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Characters / The Binding of Isaac

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A list of characters who appear in the The Binding of Isaac franchise.

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Plot-relevant characters


A little boy who flees into the basement of his house to escape from a mother who wants to kill him, and must fight for his life against a never-ending assortment of demons and mutants. Beating the game in certain ways or collecting certain items unlocks variations of Isaac with their own unique attributes.

For tropes related to Isaac and his alter-egos in gameplay, scroll down to the section on player characters. For tropes related to Isaac as the boss enemy of the Cathedral, scroll down to the section on major bosses.

  • All of the Other Reindeer: In addition to having an abusive mother and a Disappeared Dad, flashbacks also show him suffering bullying from other kids, such as having his pants pulled down while trying to impress a girl, getting crapped on (literally), getting knocked down by a dodgeball, and being made fun of for wearing a wig.
  • Break the Cutie: The entire premise of the game is one for him.
  • Children Forced to Kill: Isaac has to fight and kill plenty of enemies just to survive, up to and including his own religiously psychotic mother. Or so it seems.
  • Create Your Own Villain: Well, antagonist. Isaac would never have been forced to kill his own mother if she hadn't snapped and tried to sacrifice him in the first place. This gains some very interesting implications at the true ending of Rebirth, where it's revealed that Isaac becomes a demon or the Antichrist inside the Chest. Did Isaac have darkness inside him all along, or did he decide to become evil after all the horror that he went through?
    • As it turns out, this trope is played literally, with the revelation that the entire game is Isaac's Dying Dream.
  • Crossdresser: A few between-level cutscenes show him wearing a dress or a wig, not to mention the fact that all female "player characters" are him crossdressing.
  • Dark and Troubled Past: The horrible memories of things that Isaac suffered through are relived in level loading screens. In one ending, the photograph montage of Isaac's past leaves a lot of interpretation as to what happened to his family, namely what happened to his father (who likely left, went missing, or died). The final ending of Afterbirth+ confirms that he left, and this point is reiterated in The Legend of Bum-bo's main ending.
  • Dead All Along: After beating It Lives for the tenth time and unlocking Ending 10, Isaac comes across his corpse stuffed into a chest. At least one interpretation of this involves Isaac having been dead the whole time. The next three endings explore the events leading up to his death in reverse chronological order, first showing him willingly locking himself in the chest, then showing his self-loathing which led to this, and finally showing his tragic backstory through a heartbreaking Photo Montage. After beating Hush in Afterbirth, if you end your run there, not going on to Cathedral or Sheol, you get Ending 17, which outright confirms it, as Mom opens the Chest to find Isaac's skeletal remains. Ending 20, the true ending to the game, reveals that he has long since been Driven to Suicide and that none of the game is even happening.
  • Driven to Suicide: Isaac hangs himself upon finding Transcendence (a noose) in Ending 2. This is Played for Drama in the final few endings: After we see that Isaac has been Dead All Along in the tenth ending, we are shown him willingly entering the chest himself in Endings 12 and 13, and the twentieth ending reveals that it was due to his self-loathing as he sees himself as a demon after his family breaks apart.
  • Dying Dream: Ending 20 reveals that the whole game is this, including the thought of his mother attempting to kill him.
  • Enemy Without: There are four variations of Isaac that serve as bosses: It Lives, the boss of Womb II confirmed to be Isaac as an embryo; normal Issac, the boss of Cathedral; Hush, the boss of the Blue Womb and a suffocating version of Isaac; and finally ???, boss of the Chest and Isaac after suffocating to death.
  • Full-Frontal Assault: Unless an item is picked up, Isaac is battling the monsters of the basement stark naked.
  • Hilariously Abusive Childhood: Many of the level intermission vignettes have Isaac getting picked on by kids, being dressed in drag, getting poop as a birthday gift, realizing he has no toilet paper while he's on the toilet, and the list goes on. And that's not even speaking of some of the items — the Wooden Spoon gives you scars, implying Isaac was beaten with it by his mom, the Belt is self-explanatory, and many of the food items aren't exactly fit for human consumption.
  • Ironic Name: "Isaac" means "he laughed" or "he who laughs." Not much laughing occurs. Quite the opposite, really. invoked
  • It's All My Fault: The ending you get for beating the Chest seems to imply that the cause of Isaac's self-loathing is because he blames himself for his father leaving. His mother seems to blame him as well. Ending 20 eventually reveals that he does blame himself, and this is what ultimately causes him to be Driven to Suicide.
  • Kindhearted Cat Lover: Whenever the player gets a Game Over, Isaac usually states in the diary that he will give what he collected to his pet cat, Guppy.
  • Madness Mantra: BAD BAD BAD BAD I'M THE DEVIL...
  • The Mentally Disturbed: With all said and done about the new endings in Afterbirth+ comes the spine-chilling conclusion that, by experiencing losses too grave for his age, together with the outcast status forcefully pinned by other children, this whole game can be interpreted as Isaac's slow descent into schizophrenia. Small wonder that the game seems to run on Black Humor and widgettiness now, huh...?
  • Mr. Imagination: Horribly deconstructed. Isaac has the vivid imagination expected of a child his age, but his troubled childhood and self-loathing lead to his imagination going to very, very strange and dark places. Even as he suffocates inside his toy chest.
  • Naked on Arrival: He is naked throughout almost the entire game.
  • Sanity Slippage: Isaac is slowly going insane the longer he is in the chest, as shown by the final level and boss being amalgams of previous levels and bosses.
  • Suddenly Voiced: One of the main endings of The Legend of Bum-bo features Isaac's first spoken words in the series, begging Mom to leave his cardboard toys alone.
    No, no, mama, please!"
  • Then Let Me Be Evil: It is strongly implied that at the ending of Rebirth, Isaac becomes a demon or The Antichrist in order to deal with all the horror he went through, up to and including his mother. Ultimately subverted, as this is how he sees himself, for, in his own mind, being the reason his father "left forever".
  • Troubled Fetal Position: Isaac's signature pose.
  • Troubling Unchildlike Behavior: With the game's reveal that it was just all in Isaac's head, one could wonder what exactly is going on inside this kid's head, with the game's vast amount of Body Horror and violence. Even the items leave disturbing implications, with the item pool including a gimp mask, a razor blade for self-harm, a suicide vest, drug needles, literal cancer, ect. Just what kind of stuff has Isaac been exposed to?!
  • Vague Age: Fans have theorized Isaac being from a toddler to at most seven years old. He's at least old enough to walk and go to school, and The Legend of Bumbo reveals that he can talk. Edmund also tentatively Hand Waved in a tweet that Isaac is five.
  • Walking Spoiler: Due to the endings revealing more and more of what is actually going on between him and his family, it's only a given.


    Mom/Magdalene O. Moriah 

Debut: The Binding of Isaac

Isaac's mother. A devoutly religious woman who, in a fit of rage/insanity/fanaticism/whatever you think it is, tries to kill Isaac, forcing him to flee to the basement.

For tropes relating to Mom as a boss enemy, scroll down to the section on major bosses.

  • Abusive Parent: Takes away all her son's stuff, locks him in his room, and then tries to kill him. Convinced by God to do so or not, that's all the evidence you need. However, the true ending reveals that this is possibly a subversion, depending on whether you see the between-level cutscenes as being canon or not.
  • The Bad Guy Wins: It's revealed that Isaac suffocated to death while inside the chest. She wanted Isaac to die because of an (alleged) order from God, do the math. However, subsequent endings reveal that Isaac locked himself in the Chest before the events of the game, and Afterbirth+ reveals that she was never intending to kill him and that Isaac saw himself as a demon and the cause of his family breaking apart, making this a cruel subversion.
  • Big Bad: The game is kickstarted by her attempting to murder her son. Ultimately subverted; the only evidence of this comes from Isaac's own mind, which is unreliable at best.
  • The Extremist Was Right: She's a religious fanatic that appears to think that she's on a mission from God, which is clearly not the case. At least until the end of Rebirth, strongly implying that Isaac either was or now is a demon. If you subscribe to the "just insane" theory, then she's Right for the Wrong Reasons.
    • Subverted as of Ending 20: Isaac made up the story, possibly to explain why she was acting so abusive without taking the blame off of himself.
  • The Faceless: While you see her face in Isaac's doodles, the actual Mom gets the Wilson treatment in that you never get to see her entire face at once, only a single eye, or the lower half of it if you use Mom's Bra.
  • Foreshadowing: The opening pretty much implies she's reenacting the role of Abraham in Yahweh's covenant. Which means, in case you're not a Bible buff, that this whole act is doomed to fail if she plays it as intended, as this time there's no angel to stop her and save her son's life.
  • The Fundamentalist: She's heavily Christian, and her hearing the voice of God is what kicks off the plot.
  • Gonk: To grotesque, nauseating levels. Subverted, as the new endings hint at the possibility that this is how Isaac's addled mind interprets her appearance.
  • Hidden Depths:
    • Ending 13 note  reveals that she used to be completely sane, and the caring and loving mother of a fully-functional family. However, as the family fell apart, so did her sanity.
    • Endings 15 and 17 suggest that in the end, she might be at least somewhat concerned about her son's well-being.
    • The final ending, 20, confirms that Mom is nowhere near the psycho that Isaac's brain made her out to be, and never intended to kill him at all. She's seen weeping in front of the television after his father leaves the family.
  • Knife Nut: She's holding her knife in almost every cutscene she appears in, and you can unlock said knife as a usable weapon in-game.
  • Maybe Magic, Maybe Mundane: Is she really hearing the voice of God, or is she just completely insane? The best we get from McMillen is him stating:
    “It was never implied that [Mom's] insane. And if you're going by the Bible and you believe all the stories, then why wouldn't you think that it's possible now for that stuff to happen?
  • No Name Given: Unlike Isaac, even her first name is unknown in the game prior. According to the 'Credit Card' card from Binding of Isaac: Four Souls, her full name is Magdalene O. Moriah. "Moriah" is the location where the biblical Isaac was to be sacrificed.
  • Offing the Offspring: Her ultimate goal in Isaac's Dying Dream.
  • One Bad Mother: Bonus points for actually being the main character's mother.
  • Suddenly Voiced: One of the main endings of The Legend of Bum-bo features the real Mom speaking full sentences for the first time.
    "Isaac... who were you talking to?"

    God/The "Voice From Above" 

In the opening narration, a voice from above claims to be God to Isaac's mother and instructs her to kill him.

  • Ambiguous Situation: Is it really God's voice, Satan's, or someone else's? One of the between-floors clips added in Afterbirth shows the scene of Mom hearing the voice from above, except the camera, moves up to show the Lost speaking. The final ending implies that there was no "voice" to begin with, and Mom was never trying to kill Isaac.
  • The Ghost: Despite playing a part in the game's initial story, God never actually appears in-game. Even the holy counterpart to Devil Rooms are Angel Rooms, which have Uriel and Gabriel in them instead. The only item outright said to be God-relatednote  is Godhead, which gives Isaac a third eye and a glow on his head.
  • Secret Test of Character: The Epilogue suggests this was the case with Mom, as the narrator describes her death as "God intervened" despite supposedly ordering her to kill Isaac in the first place.
  • Third Eye: Suggested with the Godhead item, as it gives Isaac a third eye and "God tears." If the item is considered as adding a God-like eye to Isaac's head, since Isaac's "normal" eyes are unchanged and the item itself just shows one eye in a triangle, then this game's depiction of God might have only one eye instead.
  • The Unfought: Isaac never encounters God in-game. Even when going to a cathedral, the boss of that is Isaac himself, and the floor after that is not another holy location so much as it is a chest where Isaac's post-mortem counterpart lies (and where Isaac must confront reality).


Isaac's father, who is not part of the family by the time the game takes place.

  • Abusive Parents: Some of the items in the game (bad/rotten food for "breakfast/lunch/dinner," the Belt and Spoon being speed boosters, etc) suggest that Isaac has at least one abusive parent. Ending 20 suggests that it may or may not be Mom, which would logically point to Dad if that is the case. Either way, collecting the passive item Dad's Lost Coin makes poor Isaac look miserable.
    • However, The Legend of Bum-bo implies in its final ending that Dad was not the abusive one. He gave well-intentioned advice to Isaac about fueling his imagination to help cope with reality, and claimed that he will always be with Isaac in spirit. That said, he's also the one who made the cardboard toys Isaac plays with, which are... mature, disturbing, and grotesque, to say the least. Certainly not appropriate for a five-year old to play with.
  • Alcoholic Parent: The Dad's Lost Coin card in The Binding of Isaac: Four Souls is an Alcoholics Anonymous chip.
  • Disappeared Dad: Right from the beginning of the game, the intro states that Isaac lives alone with his mother. The final ending implies that something happened which caused him to leave in anger and drove him away from Mom, and by beating the Boss Rush as The Forgotten, you unlock the Divorce Papers. Notably, the Dad's Key item lets Isaac open any door note  — in other words, leave the given room he's in.
  • The Ghost: Justified considering the game's setting. He's already out of the family, and Isaac instead wanders the Basement fending off demons. However, even as it becomes clear that the gameplay is set in a Dying Dream, Dad himself is never directly encountered.
  • Greater-Scope Villain: Subverted; he is mostly responsible for the deranged setting and monsters that Isaac encounters, but he only created them in the hopes that Isaac would learn to use his own imagination as a coping mechanism.
  • Unwitting Instigator of Doom: The Legend of Bum-bo reveals that he (at least partially) created the "world" that both it and The Binding of Isaac take place in, with the intention of teaching Isaac to rely on his own creativity in order to deal with the stresses of reality. Unfortunately, Isaac becomes too delusional with the mental world he and Dad formed together, and ultimately chooses to commit suicide instead of moving on with his life.
  • Walking Spoiler: Plays a part in the game's overall lore, but is not really hinted at doing so until around unlocking the Polaroid/Negative, which takes over a dozen playthroughs (assuming no skipping involved with items, buttons, or Error/Black Market rooms generating trap doors). Or by going through Hush and Delirium and seeing Ending 20, since it is possible yet difficult for newer players to beat that path before unlocking either photograph. The Legend of Bum-bo takes it even further by revealing Dad's true significance in the setting of both games.



A naked baby who lives with his trash. He's the protagonist of "The Legend of Bum-bo," when a monster steals his precious golden coin.

  • Berserk Button: He’s very attached to his single coin, so when a monster takes it away, he does not hesitate in following it and beating up any other monster who stands in his way.
  • Boisterous Bruiser: He’s a loud, brave bum who likes to punch his enemies into mush. It’s especially evident whenever he kills a boss, letting out a triumphant “OOOOH YEAH!” as it explodes into gibs.
  • Breakout Character: Originally a familiar for Isaac to recruit, Bum-bo saw a considerable rise in popularity before starring in his own game.
  • Contrasting Sequel Main Character: Isaac is a scared child who enters the unknown depths to escape from his mother, and primarily attacks with ranged tears. Bum-bo, however, is brave and cheerful, willingly follows a monster into the unknown depths after it takes his coin, and prefers to smash enemies with his fists.
  • The Gambler: Despite his obsession with the coin, one ending features him feeding it to a slot machine (though he hesitates for a long while before doing so).
  • Magikarp Power: How he works as a familiar in The Binding of Isaac. Bumbo starts out doing nothing but taking money (which makes him even worse than Bum Friend, who at least gives you stuff in return), but as he collects more coins, he gains more abilities. Once he's fully powered up, Bumbo is easily the strongest familiar in the game, capable of spitting out tons of items and single-handedly murdering most bosses.
  • Spell My Name with an "S": As a familiar in Isaac, his name is spelled as "Bumbo" without the hyphen. Also Early Installment Weirdness as the hyphen was added after he got his own game.
  • Third-Person Person: He mostly speaks this way whenever he’s narrating a cutscene. This may be because "Bum-bo" is in fact Isaac's dad, narrating the setting of the world Isaac would escape to if he ever becomes too stressed.
  • Wham Line: In the true ending, Bum-bo talks about making his "kingdom" and expanding it, filling it with adventure, until his voice suddenly changes, and reveals that his kingdom was made for Isaac and that "Bum-bo" was in fact his father, who did it all to help Isaac escape the stresses of reality.


