifies (which is reversible). In Chamber of Secrets it's revealed ghosts who make eye contact — even direct eye contact — are also petrified, since you can't exactly kill them again.
- The scream of a mature mandrake will instantly kill anyone who hears it. In Deathly Hallows during the final battle, the seventh year Herbology students start throwing them out the windows and right onto the Death Eaters.
- In the second series of The Chronicles of Amber, Merlin knows a "neat little cardiac arrest spell." He only uses it once, but he just obliterates a Jabberwock with it. Apparently, he has a separate "death spell," but he never uses it. However, he does note that the first spell wouldn't have been a One Hit Kill on a fire angel, as they have three hearts.
- In Michael Moorcock's novel "The Eternal Champion", when the Eldren use their ultimate weapon, a high-powered energy gun, against their opponents, who are using classic Middle Ages armor, their attack is a One Hit Poly Kill, obliterating entire lines of their opponents each shot.
- The Ivory Knife in P.C. Hodgell's Chronicles of the Kencyrath, a mere scratch from which will kill; it is described as "the very tooth of Death". As one might imagine, this can be somewhat dangerous for the wielder as well. Heroine Jame carries it in her boot sheath for a long while, at first because she doesn't realize what it is, then after she knows, because she doesn't have anywhere safe she can leave it.
- Balefire in The Wheel of Time instantly erases from existence anyone it hits retroactively. And it kills in such a way that even the Dark One (who has power over death and can reincarnate people) can't save them. Balefire comes at a very high price, though. Since it kills retroactively, the past will be changed - any actions performed by the killed within for everything for a minute back to days (all according to the power of the Balefire) will now not have happened. If this happens too much, reality itself unravels, causing a Temporal Paradox that can destroy the world.
- The Vord Queen in Codex Alera has become powerful enough by First Lord's Fury that, when an Aleran High Lord takes the field at the battle of Alera Imperia, she blasts him out of the sky with one hit. When he's protected by dozens of Citizens and knights. Cue the Mass "Oh, Crap!".
- The demon-in-the-form-of-a-sword "Stormbringer" in Michael Moorcock's Elric of Melnibone series kills any non-magically protected human in one blow (it also eats the victim's soul). "Mournblade" is a similar demonic sword, and one story reveals that there is an entire race of these demons — all of them taking the form of swords.
- In Warbreaker, Vasher uses his sword "Nightblood" to dispatch numerous Mooks. Nightblood, when fully drawn, will completely obliterate its victims, soul and all, in a single strike, leaving nothing but a brief cloud of black smoke where they were standing. Wielding Nightblood in this manner comes with severe drawbacks.
- "Morganti" weapons in Dragaera all destroy the soul of the victim upon entry, making revivification impossible, and also making it impossible for the victim to travel the Paths of The Dead to the afterworld. (Assuming the victim has a means of both suiciding and entirely disassociating their soul from their body before contact — a never certain process, aside from its obvious drawbacks — they damage the corpse as an ordinary weapon of their type.)
- Any of several magic words in the Inheritance Cycle which cause instant death to whoever they were directed at.
- In Fred Saberhagen's Book of Swords series, Farslayer can kill anyone (including demons and gods) anywhere as long as they don't have Shieldbreaker or Woundhealer to save them.
- In The Chronicles of Narnia, Jadis uses the deplorable word and basically one-shots an entire planet, resulting in no more subjects for her to rule. But that's okay, a pair of children help save the day on Earth and Narnia
- Shardblades from The Stormlight Archive cut the soul of living things rather than the flesh, and cut straight through almost any inanimate matter without any effort. Slicing the blade through one of a victim's vital organs kills them instantly. Slicing it through a limb "kills" that limb, rending it permanently paralyzed and numb. The only beings that are likely to give somebody with a Shardblade a problem are those with a suit of Shardplate, (which can withstand a Shardblade, at least for a while) or beasts so large that the blade can't easily be sliced into their vital organs (and these are BFSs an average of six feet long, so the fact that there ARE beasts that big, and a lot of them, says something about this world).
