- The Daemites are pretty scary in themselves, due to their Puppeteer Parasite nature, grotesque appearance and the fact that they just won't die, shrugging off the damage dealt to their host body and simply leaving it for another when it is too battered. However, they are at their scariest in "Lurking Underground" episode, where they are introduced. It marks a sudden and unexpected Genre Shift from action to horror, which you will be most likely unprepared for, unless you knew of their existence before playing the game.
- Up until now, you've spent the entire second act fighting through a Nazi stronghold, wiping out entire squads of ordinary human soldiers with ease. At the beginning of this episode, you follow one of their officers taking a ride to an underground storage area, only to get a glimpse of him and other soldiers screaming in horror and being attacked by something, before a closing gate bars you from seeing what's happening out there. When you finally enter the room, you find nobody in there. Nobody. There's just some blood and weapons laying around, but no corpses. The previously visited parts of Nazi base were full of people, but now, the whole area is suddenly completely devoid of life. Heck, even the music, which has been accompanying you before, now goes completely silent. Rayne, who's been quite unflappable before, loses her normal composure and gets slightly, but visibly creeped out.
- It gets worse. When you proceed to the next room, suddenly there are those otherworldy, disembodied voices which seem to come from all directions, mocking Rayne and repeating her earlier words like echo. And everything is accompanied by hellish laughter. Followed again by complete and total silence. Even Rayne fails to come up with a wisecrack this time. When you go further, the music is back on... but unlike earlier, quite kickass tunes, now it's suddenly minimalistic and really creepy, enough to send shivers down your spine.
- In order to open the gate and proceed further, you need to enter a small room, with only a few Nazi corpses lying inside, to turn a lever. Seems easy enough. But the moment you burst in there through window, the previously quite dead bodies suddenly start screaming in excruciating pain and rising on their feet. Then their heads are ripped apart from inside, replaced by grotesque visage of parasites which took possession of their bodies.
- And then, to put a cherry on top, Daemites are much harder to actually kill than anything you fought before. As noted above, previously you've been effortlessly cutting through scores of ordinary soldiers, which undoubtedly gave you a feeling of invincibility. Daemites, however, would deprive you of that feeling. None of usual tactics work well on them — they control the bodies of their hosts like puppets, meaning that they shrug off wounds that would easily incapacitate normal human, they take a lot of damage before finally going down, and when it eventually happens, they don't die, but merely leave their host body. Which means that you cannot dispatch them quickly by draining them of blood either. In short, this is a fight you will be woefully unprepared for.
- One of the antagonists introduced late in the game is Hedrox the Infinite, an ancient vampire chieftain from a closed off region in the world and his appearance is completely inhuman in contrast to Rayne and other vampires introduced, with a vaguely chiropteran face and two clawed hands with mouths. But that is not the worst part: his regenerative powers are so powerful that any severed limb can regenerate into a Hedrox clone. If Rayne tried to cut him into pieces with her blades, she will just create an army out of Hedrox. If it wasn't for water being the only feasible way to destroy him, it would have been impossible to destroy such creature.
- Belial, the ancient previous ruler of Hell before being deposed by Lucifer, most certainly wasn't a Big Red Devil. Instead he looks like this.
- Rayne's daddy dearest Kagan. He is a vampire lord who raped Rayne's mother just to give birth to a Dhampyr child and then murdered every single one of her relatives. What makes this truly twisted is that Kagan does it as official policy for any of his children, so they wouldn't have any other family to turn to but him. The only reason Rayne didn't join his family was because a kindly scientist took her up and raised her as his child. What does Kagan do when he finds said scientist though? He beats him to a pulp, tears out his intestines and chokes him with them.
- Right in the first level, Rayne has to infiltrate a ball party being pulled by Zerenski, which has invited several wealthy guests such as executives, mobsters, politicians and etc. And then Zerenski has everyone in the party killed. You don't see the slaughter happening (only its aftermath), but you hear the people screaming over the radio while you are unable to do anything about it.
- Some of the finishing moves in the game are so gruesome that they wouldn't be out of place in Mortal Kombat.
- The Shroud. For starters, its a substance created from the bodies of homeless vagrants and street walkers which we see its development production (their bodies are grind through machinery until they are liquid) and turned into a gaseous form that when released into the air allows vampires to walk unharmed during daylight. That on itself is bad enough, but the Shroud also causes some aberrant effects on nature: plants and trees wither and burn, while animals are mutated by it, though thankfully we don't see any of them. Judging the effect it has on insects (read further down) it must probably not be very pretty.
- If you thought Hedrox was horrifying, just look at the new vampire enemies introduced in the second game:
- Brutes (pictured above) are horribly mutated feral vampires of great strength, size and ferocity serving as Boss in Mook Clothing. Their brutality is displayed in "the Dawn of the Vampiric Age" cinematic, where they tear down people as if they were made of paper.
- The Foremen are also equally mutated and implacable, only they are dressed in industrial clothing and use large hammers as weapons.
- The biggest example (quite literally) is Slezz, an monstrously-inhuman vampire living in the sewers said to be from an ancient breed referred as Babylonian Winged Shakab. One of her attacks includes shooting acid out of her breasts and in order to beat her, Rayne has to blow up her belly, enter inside her and destroy her heart from within. While she is a very easy to beat boss, it doesn't make her appearance any less disgusting. Also, there is the fact that Slezz refers to Kagan as "my love", the implication being that Kagan probably mated with ''that''.
- When you visit the Twisted Park, you see several corpses on display that are inexplicably twitching, which freaks Rayne out. Then several insects burst out from the corpse, forming The Worm That Walks enemy, that is completely invulnerable to attacks and can only be warded off with fire.
- One of the deleted enemies of the game was the Roach Queen, a dead woman who controlled the insects in the Twisted Park and was supposed to be a boss fight, but got cut due to time constraints. Its probably fortunate for gamers with entomophobia that they never go to fight this.
- The dissonant soundtrack played during the final level is very unnerving to say the least.