Playable Characters

    In General 
  • Acrofatic: Several items make your character fatter, and most don't negatively impact speed. Combine these with items that increase your speed and you have this trope.
  • Amazing Technicolor Population: Stat-boosting pills change the character's color (Green for Luck, red for Health, etc), as do a few of the items. Most demon-related items turn the character into a black-skinned demonic hybrid, and Anti-Gravity turns them blue, for two examples.
  • Badass Adorable: He's still a child at the end of the day.
  • Berserker Tears: Unlike most examples, he fights by crying.
  • Blessed with Suck: Guppy's Tail makes you find golden treasure chests more often. This comes at the expense of keys needed to open those chests, though if you're lucky, the chests cough them up. Works wonders with items that can create keys, such as the Skeleton Key or a Flat Penny. This is made potentially worse or better with The Left Hand trinket that changes all chests to Red Chests. They don't require a key to open, but half or more of the things that come out of a red chest are not something you want (including enemies and troll bombs).
  • Blonde, Brunette, Redhead: The three female playable characters: Magdalene (blonde), Eve (brunette), and Lilith (redhead).
  • Body Horror: A lot of items mutilate or mutate the character in some horrific way. For example, Chemical Peel causes half of the character's face to be torn off, Growth Hormones causes hideous lumps to form over the character's body, Stem Cells causes a fetus to grow on the side of the character's head, The Parasite burrows into the character's skull and dyes their tears a disgusting orange-brown, and 8 Inch Nails has two nails shoved in each of of the character's eyes.
  • Bring My Brown Pants: Entering a room with half a heart makes the player leave yellow urine stains on the floor (unless playing as Eve, whose stains are red instead).
  • Bullet Hell: It's possible to get a character that shoots a four-way bullet spread at the speed of a machine gun with additional single shots from the other three cardinal directions. And honestly, that's a pretty tame possibility.
  • Dark Is Not Evil: An Isaac with a lot of Devil items is still just looking to survive.
  • Did You Just Punch Out Cthulhu?: Isaac can tear apart any number of bosses over the course of the game, including Satan.
  • Empowered Badass Normal: No matter which version you choose, you'll inevitably turn him into a supernatural being in the process of beating the game.
  • Fantasy Character Classes: The characters are based on archetypal RPG classes (with a few exceptions).
  • Flash of Pain: His sprite blinks when he takes damage.
  • Flight: Plenty of items, both permanent and temporary. You can become an angel, a demon, an angelic ghost, a demonic ghost, a floating head, and a cat (which somehow flies). All of these let you pass through rocks and over pits, as well as over hazards like creep and spikes.
  • Full-Frontal Assault: Before the events of the game, his clothes were taken away from him as part of Mom's attempts to remove the evil around him. In most playthroughs, he fights his way through monsters naked.
  • Gasshole: Certain items can invoke this in the player, such as Butt Penny, Mysterious Candy, the "Bad Gas" pill, and pretty much all the bean items. Also combines with Fartillery if the item is used for combat.
  • Good Wings, Evil Wings: Both are possible, though not at the same time — Angel items for the "good" variant, and Devil items for the "evil" ones.
  • He Who Fights Monsters: As he fights through deformed monsters and demons, he will end up getting a lot of things that make him just like those deformed monsters and demons.
  • Improbable Weapon User: Mainly his own tears. With appropriate items, he can upgrade to teeth, urine, and explosive vomit, among other things.
  • Item Get!: Holds up new items — even in battle. You're not invincible when that happens, either.
  • Kindhearted Cat Lover:
    • Isaac seems to adore Guppy the cat the most out of his (deceased) pets.
    • He seemed to also like Max (Cricket in Rebirth) second most out of the pets, or possibly equally to Guppy because Max's head makes him cry hardest of all items.
    • There is also Tammy, who, although she doesn't evoke as strong a response as Guppy, will still make Isaac cry more than normal, translating into a 360 shot.
  • Meaningful Name: Most of the playable characters' names relate to Bible stories, with Isaac's name relating to the Binding of Isaac story the game is based on. Four Souls suggests his last name is Moriah, the mountain from the same story.
  • No Name Given: His surname is never known in-game. When Four Souls confirmed Mom's name, his last name would logically be Moriah — the mountain in the Biblical story of Isaac. The only hazy part is whether or not that's Mom's maiden name, and whether she and/or Isaac have it after Dad left.
  • Ocular Gushers: Most playable characters have a constant stream of tears running down their faces. After all, they are Isaac's main weapon.
  • Paper-Thin Disguise: It is strongly implied in-game (and confirmed by Word of God) that all the characters are just Isaac putting on a wig, eyepatch, hat, etc.
  • Secret Character: There are numerous transformations available, which are activated by collecting three items of a particular set (flies, cats, etc.), after which the transformation effects are permanent for that run. The three items only need to have been held once, even if replaced (for Active items) or rerolled (for passive ones). The original had only Guppy, while Rebirth added Lord of the Flies. Afterbirth added eight more, and Afterbirth+ added another three.
    • Guppy, activated by picking up three Guppy items, transforms the player character into Isaac's pet cat. Doing so unlocks a new item (the first time), gives you flight, and applies a buffed version of the Mulligan that spawns a fly upon every hit.
    • Lord of the Flies/Beelzebub, activated by picking up three fly-related items, turns the player into a humanoid fly, grants flight, and turns all regular flies into kamikaze flies.
    • Seraphim, activated by picking up three holy items, gives Isaac angel wings for flight and three soul hearts.
    • Bob, activated by picking up three Bob items, turns Isaac green and causes him to release a trail of green creep where he walks.
    • Leviathan, activated by picking up three satanic items, transforms Isaac into a mini-Cthulhu, granting flight and three black hearts.
    • Spun, activated by picking up three syringe items, makes Isaac buff, gives a damage increase, and spawns a random pill.
    • Yes Mother, activated by collecting three Mom items, dresses Isaac as Mom and creates a copy of Mom's knife which trails behind the player (not as a familiar, but as an inverted copy of the knife controlled by movement).
    • Fun Guy, activated by picking up three mushroom items, gives Isaac a mushroom hat and adds a heart container.
    • Oh Crap, activated by picking up Flush, The Poop, and E. Coli, turns Isaac into a walking poop and heals him by half a heart every time a poop is destroyed.
    • Super Bum, activated by picking up the three Bums, combines the three Bums into a single Bum that grabs every pickup in the room and drops twice as many in return.
    • Conjoined, activated by picking up three of a certain set of familiars (Brother Bobby, Harlequin Baby, Headless Baby, Little Steven, Mongo Baby, Rotten Baby, and Sister Maggy), causes Isaac to grow two tumors on either side of his face, giving him permanent diagonal tears similar to The Wiz, at the cost of slightly lowered tears and damage.
    • Bookworm, activated by picking up three book items, gives Isaac a monocle and lets him occasionally shoot from both eyes at once.
    • Spider Baby, activated by picking up three spider items, gives Isaac a spider familiar that applies random status effects to enemies.
    • Adult, activated by taking three Puberty pills, makes Isaac's voice deeper and gives him a scruffy beard and a heart container.
    • Stompy, activated by increasing in size three times through any combination of Leo, Magic Mushroom, and the One Makes You Larger pill, causes Isaac to create dust clouds when walking and lets him occasionally release rock waves when taking damage.
  • Swiss Army Tears: As a weapon! With the appropriate items, Isaac can get poison tears, homing tears, fear-inducing tears, spectral tears, magnetic tears, petrifying tears, exploding fire tears, tears that summon beams of light from Heaven, or any combination thereof. And that's not even a complete list.
  • Tears of Fear: Pretty understandable given the situation he's in.
  • Throw Down the Bomblet: The bombs he can carry around are pretty good for killing things as well.
  • Took a Level in Badass: Throughout the game, if the right items are acquired, Isaac starts the game as a crying child and can potentially end it as a flying demon that can demolish bosses in seconds with giant lasers.
  • Winged Humanoid: Possible with certain items.


Debut: The Binding of Isaac
Named after the biblical son of Abraham, is playable from the start and has no defining accessories. According to Edmund McMillen, he represents the fighter class of traditional games and begins with no items.
  • Badass Normal: He's the only playable character that starts off without any sort of items or supernatural assistance. Even the D6 is merely a six-sided dice.
  • Bald of Awesome: Being a young child, he has no hair normally. It doesn't hinder him at all from kicking Satan's ass.
  • Boring, but Practical: In both the Flash and Rebirth versions, he always starts with a single bomb. It seems like nothing much, but it guarantees you'll be able to blow up a marked rock (and get DMG up and/or Soul Hearts) should you encounter one, or take a shot at finding a secret room.
  • Heart Is an Awesome Power: His unlockable starting item is merely a six-sided dice. Many players agree that it is among the best starting items in the game regardless, since it rerolls any pedestal items in the room into potentially better ones.
  • He Who Fights Monsters: Isaac himself is an alternate True Final Boss Disc Three Final Boss that can be fought instead of Satan. More details below.
  • Jack-of-All-Stats: Average in all stats except for having 3 starting hearts.
  • Luck Manipulation Mechanic: The all-mighty D6 dice! An activated item capable of transmuting any pedestal item into a different one.
  • Magikarp Power: At first, he'll be outclassed by almost every other character you unlock, as they are more durable, faster, more powerful, and/or more useful than him. But if you take your time and persevere in order to unlock his starting item, he'll become the most versatile and flexible of them all.
  • Master of None: His stats are middle of the road, and he gets no starting item to work with, unlike the others. ...Until you unlock the D6.
  • Meaningful Name: The Biblical Isaac was going to be sacrificed to God by his father Abraham under orders from God himself. Sounds a lot like what's happening to Isaac... sort of.


Debut: The Binding of Isaac
Named after a friend of Mary, the mother of Jesus, she is distinguished from Isaac by her blonde hair and bow. Maggy represents the cleric class from traditional games and starts with the Yum Heart: an activated item that restores one heart upon use.
  • Boring, but Practical:
    • Her gimmick is somewhat bland compared to the others, but having four red hearts to work with allows for Devil Room deals early on without severe consequences. Additionally, the Yum Heart restores a red heart every 4 rooms (without any items that accelerate charging), which keeps her healthy and can be a godsend during the later chapters.
    • In Afterbirth+, you can unlock a starting Speed Up pill for her through the challenges. Not flashy, but it does patch up her biggest weakness, and it takes up a slot in the pill pool that could otherwise be occupied by something less desirable.
  • Combat Medic: Called "the cleric" in the art booklet.
  • Dead Person Impersonation: The death of the real Maggy seems to be what caused Isaac's family to fall apart.
  • In-Series Nickname: Usually referred to as Maggy.
  • One Steve Limit: Averted; she as the same first name as Mom.
  • Stone Wall: Maggy has low speed and bad tear damage, but has the highest starting health and the Yum Heart by default.
  • Tertiary Sexual Characteristics: Longish hair and a bow.
  • Useless Useful Spell: Yum Heart with certain playstyles can become this. If you need to use it (read: took red heart damage), your chance at getting powerful Devil Deal items got severely cut.


Debut: The Binding of Isaac
Named after the biblical son of Eve and first murderer, he is distinguished from Isaac by an eyepatch. He represents the Thief class from traditional Role-Playing Games and starts the game with the Luck Foot: a passive item that improves random events in various ways. In Afterbirth, donating 67 coins to the donation machine at the end of Greed Mode allows him to start with the Paper Clip, a trinket that allows him to open chests without using keys.
  • Bald of Awesome: Just like Isaac.
  • Born Lucky: Cain's starting item gives him increased luck in certain situations.note 
  • Eyepatch of Power: He has an eyepatch, and also starts with higher attack than most other characters.
  • Fragile Speedster: Starts with great speed and attack and an average rate of fire, but suffers from low range and health. Outright called "the thief" by the art booklet.
  • Glass Cannon: Starts with great attack and a good rate of fire, but lower health than usual.
  • Heart Is an Awesome Power: After the release of Rebirth, Cain was widely considered the worst (non-joke) character with his sub-par stats and his newly nerfed items. His only saving grace was that when it came to money, there was no one who could reliably get and keep as much as him. Come Afterbirth, Cain became widely considered the absolute best character for the new Greed Mode, which is all about money (his new general stat buffs certainly didn't hurt either).
  • Master of Unlocking: In Afterbirth, where you can unlock the Paper Clip trinket as a starting item for him, allowing him to unlock golden chests without using keys.
  • Name of Cain: While not outright evil, Cain is somewhat shady-seeming — he wears an Eyepatch of Power and his abilities make him resemble a "rogue" class.
  • Nerf: The mechanics of Lucky Foot changing in Rebirth indirectly hurt him REALLY bad. Afterbirth compensates a bit, as stated above.
  • Unexpectedly Realistic Gameplay: Downplayed and it doesn't cause any real puzzles, but his eyepatch does factor into gameplay. For most characters, Technology 2 stacks the beam on top of their tears. Cain's the exception, his tears being shut off due to his eyepatch. Chemical Peel and Blood Clot are changed, too; while with other characters, every other tear will have increased damage due to one half of the face being scarred, with Cain, every tear has a 50% chance of dealing increased damage.


Debut: The Binding of Isaac
Named after the first woman and original sinner, Eve is distinguished from Isaac by long dark hair and eyeshadow. Representing the druid class from traditional games, she starts with The Whore of Babylon, which turns her into a demon at low health, and the Dead Bird, which fights for her when she is damaged. After donating 439 coins to the Greed Machine, she also starts with the Razor Blade, which lets her damage herself on demand.
  • Adam and/or Eve: Named for the Biblical Eve.
  • Attack Animal: The Dead Bird.
  • Awesome, but Impractical: In the normal game, her Razor Blade is this. It damages the player and gives an attack boost for the current room, which is fairly useless over multiple rooms and only good for getting the Whore of Babylon to activate on the first floor. In Greed Mode, however, it's a lot more useful since Angel/Devil Rooms are guaranteed by beating the final wave.
  • Cast from Hit Points: The Dead Bird is activated by taking damage in a room and works as a faster level three Meat Boy for the room in which it activates. The Razor Blade removes a full heart when used, and increases damage for one room in return.
  • Combat Sadomasochist: Both of her starting items (and the items she can unlock) are Cast from Hit Points, and she is the only character who doesn't leave a puddle of urine upon entering a room with half a red heart; instead, she leaves blood. Afterbirth ups the ante if you donate enough coins in Greed Mode, by giving you the Razor Blade.
  • Critical Status Buff: When she's down to half a heart, her Whore of Babylon powerup grants her greatly increased attack. Rebirth buffed this by allowing it to activate at one full heart.
  • Cursed with Awesome: The "curse" that Eve starts the game with.
  • Difficult, but Awesome: Starts with terrible attack stats, but getting the most out of Eve's Critical Status Buff makes her a One-Hit Point Wonder with higher starting attack than most other characters.
  • Emo Teen: Definitely evokes the stereotype, both in looks and in playstyle. You can even unlock the Razor Blade as a starting item for her, as if it weren't obvious enough.
  • Four Is Death: Eve is the fourth playable character, with a risky playing style that actually benefits from being close to the brink of death. In Ending 11, the character montage showed Eve being present at the game's fourth level, the Womb. And considering how Mom is...
  • Fragile Speedster: High speed, low health, low attack unless reduced to critical health.
  • Glass Cannon: Becomes one when hurt due to her Critical Status Buff.
  • Looks Like Cesare: Has eyes encircled with black as well as black hair (though not scraggly).
  • No Periods, Period: Averted via an Easter Egg. Every other character leaves a puddle of urine if they enter a room with half a heart left, but Eve leaves a bloodstain.note 
  • Secret Art: Eve is the only character that activates Whore of Babylon at one full heart remaining rather than half a heart. Additionally, it also changes her innate damage multiplier while active (Eve normally has a 25% damage penalty that is removed when Whore of Babylon activates), which it doesn't do for any other character.
  • Tertiary Sexual Characteristics: The Dead Bird in her hair looks like a bow.
  • Useless Useful Spell: A few items that regenerate half-red hearts passively are normally somewhat useful, but can be detrimental to Eve if they take her out of her Critical Status Buff and has soul/evil hearts protecting her red hearts.


Debut: The Binding of Isaac
Named after the disciple who betrayed Jesus, he has a fez to distinguish himself from Isaac. He represents the mage class from RPGs and starts the game with the Book of Belial, an activated item that increases attack power for one room. In the original game, he unlocks after beating the Womb for the first time. In Rebirth, he unlocks after beating Chapter 5 for the first time.
  • Bald of Awesome: Just like Isaac.
  • Deal with the Devil: While holding the Book of Belial, the chances of a Devil Room appearing are increased. Unfortunately, Judas' starting 1 heart makes it impossible to make deals unless he gets more heart containers or soul hearts, or buys an item that grants him black hearts. Fortunately, passing up Devil deals means that subsequent Devil Rooms can be replaced by Angel Rooms, which give you free stuff.
  • Difficult, but Awesome: Starts off with the most consistent damage of all the playable characters (Eve and Samson's powers are conditional), but with only one starting heart and average speed for dodging, you don't have much leeway to screw up.
  • Glass Cannon: More so than Cain. Starts with an average rate of fire, range, speed, and high attack power, further bolstered by his Book of Belial. In exchange, he starts with only 1 heart.
  • Nice Hat: Edmund based Judas' Fez on Phil Fish, due to him voting against Edmund and his comrades at the Independent Games Festival... although Edmund later stated that said explanation wasn't true, but he went along with it for a while because he found it funny.
  • Secret Character: There's a form of Judas in Rebirth only attainable by dying with the Judas' Shadow item. For the rest of the run, you will play as a character known as Black Judas in-game, who has a 2.0 damage multiplier but starts only with two Black Hearts. Finishing a run as Black Judas counts as a Judas run for unlocks and achievements.
  • Squishy Wizard: The artbook refers to him as the "mage", fitting in the other RPG archetypes. It fits since Judas has high starting damage (especially with the Book of Belial active) but very low starting HP.
  • Status Buff: The Book of Belial increases his damage for a single room, which is especially handy for multi-wave rooms like challenge rooms, Greed mode, or the Boss Rush.


