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Nausea Fuel / The Binding of Isaac

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The Binding of Isaac, to lightly put it, is a really gross game, filled to the brim with Body Horror, Gorn, and Toilet Humor. While the cartoonish artstyle makes most of it slightly more easier on the eyes than it should be (if you're not too easily disgusted that is), you'll still find yourself cringing over what you'll come across.

  • Really, the environments and enemies in general, from the giant turds lining the floors, the enemies that look like giant anuses firing out laser beams, grotesque monsters lined with all manner of horrific markings... ich. The Rebirth remake adds more details, including things like tiny maggots crawling around the floor in large numbers.
  • The Womb, as the name implies, is a level that literally takes place in a womb, filled with rocks made of flesh, fetus or cell-like enemies, and spikes that look like jagged, sharp teeth.
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  • The Womb's music track in Rebirth, "Viscera", contains... indescribable fleshy sounds that might be a little unnerving to some players.
  • The Scarred Womb in Afterbirth may be the most nauseating environment to look at in the entire game. The name should sum it up quite well.
  • Mom herself. She looks rather normal in the opening cutscene, but if you use Mom's Bra or fight her as a final boss, she turns into a straight-up Gonk.
  • Mom's. Pad. Also complete with a Gross-Up Close-Up. Even the enemies are horrified!
  • There is a "Gulp!" pill, which destroys trinkets and adds their effects to you permanently - Presumably by swallowing them. There are trinkets like a used diaper, a dead fish head, a cancer tumor, the heart of a child... Draw your own conclusions.
  • In an example of Shown Their Work, there's a striking amount of enemies and items in the game that are based on real life medical terminology and phenomena. Such examples like the "Fistula" and "Teratoma" bosses, the "Proptosis" item and many more that aren't immediately obvious. This could lead to players searching it up on the internet with unintended results...
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  • The game's massive amount of Body Horror, from most of the power-ups that affect Isaac in gruesome ways, to almost all the enemies. Some enemies, like Gurdy or the Stain, seem to be made completely out of flesh, body parts, and viscera.
  • Some items can dye your tears with blood, such as toothpicks which props your eyes open.
  • The Placenta power-up. Isaac presumably uses it by eating it, and you're forced to look at his blood-smeared mouth for the rest of the run.
  • The Ipecac power-up, a rather literal example. Ipecac in real life is a powerful emetic. So upon getting this power-up you get to witness Isaac green, vomit-covered, and violently ill-looking as he pukes up poisonous bombs. Ouch. Just imagine how miserable the poor kid feels.
  • The aftermath of any room clearing, which leaves the entire room covered in blood, guts, bones, and destroyed piles of poop. The worst is probably after any fight with Larry Jr., who poops all over the room, leaving the entire room practically smothered with blood and feces.
  • Mega Fatty, while probably not the most horrid-looking boss (although its bleeding from the mouth and eyes and grotesque obesity doesn't make it look pleasant in the slightest either), definitely has some of the most disgusting attacks, which includes projectile puking upwards which sends down a rain of vomit, and letting out a fart that either sends a wave of damaging diarrhea or produces Dips. That's right. There's a boss that attacks you by sharting.
    • The Cage is just as gross, if not grosser, which is a given since he's the rotting corpse of Mega Fatty. Not only does he vomit greyish bullets from his decapitated body, but is also stained with a greenish substance (likely vomit) and has an attack where he opens up the huge stitch on his stomach to send out Vises that fire puke-green brimstone lasers.
    • The Fatty enemies whom Mega Fatty basically serves as a King Mook to aren’t as bad but they do have their share of gross attacks, such as farting on you. But the really disgusting ones are the Fat Sacks and Conjoined Fatties, the former who has empty eye sockets that bleed profusely, and the latter who like Mega Fatty also has a diarrhea-based attack, except it's vivid green slime that damages you.
  • Mama Gurdy is another nausea-inducing boss, from her deformed appearance to having an attack where she vomits up a pale orange substance on you. Seems like most of the bosses in this game are fond of using vomiting as an attack method...
  • Brownie is among one of the grossest bosses in the game, as he's a giant turd full of corn that leaves trails of poop everywhere he goes and spawns Corn Dips. What's even worse is his black champion version, where instead of smaller poop-based enemies, he spawns Chargers, which are maggot-based enemies. Yes, poop filled with maggots. Make that as you will.
  • And of course there’s Peep, who uses URINE as his weapon. And he’s one of the more mild examples.
  • The item "Harlequin Baby" is a reference to the rare and horrifying real-world disorder Harlequin Ichthyosis, which causes babies to be born with puffy red eyes, green or red crackled/scaly skin, and stretched out lips.
  • Some of the health items you get, "Breakfast," "Lunch," "Dinner," and "Dessert," are rotten milk, old meat, and wet and dry dog food. Not only is it repulsive, they also have some depressing implications.

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