The longest run of Spider-Man by any writer in its history branching off from Brand New Day, saw Dan Slott, who had been contributing to the previous era's "Webhead" brain trust since 2008, emerge as the sole writer starting in 2010. Dan Slott's helm as writer has seen the franchise achieve several critically and commercially well-received story arcs. The creation of several popular spin-off titles have also resulted in the comic line effectively evolving into becoming a "Spider-Family." Slott ended his run with one last story arc — Go Down Swinging — in 2018, succeeded by Nick Spencer.
Several notable changes that Slott has introduced into the mythos includes Peter finally transitioning from being a photographer into being a full-blown scientist, first working for Horizon Labs and then later, after the Superior Spider-Man incident, working as the owner of Parker Industries, Black Cat's return to villain-hood as the new "Queenpin of Crime", several large stakes events that had Peter fight for not only the safety of New York, but the multiverse itself, and the Spider-Family becoming solidified both in universe and in Marvel proper as a sustainable pillar to the comics.
Notable storylines created during this run includes:
- Big Time published at the end of Brand New Day that saw him introduce the original villain Mr. Negative.
- Ends of the Earth
- Superior Spider-Man
- A group of story arcs about Peter becoming a successful tech tycoon and having Spy Fiction adventures, collected as Worldwide volumes 1-7.
- Dead No More: The Clone Conspiracy
- Go Down Swinging
This run has also produced a number of spin-off titles, and characters as well as AU versions such as:
Dan Slott's Spider-Man provides examples of following tropes:
- Arc Welding: Tiberius Stone, a villain from a villain from Frank Tieri's Iron Man run reappeared—and was revealed to by the father of Tyler Stone and thus the grandfather of Miguel O'Hara.
- Big Bad: With Norman Osborn Out of Focus for much of the first run, Doc Ock ends up stepping back up as Spider-Man's Arch Villain.
- Book-Ends: Slott's first storyline, Big Time, started with Phil Urich murdering Hobgoblin (in this case Roderick Kingsley's brother). His final storyline, Go Down Swinging, starts with Norman Osborn murdering Phil.
- Broken Aesop: Dan Slott intended Superior Spider-Man to show why Otto's approach to fighting crime was ultimately inferior to Peter's. The problem is that unlike the case of DC Stories which experimented with Anti-Hero Substitute, Superior Spider-Man runs for 30+ issues, and creates a status-quo that remains default for the remainder of Slott's run and well into Spencer's run. In other words, Otto's crime-fighting methods and abilities are shown as effective until the inevitable Reset Button and the idea that Peter is the real deal is more informed than shown and by letting Otto of the hook for his actions in Ends of the Earth and for hijacking his identity at the end of his run, Slott has his cake and eats it too.
- Continuity Porn: Many minor supporting characters make a surprise appearance, especially in issue #655, No One Dies. In Issue 795, Loki mentions still owing Peter a favour and Peter vaguely recalls "making a deal with someone like Loki, then losing something very important", both plot points from the JMS run on the book (and, infamously, One More Day). Slott did this deliberately to create a cohesive impression that somehow every Spider-Man story Post-OMD still happened, even if the context was altered.
- Cool Old Lady: Aunt May takes a level or two in badass after Worldwide, helping to manage Parkertech.
- Crazy Jealous Guy: Peter Parker during the entire Regent arc. He literally goes berserk at the thought that Mary Jane could be dating Tony (even if they weren't), and that extends to him getting into a Testosterone Poisoning slug fest with Iron Man over things as petty as Youtube commenters liking Iron Man more, to Tony befriending Miles Morales, and finally culminating, after Stark good-naturedly jibing that he could give Spidey better tech than Peter, with Peter punching Iron Man in a face and starting a brawl for no real reason other than maybe his ex is moving on without him (just like he's been doing with many girls).
- Crimefighting with Cash: The Worldwide era.
