The cast and showrunners at the celebration for the show's 400th episode.
A list of actors and actresses who have appeared in the Family Guy universe.
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A-C
- Paula Abdul: Herself
- J. J. Abrams: Himself
- Lori Alan: Diane Simmons/Coco/Eva Braun/Jane Jetson/Various
- Jason Alexander: Saul Friedman
- Will Arnett: Gen. Richter
- Edward Asner: Steve Bellows
- René Auberjonois: Odo
- Dan Aykroyd: Himself
- Hank Azaria: Apu Nahasapeemapetilon/Carl/Chief Wiggum/Various
- Lauren Bacall: Evelyn
- Laura Bailey: Dutch Daughter/Judge
- Dee Bradley Baker: Squirrel/Barnaby Bananas/Demagorgon/English to Raccoon Translator/Various
- Scott Bakula: Himself
- Fairuza Balk: Connie D'Amico
- Elizabeth Banks: Pam Fishman
- Christine Baranski: Newport Heiress/Herself
- Bob Barker: Himself
- Troy Baker: British Radio Announcer/Jorah Mormont
- Ike Barinholtz: Dane Cook
- Majel Barrett: Ship Computer
- Drew Barrymore: Jillian Russell/Mrs. Lockhart
- Meredith Baxter: Elyse Keaton/Herself
- Stephanie Beatriz: Boy/Esperanza/Hostess/Lola/Student
- Kristen Bell: Martha
- Michael Bell: Allstar Seaworthy
- H. Jon Benjamin: Carl/Bob Belcher/Carl as Yoda/Various
- Jeff Bennett: Announcer in Parody Sequence
- AJ Benza: Himself
- Candice Bergen: Gloria Ironbox/Murphy Brown
- Jeff Bergman: Fred Flintstone/Homer Simpson/Barney Rubble/Joe Piscopo/Various
- Mary Kay Bergman: Sherry
- Valerie Bertinelli: Herself
- Jessica Biel: Brooke
- Cate Blanchett: Penelope/Queen Elizabeth II
- BRIAN BLESSED: Prince Vultan
- David Boreanaz: Himself
- Alex Borstein: Lois Griffin/Tricia Takanawa/Barbara Pewterschmidt/Loretta Brown/Old Lady/Girl/Jewish Woman/Various
- Tom Bosley: Howard Cunningham
- Julie Bowen: Claire Dunphy/Herself
- Karan Brar: Chase
- Alexandra Breckenridge: Girl/Rape Victim/23-Year-Old Woman/Angry Mob Woman/Bond Girl/Various
- Paget Brewster: Gretchen Mercer/Madison
- Patrick Bristow: Cheesy Charlie's Manager/Hector/Various
- Connie Britton: Herself
- Kimberly Brooks: Black Sitcom Mom
- Clancy Brown: Toilet Announcer
- Dusan Brown: Bully
- Yvette Nicole Brown: Black Woman/Jerome's Mom/Black Sassy Nurse
- Laura Bell Bundy: Holly/Miss Laura
- Max Burkholder: Pudgy Kid/Justin Bieber/Harry Potter/Kid/Various
- Ty Burrell: Himself
- LeVar Burton: Himself/Vern
- Amanda Bynes: Anna
- Eugene Byrd: UPS Deliveryman
- James Caan: Himself
- Nick Cannon: Himself
- Lizzy Caplan: Woman Arguing with Quagmire
- Drew Carey: Himself
- Adam Carolla: Death/Super Death
- Tia Carrere: Hawaiian Woman
- Aimee Carrero: Hispanic Girl
- Nancy Cartwright: Bart Simpson/Daffney Griffin/Various
- Dan Castellaneta: Homer Simpson/Barney Gumble/Blue-Haired Lawyer/Various
- Lacey Chabert: Meg Griffin[[folder]]first voice[[/note]]/Jan Brady/Nancy Bradford
- Kyle Chandler: Coach Doyle
- Stockard Channing: Lydia Waterman
- Max Charles: Kid/Charlie Bucket/Davy Crockett/Various