- In The Destroyer book series, the martial art of Sinanju is mostly one-hit kill moves. The (very long) series isn't entirely consistent on how much of this is based on actual precise technique targeting vital spots, and how much is because practice of Sinanju raises basic physical abilities to the point where pretty much any imaginable attack can be used to do lethal damage.
- In Billy Budd, the eponymous character is accused of conspiracy and mutiny aboard a British man-of-war by the ship's master-at-arms, who is doing this to fight off his "strange attraction" to the androgynous sailor. Upon hearing this, Billy freezes up, unable to say anything in his defense. Eventually, he answers the only way he can - by punching the liar in the temple. The man dies on the spot. Unfortunately, Billy is found guilty of murder by the tribunal of officers, despite them all being sympathetic to the boy, and hung the next day. Interestingly, the tribunal was about to find him not guilty as a weird case of self-defense, when The Captain intervened and convinced them of the necessity of the execution.
- In the Star Carrier series H'rulka weapons easily one-shot smaller Confederation ships, being as how their ammunition consists of what amounts to miniature black holes. They also outrange most Confederation weapons.
- Honor Harrington delivers a One Hit KO to the Honorable Sir Reginald Houseman in Honor Of The Queen, after he demands that she pull her forces out of Yeltsin's Star, leaving the Graysons to be conquered or nuked by Masada. It worked not only because Honor is a Heavy Worlder, but that he was such an Entitled Bastard that he had no idea at all that she would dare to actually strike him.
- In A Song of Ice and Fire, it's not that Gregor Clegane has any magical trick or secret technique that suddenly turns him deadly. He's just that big, strong, and able to wear so much armour and wield a cavalry weapon that's just that big (while he's on foot; in a single hand, no less) in such a way to lay waste to even the most heavily armoured of knights in one swing thanks to the sheer power he can put behind it. Now, add a horse's mass and velocity to this equation... If he makes contact, you're dead (and, probably even the guy next to you and the one next to him). It's simple physics and psychotics. The downside is that he isn't the fastest (still faster than you'd expect, considering how much he and his poor horse hauls about) and he suffers chronic physical pain thanks to his gigantism for which he's on constant medication. But, if you think that's a bonus, it just means you need to hurt him more (all while dodging the inevitable) for him to register it.
- The Magic Wand that Griswalda gives Lucifer in The Vagina Ass Of Lucifer Niggerbastard. Lucifer, "tests", the Magic Wand out on Griswalda.
- In Sword Art Online, the boss of the 75th floor. It's bad enough that the only door out closes and disappears, and teleport crystals don't work, so the raid group is trapped until they either win or get wiped out. But on top of that, it also one-shots almost everyone unlucky enough to get hit by it. Most of the fighters are suitably terrified. By the end, 14 out of 32 are gone.
- In Changes, Ebenezar McCoy casts what essentially is a mass version of aforementioned Avada Kedavra onto two hundred or so Mooks. There's no flash, no sound or anything, he just makes a wide gesture with his staff and those he points to simply drop dead.
- In Doctor Who the Dalek race's beams are this, even for other daleks, who are usually really hard to even scratch. There's a very memorable scene in the 9th Doctor's first Dalek episode where a room full of soldiers shoot at a Dalek uselessly and instead of shooting back the Dalek just hits the fire sprinkler on and shoots one death beam and electrifies all the wet soldiers in one.
- Game of Thrones: As Bronn stated, one can attempt to fight Gregor by out-maneuvering him. But if he gets one hit in, that person is dead. This is illustrated in "The Mountain and the Viper." After spending an entire fight flailing at— and missing— the much more nimble Oberyn Martell, Gregor manages to get his hands on him and ends the fight in seconds.
- In Smallville, especially early seasons, there are very few opponents that Clark doesn't take out in one hit.
