- Creator Backlash: When shown the show's official soundtrack by a fan on social media, James Gunn (who directed the movies) said that he "Wasn't a fan" of the choices.
- International Coproduction: Not the show itself, but the Latin American-Spanish dub, while show mostly with Mexican voice actors but share with Argentinian voice actors who have also done the most parts in series like Ultimate Spider-Man, Avengers, Assemble! and Hulk and the Agents of S.M.A.S.H. (in fact, all the show share Mexican actors in later seasons).
- Ink-Suit Actor: J'son looks almost exactly like Jonathan Frakes.
- The Other Darrin:
- Vanessa Marshall replaces Nika Futterman and Laura Bailey as Gamora, despite Futterman coming back later as Angela. Marshall also replaces Cree Summer as Meredith Quill.
- Jonathan Adams replaces James C. Mathis III as Ronan.
- Despite voicing Rhomann Dey, Jeff Bennett is replaced as the Collector and Grandmaster by, respectively, Tom Kenny and Jason Spisak. It's especially noticeable given that the Contest of Champions arc is being adapted in Ultimate Spider-Man at the same time the early episodes of this series are airing: in what is thought of as a linked universe, you're watching them in one show, and then hearing them sound very different in a show that airs the same day.
- Also, though his new portrayal has spread to the other shows, Will Friedle replaces Chris Cox as Star-Lord, making him sound very different from what viewers of Ultimate Spider-Man, Avengers, Assemble!, and/or Hulk and the Agents of S.M.A.S.H. were used to.
- James Urbaniak replaces Rene Auberjonois as Ebony Maw.
- Averted in the Mexican dub. All characters have same voice actors as in the movie, with exception of Ronan the Accuser (Eduardo Fonseca replace Rubén Moya).
- Ditto in the Japanese dub, with the sole exception of Rocket Raccoon's voice actor, who went from Kouji Kato to Setsuji Sato.
- Mick Wingert replaces Adrian Pasdar as Iron Man in the crossover with Avengers, Assemble!, which will carry on in Secret Wars.
- Grey DeLisle voiced Tana on Ultimate Spider-Man. In this series, she's voiced by Jessica DiCicco.
- Relationship Voice Actor:
- Star-Lord, Groot, and Drax are, respectively, fellow aliens Bumblebee, Bulkhead and Shockwave.
- Star-Lord and Groot are also Lion-O and Panthro.
- J'son , The Collector, Captain Marvel, and Groot are also Vinnie Callisto, Leo Callisto, Stella, and Mirandos' father respectively. Given that Lisa Schaffer is the voice director for both shows, it's not much of a surprise.
- Shout-Out: This show rewrites Drax's backstory to make him a former arena fighter, like the man who portrays him in the movies, Batista.
- Schedule Slip: The first half of season 3 finished on April 29, 2018. The second half premieres on May 5, 2019, which is over 1 year later.
- Screwed by the Network: In addition to the above mentioned schedule slip, reruns have been greatly reducing. It's only airtime is on Sunday mornings, and even then, not every Sunday, and mostly just for new episodes.
- When the show came back for the second half of season 3, new episodes moved to Sunday nights at 9:30 pm .
Trivia / Guardians of the Galaxy (2015)