Debut: The Binding of Isaac

Unlocked after defeating Mom's Heart/It Lives ten times, ??? is a shout-out to Edmund McMillen's Newgrounds account (specifically his "Dead Baby Dressup" game). Starts with The Poop, which creates a pile of dung once per room. Whilst his official name is ???, his nickname is "Blue Baby", which is how he signs his death note on the Game Over screen (and how he's listed on the PSN Trophies list for Rebirth). ??? starts with three soul hearts and is unable to use red hearts at all. Any red heart-granting items will be converted into soul hearts.

Despite being a Joke Character gameplay-wise, he is possibly one of the most plot-relevant characters in the game. His reveal indicates that the vignette of Isaac suffocating in the chest is canon, and not only that, but he somehow died of asphyxiation whilst there. At this point, it is implied that Isaac has been Dead All Along and Endings 11 and 12note  seem to indicate that Isaac actually locked himself in the chest after being Driven to Suicide.

  • Amazing Technicolor Population: Justified, since he's dead and cyanotic.
  • Jack-of-All-Stats: No outstanding stats or notable starting item, with the exception of his "-1 HP", meaning that he depends on soul hearts just to live. However, he is actually slightly faster and stronger than Isaac.
  • Joke Character: Blue Baby is incapable of gaining red heart containers; any situation that would give him red hearts instead converts them to soul hearts. Also, soul hearts remain much rarer drops than regular hearts, making getting hit even less feasible. At least he can still gain black hearts...
    • Lethal Joke Character: Since his health can only be composed entirely of soul and black hearts, he can exploit certain health-based mechanics (such as the Whore of Babylon, which is permanent if picked up), leading to quite a few potential and powerful combos. He also has permanent access to Devil and Angel Rooms, since he's not taking red heart damage.
  • Joke Item: The Poop; it only creates a mound of poop like those you usually see. However...
    • Lethal Joke Item:'d be surprised how situationally useful The Poop can be. A pile of poop spawned can be used to create a temporary cover, and can be bombed like a rock to cross single-tile-wide gaps. It is affected by the Petrified Poop trinket (which it can also create), meaning you can get a coin every room or two if you have it. In Afterbirth, using the Poop deflects incoming projectiles a la buffed Butter Bean.
  • Mechanically Unusual Class: Tamer than later examples, but his restriction on hearts makes quite a few items work very differently for him as noted. Most health ups are bad or useless, but anything that gives soul hearts is exponentially more powerful.
  • My Name Is ???: A unique example in that it's never revealed what the question marks are obscuring (unless you go with the theory that he's just a postmortem Isaac).
  • No Dead Body Poops: Oh yes they do. Which is the whole point of his Joke Item.
  • Not Quite Dead: Well, his body is dead, but he's moving around and acts normally despite being a corpse.
  • Secret Character: While he's on the menu from the very start, new players probably won't assume that "???" is his actual name. His secrecy is lessened by him being first Secret Character players are likely to unlock, and the only one unlocked by playing the game normally.
  • Toilet Humor: You can't get much closer to this than being able to poop on command.
  • Undead Child: He's the corpse of a child that's somehow still animate.
  • The Unpronouncable: He's usually just referred to as "Blue Baby", even on his last will, since "???" isn't exactly easy to pronounce.
  • Wingding Eyes: Crossed-out eyes.


Debut: Wrath of the Lamb
Introduced in Wrath of the Lamb and named after the biblical strongman, he has long, brown hair and Big Ol' Eyebrows. He also starts with a red headband called Bloody Lust. This is fitting with the fact that he represents the Berserker class. An extremely important part of this character is how he was substantially changed. In the original, Samson started with one heart container and gained a damage boost for every enemy he kills in a room. In Rebirth, he starts with three heart containers and gains a damage boost every time he takes damage, which lasts for an entire floor.
  • The Berserker: Bloody Lust can actually support Attack! Attack! Attack! to an extent, with the damage he takes actively improving how fast he can end the fight and letting him keep that improved damage for the whole floor.
  • Blood Knight: His trademark power-up is called Bloody Lust, after all!
  • Conservation of Ninjutsu: Invoked by his special hair-band. The more enemies you face in a room, the more powerful you'll get! But single-target rooms won't trigger any attack-boost. This is changed in Rebirth, although re-added in Afterbirth as an unlockable item called Lusty Blood.
  • Critical Status Buff: In Rebirth, Bloody Lust makes Samson deal more damage as he takes damage, with him reaching near maximum damage for having taken several hits in a row. In this case, he literally Turns Red to reflect Bloody Lust activating.
  • Difficult, but Awesome:
    • In Wrath of the Lamb, Bloody Lust makes Samson powerful... if you manage to survive the hordes of enemies that give him his strength. Only having a single heart (later a soul heart as well) makes that easier said than done.
    • In Rebirth, this mechanic is changed, although he's still a challenging character. Bloody Lust now only triggers when taking damage and the bonus is lost at the end of the floor. That means he has mediocre damage if you don't take hits, and can't manipulate it the same way Eve can.
  • Gathering Steam: In the original, he gains damage as he kills enemies, but loses it after he leaves the room.
  • Glass Cannon: With just 1 starting heart container, he's as fragile as (and under some circumstances, even more than) Judas. However, his special gear makes him extremely effective against large groups of enemies and/or mook makers. This is changed in Rebirth, which gives him much more starting health; however, in order to max out his damage output, he has to deliberately take a lot of damage.
  • Martial Arts Headband: It's the source of his Blood Lust passive ability.
  • Powerup Letdown: He's probably the most difficult character to unlock in the original (with ??? possibly being more tedious than difficult), as it requires you to pass on 2 free items on a regular run... and its capacity is dubious, to say the least. After months of complaints, Edmund promised a buff to Samson. The buff was starting with a soul heart on top of his single regular heart... which didn't change all that much. He became much more useful in Rebirth, as he now starts with three regular hearts and his buffs from killing enemies and taking damage remain until you leave the floor. On the other hand, now you have to clear two floors in a single run without taking any damage to unlock him, which is arguably even more difficult.
  • Took a Level in Badass: In Rebirth, Samson starts with a much more forgiving 3 hearts and gets to keep his buffs until he leaves the floor. This is a major improvement from his previous incarnation.
  • Unstoppable Rage: What Bloody Lust represents as of Rebirth.


Debut: Rebirth
Named after the one that was brought back from the dead. Unlocked in Rebirth by having four or more soul hearts at once. He starts with average stats, but has Lazarus' Rags, which allows him to return as Lazarus Risen after dying and giving him Anemic. His gameplay is unique in that to gain a fairly powerful item and stat boosts, the game encourages you to kill yourself.
  • Back from the Dead: Starts play with one extra life.
  • Born Unlucky: He starts with negative luck, although this is cleared upon resurrecting.
  • Bloody Murder: After he uses his extra life, he gets the Anemic item, which lets him leave a damaging trail of blood for the duration of the room upon taking damage. Beating the Backasswards challenge makes this trail permanent instead.
  • Came Back Strong: Lazarus Risen is statistically better than normal Lazarus in every way aside from health, in addition to gaining Anemic (or, if unlocked, leaving a permanent blood trail). Many players choose to kill themselves as soon as they have a health up available, circumventing the lower health and coasting off the increased stats.
  • Crutch Character: One of the first characters available to unlock, he has a higher tolerance for damage than Isaac, with the only apparent downside being his negative luck. After unlocking the D6, however, his advantage seems rather insignificant. Without using his extra life very tactically, he ultimately plays like a less lucky Cain or a less powerful Judas... until you complete Challenge 31 in Afterbirth+.
  • Master of None: Apart from his resurrection ability, he essentially plays like Isaac without a D6.
  • Meaningful Name: Who else but Lazarus would start with the ability to rise from the dead?
  • Not Quite Dead: His gimmick is being able to resurrect instantly, rather than outside the room he died in (forcing him to restart it).
  • Powerup Letdown: His extra life only resurrects you with exactly one heart container, and only gives you a blood trail for the current room if you get hit once. On the other hand, it does resurrect you on the spot (unlike the other extra lives that return you to the previous room), possibly allowing you to finish off whatever killed him. Lazarus also receives a considerable boost in Luck, Range, Damage, and Speed, but still, that one heart container makes it a tricky run.
  • Took a Level in Badass: Completing Challenge 31 in Afterbith+ allows him to use Anemic right from the start without losing his extra life first. Additionally, it is activated permanently if Lazarus dies and is resurrected (or another character resurrects as him), with no need to take damage.
  • Touched by Vorlons: Downplayed with his Lazarus' Rags item. Before dying, his stats are nothing to write home about. After dying and reviving, his stats receive a buff and he now leaves a trail of blood whenever he takes damage (or permanent if Challenge 31 in Afterbirth+ is cleared).


Debut: Rebirth
A demonic-looking character whose name is associated with evil. Unlocked in Rebirth by making three deals with the devil in one run. Starts with the ability to fly and a short ranged version of Brimstone.
  • Action Bomb: He starts with only black hearts, which trigger the Death effect when depleted.
  • Close-Range Combatant: Until The Forgotten, he was the closest thing that Rebirth had to one, since his starting weaponry forces him to get relatively close to enemies. He compensates by possessing above-average speed and flight.
  • Crutch Character: Despite his low range, Azazel's flight and high damage make him by far the easiest character to play as. However, he plays entirely differently from every other character, meaning that playing with him doesn't build the skills you need to be good with the rest of the characters. In addition, many items have no effect on his short-range Brimstone, so he's locked out of a lot of neat synergies. Finally, the final bosses indulge in Bullet Hell, which makes them much tougher to beat with Azazel since you constantly risk getting shot in the face.
  • Dark Is Not Evil: He's a demon and starts with Black/Evil Hearts, but he's still a playable character just trying to escape the basement dungeon.
  • Disc-One Nuke: His flight and Brimstone are a major advantage in the early game, and flight remains an important bonus throughout. However, his limited range will really begin to catch up to him when it comes time to face the endgame bosses.
  • Dungeon Bypass: Possessing flight lets him ignore spikes, rocks, and other terrains right from the start. Rather useful.
  • Fragile Speedster: Fast, possesses flight and has high starting damage, but at the cost of poor range that cannot be increased and having to charge Brimstone for attacks. His black hearts damage everything if one gets depleted and he can eventually gain red heart containers through Health Up items, but he is overall much frailer than characters who can pick up red hearts from the get-go.
  • Frickin' Laser Beams: His starting attack is a limited-range Brimstone.
  • Glass Cannon: High damage, but starts with no red hearts.
  • Good Wings, Evil Wings: Subverted. Azazel has demon wings but is good (or at least on Isaac's side) and also on the same side as Apollyon, who has angel wings.
  • Hit-and-Run Tactics: Unlike others who depend on kiting with tears, Azazel often has to fly in, blast several enemies with brimstone, then get out of there before the rest retaliate. He can also strafe multiple enemies for the duration of his Brimstone, but again, he has to be closer than normal for tear-strafing.
  • Horned Humanoid: One of his horns is broken.
  • The Last of These Is Not Like the Others: At the time of his release, Azazel was by far the most different from the other playable characters, since he starts with miniature brimstone instead of tears, has evil hearts (but can gain red ones, unlike ???), and has flight (which only The Lost shares). The result is a rather different playstyle, including item selection, since his smaller brimstone makes many items useless/redundant, but makes others extremely powerful.
  • Necessary Drawback: Though Azazel can increase his Brimstone's range with upgrades, the benefit is almost entirely negligible unless you pick up several of them, which is unlikely without the use of items and consumables which can re-roll items. In addition, his short range negates any homing effects.
  • Red Eyes, Take Warning: He has these to add to his demonic appearance and he's one of the most powerful characters in the game.
  • Required Secondary Powers: At the time, a melee character would've been an interesting addition to the roster, but being forced to rely on an actual melee attack would make multiple rooms Unwinnable by Design. Azazel being equipped with the piercing brimstone and flight fixes both of these problems. A true melee character eventually came along in the form of The Forgotten, which has its own set of Required Secondary Powers.
  • Winged Humanoid: Starts with flight.


Debut: Rebirth
Named after the biblical garden, Eden's stats and starting items are randomly generated every time you play as them. Their gender is undefined, and to play as them requires the use of one "Eden token", earned by beating Mom's Heart/It Lives! or Ultra Greed. Unlocks in Rebirth after beating the Womb for the first time.
  • Anime Hair: The hairstyle is random, and many options look like this. The colour is always white.
  • Confusion Fu: Always starts with a random set of items and stats.
  • Luck-Based Mission: The stats and item(s) you start off with are randomized each time, making it equally possible to have a strong early advantage or a really weak one. Most character power level discussions simply leave Eden out because of how much inconistent Eden runs are.
  • Monochromatic Eyes: In the ending that unlocks the character and on the character select screen. You can give any character these eyes by picking up Eden's Blessing.
  • Mystical White Hair: The mystical part coming from their random stats and starting items.
  • Necessary Drawback: As Eden's random stats can potentially give you either very good or very bad combinations, each Eden run consumes an Eden token, and you only earn one each time Mom's Heart/It Lives/Ultra Greed is beaten. This is to discourage reset spamming for a good/game-breaking item combination.
  • Otherworldly and Sexually Ambiguous: Word of God is that Eden lacks gender. As described by Edmund McMillen:
    Eden isnt a man, nor are they a woman.. they just are.

    The Lost 

The Lost
Debut: Rebirth
A ghost character, and one of the only characters not based off of any sort of religious contextnote , next to ???. It is the secret character of Rebirth and had a very complicated unlock process… until Afterbirth came along.

In Rebirth, The Lost starts with flight, but dies if he takes any damage, with the inability to ever pick up health. Afterbirth significantly buffed The Lost, granting him spectral tears and The D4 by default, as well as letting him unlock Holy Mantle, giving him a shield that blocks one hit per room.
  • Balance Buff: Afterbirth gave him the potential to start with the D4 and the Holy Mantle. Plus, he gained spectral tears, letting him cheese difficult rooms by hanging out over a rock and shooting enemies from safety.
  • Chekhov's Gunman: Actually, it appears several times prior to being unlockable, albeit so briefly that few players would actually notice. Specifically, it is the ghost that departs from Isaac every time he dies.
  • Difficult, but Awesome: With zero health and only one free hit per room with the Holy Mantle, you need to be good at dodging. If you can manage, however, and get lucky with free Devil Room deals, Black Market deals, and cursed room items, you can end up with a flying Glass Cannon powerhouse.
  • Glass Cannon: And how! It has zero health and can't gain any type of hearts, period. The only upside to this is that it takes Devil Room and Black Market upgrades for free, possibly resulting in a One-Hit Point Wonder powerhouse early on.
  • Guide Dang It!:
    • Unlocking it is a bit... convoluted. First, you need to let yourself get killed by a Mulliboom in the basement as Isaac. Next, you need to blow yourself up with one of your own bombs as Maggie in the caves, then let yourself get killed by Mom's foot as Judas. Finally, you need to let yourself be stomped to death by Satan's hoof as Azazel. And you need to do all of this in a row, without winning or dying in any other way. Mess up once and you have to start all over again. Not very easy, to say the least, although the at the very least you get (cryptic) hints as to the next step once you've completed one, and you can use seeds to make it easier, in contrast to almost every other unlock. The "guide" was at least hidden in-game, though it would have been hard for one person to piece together. Dying in a sacrifice room while holding the Missing Poster trinket shows a puzzle piece as a cause of death. Putting the puzzle pieces together show the four game-over screens required to unlock The Lost.
    • Afterbirth vastly simplified the unlock process; you just need to die in a Sacrifice Room while holding the Missing Poster. Of course, nowhere in the game does it tell you this, and the fact that the former method is much better-known doesn't help.
  • Joke Character: Starts with the ability to fly and shoot spectral tears (which lets its attacks pass through objects)... with the downside of having absolutely no HP, meaning it will die after a single direct hit.
  • Lethal Joke Character:
    • Its lack of HP means that it can take Devil items (some of the most powerful items in the game) for no cost at all; normally, it would cost one or two heart containers for one of those items. This can lead to very powerful combos, turning it from a joke character into a feasible Glass Cannon if you get multiple deals with the Devil in a single run.
    • In Afterbirth, this is cranked up hugely due to the Holy Mantle being unlockable as a default item. This means it can take an extra hit per room (so you both don't have to be absolutely perfect) that he can heal back each time you enter a room. It also has access to curse rooms at no cost.
  • Lethal Joke Item: A handful of terrible items become better in The Lost's hands, such as Glass Cannon not having a downside since you don't actually have any health to reduce.
  • One-Hit Point Wonder: Dies in one hit from anything. Earlier versions had him die from continuing a run. In Afterbirth, however, it is possible to earn the Holy Mantle shield as a starting item for him.
  • Our Ghosts Are Different: This one gets blown away by a stiff breeze.
  • Power-Up Letdown: Some thought that Samson and ??? weren't worth the effort it took to unlock them, but The Lost is quite possibly even worse in this regard, especially since unlocking it involves a dose of Guide Dang It! too. Afterbirth mitigates this by having The Lost start with the D4 (which allows it to reroll any items it is carrying) and spectral tears, as well as the Holy Mantle once you donate enough coins to the Greed Machine. Most notably, the powerful items you unlock by beating the game with are why people get him. As soon as that's over with, many players will choose to forget he even exists.
  • Useless Useful Spell: Once you unlock the Holy Mantle for the Lost, the D4 becomes this, simply because the ability to actually take a hit per room outweighs just about anything it can potentially be rerolled into. A large portion of the items in the game also fall into this category, namely any item that gives only health and anything that activates on taking damage.
  • Walking Spoiler: Naturally, being the secret character of Rebirth.
  • Wham Shot: Afterbirth adds a new, interesting loading screen. That voice that told Isaac's Mom that he was evil? It was the Lost, speaking from the attic.