- Every single vampire goes down (turns to dust) with one stab of a wooden stake (or sharp wooden object) to the heart. Usually there's a drawn out fight at the very least to showcase vampires as powerful foes, then at other times they get staked instantly, and some don't even make it out of their own graves before Buffy dusts them. Sunlight also ends vamp-fights quickly e.g Russel Winters in the first episode of Angel who is pushed out a skyscraper's window by the titular hero and doesn't make it to the ground.
- Despite how much a threat they are played up to be, most Big Bad(s) in both Buffy and Angel are taken out in one attack such as The Master, The Judge, The Beast and Jasmine.
- Before Saitama there was Illyria in Angel series 5.
- Game Shows: In its simplest sense, the one-hit kill was a contestant winning the game outright on the first play of the game, before his opponents even have a chance to play. Although rare, the most notable examples were:
- Tic-Tac-Dough: The "red box" "Bonus Category," which immediately allowed the contestant another turn if he/she answered a three-part question correctly. The categories were moved to other boxes after the question, and the "Bonus Category" always appeared in an adjacent box or other space that allowed him/her to set up and eventually complete a tic-tac-toe. Played correctly – and it often was a tic-tac-toe was completed without the opponent getting a chance to play (although he/she was always invited back to play the next game). Eventually, in the interest of fair play, the category was retired, in lieu of the modified "Double-or-Nothing."
- The Joker's Wild:
- Spinning three jokers on a single spin automatically won the game for that contestant ... provided he/she correctly answered a question. While it has happened several times on the game's first spin, only once – the first time it happened – did it result in the opponent not getting to play. (The opponent, a challenger, forced his smile as he was on and off the show in roughly 90 seconds.) The ""first-spin triple joker" quick kill was averted thereafter by allowing the challenger – who always played second – an opportunity to catch up by continuing to answer questions until they either caught up, won by surpassing the opponent's score or giving an incorrect answer; however, the game would end if the challenger spun the triple joker and answered the question correctly.
- Like its sister show Tic Tac Dough, the 1977-1986 syndicated version had special scoring categories, which could be used on the player's first turn to build a huge lead and virtually assure themselves a win, simply by severely pressuring the opponent. Categories fitting this example were "Fast Forward" and "Bid," both which allowed contestants to answer multiple questions in a single turn until they either stopped and kept their winnings ("Fast Forward") or completed the terms of their bid to earn the cash ("Bid").
- Concentration: Solving the puzzle after making a match on the game's first turn.
- In the finale of Life, Crews kills Roman with one blow to the throat.
- In the competitive robot combat show Robot Wars robots could be battered into submission and some robots were in fact powerful enough to disable an opponent with a single lucky blow. Robots could also be flipped over and those with no way to right themselves were immobilized and defeated. However there was only one guaranteed way to defeat an enemy robot in a single strike: throwing it over the wall and out of the arena. The first time it happened, no one could believe their eyes. Not to mention, the pit.
- The Zat'nik'tel in Stargate SG-1. Although it takes two shots to kill, one shot delivers excruciating pain, enough to neutralize any target that's not protected against it.
- Done on CSI: NY, where a martial arts expert killed the victim of the week with a single blow to the back of the neck.
- Star Trek: Voyager: In the final episode (Endgame), Voyager gets upgraded with technology from the future. It gets armor that makes it immune to Borg weapons, and it gets special torpedoes that can destroy Borg cubes in one hit.
- The Colt is a magical gun that can one-shot nearly anything in existence, even beings that would normally be considered unkillable. However, there are a few cosmically powerful creatures that it can't outright kill. Dean and Sam learn a bit too late that Lucifer is one of them.
- Most of the highest ranking angels enjoy doing this to anyone less powerful than them who manages to piss them off, with Lucifer being the standout example. One snap of his fingers is usually enough to turn just about anyone into a red paste.
- It's pretty common in North America for a pro wrestler's Finishing Move to be used as a One Hit Kill. There are many, many matches where one participant spends the whole match getting the snot beaten out of him, then seizes an opportunity to hit his finisher and win the match. Note that this is less common in Mexico, Japan, and Europe.