- FaceHeel Turn:
- In the post-Superior Spider-Man relaunch, Black Cat becomes a villain once more, feeling betrayed and humiliated that "Peter" caused her to go to prison. Even after learning that it was Otto controlling Peter's body, Felicia rebukes any appeal for redemption. She eventually changes this stance after making peace with Spider-Man, and Eddie Brock convinces her to return to her roots as an anti-hero thief.
- Also in the Clone Conspiracy storyline, where central antagonist The Jackal is revealed to be Ben Reilly, the original Scarlet Spider.
- Failure Hero: A reoccurring trend saw Peter unable to prevent the deaths of past members of the supporting cast; Billy Connors, Marla Jameson, Silver Sable. By the end, they were all clearly taking a toll on him.
- Grand Finale: The "Go Down Swinging" arc will be Slott's final work on Spider-Man.
- Heroic BSoD: Peter undergoes one after the death of Marla Jameson. In his stressed induced unconsciousness, he's surrounded by everyone he's known that has died since taking the mantle.
- I Have No Son!: Inverted. Harry disowns Norman as his father and takes on his mother's maiden name in retaliation.
- Irony: In Worldwide, Peter is a tech magnate like Tony Stark. Which book did Slott leave ASM to go onto next? Yes, Iron Man, a hero who has that setup as his default status quo.
- The Hero Dies: Peter himself, in Amazing Spider-Man 700, thanks to getting stuck in Doctor Octopus' dying body. He gets better.
- Kafka Komedy: A lot of the humor of the series often came at the expense of Peter Parker. He had a tendency to face hardships and embarrass himself, often as a result of his poor decisions.
- Killed Off for Real: Marla Jameson, MC2 Peter Parker, and Ashley Kafka.
- Large Ham: Doctor Octopus just can't stop with the monologuing, ever. It becomes even more pronounced after Superior Spider-Man.
- Long Runner: Slott's run with the title lasted for close to a decade, and that's not counting his tenure as one of the rotating writers during Brand New Day. He even jokingly mentioned that had he known that Brian Bendis was leaving for DC sooner than he did, he would have stuck with the title even longer so that he could break Bendis' record for longest run with the character.
- Never Found the Body: Silver Sable presumably bites the bullet in the Ends Of the Earth storyline. She eventually came back in 2017, revealing she'd actually survived and gone into hiding.
- Remember the New Guy?: Remember Clash? That sound-based supervillain who was Spidey's first real adversary following Uncle Ben's death? No? That's because Dan Slott retconned him into Peter's origin in Learning To Crawl.
- Screw the Rules, I'm Doing What's Right!: Mockingbird assists Spidey with his hunt for Norman Osborn, eventually quitting SHIELD when they demand Spider-Man turn himself in.
- Ship Sinking: Peter with both Carlie Cooper and Mary Jane in the wake of Superior Spider-Man, where both women agree that the price was too high to be in a relationship with Peter.
- Spy Fiction: Much of the Worldwide era. Tuxedo and Martini variety.
- Status Quo Is God: Quite the victim of this. It seems that any shocking developments Slott presented was destined to be undone in favor of going back to basics once more. Superior Spider-Man? Doc Ock's mind is erased and Peter Parker is given back his body. Parker Industries? Self-destructed and Peter is back to being an everyman who's going to go back to working for the Daily Bugle once more. Felicia Hardy becomes a criminal mastermind trying to end Spider-Man? Not only does she eventually lose her entire criminal empire, she later makes peace with Spidey and is convinced to return to her roots as a thief with a heart of gold. Norman Osborn regaining his sanity? He would later work to lose it once more to bring back the Green Goblin.
- Take That, Audience!: He has a habit of insulting the more critical fans of his run.
- Uncle Pennybags: The Post-Secret Wars storyline sees Parker Industries become a global sensation and Peter essentially become the new Tony Stark.
- Unfortunate Implications: Invoked by Peter when he and Mockingbird beat up some guys in a Hong Kong backhouse, because they're all Asians, and it makes Peter feel uncomfortable.