Debut: Afterbirth
Named after Adam's first wife who defected from Heaven with Samael. She's also known as "The Mother of Demons." Unlocked in Afterbirth after clearing Greed Mode with Azazel. Starts out blindfolded, meaning she is unable to shoot tears, but also starts with the Incubus familiar whose tears have the same properties as hers, the Box of Friends active item which duplicates her familiars for one room, and the Cambion Conception passive item which permanently grants a new familiar upon taking a certain amount of damage.
  • Awesome, but Impractical: Some of the Cambion Conception minions are extremely good, like Brimstone Baby or Dark Bum (!!), especially when doubled with Box of Friends. You'll need to take at least 15 hits per minion though, which is easier said than done with Lilith's starting health.
  • Cute Monster Girl: Appart from her bloody, bandaged eyes, she's a demon girl who is very human-looking.
  • Eye Scream: Implied by the bloodstains on her blindfold.
  • Glass Cannon: Box of Friends effectively doubles her damage output for a room, allowing her to deal significant amounts of damage, but with only one red heart, she struggles at taking hits.
  • Lethal Joke Character: While incapable of shooting tears herself, she starts with the item 'Box of Friends', which adds a copy of any familiars she has for a single room and takes four rooms to recharge. This makes her the best character by far in Greed Mode, as the battles on each floor take place in a single room, and she recharges the item every four waves of enemies. At a minimum, you can quadruple your friends by the end of the floor.
  • Horned Humanoid: Has demon horns.
  • Magikarp Power: If you can pick up more familiars or find a way to spawn at least one more with Cambion Conception without dying, Box of Friends' effectiveness begins to multiply. Gaining boosts to spacebar charge rate increases how often she can double her army of minions, and BFFS just makes everything stronger.
  • Mechanically Unusual Class:
    • Lilith has a blindfold over her eyes, similar to challenge runs where you can't shoot any tears, or other tear-replacing attacks like Mom's Knife or Brimstone. She compensates for this by starting out with the Incubus, a powerful familiar that copies (for the most part) the player's tear stats.
    • Lilith's Incubus is part of being Lilith. It will not reroll even with a full run re-roll; you can pick up a second Incubus normally; and if you somehow change from Lilith to another character, you lose the Incubus.
  • Nerf: Her active item, Box of Friends, was nerfed in a patch about a week after Afterbirth's release, making it a 4-room charge instead of 2. This brought Lilith down from "Amazing character that can cut through the game with ease with her army of minions" to "Good, but not great."
  • The Minion Master: Starts with a familiar as her only way to deal damage. Her Box of Friends active item creates a copy of each familiar she possesses when used (copied familiars don't count, so only the originals are duplicated), and her Cambion Conception gives her another (permanent) familiar if she is damaged a certain number of times (which, as stated under the Glass Cannon entry above, can be tricky due to her low starting health).
  • Mook Maker: Playable variant. Lilith starts with Cambion Conception, which permanently spawns a new demonic buddy after taking enough damage by giving birth to it, if the progressively more and more pregnant appearance is anything to go by.


Debut: Afterbirth
A character unlocked by the efforts of the community in the Afterbirth ARG, Keeper is the corpse of Isaac that killed himself by hanging. He becomes playable by donating 1000 coins to the Greed Machine. His name refers both to the shopkeepers he resembles and to Cain's words in the book of Genesis, "Am I my brother's Keeper?" He starts with a triple shot, is healed by pennies, and cannot pick up hearts. Hearts he is given become Blue Flies.
  • Back from the Dead: Like ???, he is an undead Isaac. In this case, one who paid for his greed and became one of the greyed corpses you see running the shops.
  • Chekhov's Gunman: He appears in Ending 18 as the corpse of Isaac that shrivels up to a shopkeeper.
  • Double Unlock: Although the ARG "unlocked" him by adding him to the game, he's only playable after donating one thousand coins to the Greed Machine.
  • The Gambler: He has a lot of coin-themed unlocks, which are frequently chance related. Once Isaac is defeated he also starts with the Wooden Nickle, which gives him a 50/50 at generating one coin per room.
  • Good Counterpart: He's a Keeper monster who's on Isaac's side, and his combat style is identical to that of that of Greed.
  • Glass Cannon: By default, he has above-average damage and a triple shot. Just giving him some fire rate boosters makes him dish out pretty decent damage. However, he is usually never more than two hits away from death, with special items like Holy Mantle (and its weaker counterpart the Wooden Cross and Safety Blanket) and Greed's Gullet being the only ways to extend that.
  • Guide Dang It!: Not necessarily his unlock, but to unlock his unlock. A long series of cryptic hints led to a treasure hunt in Santa Cruz, CA, culminating in the discovery of a small buried Keeper doll. This led to the patch being released on Steam that added Keeper to the game.
  • Joke Character: Probably the biggest of the three.
    • Instead of hearts, Keeper has two coin slots (and can only have a maximum of two); any kind of damage takes a health coin (which still counts as red heart damage for the purposes of Devil/Angel Room generation), but taking another coin on the floor heals it back without increasing your coin count. This means that Curse Rooms (without Holy Mantle) and two-heart Devil deals will straight-up kill him, while one-heart Devil deals leave him as a One-Hit Point Wonder. All health-increasing items are worthless unless you've lost one coin slot already. He also can't take soul or black hearts, as they get converted into flies.
    • Keeper has an innate triple shot, but his fire rate isn't programmed as the normal Inner Eye item would, so it's effectively even lower than that of The Inner Eye.
    • Keeper's starting items aren't available until you unlock them, and they're mundane at best. The Store Key trinket only opens access to shops, whereas the Wooden Nickel has a chance to fail, as seen in Lethal Joke Item below, and he only starts with a bomb (and a penny when you unlock it... by beating Hush).
  • Lethal Joke Character: In a few ways, though still less so than its counterparts.
    • Since Keeper's triple shot's fire rate isn't programmed as the normal Inner Eye item would, by picking up enough Tear stat boosters (and by enough, we mean A LOT), it's still possible to end up with the regular maximum fire rate possible.
    • It's possible to extend his life with a few items. A Swallowed Penny or the Piggy Bank drop coins in battle if he gets hit, which will restore his health if picked up. Meanwhile, Greed's Gullet is the only item capable of extending his health above the maximum by picking up coins and never spending them.
    • In Greed Mode, Keeper effectively gets hearts every wave that can be picked up mid-combat provided the player is fast enough. The only downside is that doing so decreases the money available to buy pickups and items. This extends to Ultra Greed's battle; since his attacks make you drop coins on contact, you just keep getting health back, and since Ultra Greedier's attacks generate coins during the fight, you'll never run out short of gross incompetence.
  • Lethal Joke Item: Zig-zagged. By unlocking the ability to start with the Wooden Nickel, it's possible to generate a coin to heal him back. Problem is, it has a 50/50 chance of working.
  • Mechanically Unusual Class: Has the most unconventional playstyle of the Joke Characters. He has only two hit points, but those are coins instead of hearts. Any heart pickups that appear are replaced by friendly flies.
  • Magikarp Power: Downplayed. He's a difficult character to play as, but by defeating certain bosses as Keeper, you can get some mundanely useful starting items for him (and a single dumb penny), making him... still pretty difficult to play, but at least a little better. He's much more useful in Greed Mode, as he can rapidly build up coins and heal back any damage taken. The Wooden Nickel item is also quite nice, if unreliable.
  • Secret Character: Doubly so. He isn't listed on the character screen until he's unlocked. More than that, he wasn't even added to the game data until a real-life ARG was completed, preventing the datamining debacle that uncovered The Lost.
  • The "The" Title Confusion: Unlike fellow secret characters The Lost and The Forgotten, Keeper is just Keeper. That doesn't stop most of the community from referring to him as The Keeper anyway.
  • Undead Child: Distinct from ??? in that his cause of death is from hanging, not suffocation.
  • Walking Spoiler: Like the Lost, he is a heavily hidden character. The developers even took care for him to not be discovered by hackers before his ARG had been concluded.


Debut: Afterbirth†
A mysterious new character who debuted in Afterbirth† who is unlocked by killing Mega Satan for the first time. He starts with the Void item, which destroys and copies the effects of activated items while turning passive ones into random stat boosts. Apollyon is the Greek name of (and he therefore represents) Abaddon, the angel of destruction and the abyss in Revelations, the last book of the Bible.
  • The Assimilator: Void destroys passive items and turns them into stat boosts, and gains the effects of any active items it destroys. The latter can stack indefinitely, so Void can become a pretty ludicrous item by the end of the game.
  • Black Eyes of Evil: His eyes are completely black. On the loading screen between floors, they look like hollow holes.
  • Difficult, but Awesome: Using the Void item to its fullest potential (and therefore mitigating Apollyon's pitiful stats) requires to player to understand how pretty much every item in the game works and whether or not they're worth picking up vs. Voiding vs. leaving it behind altogether.
  • Fallen Angel: Mentioned to be one of his character traits in the blog post. In addition, his name is Greek for the Hebrew word Abaddon, which means he could represent the angel of destruction and has a relation to Sheol.
  • Good Wings, Evil Wings: He has a pair of feathery wings. He is one of the playable characters, so he's good.
  • Horned Humanoid: He has two small black horns.
  • Magikarp Power: Starts with 2 hearts and average~low stats, and his starting item Void does nothing initially. However, Void can convert unwanted passive items into random stat boosts and absorb the effects of activated items permanently. This allows you to turn useless items into damage or other benefits, and Void's ability to stack effects allows for insane combos that can shatter the game if you luck out and find the right items.
  • Meaningful Name: His name is the Greek word for "destroyer". Sure enough, his main ability is to destroy items to gain their abilities or stat bonuses.
  • Mundane Utility: Void allows Apollyon to turn cruddy or detrimental passive items into more useful stat boosts, though he's out of luck if he finds bad or detrimental active items.
  • Nerf: Void initially kept any single-use items it sucked up, allowing them to be used again and again. This caused some truly gamebreaking stuff, like having Mama Mega every floor. It was quickly changed to use the item once and never again, to very few people's complaint.
  • Power of the Void: A successful Apollyon run depends in big part on judicious use of his Void starting item, which can turn into an all-powerful item and/or give Apollyon massive stat increases by the end of the run.
  • The Swarm: Not in-game, but most of Apollyon's unlocks are locust trinkets of some kind, as a reference to the biblical Apollyon's status as the king of an army of locusts.
  • Wings Do Nothing: Unlike Azazel, he doesn't use his wings for flight. They're just decoration.

    The Forgotten 

The Forgotten and the Soul
The Forgotten
The Soul
Debut: Afterbirth†

The Forgotten is a skeletal character added in the fifth Booster Pack for Afterbirth†. He has a melee attack and uses a special type of "bone hearts," and can switch to a ghost called the Soul, which plays similarly to the Lost and is chained to the Forgotten. All red hearts become bone hearts and are given to The Forgotten. All soul and black hearts go to The Soul. He is unlocked by assembling a special shovel and using it on a room late in the game.

  • Ballistic Bone: The Forgotten can throw his bone like a boomerang, the distance determined by how long you charge it. It's much weaker if used as such, though, making the Soul preferable for ranged attacks.
  • Barred from the Afterlife: Rather than moving on after death, the Soul is forever bound to the Forgotten. This is implied to be Isaac's final fate after committing suicide in the Chest.
  • Can't Live Without You: Dying as the Forgotten or the Soul is Game Over, regardless of the health of the other party. However, it is possible to kill the Soul through a Devil Deal and survive if you swap back to the Forgotten during the Item Get! animation; if you do this, the Soul will be disabled until you collect a Soul/Black Heart to restore it. Using the Converter to drain the Soul also won't kill you, merely force you back to the Forgotten once you've done it.
  • Close-Range Combatant: The Forgotten's bone club attack is fairly powerful, but requires him to get up close to use it. It can be thrown, but the damage is weak enough that it's easier to just use The Soul.
  • Dem Bones: Well, he is a skeleton. The special bone hearts he uses (which become available as drops for all characters after he's unlocked) take three hits to deplete and can be refilled with red hearts, but are lost forever if they're destroyed.
  • Difficult, but Awesome: He plays nothing like any other character in the game, and you have to master being able to switch between the skeleton and its Soul when the situation best calls for it, which isn't easy considering that both the skeleton and the soul use different forms of health, and because of how they work, you can never have more than six bone hearts or six soul hearts. However, his melee attack is very powerful, and while the Soul is active, you can use the inactive skeleton to shield yourself from bullets without taking damage. The Soul also has flight and spectral tears, enabling him to fly over obstacles, pick up items, and fire through rocks just like the Lost, but without being a One-Hit Point Wonder. Additionally, the bone hearts are not counted as red health unless you completely break a bone heart, so you won't lose a chance at a devil deal just from taking damage as long as you can heal up. However, Devil Deals can only be taken by the Soul, so you have to have enough Soul/Black Hearts to survive it.
  • Game-Breaking Injury: Any heart container that he would normally acquire gets replaced by special Bone Hearts. Bone Hearts deplete within three hits instead of two: two for the heart, one for the bone covering. As long as the bone part remains, a normal red heart can refill it. However, if a Bone Heart is completely destroyed, it's gone for good until you collect another item that grants extra health or find a special Bone Heart pickup.
  • Ghostly Gape: The Soul has blank, black eyes with no reflections and an open mouth.
  • Guide Dang It!: His unlock method is pretty convoluted. First, you need to kill the Basement I boss within one minute. If you manage it, you'll hear Mom calling for Isaac and loud footsteps. Return to the starting room and plant a bomb, then the first half of Mom's shovel will fall from above. This shovel will make Mom constantly try to stomp you through the entire time you hold it, and its active effect only stops this for one room or one Boss Rush wave. Oh, and it vanishes if swapped out for another active item. Then, beat the Boss Rush while holding the Shovel part to get the second part of Mom's Shovel, while handling the above stomping. Once the Shovel is complete, get to the Dark Room and find a room with a small mound of earth on it. Dig that mound with the Shovel and you'll unlock the Forgotten.
  • Hit-and-Run Tactics: Like Azazel, sometimes as the Forgotten you'll need to run in, take a swing or two with your bone club, then either run away or dodge before they retaliate before swinging at them again.
  • Immune to Bullets: While you're controlling the Soul, the Forgotten becomes an immobile, invincible skeleton. He can be used as a bullet shield in this state, and even attracts bullets to himself in a very short radius.
  • The Last of These Is Not Like the Others: To start with, he's a skeleton. He's also the only character who has a proper melee attack. On top of that, he's two characters in one and you can switch between the two on the fly.
  • Lethal Joke Item: Size up items not only increase the Forgotten's size, they increase the size of his melee weapon, giving him greater reach. If you manage to stack enough of them, you don't even need to aim. Conversely, size down items should be avoided, as they will reduce his range for the same reason. Thankfully, there is a hard minimum for the melee attack, so you can't render it completely useless.
  • Mechanically Unusual Class: The Forgotten is a double-character, with one side having a melee attack, and the other sharing mechanics of the Lost (flight and spectral tears) and ??? (can only collect soul hearts). Additionally, the Forgotten's melee attack interacts very differently with tear-changing powerups compared to other characters; for example, getting Mom's Knife sticks the knife on the end of his bone, increasing damage and the range of the swing.
  • Mundane Utility: The Forgotten's melee attack can be used to open spiked chests without taking damage. Furthermore, hitting anything with the melee attack counts as touching it for the purposes of collection, which can be used to grab collectibles (but not items) from behind rocks or over short pits. This is normally redundant with the Soul's flight, but can come in handy if the Soul is disabled.
  • Necessary Drawback:
    • Because the Soul possesses every advantage of the Lost except with the ability to gain health, he's chained to the Forgotten at all times, limiting your movement radius to a half-dozen tiles or so. This prevents you from fully exploiting his flight to avoid enemies, though it's more than enough to collect anything in a given room most of the time.
    • Since the character uses dual health bars, the Forgotten and the Soul can only have 6 hearts total each. This is lessened by bone hearts being tougher to lose than normal hearts, but it's further exacerbated by them being rare and permanently destroyable. Also, you can't use soul hearts to protect your bone hearts, since they go straight to the Soul.
  • Required Secondary Powers: As the true melee character, The Forgotten has a few attributes to prevent certain rooms from being unbeatable, most notably the ability to either throw his bone club or switch to The Soul to deal with enemies across gaps or under spikes. The ranged abilities are also necessary to deal with self-destructing enemies without losing hearts.
  • Tag Team: Their whole gameplay is based on the ability to switch between the Forgotten and the Soul at any time. Also, if one of them is killed, it's game over for both.
  • Undead Child: Heavily implied to be Isaac's skeleton, after his corpse spent God knows how long locked inside the chest.
  • We Cannot Go On Without You: If one character runs out of health, both characters die and the run is over. The are some exceptions, notably that by quickly switching back to the Forgotten after a Devil Deal that uses up all of the Soul's spirit/evil hearts, you can go on with the Soul being disabled until you get more of them.