- Chevy Chase: Clark Griswold/Himself
- Michael Chiklis: Big Fat Paulie/Bronx Guy #1/Cartoony Crewman/Henessy/Mechanic
- Margaret Cho: Hee-Sun
- Louis C.K.: Himself
- Glenn Close: Herself
- Mindy Cohn: Natalie Green
- Gary Cole: Principal Shepherd/Mike Brady/Michael Eisner/Security Guard/Bill Lumbergh/Various
- Monique Coleman: Fontaisha
- Chris Colfer: Kurt Hummel
- Mo Collins: Daycare Teacher/Various
- Rob Corddry: Ben
- David Costabile: The Prof
- Simon Cowell: Himself
- Chris Cox: George W. Bush/Man/Ross Fishman/Student/Angry Mob Man/Various
- Bryan Cranston: Bert/Arby's Executive/Himself/Dr. Jewish/Hal/Judge
- Chace Crawford: Jock #2/Luke/Paul/Popular Kid #4/Trainer
- Darren Criss: Hunter
- Denise Crosby: Herself
- David Cross: Jerry Kirkland
- Jim Cummings (1952): Winnie the Pooh
- Elisha Cuthbert: New Bedford
D-G
- Jon Daly: Javier Bardem/Kelsey Grammer/Lion/Oliver Platt/William Shakespeare
- Beverly D'Angelo: Ellen Griswold
- Jeff Daniels: Himself
- Tony Danza: Himself
- Keith David: Jazz Documentary Narrator
- Lucy Davis: Joanna Finn
- Thomas Dekker: Kid in Bathroom
- John de Lancie: Pewterschmidt Industries Executive
- Johnny Depp: Edward Scissorhands
- Portia de Rossi: Bonnie Swanson's Prank Call Voice
- Emily Deschanel: Julia Roberts/Herself
- Loretta Devine: Shirley
- Chris Diamantopoulos: Dean Martin/Frank Maxwell/Millipede/Parker Stanton/Stryker Foxx
- Nina Dobrev: Lois' High School Bully
- Snoop Dogg: Himself
- Michael Dorn: Lt. Worf/Himself
- D.C. Douglas: Imperial Guard #3/Superman
- Robert Downey Jr.: Patrick Pewterschmidt
- Brian Doyle-Murray: Bidder #2/Luke/Salty
- Rachel Dratch: Maggie
- Richard Dreyfuss: Himeslf/Narrator
- Patrick Duffy: Bobby Ewing/Jack/Salesman/Teacher
- Michael Clarke Duncan: Black Co-Worker/Boy on Mushrooms #1/Fozzie Bear
- Eliza Dushku: Herself
- Billy Eichner: Billy on the Street
- Sam Elliott: Wild Wild West/Himself
- Cary Elwes: Charles Dickens/Chris Martin/Cyrano de Bergerac/Various
- Bill Engvall: Duke Dillon
- R. Lee Ermey: Coach/Warden
- Erik Estrada: Ponch
- Jimmy Fallon: Himself
- Dakota Fanning: Little Girl
- Dennis Farina: Himself
- Jamie Farr: Himself
- Jon Favreau: Host of KISS Forum
- Nat Faxon: Water Park Employee/coach Herrera/Jet Li's Nemesis/Raymond the Bear/Apologetic Janitor/Foster Dad
- Craig Ferguson: Himself
- Alex Fernandez: Gerardo/Various
- Will Ferrell: Fat Greek Guy/Miles 'Chatterbox' Musket/The Black Knight
- Harvey Fierstein: Buster Keaton/Tracy
- Carrie Fisher: Angela/Mon Mothma
- Colin Ford: Kid/Various
- Faith Ford: Corky Sherwood/Various
- June Foray: Rocket J. Squirrel
- Will Forte: Principal Wally Farquhare/Various
- Jonathan Frakes: Commander William T. Riker/Himself
- Josh Gad: Droopy/Pimp
- Johnny Galecki: Leonard Hofstadler
- Peter Gallagher: Jared
- Paul Ganus: Falcor
- Aimee Garcia: Isabella/Nicole
- Billy Gardell: Mike Biggs
- Jeff Garlin: Himself