- The One Hit Kill effect is essentially what made Diamond Dallas Page so dangerous in WCW. You could beat him up all day, but all he had to do was hit the Diamond Cutter and he'd come out on top — and he could hit the Diamond Cutter at a moment's notice, from fifty-two different positions.
- As well as Randy Orton's RKO.
- Also witness this WWF title match between Bob Backlund and Diesel. Kick, Jackknife Powerbomb, match over.
- Though he didn't use it for obvious reasons, Michael Tarver of The Nexus once had the gimmick of the 1.9 second punch, a punch that would instantly KO anyone.
- Santino Marella has The Cobra, a jab to the throat. He's still mostly a Jobber because he wastes so much time signalling for it that he's almost always intercepted.
- And then after months, he finally hit the move for the first time on Zack Ryder...and still ended up losing the match.
- People now have to sell the damn thing.
- Umaga's Samoan Spike.
- Shawn Michaels and Sweet Chin Music.
- The Tombstone Piledriver: In the 2 decades that The Undertaker has been using it, you can count the amount of people who have even kicked out of it once on your fingers. In fact, when Shawn Michaels kicked out of it at WrestleMania XXV, the look on Undertaker's face was something akin to "WHAT IN THE HOLY HELL OF FUCKNESS JUST HAPPENED?!?!"
- Kenta Kobashi's Burning Hammer can actually one-up on the Tombstone: nobody has ever kicked out of it. As a result, he's only used it seven times to maintain its special-ness. Well, eight if you include the time he used it on his cancer.
- Sheamus. The Brogue Kick.
- The Big Show. The Knockout Punch aka The Weapon of Mass Destruction.
- Spike Dudley's Acid Drop/Dudley Dog.
- A simple roundhouse kick to the head is a staple of the Japanese shoot-style finishing offensive. It's credible enough to pass for a real KO, and the Mixed Martial Arts world has taught us that it's indeed as powerful. This is seen in Yoshi Tatsu's debut match in WWE's ECW against Shelton Benjamin. Benjamin got distracted at the beginning of the match with mocking Tatsu's Japanese salute... and hitting the roundhouse kick was all Yoshi had to do for the win.
- Sluggy Freelance:
- The talking sword Chaz can kill pretty much anything with a single swing. Even a scratch will suffice in most instances. The Demon King of the Dimension of Pain managed to survive getting scratched, but was still permanently crippled. The only limitation is that Chaz only has this power after bathing in the blood of the innocent.
- Later, 4U City's military is shown using weaponized teleporters which transport whatever they hit into Another Dimension. Not really a one-hit kill, but definitely a one-hit victory.
- The Golden Arrows from Slightly Damned tend to take football sized chunks out of their targets. It's not a guaranteed kill, but it's pretty close.
- SCP Foundation:
- SCP-544 perceived threads extending upwards from the heads of others, as well as from other living things, and could kill anything instantly by cutting its thread with his mind.
- One of the 001 proposals can obliterate anything in a single strike of its flaming blade, from people to missile bases, 049 has an extremely effective Death Touch, 956 will petrify you with a single look (while not immediately fatal, you'll wish it was), and witnessing anything done by someone infected by 370 will mean You Are Already Dead.
- Art of the Instakill celebrates the trope in several modern game franchises. Visual Effects of Awesome included. Here's a reference for those who may not know.
- Red vs. Blue:
- Season 1 has Donut throw a plasma grenade and oneshot Tex, who was halfway across a canyon and in a tank. This gets a Call-Back in season 10, where he manages to lob three plasma grenades in one throw to kill three soldiers.
- In Season 10, Agent Maine does this to The Big Guy of the enemy team to show off his new Super Strength. The guy is killed in a single punch (which also either knocks his reinforced titanium helmet off or out-and-out decapitates him... the camera angle leaves this unclear).
- One of Cracked's 31 Life Lessons You Can Only Learn From Video Games is that "no matter how strong and powerful you are, some scrub will take you out with a death spell."