In General

  • Airborne Mook: Making them immune to floor hazards, and allowing them to pass over obstacles.
  • Big Creepy-Crawlies: Even the weakest variety of fly (that you can actually fight) is still the size of one of Isaac's eyes.
  • The Goomba: Though these ones are killed by shooting at them with tears instead of jumping on their heads.

Black Fly/Attack Fly/Large Attack Fly/Ring Fly/Swarm Fly/Dart Fly/Hush Fly/Moter
Debut: The Binding of Isaac (Black Fly, Attack Fly, Moter)
Rebirth (Ring Fly)
Afterbirth (Swarm Fly, Dart Fly, Hush Fly)
  • Asteroids Monster: Moters split into two Attack Flies when killed.
  • Bee Afraid: Swarm Flies and Dart Flies are likely bees or wasps given their colouring and buzzing sound.
  • Bulletproof Human Shield: As the Halo Of Flies and Pretty Fly powerups. The Forever Alone and Distant Admiration powerups spawn one capable of dealing good damage.
  • Early-Bird Cameo: If you start your Isaac experience with Afterbirth +, you may encounter Hush flies long before you fight Hush himself.
  • Everything's Better with Spinning: Ring Flies converge to form a spinning ring which tracks you as a group. As they're destroyed, they keep up the circle with wider gaps.
  • Mascot Mook: The black variety is featured prominently in the artwork, and easily has the most related items.
  • Mook Promotion: If allowed to approach a pile of poop, a black fly consumes it and turns into a Pooter.
  • Zerg Rush: Swarm Flies join into a clump and then rush you.

Level 2 Fly/Full Fly
Debut: Rebirth
  • Elite Mooks: As the name suggests, they are standard Flies, but larger and stronger.
  • Kaizo Trap: Full Flies release six bullets on death.

Pooter/Fat Fly (Super Pooter)
Debut: The Binding of Isaac (Pooter)
Wrath of the Lamb (Fat Fly/Super Pooter)
  • High-Pressure Blood: One of the first enemies you'll see that can fire blood shots.
  • Mook: Not any more dangerous than the normal flies.
  • Retcon: The Fat Fly was renamed "Super Pooter" in Afterbirth+.

Boom Fly/Red Boom Fly/Drowned Boom Fly
Debut: The Binding of Isaac (Boom Fly, Red Boom Fly)
Afterbirth (Drowned Boom Fly)
  • Action Bomb: With the exception of the Red Boom Fly, they explode when killed.
  • Disaster Dominoes: An efficient way to clear a Boom Fly room is to kill one of them while they're all flying in a cluster. Doesn't work with Red Boom Flies, which shoot blood shots in 6 directions on death instead of exploding.

Sucker/Spit/Soul Sucker
Debut: The Binding of Isaac (Sucker)
Wrath of the Lamb (Spit)
Afterbirth† (Soul Sucker)
  • Action Bomb: Spits.
  • Disaster Dominoes: In a room with several Spits, killing one while standing in the right direction will often cause a chain reaction of vomit bombs that kill the rest of them. The same goes for Soul Suckers, which will frequently kill every other Soul Sucker in the room.
  • Taking You with Me: They release hard-to-dodge ranged attacks for Suckers, vomit bombs for Spits, and Brimstone lasers for Soul Suckers when killed.

Eternal Fly
Debut: Wrath of the Lamb
  • Invincible Minor Minion: Until the monster or poop they orbit is destroyed, at least.
  • Meaningful Name: As mentioned above, the Eternal Fly is, well, eternal, until the poop or monster they orbit is destroyed, turning it into an Attack Fly.



Gaper/Frowning Gaper/Flaming Gaper/Cyclopia/Greed Gaper/Blue Gaper
Debut: The Binding of Isaac (Gaper, Frowning Gaper)
Afterbirth (Flaming Gaper, Cyclopia, Greed Gaper, Blue Gaper)
  • Creepy Child: Gapers; They look much like your player character, but with Tears of Blood and a creepy smile.
  • Cyclops: Cyclopia, which move slower than Gapers but can fire blood tears.
  • Elite Mooks: Frowning Gapers to Gapers.
  • Eye Scream: Gapers have empty eye sockets filled with blood. The Cyclopia has only one eye in the middle of its head bleeding Tears of Blood.
  • Infernal Retaliation: Flaming Gapers move faster than normal. However, normal Gapers can't become Flaming Gapers by touching fire.
  • Losing Your Head: All Gaper varieties can become Pacers or Gushers when killed.
  • Tears of Blood: Gapers have them on their faces. Cyclopias weaponize them in the form of creep and bullets.
  • Unique Enemy: In Afterbirth, Blue and Greed Gapers only spawn as part of the Hush and Ultra Greed fights respectively. Averted in Afterbirth+, since Greed Gapers can now spawn in item rooms and Blue Gapers can very rarely appear as regular enemies.

Pacer/Gusher/Black Globin's Body
Debut: The Binding of Isaac (Pacer, Gusher)
Afterbirth (Black Globin's Body)
  • Elite Mooks: Gushers to Pacers. Black Globin's Bodies are even more elite, spawning only in Sheol and shooting spiders instead of bullets.
  • High-Pressure Blood: Gushers shoot out a fountain of blood from their necks, but only the occasional blood shot can actually deal damage.
  • Overdrawn at the Blood Bank: Gushers, as the name implies, have a constant stream of blood flowing from their necks.

Debut: Wrath of the Lamb (Gurgle)
Rebirth (Splasher)
  • Losing Your Head: Starting from Rebirth, Gurgles have a chance to become Splashers when killed.
  • Super Spit: They hack up explosive Ipecac shots rather than the usual damaging blood.

Debut: Rebirth

Horf/Psychic Horf
Debut: The Binding of Isaac (Horf)
Rebirth (Psychic Horf)

Hopper/Flaming Hopper/Leaper
Debut: Binding of Isaac (Hopper, Flaming Hopper)
Wrath of the Lamb (Leaper)
  • Bullet Hell: Leapers shoot bullets in all four cardinal directions when they jump. If five end up in a room, be prepared to dodge.
  • Elite Mooks: Fire Hoppers and Leapers, the former being stronger and the latter shooting bullets.
  • Infernal Retaliation: Hoppers move twice as fast, jump twice as far, and inflict more damage when they're on fire.
  • Mook Promotion: A Hopper that touches fire becomes a Flaming Hopper.
  • Violation of Common Sense: Not only does every other enemy (or character, even) take damage themselves from fire, but Isaac's main combat strategy is attacking enemies with water. Despite that, they seem to have double health.

Maw/Red Maw/Psychic Maw
Debut: The Binding of Isaac (Maw, Red Maw)
Wrath of the Lamb (Psychic Maw)
  • Elite Mooks: Red Maws, with their lips stitched, can't shoot, but chase you pretty fast. They also get knocked away farther when hit, offsetting their speed in terms of how easily you can keep them at bay (especially if you have a high rate of fire), but making it difficult to line up multiple shots against them.
    • Psychic Maws also have their eyes stitched. They have a Third Eye which shoots homing tears, and an Eternal Fly circling them.
    • Maws themselves are basically Horfs, only with the ability to move, which eliminates the tactic of staying just outside of their range and shooting.
  • Tears of Blood: The Psychic Maw has this. The other Maws may have this, but it looks more like their eyes may have exploded out of their sockets instead.

Mr. Maw/Mr. Red Maw/Mr. Mine/Swinger
Debut: Wrath of the Lamb (Mr. Maw)
Rebirth (Swinger)
Afterbirth† (Mr. Red Maw, Mr. Mine)
  • Aquatic Mook: Mr. Mines only appear on the Flooded Caves. Makes sense, considering they're meant to be sentient sea mines.
  • Asteroids Monster: Depending on whether you kill it by shooting it in the head or "body", Mr. Maw will spawn a Maw or Gusher, Mr. Red Maw a Red Maw or Gusher, and Swinger a Maw or Globin.
  • Detachment Combat: Mr. (Red) Maws and Mr. Mines will swing their heads out at you when you get close. Swingers are perpetually swinging, as their name suggests. Mr. (Red) Maw can also voluntarily separate into a (Red) Maw and a Gusher.
  • Epic Flail: Their heads can be swung around like these.
  • Kaizo Trap: Mr. Mine doesn't have a body to break apart into, but fires six shots in all directions upon death.

Debut: Rebirth (Skinny, Rotty)
Afterbirth† (Crispy)
  • Body Horror: It has a more deformed appearance than most humanoid enemies.
  • Critical Status Buff: Cripsies gain more movement speed the lower their health is. Given that they're on fire, they also slowly power themselves up.
  • Incendiary Exponent: Crispies are on fire and eventually burn to death.
  • Punny Name: "Skinny" not only refers to the folds of skin hanging off their faces but also sets them up as a Fat and Skinny duo with the Fatty.
  • Stripped to the Bone: Non-fatal variant; killing a Rotty will sometimes cause it to become a Bony.

Bony/Black Bony
Debut: Rebirth (Bony)
Afterbirth (Black Bony)

Fatty/Flaming Fatty/Pale Fatty/Fat Sack/Blubber/Half Sack/Conjoined Fatty/Blue Conjoined Fatty/Stoney/Cross Stoney
Debut: Rebirth (Fatty, Pale Fatty, Fat Sack, Blubber, Half Sack)
Afterbirth (Flaming Fatty, Conjoined Fatty, Blue Conjoined Fatty)
Afterbirth† (Stoney, Cross Stoney)
  • Acrofatic: While they're normally slow and bumbling, Fat Sacks have an attack where they jump high in the air and slam down. Averted with Stonies, who get out-of-breath after a while of chasing after Isaac.
  • Amazing Technicolor Population: Blue Conjoined Fatties, a rare enemy with a rather outlandish skin tone.
  • Dead Weight: Fat Sacks are fat zombies.
  • Fat Bastard: It's all in their names.
  • Gasshole: Fatties can fart to push things away. Pale Fatties shoot blood when they do this.
  • Infernal Retaliation: Flaming Fatties are faster than normal.
  • Invincible Minor Minion: Stonies behave just like Fatties but only die when every other enemy is killed.
  • Kevlard: They're decently durable, and that probably comes from their immense fat.
  • Multiple Head Case: Conjoined Fatties have two heads. "Killing" it only destroys one head, reducing it to a regular Fatty.
  • Nerf: Stonies were eventually changed to catch their breath every so often instead of chasing players without pause, as their release version made rooms too hard to clear.
  • Nightmare Face: The Fat Sack's face, with the empty eye sockets and Tears of Blood.

Mulligan/Mulligoon/Mulliboom/Nest/Hive/Drowned Hive/Leper/Swarmer
Debut: The Binding of Isaac (Mulligan, Mulligoon, Hive)
Wrath of the Lamb (Mulliboom, Swarmer)
Rebirth (Nest)
Afterbirth (Drowned Hive)
Afterbirth† (Leper)
  • Action Bomb:
    • Normal Mulligans puff up and explode into flies if they survive long enough and get cornered.
    • Mulligoons replace the flies with a 4-way shot plus a troll bomb.
    • Mullibooms come with bombs implanted in them and will charge and blow up on you.
    • The Swarmer spawns a Bomb Fly upon death.
  • Asteroids Monster: As Lepers takes damage, small pieces of Leper Flesh will break off until the Leper turns into a Gusher.
  • Body Horror:
    • The tumour-headed Mulligan grows more decayed as the flies inside it transform it into the Hive. From there, the Hive becomes a Swarmer, a rotten head filled with flies.
    • Leper heads are mostly comprised of Fistula-like flesh barely held together by gristle. As pieces continue to break off, the Leper's slowly gets reduced piece-by-piece until it loses its head entirely and becomes a Gusher.
  • Incurable Cough of Death: Has a very distinctive-sounding one when it spits up flies to attack you.
  • Mook Maker: Hives and Nests occasionally cough up flies and spiders respectively before spitting them at you, and Swarmers constantly spawn small flies as well as Pooters and Fat Flies when damaged. All varieties, other than the Mulliboom and Mulligoon, spawn various enemies when killed.
  • Taking You with Me: Unlike his cousins, the Mulliboom (the one with a bomb stuck in his head) will rush straight at you and try to suicide-bomb you.

Globin/Gazing Globin/Dank Globin/Black Globin
Debut: The Binding of Isaac (Globin, Gazing Globin)
Afterbirth (Dank Globin, Black Globin)
  • Artificial Brilliance: They will move coordinately to trap you. Especially problematic in rooms with obstacles.
  • Elite Mooks: The versions with one eye are faster and have more health. Their meat pile also slides away diagonally a short distance to avoid being hit. Dank Globins spawn a spider and a puddle of tar whenever they collapse.
  • Pulling Themselves Together: When killed, they will become a pile of goo and then recover. Luckily, they will take less to kill next time.
  • Punny Name: With "goblin" and "hemoglobin".
  • The Last of These Is Not Like the Others: Unlike its cousins, the Black Globin doesn't collapse into a pile of goo when killed. It instead separates into a head that trails creep and a body that spawns spiders.
  • Why Won't You Die?: Unless you finish off the pile of goo, this will happen. The main problem is attacking the goo while several others are chasing you.

Knight/Selfless Knight/Floating Knight/Bone Knight
Debut: The Binding of Isaac (Knight, Selfless Knight)
Rebirth (Floating Knight)
Afterbirth (Bone Knight)
  • Airborne Mook: Floating Knight are flying Knight heads, ignoring pits and barriers.
  • Attack Its Weak Point: The front of them is solid bone or petrified flesh. The only way to actually damage it is to hit it in the back of its head, the exposed brain.
  • Bloody Murder: Bone Knights trail damaging creep behind them, making it more difficult to target the exposed brain.
  • Elite Mooks: Its second variety chases the player instead of wandering aimlessly. They have a crying Isaac face instead of a brain on their back. Bone Knights are even more elite, leaving a trail of red creep as they walk.
  • Shield-Bearing Mook: As customary, the solution is to flank it where its shield can't protect it.

Vis/Double Vis/Scarred Double Vis/Chubber
Debut: The Binding of Isaac (Vis)
Wrath of the Lamb (Double Vis, Chubber)
Afterbirth (Scarred Double Vis)
  • Body Horror: They look like headless humans, only with a gaping hole on their chests that shoots Brimstone lasers in one or multiple directions.
  • Bloody Murder: Fires what appears to be blood in a wide beam across the room it's in.
  • The Computer Is a Cheating Bastard: The Chubber is a variation that fires Lil' Chubby instead of a beam. Their Lil' Chubby can go through rocks and deal damage on the return trip, but yours can't do either.
  • Elite Mooks: As of the Wrath of the Lamb DLC, Vis has a second form which fires Brimstone both in front of and behind it. Afterbirth adds the Scarred Double Vis, which shoots in all four cardinal directions.
  • High-Pressure Blood: They shoot huge streams of blood that pass through all obstacles. In fact, they're probably the first enemy you'll see that can use Brimstone.

Baby/Angelic Baby
Debut: The Binding of Isaac (Baby)
Wrath of the Lamb (Angelic Baby)
  • Body Horror: Flying, blood-covered fetuses.
  • Elite Mooks: Has an angelic version that shoots a three-way spread shot instead of one bullet.
  • Fetus Terrible: Think of the familiar babies you can get, only shrieking and bloody.
  • Light Is Not Good: The friendly and less harmful looking Angelic Baby is actually more dangerous due to it having a spread attack.
  • Teleport Spam: Will frequently disappear into the nether before reappearing elsewhere a moment later.

