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Memes / The Binding of Isaac

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Amidst all the horrors lurking within the Basement, there are also some incredibly memetic things.

Please add entries in the following format:
  • The meme. [[labelnote:Explanation]]The explanation behind the meme, if necessary.[[/labelnote]] Explanation 
    • Further mutations and successor memes, if any.

  • One of the most popular emoticons on Twitch is BibleThump, which is Isaac's default crying face.
  • Due to the wide variety of items you can pick up, the game is also known for causing a lot of It Makes Sense in Context moments, particularly for things like Cancer, Dark Bum, and Dr. Fetus.
  • "It's not a won run yet!"Explanation 
  • "You missed a Tinted Rock."Explanation 
  • Advertisement:
  • "Isaac and his Isaac lived alone in a small Isaac on an Isaac."Explanation 
  • CHUB DISLIKES SMOKE!Explanation 
  • Yay, Cancer!Explanation 
  • FUCK BLOATExplanation 
  • Advertisement:
  • "Are you enjoying the steak? Remember to chew it slowly or else..."Explanation 
  • 109Explanation 
  • "Shh, don't let Edmund hear about [X], he might nerf it..."Explanation 
  • Ultra Greed's AssExplanation 
  • Dank Depths Explanation 
  • "SISSYYYY! How ya doin' Sissy? Little Sissy!"Explanation 
  • "By gawd, it's Pin (with a steel chair)!"Explanation 
  • "AS IF I REALLY LOOK LIKE THIS!"Explanation 
    • "THE ANGER OF GOD IS COMING!" Explanation 
    • Living in the Light's "lyrics" in general are popular copypasta fodder.
  • Jacob and the Red Hitbox Explanation 
  • You litte F**ker You made a shit of piece with your trash Issac it’s f**King Bad this trash game I will become back my money I hope you will in your next time a cow on a trash farm you sucker Explanation 
  • BLOOD PUPPY!Explanation 
    • "BAD PUPPY! BAD!"Explanation 
  • YEET THE BONES!Explanation 
  • BETTER ITEMS! Explanation 
  • Henry.Explanation 


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