- Whateley Universe: Tennyo's 'death blow' can kill anything - including Physical Gods and Eldritch Abominations - Deader Than Dead. Even the sub-atomic particles that made up their body simply decay into nothingness.
- Dreamscape: The Overlord of Evil can fire a small laser that annialates whoever is hit. Unless you have Resurrective Immortality like Melissa, you're done for.
- Avatar: The Last Airbender:
- The series gives the impression that the advanced Firebending ability to shoot lightning is a One Hit Kill if it manages to get a direct hit. This is offset by the difficulty of shooting lightning in the first place (it requires a mindset which is opposite to the usual for Firebending, and insufficient skill is likely to cause it to explode in the users face), and even when mastered the time it takes to build up the charge tends to telegraph the attack.
- In the grand finale, Aang's use of 'Soul Bending' borders on a peculiar sort of Have-a-Heart instant neutralization.
- Ty Lee was also feared enough for her ability to temporarily kill someone's Bending. Not a 'kill', but in a world where children can throw fireballs it leaves you pretty helpless (various big name mundanes aside).
- In My Little Pony: Friendship is Magic, the main characters use the Elements of Harmony twice: once to take down Nightmare Moon, the evil ruler of the moon, and again on Discord, the omnipotent dark god of chaos.
- Even without the Elements, a Circle of Friendship attack has enough power to One Hit Kill a trio of Windigos, powerful monsters capable of causing a world ending blizzard.
- Kramer vs. Predator, as seen on Family Guy.
- Celebrity Deathmatch:
- The Loch Ness Monster gets one on Bigfoot during their fight when he slices Bigfoot in half.
- In Spice Girls vs. Hanson, Marilyn Manson gets one on both combatants by crushing them under the light rigging.
- In Kid Rock vs. Eminem, Joe C jumps into the ring and eviscerates guest referee Carson Daly, but not before Carson kicks him into the air. He lands on Eminem, and takes control of Eminem's body, which he uses to take out Kid Rock with one hit.
- Jean-Claude Van Damme cuts Chuck Norris in half with one hit.
- Samurai Jack Season 5; Jack most likely kills one of the Daughters of Aku with a single punch to the face, snapping her neck in the process.
- In general, unless you're Vlad Masters, if you find yourself on the receiving end of Danny Phantom's Ghostly Wail, you're about to go down and stay down. Good thing, too, since the attack is so draining it usually leaves the hero de-powered and severely weakened afterward, stopping it from being a Story-Breaker Power.
- With the amount of damage the gems in Steven Universe can take, it's easy to forget that humans don't have the same luxury. Therefore, Lars dying in a Robonoid explosion was one of the most shocking moments in the show.
- In Miraculous Ladybug, Cat Noir's Cataclysm power will almost instantly destroy anything he touches. As we are reminded every time he ends up Brainwashed and Crazy, this very much could include human beings.
- Truth in Television. Many weapons don't need many hits to kill a person, especially if they hit the brain.
- This is the aim on both kendo and German School of Swordsmanship.
- It is entirely possible to kill or knock out a person instantly with a single surprisingly gentle blow. However, beyond accidental cases there is little evidence for the existence of a reliable martial technique. Chances of an instant knockout are significant if any highly trained fighter is given a reason to go all out against an opponent with little or no conditioning. Even if the attacker has no training, (un)lucky hits can lethally aggravate a pre-existing condition (aneurysms are particularly infamous) and kill in short order. If the initial blow causes the victim to fall over (not necessarily unconscious), the fall can easily cause a fatal head impact.
- It is very possible, if very rare, to cause someone to go into fibrillation (heart beating so rapidly and without any rhythm, such that it doesn't actually pump any blood) simply from hitting them in the right place, with the right force, at the right point of a heartbeat. It doesn't even have to be a hard hit. It is unfortunately common in athletes. One minute they're active, then they get what seems to be a hard bump to the chest, and then they're down and out. Of course, CPR and defibrillation, as well as quick medical treatment has a chance of bringing them back. But for all intents and purposes, until their heartbeat goes back to normal, they are dead.