- Leif Garrett: Himself
- Ana Gasteyer: Speed Dater
- Gina Gershon: Policewoman
- Ricky Gervais: Billy Finn
- Elizabeth Gillies: Alana
- Zachary Gordon: Grandchild #1
- Mark-Paul Gosselaar: Zack Morris
- Louis Gossett Jr.: Drill Sergeant
- Gilbert Gottfried: Dog Whistle/Himself/Horse
- Lucas Grabeel: Student/Airplane/Amusement Park Manager/Various
- Lauren Graham: Mother Maggie
- Ariana Grande: Italian Girl
- Ari Graynor: Kitty Hawk Woman
- Jake Green: Simon Cowell
- Seth Green: Chris Griffin/Neil Goldman/Matthew McConaughey/Various
- Judy Greer: Bozo's Client/Hope/Various
- Scott Grimes: Kevin Swanson/Michael Buble/Michael Pulaski
- Michael Gross: Steven Keaton
- Ioan Gruffudd: Man/National Geographic Narrator/Prince Charles
- Bob Gunton: Warden
H-L
- Olivia Hack: Cindy Brady/Melissa Rivers/Various
- Julie Hagerty: Carol Pewterschmidt/West
- Tony Hale: Alan
- Mark Hamill: Luke Skywalker/Obi-Wan Kenobi
- Jon Hamm: Himself
- Chris Hardwick: Johnny Lawrence
- Mark Harmon: Leroy Jethro Gibbs
- Estelle Harris: Death's Mother
- Neil Patrick Harris: Barney Stinson
- Justin Hartley: Jamie
- Anne Hathaway: Hot Blonde/Mother Maggie/Herself
- Tony Hawk: Himself
- Erinn Hayes: Attractive Mom
- Ed Helms: Al Gore
- Sherman Hemsley: Himself
- Florence Henderson: Nanny Barbara/White Woman
- Taraji P. Henson: Chanel
- Jennifer Love Hewitt: Herself
- Tom Hiddleston: Statue Griffin
- Judd Hirsch: Himself/Judd Hirsches
- Tom Hollander: Contestant/Distinguished Man #2/James Corden/Sorting Hat/TV Announcer
- Jan Hooks: Mrs. Kellogg
- Michelle Horn: Eliza Pinchley
- Bryce Dallas Howard: Herself
- Glenn Howerton: Other Co-Worker at Meeting
- Rob Huebel: Business Meeting Leader
- Arianna Huffington: Herself
- Toby Huss: Tutor
- Kate Jackson: Mrs. Amanda King
- Allison Janney: Crystal Quagmire/Mistress Vita/Teen People Editor
- Gregory Jbara: Jonathan/Nazi General/Nazi Guard/Priest
- Caitlyn Jenner: Bruce Jenner
- Juanita Jennings: Miss Clifton
- Penn Jillette: Magical Johnson
- Ashley Johnson: Lisa
- Dwayne Johnson: Himself
- Rashida Jones: Daisy
- Kathryn Joosten: Hazer
- Mike Judge: Hank Hill/Bevis/Butt-Head
- Sung Kang: Soap Opera Actor
- Anil Kapoor: Prem
- Julie Kavner: Marge Simpson/Patty Bouvier/Selma Bouvier
- Anna Kendrick: Nora
- Tom Kenny: Dr. Fist
- Jimmy Kimmel: Death's Dog/Man in Suit/Renaissance Guy
- Richard Kind: Rabbi Goldstein
- Matthew Yang King: Bruce Lee/Chinese Man/Waiter
- Johnny Knoxville: Himself
- Nick Kroll: Ricky
- Mila Kunis: Meg Griffin/Bank Teller/Elizabeth/Mary Ellen/Various
- Ashton Kutcher: Himself
- Don LaFontaine: Narrator/Fox Announcer
- Maurice LaMarche: Ralph Kramden
- Phil LaMarr: Ollie Williams/Judge/Doctor/Minister/TV Announcer/Alfonso Ribeiro/Various
- Ted Lange: Himself
- Sanaa Lathan: Donna Tubbs/Fangirl/Backup Singer/Clair Huxtable/Muhammad Ali's Wife
- Hugh Laurie: Bar Patron/Dr. Gregory House
- Cloris Leachman: Herself