Dople/Evil Twin
Debut: The Binding of Isaac
  • Doppelgänger: The Evil Knockoff variety.
  • Elite Mooks: The Evil Twin. Instead of looking like a meat puppet, it looks like a demon that can: fly, shoot a triple-shot and do more damage. Thankfully, its bullets travel slower and it has a fixed fire rate, giving you time to dodge and shoot.
  • Enemy Without: They mirror the player's movements, including shooting, but most rooms come with a mechanism with which to destroy them. There are also bombs, and praying that whipped shots will work.
  • Flaying Alive: Dople has no skin.
  • Foreshadowing: The appearance of these foreshadows the nature of Isaac the boss.
  • Mirror Match: They can perfectly mimic Isaac's movements and attack at the same time, though they cannot replicate certain tear properties.

Debut: Wrath of the Lamb
  • Adorable Evil Minions: The Keepers to Ultra Greed, as he will spawn them during his boss battle. The idea of small head creatures flopping clumsily around a boss arena doesn't sound too threatening, does it?
  • Airborne Mook: Hangers dangle from the ceiling, letting them pass over pits and obstacles.
  • Bandit Mook: When they hit you, you lose three cents. Only two of those cents fall onto the ground to be picked up again.
  • Orbiting Particle Shield: Each Hanger has an Eternal Fly defending it.

Debut: Wrath of the Lamb
  • Body Horror: It's based on a baby with Harlequin-type ichthyosis.
  • Whack-a-Monster: They pop up in random areas of the room and attack either by firing an explosive shot or shooting a spray of bullets while diving through the air, before going underground and repeating the process.

Debut: Rebirth
  • Body Horror: Homunculus's warped facial features.
  • Blackout Basement: A Begotten will darken the room if it breaks free.
  • Breaking the Bonds: They become significantly more dangerous when they break their chains and can pursue you.
  • Expy: They start out trying to get at the player while chained but can break free and chase them, not unlike the Chain Chomp.
  • Invisible Monsters: Begotten becomes this once it breaks loose, similar to the Null. Fortunately, it also has the same Invisibility Flicker.

    Worms and Grubs 

Worms and Grubs

Debut: The Binding of Isaac
  • The Goomba: Has no attacks, and just wanders around the room randomly.

Charger/Drowned Charger/Dank Charger
Debut: The Binding of Isaac (Charger)
Afterbirth (Drowned Charger)
Afterbirth† (Dank Charger)
  • Deadly Lunge: If they spot Isaac, they will open their mouths wide and speed towards him... exactly like Chub does. Dank Chargers also bounce around the room afterwards, but have to catch their breath before they can charge again.
  • High-Pressure Blood: What sets Drowned Chargers apart is that they burst into shots of blood when killed.
  • Oil Slick: Like a lot of Dank Depths enemies, Dank Chargers leave slippery oil everywhere they crawl.

Spitty/Conjoined Spitty
Debut: The Binding of Isaac
  • Multiple Head Case: The conjoined version has a head on both ends, letting it spit blood in both directions simultaneously.

Leech/Kamikaze Leech/Holy Leech
Debut: Wrath of the Lamb

Debut: Rebirth
  • Asteroids Monster: Each of its segments becomes a lesser variety of maggot on death.
  • Boss in Mook Clothing: Grubs are basically a stronger version of Larry Jr. In some boss fights against the latter, one of them is replaced with a Grub.

Round Worm/Nightcrawler/Tube Worm/Roundy/Ulcer
Debut: The Binding of Isaac (Round Worm)
Rebirth (Nightcrawler)
Afterbith (Roundy, Ulcer)
Afterbirth† (Tube Worm)
  • Bullet Hell: The Tube Worm attacks by spraying a massive barrage of tears in the air, which fall near Isaac.
  • Fast Tunnelling: All of them can submerge and re-emerge anywhere in the room quickly.
  • Mook Maker: Ulcers will spawn Dart Flies if left alone.

Para-Bite/Scarred Para-Bite/Cod Worm
Debut: The Binding of Isaac (Para-Bite)
Rebirth (Cod Worm)
Afterbirth (Scarred Para-Bite)
  • Counter-Attack: Shooting at a Cod Worm while it is hiding in its shell will cause it to retaliate with a burst of tears.
  • Losing Your Head: Scarred Para-Bites are Para-Bites with their heads ripped off.
  • Shield-Bearing Mook: Cod Worms are entrenched in hard shells which they can retreat into at will.
  • Zerg Rush: Para-Bites will bum-rush you endlessly, only briefly backing away to repeat the process.

Debut: Afterbirth†
  • Body Horror: As the name implies, it's a tiny Fistula.
  • Kaizo Trap: Fires a maggot towards Isaac on death.



Spider/Big Spider
Debut: Wrath of the Lamb
  • Alien Blood: Inverted. The spiders in this game have red blood despite spiders in real life actually having pale blue blood.
  • Asteroids Monster: Big Spiders split into two after death.

Level 2 Spider/Ticking Spider
Debut: Rebirth
  • Action Bomb: Ticking Spiders explode when killed.
  • Elite Mooks: Like the Level 2 Fly family, they are improved versions of standard spiders.

Baby Long Legs/Small Baby Long Legs/Crazy Long Legs/Small Crazy Long Legs
Debut: Rebirth
  • Mook Maker: Baby Long Legs make Spiders, while their Small counterparts create Sacks.
  • Weaponized Offspring: Both versions of the Baby Long Legs spawn spiders to attack Isaac with, though they don't seem too happy about it.

Wall Creep/Blind Creep/Rage Creep/The Thing
Debut: Rebirth (Wall Creep, Blind Creep, Rage Creep)
Afterbirth† (The Thing)

Trite/Ragling/Rag Man's Ragling/Blister
Debut: Wrath of the Lamb (Trite, Ragling)
Afterbirth (Rag Man's Ragling)
Afterbirth† (Blister)
  • Deadly Lunge: They normally hop around the room randomly, but if the player gets close, they will actively leap at the player; notably, when attacking, they can leap much farther than normal.
  • Giant Spider: They're about the size of Isaac's head.
  • Shout-Out: A Trite is a head-on four legs, with an eye-like mouth in the centre. In other words, a tektite.
  • Tears of Blood: The Trite.



Dip/Corn/Brownie Corn/Squirt/Dank Squirt/Dinga
Debut: Rebirth (Dip, Squirt, Dinga)
Afterbirth (Corn, Brownie Corn, Dank Squirt)
  • Asteroids Monster: Dingas split into two Squirts when killed, while Squirts split into two Dips. Dank Squirts split into two Clots instead.
  • One-Hit Kill: Using Flush! will instantly kill any of them instantly, without turning them into "regular" poop.
  • One-Hit Point Wonder: Corns and Brownie Corns are the weakest enemies in the game, dying in only one hit just with regular tear damage. Dips are only slightly tougher, taking two hits.
  • Stealth Pun: Dips. (Which are made out of...)
  • Talking Poo: Actually, it's more like yelling poo.
  • Toilet Humor: Regular poop lying everywhere not good enough for you? Now you can fight the poop!

Clot/Clotty/Mega Clotty/I. Blob/Ministro
Debut: The Binding of Isaac (Clot, Clotty)
Wrath of the Lamb (I. Blob)
Afterbirth (Mega Clotty)
Afterbirth† (Ministro)
  • All Your Powers Combined: The I. Blob's projectiles, which are a combination of the Clot and Clotty.
  • Asteroids Monster: Mega Clotty will split apart into two Clotties on death.
  • Blob Monster: Meat blob, tar blob, and... whatever the I. Blob is made of.
  • Bullet Hell: They tend to shoot haphazardly, and very often, in every direction.
  • The Cameo: Clot is very similar to Gish.
  • Elite Mooks: The I. Blob variant shoots projectiles in all eight directions. Ministro forgoes directional shots and does a Monstro-type spray attack.

Host/Red Host/Walking Host/Walking Red Host
Debut: The Binding of Isaac (Host)
Wrath of the Lamb (Red Host)
Rebirth (Walking Host, Walking Red Host)
  • Attack Its Weak Point: Only in the grey variation. To hit them, you must wait for them to expose the flesh under the skull. Moving them over spikes will also kill them.
  • The Cameo: From a multiplayer flash game with the same name.
  • No-Sell: Regular Hosts are protected by their skull when they aren't firing. Trying to hit them does nothing. Trying to bomb them just causes them to make a troll face.
  • Shield-Bearing Mook: The skulls the normal variety cover themselves with are impervious to pretty much any normal damage source.

Debut: Afterbirth
  • Body Horror: It's a sentient lump of mangled meat with an exposed skull that becomes a Host when damaged enough.
  • High-Pressure Blood: Its main attack is to spew a veritable fountain of bloody tears.

Brain/Poison Mind/Black Globin's Head/MemBrain
Debut: The Binding of Isaac (Brain, MemBrain)
Afterbirth (Black Globin's Head)
Afterbirth† (Poison Mind)
  • Asteroids Monster: MemBrain splits into two Brains when killed.
  • Brain Monster: Of the "Just Brain" variety.
  • Losing Your Head: As the name implies, Black Globin's Head is the head of a Black Globin. They behave like brains.
  • Underground Monkey: Poison Minds move diagonally and leave green creep instead of red, but are otherwise identical to Brains.

Guts/Scarred Guts/Mama Guts
Debut: The Binding of Isaac (Guts, Mama Guts)
Afterbirth (Scarred Guts)
  • Asteroids Monster: Like the MemBrain, Mama Guts breaks apart into two Guts on death.
  • Body Horror: Does a rolling ball of organs sound pleasant to you?
  • Elite Mooks: Scarred Guts leave creep while they roll, and are slightly harder to kill.
  • Organ Autonomy: Quite literally, they're organs that move on their own.
  • Rolling Attack: Guts and Scarred Guts only behavior is rolling around aimlessly on walls.

Poky/Slide/Wall Hugger
  • Anti-Frustration Features: Wall Huggers will have their spikes retracted for a few seconds upon entering a room, giving you time to get out of their way without taking damage from them.
  • Invincible Minor Minion: All varieties are immune to everything other than the Chaos Card. Pokies will die if the other enemies in the room are killed; Slides and Wall Huggers will not, and thus remain dangerous if you have to traverse the room again.
  • Spikes of Doom: Mobile blocks covered in dangerous spikes.

Stone Grimace/Vomit Grimace/Cross Grimace/Gaping Maw/Broken Gaping Maw/Turret Grimace/Stone Eye/Brimstone Grimace
  • Disaster Dominoes: Vomit Grimaces are often found together with Boom Flies, which are not immune to the vomit projectiles.
  • High-Pressure Blood: Brimstone Grimaces can shoot blood in a strong beam.
  • Invincible Minor Minion: They usually shut off after all other enemies in a room are dead, however.
  • Living Statue: Statue heads which fire projectiles.
  • Obvious Rule Patch: The Broken Gaping Maw was originally created for one room, for only one purpose; because the room used to house four standard Gaping Maws in the center, and a player character with flight and sufficiently low speed could become trapped forever in the center of their combined gravity. The Broken Gaping Maw shuts off periodically, allowing the player to escape. Booster Pack #5 made them far more ubiquitous.
  • Vacuum Mouth: Gaping Maws are constantly breathing in, which will suck Isaac and other things towards it.

Boil/Gut/Sack/Blue Boil/Walking Boil/Walking Gut/Walking Sack/Gush
Debut: The Binding of Isaac (Boil)
Wrath of the Lamb (Gut, Sack, Walking Boil, Walking Gut)
Rebirth (Walking Sack)
Afterbirth (Blue Boil)
Afterbirth† (Gush)
  • Elite Mooks: As of Wrath of the Lamb, there is the Gut, which shoots green bombs, much like Sloth. As well as mobile versions of each.
  • Healing Factor: The non-mobile versions slowly regenerate over time when damaged. However, they spawn with less-than-full HP and can't attack until they've reached their maximum health. Their health is directly proportional to their size.
  • Mook Maker: Sacks are made of spider silk, which spits out spiders. It, too, has a mobile version.
  • Oil Slick: Gush is unique because it does no damage, it just leaves oil in a growing radius around it. It can make it hard to dodge other enemies, though.

One Tooth/Fat Bat
Debut: Rebirth (One Tooth)
Afterbirth (Fat Bat)

Debut: Afterbirth
  • Mook Maker: Spawns Dart Flies as it bounces around the room.
  • Punny Name: A play on the Duke of Flies, who they resemble, and a slang word for poop.

Butt Licker
Debut: Wrath of the Lamb
  • Asteroids Monster: The segments split and act independently after one of them dies.
  • Toilet Humor: Besides constantly tossing each other's salads, they'll eat poop. Doesn't get much more toilet-humorous than that.

Eye/Bloodshot Eye
Debut: The Binding of Isaac
  • Elite Mooks: The Bloodshot Eye looks like a red (white in the original) eyeball and nothing else. It shoots Brimstone lasers instead of electrical beams.
  • Eye Beam: Their entire schtick.
  • Eye Scream: Being giant eyes, it's inevitable.
  • Faceless Eye: They're giant eyes that are found just lying on the ground.
  • High-Pressure Blood: Bloodshot Eyes fire Brimstone lasers.
  • Ironic Name: In the original, the Bloodshot Eye simply looked like a normal white eyeball, while the regular Eye looked bloodshot with various veins surrounding them. This was reversed in Rebirth.
  • Stealth Pun: Bloodshot Eye is an eye that shoots blood.

Mask + Heart
Debut: Wrath of the Lamb
  • Attack Its Weak Point: The Mask is completely immune to all damage. The Heart isn't.
  • Organ Autonomy: The hearts are not defenseless: they will attempt to run away from Isaac and will defend themselves with a four-way blood burst if he gets too close.

Death's Head/Dank Death's Head/Flesh Death's Head
Debut: Rebirth (Death’s Head)
Afterbirth (Dank Death’s Head, Flesh Death’s Head)
  • High-Pressure Blood: Flesh Death's Heads will burst into shots of blood when they die, either from manual shooting or from the room being otherwise cleared.
  • Invincible Minor Mook: The standard variety keep bouncing around the room until every kill-able enemy in it is dead. They aren't immune to the Chaos Card, but why would you waste a Chaos Card on one? Dank and Flesh varieties can be killed like any normal enemy; Dank Death's Heads must be destroyed to clear a room, while Flesh Death's Heads will also automatically die if the other enemies in the room are killed.
  • Taking You with Me: Flesh Death's Heads explode into 6 bullets launched in all directions when killed, either directly or by destroying all other enemies in the room.

Lil' Haunt/Wizoob/Red Ghost
Debut: Rebirth (Lil' Haunt, Wizoob)
Afterbirth (Red Ghost)
  • Expy: With their attack method and name, Wizoobs are clearly based off of the original Wizrobes.
  • High-Pressure Blood: The Red Ghost's Brimstone laser attack.
  • Whack-a-Monster: Wizoobs and Red Ghosts will pop up near Isaac, fire off an attack, and then disappear for an extended period of time before repeating the process.

Debut: Afterbirth
  • Artificial Brilliance: The only enemy in the game to make an active effort of anticipating incoming shots and dodging out of the way.
  • Teleport Spam: Teleports to a random spot in the room after firing 3 shots.
  • Underground Monkey: A Sheol variant of Baby enemies.

Mom's Hand/Mom's Dead Hand
Debut: Rebirth (Mom’s Hand)
Afterbirth (Mom’s Dead Hand)
  • Evil Laugh: Mom's laugh is the cue that they're in the current room.
  • Mook Bouncer: In addition to dealing damage, Mom's Hand also pulls you back to the starting room of the floor if they grab you. This can actually be helpful for a quick trip back to the starting room on a dead end, if you have the hearts to spare. Not so with the Dead variety, which simply deals damage.
  • Wall Master: They hide on the ceiling of rooms, eventually diving down on Isaac.

Tumor/Psy Tumor/Camillo Jr.
Debut: Rebirth
  • Bullet Hell: They shoot haphazardly in all directions at irregular intervals. Additionally, they shoot more frequently at low health, so fighting multiple Tumors can get messy very quickly.
  • Eye Beams: Camillo Jr. attacks with lasers rather than bullets.
  • Shout-Out: Camillo Jrs. have their name based off of Kracko Jr. However, they look more like regular Kracko, so the Jr. is likely there to make the inspiration clearer.
  • Turns Red: All varieties will shoot more frequently as they take damage.

Nerve Ending/Nerve Ending II
Debut: Rebirth (Nerve Ending)
Afterbirth† (Nerve Ending II)
  • Combat Tentacles: Nerve Ending II is one.
  • Expy: The Nerve Ending II's color scheme and method of attack bear more than a passing resemblance to a Spine Crawler.
  • Joke Character: Nerve Ending doesn't attack, it just blocks bullets. By the time you're far enough into a run to see these guys, that's already not a problem. Nerve Ending II actually does attack, though (it swats at you), which may take some players by surprise the first time they get near them. It can also replace regular Nerve Endings in room layouts, forcing you to stay on your toes.