- Nuclear weapons, capable of annihilating entire cities and the inhabitants located in them. Practically anything near the epicenter of the explosion is vaporized by extreme heat, while the resulting blast-wave can instantly demolish most structures. Anything that hasn't died from either of the above may then succumb to radiation poisoning within a matter of hours or days.
- The Box Jellyfish, the deadliest venomous animal known to exist. It generally takes somewhere between 5 minutes to a second for its sting to kill. Only one person is known to have survived from one.
- The poison dart frog poison kills in less than 3 seconds; it has to get in the blood though, so contact itself probably won't kill you. Unless it's the Golden Poison Dart Frog, which can.
- In both armoured and naval warfare, a well-aimed or lucky hit in the opposing tank/ship's magazine can lead to that unfortunate target being blown up by its own ammunition. This is what happened to three British battlecruisers at the battle of Jutland in 1916 and to the HMS Hood in 1941. It doesn't even have to be in the main magazines! At least one of the hits at Jutland (on the HMS Invincible) penetrated the roof of a main battery turret, which wouldn't have been a problem except that the Royal Navy battlecruisers' gunners were bypassing safety protocols for the sake of rapid fire and leaving a nice, flammable chain of cordite leading all the way to the magazines. That, and the fact that the cordite stock hadn't been sufficiently rotated and the stuff was a bit old and chemically twitchy, added up to cause disaster. This is how the Bismarck may have sank the HMS Hood, managing a plunging hit straight into the Hood's magazine.
- Japanese cruisers in general were vulnerable to this. This was because they carried highly volatile "Long-Lance" torpedoes, which were the most advanced torpedoes in the world by the 1940s but powered with pure and flammable oxygen. Even glancing hits from low-caliber shells could cause them to quickly cook-off and destroy or cripple the ship. In particular, during the Battle Off Samar, the USS Johnston managed to land a crippling hit onto the Japanese Heavy Cruiser Kumano completely taking it out of the battle with just one torpedo hit (the hit blew the ship's entire front end off).
- In World War I the SMS Szent István was torpedoed in the aft boiler room, killing the power needed to use the pumps and throw the water out. In fact a direct hit from a well-placed torpedo will sink most warships, with only the biggest capable of surviving. Modern torpedoes, which all use proximity fuses rather than needing to stike the target, ideally detonate a short distance below the keel of a vessel "breaking its back" under the target's own weight, causing the ship to split in two and sink relatively rapidly. The "back breaking" effect happened to one US ship during World War II from a kamikaze aircraft instead of a torpedo. The aircraft crashed in front of the ship, the ship ran over it, and was destroyed by an airplane which had already been shot down.
- In general, aircraft are extremely susceptible to being brought down by a singular cause, whether intentional or accidental. A propeller strike on a single-engined plane for instance, can effectively render a plane uncontrollable. In air-to-air combat, a direct hit by a single missile will generally suffice to bring down any aircraft.
- Hydrogen-filled Zeppelins in World War I were surprisingly resilient to being brought down by machine gun fire, though they could be downed with just one burst of incendiary ammunition or a single explosive shell in the right place.
- Similarly, anything that penetrates the armor of a tank will kill it, or at best take it out of action for the duration of the battle. This is because tanks are very compact vehicles, so anything that gets through the armor is going to hit something important. Increasingly, this “something important” is the crew itself.
- Masutatsu Oyama, founder of Kyokushinaki Karate, was considered in his time the embodiment of "One Strike, Certain Death". Three times in exhibitions, he killed a full-grown bull with a single punch.
- A lot of pesticides are made like this.
- Many combat athletes are known for their ability to end a fight with a single strike. Perhaps the best contemporary example is the UFC's Anthony "Rumble" Johnson, who, as of March 2017, shares the record for most all-time knockouts (including TKOs) in UFC history (11) with Anderson Silva, and boasts an incredible five KO/TKO victories in 51 seconds or less, with two of them coming in 13 seconds each. In the words of UFC commentator Joe Rogan, "Rumble Johnson connects on people, and they just shut off."