- Denis Leary: Car Mechanic
- Bobby Lee: Chinese Man/Sharply Dressed Asian Man
- C.S. Lee: Soap Opera Actor
- Jay Leno: Mayor Jay Leno
- Zachary Levi: Seymour
- Samm Levine: Joey
- Dawnn Lewis: Mrs. Bailey/Brunette Woman/Hostess/Receptionist
- Judith Light: Herself
- Ray Liotta: Zack
- Beth Littleford: Jane Jetson/Lois/Mother at Park
- Ron Livingston: Video Store Clerk
- David Lodge (American Actor): Kelsey Grammer
- Robert Loggia: Himself
- Nia Long: Roberta Tubbs
- Shelley Long: Carol Brady
- Mario Lopez: Himself
- Rob Lowe: Stanford Cordray/Himself
- Carl Lumbly: Loan Officer
- David Lynch: Himself/Gus
- Jane Lynch: Dotty Campell/French Teacher/Patsy Ramsey
M-P
- Norm Macdonald: Death/Himself
- Rachael MacFarlane: Miss Tammy/Barbara/Waitress/Woman/Cheerleader/Fangirl/Meg Griffin/Various
- Seth MacFarlane: Peter Griffin/Stewie Griffin/Brian Griffin/Glenn Quagmire/Tom Tucker/Dr. Elmer Hartman/Carter Pewterschmidt/Captain Seamus/God/Announcer/Jake Tucker/Kool-Aid Guy/Various
- Bill Maher: Himself
- Lee Majors: Himself
- Wendie Malick: Judge
- Camryn Manheim: Airline Passenger/Communist Mother
- Marlee Matlin: Stella
- David Mazouz: Peter's Co-Worker
- Edie McClurg: Herself
- Jennette McCurdy: Girl #1
- Gates McFadden: Herself
- Bruce McGill: John Williams/Lincoln's Cabinet Member/Santa Claus
- Ted McGinley: Helicopter Rental Agent
- Michael McKean: Andy Rooney/Camel Salesman/Pawtucket Pat/Pengrove Pig
- Ian McKellen: Dr. Cecil Pritchfield
- Kate McKinnon: Farmer's Date/Karen Griffin/Philippa
- Ed McMahon: Himself
- Katharine McPhee: Mother Maggie
- Gerald McRaney: Old West
- Christopher Meloni: George Townsend
- Scott Menville: Car Wash Guy
- Piotr Michael: Booze Cruiser/Gandalf the Grey/Police Captain/Sergeant
- Alyssa Milano: Herself
- Christina Milian: Esther
- T.J. Miller: Volcano
- Cristin Milioti: Andrea/Karen
- Wentworth Miller: Jock #4/Popular Kid #2
- Nicki Minaj: Herself
- Jerry Minor: Bumble B
- Daryl Mitchell: Maurice
- Jay Mohr: Joe Pesci/Logan/Wilshard Watkins
- Alfred Molina: Chris' Neighbor/Panamanian Man
- Ricardo Montalbán: The Cow
- Cory Monteith: Finn Hudson
- Joel David Moore: Jake Sully
- Mandy Moore: Courtney
- Belita Moreno: Rosario Vargas
- Garrett Morris: Himself
- Matthew Morrison: Will Schuester
- Tamera Mowry: Esther
- Martin Mull: Mr. Harris
- Rob Narita: Chinese Man
- Niecy Nash: Sheila
- Kevin Nealon: Himself
- Liam Neeson: Himself
- Judd Nelson: John Bender
- Nolan North: Archivist/Beaver/Cheesecake Factory Waiter/Dutch TV Announcer/Lois' Driver/Red M&M/The Turtlenecks
- Conan O'Brien: Himself
- Chris Odowd: Butler/Contestant/Guard
- Nick Offerman: Harris Grundle
- John O'Hurley: Cult Leader
- Toks Olagundoye Auctioneer/Gina
- Shaquille O'Neal: Himself
- Ed O'Neill: Bud Swanson
- Ana Ortiz: Cinammon/Maid
- Joy Osmanski: Party Guest
- Emily Osment: Ruth/Ashley's Granddaughter/Blackjack Dealer/Various