Lump/Tar Boy
Debut: The Binding of Isaac (Lump)
Afterbirth† (Tar Boy)
  • Fast Tunnelling: They can move around "underground" very quickly.
  • Teleport Interdiction: Tar Boys can only pop up in spots with oil on the ground. However, they can make oil with their shots and often spawn in rooms with Gushes that can makes lots of oil for them.
  • Whack-a-Monster: When approached, they will fire in the player's general direction to distract them, then go underground and pop up in another part of the room.

Oob/Black Maw
Debut: Rebirth
  • Action Bomb: Black Maw explodes when killed and can spawn Kamikaze Leeches, which also explode.
  • Enemy Summoner: Both are capable of spawning more enemies: Oob summons Brains, while Black Maw spawns Leeches.
  • Shout-Out: They are directly taken from Super Meat Boy, another Edmund McMillen game. The former was an enemy, the latter was an obstacle.

Debut: Afterbirth†
  • Foreshadowing: They are identical in appearance to the entrance to the Void, which is the manifestation of Isaac's mental breakdown.
  • Mook Maker: Their only purpose is to spawn random enemies until destroyed.
  • Nerf: Shortly after release, Portals were changed to expire on their own after spawning 1-5 enemies instead of spitting out enemies indefinitely until destroyed.
  • Non-Standard Character Design: Those spinning vortexes are definitely not mutilated humanoids like most of the other enemies, nor bugs, nor do they even fit the "demonic" category too well. This is suggesting that they are something "outside" of the narrative Isaac made up — they represent his mind breaking down.

Debut: Afterbirth†
  • Incredibly Durable Enemies: They have a very large health pool, especially for an enemy that can show up as early as the Caves. Attacking while their faces are exposed deals higher damage.
  • Mushroom Man: It's a mushroom with a face, though that's hardly unusual compared to some of the other enemies present.


    Basement, Cellar, Burning Basement 

Debut: The Binding of Isaac
  • Asteroids Monster: His Eternal form in the Eternal Edition splits as it takes damage. The smaller forms shoot less bullets, however.
  • Body Horror: He's some kind of deformed head, lacking a nose and most of his teeth, and features a prominent harelip.
  • Clipped-Wing Angel: The grey Champion version is bigger with more health, but it can't use the leap attack of the normal version, making it far easier to circle around and shoot with no risk to yourself. Even in pairs, it's much less of a threat.
  • Degraded Boss: After the game is beaten six times, he'll start showing up in non-boss rooms occasionally.
  • The Dragon: Oddly enough, Monstro will occasionally appear before an Ultra Greed battle.
  • Dual Boss: The red Champion version is two smaller Monstros.
  • Easter Egg: One Active item, Monstro's Tooth, calls in the aforementioned boss to body-slam enemies. On the chance that you end up getting it as one of your first items, guess which boss you can't use it against.
  • Heel–Face Turn: The Monstro's Tooth item lets you summon him to crush your enemies.
  • Warm-Up Boss: One of the less complicated bosses and one of the most likely to run into first. Many prefer getting zero-damage boss battles on Monstro to increase the likelihood of Devil Deals spawning.

Larry Jr.
Debut: The Binding of Isaac
  • Asteroids Monster:
    • Not so much as other bosses, but if the middle section is killed first in a 5-segment one, it will split into two more versions with just two segments.
    • Much easier to happen with his Eternal counterpart in the Eternal Edition, where a broken-off segment can last as just a head and can regenerate segments.
  • The Cameo: A smaller version of Larrie's Lament.
  • Degraded Boss: The most common boss enemy to find in The Womb.
  • Dual Boss: Easily the most common one; his standard fight in the Basement is always two of him. Afterbirth occasionally mixes things up with a single very long Larry Jr., but he'll likely be splitting into multiple Larries over the course of the fight anyway because of how the boss works.
  • Fluffy the Terrible: It's a blood-coated demonic giant maggot, yet has one of the most cutesy-sounding names in the game.
  • King Mook: As of Wrath of the Lamb, smaller enemies similar to it appear.
  • Segmented Serpent: Larry Jr. is composed of several body segments that have individual HP bars and can be destroyed separately. Killing a segment in the middle of its body can cause it to split into two individual worms, but a segment cannot survive if it isn't attached to another.
  • Warm-Up Boss: Shares this with Monstro. It can't even shoot at you (except for the green champion version), but its movement patterns can be erratic thanks to the poop it leaves behind.

The Duke of Flies

Debut: The Binding of Isaac
  • Body Horror: It's safe to assume that the only reason he can move around is that of the flies that have infested his bloated body. He also lacks eyes of any kind.
  • Degraded Boss: After unlocking "Everything's Terrible!"
  • Flunky Boss: "Attacks" by creating tons of flies.
  • Mook Maker: As its name implies, it creates flies.
  • King Mook: To the Dukies.
  • Taking the Bullet: Spawned flies circle the Duke until he commands them to attack you, letting them soak up your shots.

Gemini (Contusion & Suture)
Debut: The Binding of Isaac
  • Big Guy, Little Guy: Contusion is the big twin, Suture is the little one.
  • Brains and Brawn: Suture is the Brains while Contusion is the Brawn.
  • Bullfight Boss: Contusion can tire out after a few moments of charging the player. If he is killed first, Suture will turn red, give chase, and never tire out.
  • Dual Boss: Contusion, who walks towards the player and charges at them periodically, and Suture, who shoots bullets.
  • Fetus Terrible: Both of them seem to represent fetuses, even having an umbilical cord attached to each other. Suture even moreso.
  • Heel–Face Turn: The Gemini zodiac sign gives you a friendly copy of Suture who attacks your enemies.
  • Polar Opposite Twins: Contusion is aggressive and chases you; Suture looks calm and makes ranged attacks until you kill his brother, at which point it charges at you.
  • Turns Red: What Suture does when Contusion dies.

Debut: The Binding of Isaac
  • Bonus Boss: After being unlocked, occasionally replaces Gemini.
  • The Cameo: Steven is from Time Fcuk.
  • Heel–Face Turn: the Little Steven item summons a friendly version of Steven who shoots at enemies, and is almost always dropped by this boss (except when it drops the "Steven" item instead, which is just a damage upgrade).
  • Last Ditch Move: Both parts of Steven shoot bullets in all directions when they die.
  • Turns Red: When their aggregate health reaches 1/3, the small one detaches and turns red just like Gemini's.

Debut: The Binding of Isaac
  • Asteroids Monster: It has three distinct sizes. Large Fistula splits into four medium Fistulae (three for the champion version) on death, each of which splits into two small Fistulae. Small Fistula either spawns a Charger or a Boom Fly, depending on the version fought.
  • Body Horror: It's named for a real-life chunk of Body Horror in which organs try to absorb each other.
  • Degraded Boss:
    • Appears as this in later stages. Most of the time, though, it will already be broken down to its second or third stage.
    • In Rebirth, the boss is now a Chapter One boss.

Debut: Wrath of the Lamb
  • Body Horror: She's made out of a head with four eyes, leg bones, and toes.
  • Flunky Boss: Not only does she spawn spiders directly, but she can also spawn Mook Maker Sacks! And that's not even getting into the ones that can spawn bigger Asteroids Monster spiders or other kinds of Boils.
  • Giant Spider: She's a larger version of the Trites. Considering that those are already the size of Isaac, it makes for an intimidating boss fight!
  • Glass Cannon: Relatively low HP for a boss, but moves unpredictably and spits out the equally unpredictable spiders, making her harder to beat without taking any damage than most bosses early on.
  • King Mook: To the spiders.
  • Pink Means Feminine: One of her champion colors is pink, and she's one of the few female bosses.
  • Rush Boss: She's a fragile boss, but if you don't kill her quickly, you'll get overwhelmed by the spiders she summons and the speed she moves at.
  • Stealth Pun: One of her champion colours is black. A Black Widow spider.

Debut: Wrath of the Lamb
  • Sand Worm: A Sand Tapeworm at that, but nevertheless, it's a giant worm creature that attacks by burrowing through the earth and diving out of the ground.
  • Segmented Serpent: Like Larry Jr., Pin has multiple body segments that take damage separately. However, what separates Pin is that each segment does not a separate health bar, which will cause it to take significantly more damage from piercing and explosive attacks.
  • Tactical Suicide Boss: It is not immune to its exploding Ipecac projectiles, and due to a quirk in hit detection, can actually damage itself with them when it begins to bury underground. The dark grey one averts it, replacing the bombs with bullets.
  • Warm-Up Boss: Competing with Larry Jr. and Monstro for the easiest boss in the game; Relatively low health, a large hitbox, extremely predictable and avoidable attacks, and he's not immune to his own projectiles. Many players feel silly if they take any damage to this boss at all, let alone die to him.

Gurdy Jr.
Debut: Wrath of the Lamb

Blighted Ovum (Contusion and Suture, again)
Debut: Wrath of the Lamb
  • Back from the Dead: Contusion is now a zombie, and is accompanied by the ghost of his (formerly) conjoined brother, Suture.
  • Body Horror: Contusion has a gash on his head where his eye once was, lacks a lower jaw, and is either covered in blood or has no skin on his lower body.
  • Bullfight Boss: Contusion, much like his living counterpart, except he never tires, gets progressively faster, and leaves a trail of red creep behind him.
  • Invincible Minor Minion: Suture's ghost can't be harmed; the only way to get rid of him is to get rid of his brother.
  • Nerf: In the original game, both parts of the Blighted Ovum would fire bullets in all directions upon death. This ability was removed in Rebirth and given to Steven.
  • Wave-Motion Gun: The ghostly Suture fires Brimstone if you stand to the left or right of it.

Debut: Rebirth (Gurglings)
Afterbirth (Turdlings)
  • Bullfight Boss: They'll charge you if you get in their line of sight.
  • Creepy Twins: When fought as a pair. Identical and dangerous.
  • Degraded Boss: They appear as regular enemies as early as the Caves, and don't even get a health bar. On the other hand, they constantly leave behind damaging trails of creep (as opposed to only doing so when charging) and shoot six-way blood bursts rather than spawning flies, making them actually slightly more dangerous than the boss version.
  • Dual Boss: They appear as a pair.
  • Dung Fu: Turdlings leave behind brown creep when they charge.
  • Enfant Terrible: They seem to be even younger versions of Gurdy Jr.
  • Flunky Boss: One of the major differences between Turdlings and Gurglings is that Turdlings spawn several Corn Dips after their charge attack.
  • Palette Swap: Turdlings are a rare poop-themed version of the Gurglings, possessing similar attacks.

Debut: Rebirth (Dingle)
Afterbirth (Dangle)
  • Adorable Evil Minions: His Squirts.
  • Bullfight Boss: One of his attacks is to charge at you three times in succession, occasionally leaving a pile of poop on the first charge. He scrunches up just before the charge and gets pooped (heh) after the third charge, allowing you to get damage in.
  • Cute Is Evil: He's probably the cutest boss in the game, and not in an
"ugly cute" way. But just like every other boss, he still wants you dead.
  • Degraded Boss: Often appear in the Womb. Brownie always becomes a Dangle after he dies.
  • Dung Fu: Besides being made of poop, he will also frequently summon Squirts or leave more poop laying around.
  • Nobody Poops: Averted, obviously.
  • Not-So-Innocent Whistle/Enemy Summoner: He occasionally will whistle innocently (complete with a music note hovering above his head), before one to three Squirts appear beside him to fight. This is immediately followed by a bullet spread attack.
  • One-Hit Kill: Using Flush! will kill him instantly.
  • Palette Swap: Dangle is one of Dingle, possessing the same attacks but with slightly different properties. He's essentially a Champion variation with his own title screen.
  • Toilet Humor: It's a giant adorable poop. Dangle takes it a step further by shooting corn at you.

The Haunt
Debut: Rebirth
  • Adorable Evil Minions: The Lil' Haunts that surround him are this.
  • Bedsheet Ghost: What's underneath its sheet is quite a bit scarier, however.
  • Flying Face: That rips itself open to reveal a skull when its minions are dealt with.
  • Flunky Boss: He is surrounded by three Lil Haunts which attack before he does. First one attacks, then the other two do. He's invulnerable until they're dead and he moves to the top of the room. His black Champion version spawns spiders instead of shooting Brimstone.
  • Expy: Very closely resembles a Boo.
  • Heel–Face Turn: The Lil' Haunt item gives you a friendly Lil' Haunt who chases your enemies.
  • Intangibility: Until his minions are dead, the Haunt is untouchable.
  • King Mook: To the Lil' Haunts.
  • Nightmare Face: Once you kill his minions, he rips off his face to reveal his skeleton.
  • No Fair Cheating: He normally paces from side to side along the top edge of the screen, shooting downwards. If you try to move to the top where he can't shoot you, he'll immediately charge at you to cause damage. Which hurts like crazy.
  • Our Ghosts Are Different: This one has a skeleton. Which he'll gladly show to you.
  • The Pawns Go First: Sends his Lil' Haunt minions to attack you while he himself remains intangible. When they go down, then he fights you.
  • Wave-Motion Gun: In his second phase, he'll fire Brimstone downwards as he strafes along the top of the screen. It has minimal telegraphing compared to most Brimstone attacks, so stay on your toes.

Rag Man
Debut: Afterbirth
  • Alien Blood: His blood is purple.
  • Flunky Boss: He'll occasionally detach his head. Not only does the head move and attack independently from his main body, but if it isn't destroyed quickly, it turns into a Rag Man's Ragling.
  • Heal Thyself: Aside from the regrowing heads thing, Rag Man possesses the unique ability to revive the Raglings created from his heads. This also restores a small amount of his HP.
  • Losing Your Head: Detaching his head doesn't seem to bother him too much, especially since it turns into a Ragling and he can simply grow a new one.
  • Mummy
  • Psychic Powers: His primary attacks are homing psychic blasts.

Little Horn
Debut: Afterbirth
  • "Get Back Here!" Boss: Spends a lot of the fight teleporting away from the player, often leaving a Troll Bomb behind. It also flees from the player if approached.
  • Homing Projectile: It fires large homing projectiles that will track you forever until you destroy them with your own attacks.
  • Playing with Fire: The orange Champion version spits out burning Troll Bombs instead of the black homing projectiles, which deal contact damage and leave behind a damaging fire upon detonation.
  • Portable Hole: Can make these to teleport itself around the room, teleport Troll Bombs around the room, or to send straight at you so that you will fall in and take damage.
  • Screw This, I'm Outta Here!: When his health gets depleted, instead of dying, he retreats into one of his portable holes.
  • Tactical Suicide Boss: Has a tendency of teleporting into its own Troll Bombs. The boss room also tends to have fires, into which Little Horn will run if you herd him in that direction.
  • Thinking Up Portals: Can open up two holes that are linked to each other, either to teleport itself around the room or as a lead up to the following trope.
  • Throw Down the Bomblet: Attacks with Troll Bombs by opening a pair of portals between his location and the player and throwing one in.

    Caves, Catacombs, Flooded Caves 

Debut: The Binding of Isaac
  • Body Horror: She's what can only be described as a mountain of flesh and organs, with a smiling face at the top.
  • Damage-Sponge Boss: The bulkiest boss in the Caves, having more health than some of the later bosses.
  • Degraded Boss: Interestingly, the weaker version attacks very differently, charging and firing circular waves of bullets. Contrast with the other bosses made into minibosses, who are more or less identical to their original version, but weaker. Wrath of the Lamb separates the degraded form into a different boss: Gurdy Jr. But The Very Definitely Final Dungeon DOES feature Gurdy as a normal Degraded Boss.
  • Flunky Boss: Spawns Flies and Boils to assist her. Her Champion version only spawns enemies and never fires at you.
  • Stationary Boss: She always stays in the middle of the room. Even if you push her away with a fear effect, she'll move back into position when it wears off.
  • Wake-Up Call Boss: When it comes to the pre-Wrath of the Lamb bosses who gave new players trouble, Gurdy is the most infamous.

Debut: The Binding of Isaac
  • Ambiguously Human: He's the most human-looking of the monsters, save for the fact that his eyes pop out and his urine-based powers.
  • Eye Scream: It detaches its eyeballs when its HP starts getting low. They block your shots and will inflict Collision Damage on you if you touch them. Oh! And they're indestructible until you kill their original owner (unless you have the Little Horn passive item).
  • Detachment Combat: His eyes will fly off as he takes damage, becoming wall-bouncing obstacles.
  • Extra Eyes: His Eternal counterpart in the Eternal Edition has six eyes. Yes, they can all detach, but they're also destructible.
  • Fat Bastard: Obese, and one of the bosses in the game.
  • Heel–Face Turn: Not the boss itself, but The Peeper item gives you a floating eyeball familiar that moves the same way as Peep's eyes.
  • Meaningful Name:
  • Psychopathic Man Child: He smiles during the fight and cries after being defeated.
  • Toilet Humor: Attacks with urine.
  • Urine Trouble: His main form of attack.