- Haley Joel Osment: Blackbuster Employee #2/Daycare Kid/Kid in Bathroom/Leonard/Letter R in Crest Aid
- Patton Oswalt: Tyler
- Elliot Page: Lindsey
- Adrianne Palicki: Tiffani Thiessen
- Keke Palmer: Pam
- Danielle Panabaker: Hillary
- Chris Parnell: Doug/Priest/Card Store Owner/Father Raccoon/Various
- Jim Parsons: Gay-jacker/Sheldon Cooper
- Sarah Paulson: Constumed Woman/Marcia Clark/Herself
- Khary Payton: Abusive Father/Baseball Player/Benicio del Toro/Customer/Gym Instructor/King
- Josh Peck: Charlie
- Sean Penn: Himself
- Rosie Perez: Choni/Herself
- Luke Perry: Himself
- Jay Pharoah: Brick Baker/Kanye Canes/Kanye West/Rev. Lucius/Skeetle/Timothy Q. Mouse
- Regis Philbin: Himself
- Busy Philipps: Various
- Lou Diamond Phillips: Tribe Leader
- Christina Pickles: Left Eyeball/Newport Heiress/Queen Elizabeth II
- Mary Kay Place: Farting Lady
- Suzie Plakson: Ann Romano/Various
- Martha Plimpton: Stephanie
- Linda Porter: Old Woman
- Jason Priestley: Brandon
- Missi Pyle: Kitty Hawk Woman
Q-T
- DJ Qualls: Centipede
- Josh Radnor: Ted Mosby
- Sarah Ramos: Teenage Girl
- Phylicia Rashad: Dee Dee Tubbs
- Joe Regalbuto: Bull/Editor/Frank Fontana
- Carl Reiner: Fantasy Baseball Coach/Old Man
- Catherine Reitman: Wheel-Cher
- Debbie Reynolds: Mrs. Wilson
- Ryan Reynolds: Overwight Guy/Himself
- Giovanni Ribisi: Randy
- Kevin Michael Richardson: Jerome/Cleveland Brown Jr./Bill Cosby/Bouncer/Drill Sergeant/African Warlord/Various
- Peter Riegert: Max Weinstein
- Rob Riggle: Chet Butler
- Kelly Ripa: Herself
- Krysten Ritter: Gina
- Emma Roberts: Amanda Berrington
- Craig Robinson: LaVar 'Freight Train' Brown/Zeke the Town Drunk
- Alex Rocco: Bea Arthur/Soccer Mom
- Freddy Rodriguez: Handy Manny
- Seth Rogen: Himself
- Christy Carlson Romano: Quagmire's One-Night-Stand
- Robert Romanus: Mike Damone
- Rebecca Romijn: Graduate/Speaker
- Stephen Root: Allister Monkarsh/Neighbors Kellogg
- Jeffrey Ross: Jeff Ross
- Maya Rudolph: Chloe
- Olesya Rulin: Russian Meg Griffin Double
- Joshua Rush: Kid in Bed/Sears Employee/Stewie's friend/various
- Will Sasso: Bernie the Hamster/Bobby Briggs/Ken/Larry/Larry's Doctor/Max/Randy Newman/Todd
- Fred Savage: Kyle H./Himself
- Wendy Schaal: Francine Smith/Newport Heiress/Secretary
- Roy Scheider: Himself/Narrator
- Dwight Schultz: Clerk/Randall Fargus
- Amy Schumer: Crew Leader
- Rhea Seehorn: Joanie Cunningham
- Jason Segel: Marshall Eriksen
- Amanda Seyfried: Ellie
- Will Shadley: Kid Doctor
- Yara Shahidi: Little Girl
- Wallace Shawn: Bertram
- Charlie Sheen: Himself
- Kiernan Shipka: Singing Cheerleader
- Alexander Siddig: An Onlooker/Lead Archer/London Silly Nannies Player
- Laura Silverman: Amy
- Ty Simpkins: Little Drummer Boy
- Tony Sirico: Vinny/Himself
- Marina Sirtis: Counselor Deanna Troi/Herself
- John Slattery: Mayor Box
- Joey Slotnick: Angry Man/Bob/Carter/Cashier/Dick Clark/Jewish Man/Officer/Various
- Brittany Snow: Candy
- JJ Snyder: Penelope Cruz
- André Sogliuzzo: Actor/Director/Italian Tour Guide/Language Tape/Man in Restaurant/Mel Gibson/Waiter
- Aries Spears: Eddie Murphy/Shaquille O'Neal
- Tori Spelling: Donna
- Brent Spiner: Himself
- Rick Springfield: Himself
- Florence Stanley: Mrs. Griffin
- Ben Stein: Rabbi Goldberg
- Daniel Stern: Narrator
- Patrick Stewart: Baby Susie Swanson Inner Voice/Avery Bullock/Captain Jean-Luc Picard/Himself/Various
- Ben Stiller: Himself
- Tara Strong: Amanda/Little Girl/Amy Grant/Anna Paquin/Various
- Nicole Sullivan: Muriel Goldman/Tina/Alexis Radcliffe/Alice/Amber/Angelica/Various
- Cree Summer: Guest #1/Twin #1
- Kiefer Sutherland: Narrator
- Don Swayze: Patrick Swayze
- Julia Sweeney: Naomi Robinson/Woman in Bar
- JoAnna Garcia Swisher: Liddane
- Fred Tatasciore: Harvey Weinstein/John Goodman/Police Officer/Alligator/Arnold Palmer/Various
- Aaron Taylor-Johnson: Jaidan
- David Tennant: Doctor Who
- David Thewlis: British Father
- Eddie Kaye Thomas: Barry Robinson
- Lea Thompson: Lorraine McFly/Teenaged Girl in Diner
- Tracie Thoms: Beautiful Woman/Pouncy
- Jennifer Tilly: Bonnie Swanson
- Justin Timberlake: Booger/Paul
- Ashley Tisdale: Kelly/Priscilla
- Alex Trebek: Himself
- Danny Trejo: Clint Beltran
- Jacob Tremblay: Treehouse Boy
- Kathleen Turner: Herself disguised as Peter Griffin
- Neil deGrasse Tyson: Himself
U-Z
- Leslie Uggams: Herself
- Gabrielle Union: Shauna Parks
- Wilmer Valderrama: Diego
- Laura Vandervoort: Bridgit/Jenny
- Sofía Vergara: Buxom Woman/Hispanic Woman/Herself
- Gore Vidal: Himself
- Abe Vigoda: Himself
- Melissa Villaseñor: Nora Ephron
- Nana Visitor: Mother/Rita/Audition Caller/Nancy Pelosi/Various
- Patrick Warburton: Joe Swanson/Boggs/Colonial Joe/Joe's Mother/Various
- Audrey Wasilewski: Various
- Sam Waterston: Dr. Kaplan
- Michaela Watkins: Girl Pulling Train
- Cynthia Watros: Security System
- Frank Welker: Fred Jones/Megatron/Kermit the Frog/Various
- George Wendt: Norm Peterson
- Rutina Wesley: Yvette
- Adam West: Mayor Adam West/Ace Merrill/Batman/Fairy Godmother/Grand Moff Tarkin (West)/West (live action)
- Billy West: Various
- Wil Wheaton: Anti-Abortion Activist/Himself
- Betty White: Herself
- Mae Whitman: Student/Teenage Girl/Vegas Waitress/Angry Mob Woman/Annaleigh Quagmire/Various
- Kristen Wiig: Fern Stapleton
- Kathleen Wilhoite: Sam/Various
- Fred Willard: Dave Campbell
- Billy Dee Williams: Lando Calrissian
- Casey Wilson: Jess/Dottie/Gymnastics Team Mom
- Debra Wilson: Black Woman/Janet/Mrs. Kanner/Mrs. Kraner/Nurse/Sandy Belford/Various
- Rainn Wilson: Dwight Schrute
- Michael Winslow: Himself
- Dick Wolf: Himself
- Elijah Wood: Himself
- James Woods: Himself
- Robert Wu: Asian Man/Mr. Washee-Washee/Anime Father/Asian Baby/Various
- Cedric Yarbrough: Board Member/Lobster
- Owain Yeoman: Narrator
- Michael York: Documentary Speaker