Debut: The Binding of Isaac

Debut: The Binding of Isaac
  • Bonus Boss: Occasionally replaces Chub once unlocked.
  • The Cameo: C.H.A.D. is a boss from Super Meat Boy. Dropping the item Little C.H.A.D. on defeat references his post-fight cutscene from the above.
  • Heel–Face Turn: The Little C.H.A.D item gives you a friendly C.H.A.D. who "gives kisses" (half red hearts) every few rooms.
  • Obliviously Evil: C.H.A.D. is charging at you not out of spite, but because he wants a hug.
  • Turns Red: As C.H.A.D. takes damage, he gets smaller and faster but no less dangerous.

The Husk
Debut: Wrath of the Lamb
  • Back from the Dead: The Duke of Flies' rotting corpse.
  • Flunky Boss: Spawns even MORE flies than the Duke does, with some spiders thrown in for good measure.
  • Rush Boss: Like his weaker counterpart, he has low health. Unlike his weaker counterpart, he can overwhelm you with flies if he has the chance.

The Hollow
Debut: Wrath of the Lamb
  • Back from the Dead: Larry Jr. devoid of blood and with swollen eyes.
  • Money Spider: The gold champion variant, which drops coins when its segments are destroyed.
  • Power Floats: The Hollow is capable of flying... somehow.
  • Segmented Serpent: As with Larry Jr., The Hollow's body segments can be destroyed separately and can cause it to split into multiple individuals.

The Wretched
Debut: Wrath of the Lamb

Dark One
Debut: Rebirth
  • Blackout Basement: One of his attacks is to make the entire screen dark and hide in the shadows.
  • Bullfight Boss: He has a charge attack where he travels from one side of the screen to the other towards the player, similar to the charge attacks of Famine and War but harder to dodge.
  • Dark Is Evil: Obviously.
  • Degraded Boss: In Sheol.
  • Frickin' Laser Beams: Will shoot Brimstone straight down if you stand below him.
  • Offscreen Teleportation: He can dash past the edges of the screen like the Harbingers.

Mega Fatty
Debut: Rebirth
  • Acrofatic: Normally slow and fat, but it has a leap attack which is executed in under a second.
  • Ambiguously Human: Like Peep, he's mostly human-looking, but is impossibly obese, bleeding from the mouth and eyes, and has superhuman abilities such as leaping into the sky.
  • Damage-Sponge Boss: Noticeably soaks up more punishment than most normal bosses.
  • Dung Fu: His fart attack can either produce Dips or send out a large wave of poop similar to his vomit attack.
  • Fat Bastard: Obviously, as he's the King Mook to the Fatty class of enemies.
  • Gasshole: Like normal Fatties, he has a fart attack, but it shoots out feces.
  • Hoist by His Own Petard: If you have a power-up that causes tears to suspend in the air (such as Pop!), Mega Fatty's vacuum attack will suck in those tears, dealing massive damage to himself.
  • King Mook: Of the regular Fatty enemy.
  • Vacuum Mouth: One of his attacks is to suck everything in the room toward him, mimicking the effect of the item Magneto.
  • Vomit Indiscretion Shot/Waterfall Puke: After the vacuum attack, he vomits up a barrage of projectiles that cover a portion of the screen.

Mega Maw
Debut: Rebirth
  • Bullet Hell: Its purple fire attacks are reminiscent of basic Bullet Hell circular attacks. There's also his red champion version where his attacks are nothing but rapid sprays of blood bullets.
  • King Mook: He is a giant version of the Maws.
  • Mook Maker: Will spit out Hoppers occasionally.
  • Non-Indicative Name: Despite being called "Mega Maw", he looks and behaves more like a Horf.
  • Playing with Fire: One of his attacks is to shoot flames in a circle around him.
  • Stationary Boss: It always stays at the top center of the screen, no matter what.

Debut: Rebirth

The Stain
Debut: Afterbirth
  • Back from the Dead: Polycephalus reduced to skulls conjoined with bits of connective tissue, all on top of a mound of flesh. Strangely enough, The Stain can be found on the same floor as his living version (similar to the Blighted Ovum above).
  • Body Horror: Even more-so than Polycephalus. What is left of it has now become a mound of viscera and skeleton.
  • Bullet Hell: Fires a barrage of bullets in all directions around itself, often several times in succession.
  • Combat Tentacles: Has a pair of exposed blood vessels poking out from its sides, which it uses as such.
  • Flunky Boss: Occasionally spawns a pair of Chargers. The Champion version instead summons Round Worms.
  • Nightmare Face: Not that it wasn't already nightmarish to begin with, but when it unleashes its bullet hell attack, it opens a mouth really wide and distorts its body.

The Frail
Debut: Afterbirth
  • Artistic License – Biology: Tapeworms don't normally have skeletons. Of course, this makes about as much sense as anything else in the game.
  • Back from the Dead: Pin has been reduced to a rotting undead corpse. And once you kill that, you have to deal with Dem Bones.
  • Glowing Eyes of Doom: While charging and firing its Brimstone beam in its second form.
  • Rush Boss: Even with multiple health bars, the Frail goes down quickly, but once he enters his second form, he can deal quite a bit of damage with his split shots and Brimstone lasers.
  • Sequential Boss: One of the few bosses in the game with multiple health bars, and the only one that isn't a Final Boss.
  • Took a Level in Badass: In life, Pin was one of the easiest bosses in the game. As the Frail, it's surprisingly tough.
  • Turns Red: Once its health is depleted the first time, it instantly undergoes an Adrenaline Makeover, gains a new health bar, becomes faster, more aggressive, and gains several Brimstone attacks. Its black champion version skips the first phase and starts in skeletal form.
  • What Happened to the Mouse?: Most of the original bosses got undead versions back in Wrath of the Lamb... except Pin. The Frail didn't show up until Afterbirth.

The Forsaken
Debut: Afterbirth
  • Back from the Dead: Technically, the Haunt already was dead, being a ghost and all. So whatever state you put him in when you won his boss battle, he's back from it.
  • The Coats Are Off: The Haunt has taken off his cloak/skin/ectoplasm/whatever, showing his full skeletal form instead of only his skull.
  • Dem Bones: Ever wanted to know what a Bedsheet Ghost's skeleton looked like?
  • Flunky Boss: Spawns Bonies during the fight, and just like his previous incarnation, he'll go intangible if he has any minions to fight in his place.
  • Frickin' Laser Beams: Can fire Brimstone beams in three directions, and he can rotate the beams. Before doing this, he will always turn intangible and run away from you, so make sure you herd him towards the middle of the room, or else this attack may be impossible to dodge.
  • Glowing Eyes of Doom: While firing his Brimstone attack.
  • Intangibility: Will use this to flee from you so that he can fire his Brimstone attack.

Rag Mega
Debut: Afterbirth†
  • Composite Character: He's a combination of The Duke of Flies and Rag Man, with a bit of The Haunt thrown in for good measure.
  • Detachment Combat: His orbitals will break off and attempt to chase you when his health gets low.
  • Frickin' Laser Beams: Fires 3 purple beams from his orbitals.
  • Glass Cannon: He has relatively low health, but his orbitals block shots and can hurt you, he can shield himself inside his rags, and he has a projectile version of Rag Man's resurrection move. You'll spend most of the fight just trying to land a hit.
  • Mook Maker: Spawns Rag Man's Raglings throughout the fight.

Big Horn
Debut: Afterbirth†
  • Damage-Sponge Boss: Not as tanky as Mega Fatty, but still on the high end. His constant teleporting doesn't help.
  • Degraded Boss: Can summon a significantly weaker version of Little Horn during the fight.
  • Feed It a Bomb: When his mouth opens, you can kick a bomb into it. This will stun him for a bit and cause him to take 20% more damage.
  • Flunky Boss: Occasionally summons Little Horn, though thankfully he doesn't have nearly as much health as he did as a stand-alone boss.
  • "Get Back Here!" Boss: Ducks underground constantly, then reappears somewhere else in the room.
  • Portable Hole: He creates two or three holes around the room as his main attack, which either expands to become pitfalls or his hands will stick out and either throw bombs or chase the player. His whole body is also sticking out of one.
  • Throw Down the Bomblet: One of his attacks has him throw several bombs at the player. These can be a few troll bombs, a hot bomb, or even a mega troll bomb.

    Depths, Necropolis, Dank Depths 

Debut: The Binding of Isaac
  • Big Red Devil: Has the stereotypical red devil appearance, although he appears to be smaller than other bosses.
  • Hoist by His Own Petard: If you can kill his Boom Flies as soon as they spawn, they will blow up on him.
  • Flunky Boss: Summons Boom Flies periodically.
  • Heel–Face Turn: The Little Loki item gives you a friendly Loki who uses its four-way-bullet attack. It isn't dropped by the Loki boss, though.
  • Tactical Suicide Boss: The Boom Flies it spawns will often explode on him, given how powerful you should be by the time you fight him.
  • Teleport Spam: Frequently teleports away during the battle.

Monstro II
Debut: The Binding of Isaac
  • A.I. Breaker: In the original game, Monstro II could be locked into his Brimstone attack by standing beside him to trigger the attack, then moving to his other side to make him shoot Brimstone in the other direction, and repeating the process as necessary. It's no longer possible with his Rebirth incarnation.
  • Back from the Dead: He is the zombified husk of Monstro.
  • Body Horror: He's three-fourths skeleton, and the one-fourth of him left isn't looking much better.
  • Damage-Sponge Boss: Much bulkier than the other Depths bosses.
  • Degraded Boss: In Sheol and the Cathedral.
  • Flunky Boss: Summons Suckers on his second jump attack.
  • Frickin' Laser Beams: Replaces his shower of bloody tears with a Brimstone attack. He'll only fire it if you're standing directly to his left or right, though.

Debut: The Binding of Isaac
  • Blob Monster: A giant tar blob.
  • Bonus Boss: After being unlocked, Gish will occasionally replace Monstro II.
  • The Cameo: From a game with the same name, Gish.
  • Flunky Boss: Spawns Clots.
  • Heel–Face Turn: The Little Gish item gives you a friendly version with slowing attacks, and is usually dropped by the boss.
  • King Mook: To the Clots.
  • Underground Monkey: He can shoot in any direction like Monstro, summons mooks like Monstro II, and has his own unique explosive shots.

Mask of Infamy
Debut: Wrath of the Lamb
  • Attack Its Weak Point: The mask is invincible until you destroy her heart. Even after that, you need to hit her from behind.
  • Cat-and-Mouse Boss: The first phase of the fight: you chase the heart, while the mask chases you.
  • Chasing Your Tail: The second phase of the fight has you trying to attack the mask's vulnerable rear, while she continues to try and run you down.
  • Interface Screw: The only boss without a health bar in the original version, though fixed in Rebirth. The fact that it's not easy to land a shot in the last stage makes the fight look depressingly long.
  • Queen Mook: A beefed-up version of the Mask + Heart enemies also added in Wrath of the Lamb. Her second phase behaves much like a faster version of the Knight enemies.
  • Samus Is a Girl: Confirmed to be female by Word of God.
  • Shout-Out: Inspired by Carmillia's mask in Castlevania.
  • Tears of Blood: Bleeds from her eye sockets in a manner that makes it look like she's crying.
  • White Mask of Doom: She IS one.

The Bloat
Debut: Wrath of the Lamb
  • Ascended Meme: His infamous reputation as a hated boss by the community is reflected in Afterbirth+ challenge Aprils Fool, where he's the boss on every floor.
  • Back from the Dead: What remains of Peep's bones are broken, and his eyes are swollen.
  • Body Horror: A blobby, rotting, bleeding pile of flesh with disembodied eyes that float right next to him.
  • Combat Pragmatist: Since he fires his Brimstone lasers the moment you're to his side or in front, chances are he may well attack you the instant the battle starts.
  • Dead Weight: He's a zombified version of the already obese Peep.
  • Detachment Combat: Like Peep, except both his eyes are now detached from the beginning of the fight.
  • Eye Scream: His eyes are covered in red growths, and aren't attached to him.
  • Fat Bastard: Infamously morso than his alive version.
  • Frickin' Laser Beams: He'll fire dual Brimstone lasers from his eye sockets if you so much as put a toe in front of or beside him. This is one boss you'll always want to attack from the back, even more so than Mask of Infamy.
  • Meaningful Name: "Bloat" is the medical term for abdominal distention, and he is a Fat Bastard. Could also be attributed to the fact that he's the rotting corpse of Peep (i.e. "bloated corpse").

Carrion Queen
Debut: Wrath of the Lamb
  • Attack Its Weak Point: Can only be hit from behind, except when exploiting its other weak point (see Feed It a Bomb below).
  • Back from the Dead: A mostly-skeletal Chub.
  • Dung Fu: Randomly produces Red Poop that damages you if you touch it and always regenerates when it's destroyed. Also can bounce off the poop as if it's a wall.
  • Feed It a Bomb: Same as Chub, though it becomes impossible once she starts moving diagonally as she no longer charges with her mouth open.
  • Turns Red: Will bounce aimlessly around the room once her health is down to half.

The Adversary
Debut: Rebirth
  • Back from the Dead: He is the posthumous version of the Dark One, covered in bandages and with a shattered horn.
  • Blackout Basement: Can turn the screen dark for his attacks.
  • Dishing Out Dirt: He can jump up in the air and slam down, creating a circular wave of rocks around him.
  • Flunky Boss: Occasionally spawns spiders from the hole in his chest.
  • Frickin' Laser Beams: He can now shoot Brimstone in any cardinal direction, but don't think you're safe if you stand at a diagonal, because it curves towards you.
  • Silliness Switch: Compared to the other posthumous bosses, the Adversary is pretty goofy. The only comparable one is Lokii, and he at least comes from an already cartoony boss. And yes, the dark and edgy name only makes him funnier.

The Cage
Debut: Rebirth
  • Back from the Dead: He is a posthumous version of Mega Fatty, with his head being absent (assuming it got chopped off) and his body rotting, along with a new stitch across his stomach, making him resemble a giant Vis.
  • Damage-Sponge Boss: Notably, he has more health than Mom.
  • Dead Weight: It's the zombified version of Mega Fatty, so naturally he is mobidly obese.
  • Dishing Out Dirt: His jumping attack now creates sharp rocks like the Adversary's, but he creates lines of them that travel outwards in several directions until they hit a wall.
  • Dual Boss: The pink Champion variant pits the player against two Cages.
  • Giant Mook: He's basically been turned into a Vis, making him this.
  • Mook Maker: He can spawn discoloured Vis that fire sickly grey Brimstone lasers.
  • Rolling Attack: He can curl up in a ball and roll around the floor in an attempt to hit Isaac.
  • Zombie Puke Attack: It manages to do this without a head.

The Gate
Debut: Rebirth
  • Back from the Dead: He is a posthumous Mega Maw, as the flesh from his face leaks to the lower half of his head, his skull remains animated for the time it's alive.
  • Flunky Boss: Spawns a series of Leapers in order to set up his Brimstone attack.
  • Meat Puppet: A pair of eyes can be seen whenever The Gate opens his mouth. When defeated, something that looks like a tiny Isaac peeks outside a crack right before expiring.
  • Reflecting Laser: One of his attacks is to spawn three Leapers and then fire a Brimstone laser that connects between the three and deals a whole heart of damage. Killing the Leapers before he fires it causes the beam to simply travel straight down instead. Interestingly, the effect isn't just limited to Leapers - if the Gate spawns with other enemies (e.g. Greed Mode and Boss Rush), the laser chains to those enemies as well and will most likely kill them for you.
  • Stationary Boss: Just like its living counterpart.

Debut: Afterbirth
  • Abnormal Ammo: Corn.
  • Bullet Hell: Tends to fire much larger volleys of projectiles than most bosses. Also drops Corn Mines that explode into even more projectiles.
  • Flunky Boss: Spawns Brownie Corns in large numbers throughout the fight.
  • One-Hit Kill: Using Flush! will instantly kill him and any Brownie Corns, without him turning into Dangle.
  • Rush Boss: Although its attacks and minions can be difficult to dodge, Brownie doesn't have a particularly large health pool. The fact that one of its attacks is essentially Cast from Hit Points doesn't help its case.
  • Tactical Suicide Boss: The exploding turds Brownie places down can not only damage it, they can also poison it. Zig-zagged in that Brownie also trails poisonous creep while poisoned.
  • Toilet Humor: How else does one describe a giant ball of poo that shoots corn?
  • Turns Red: Inverted. When its health drops low, it turns into Dangle.

Sisters Vis
Debut: Afterbirth†
  • The Cameo: Originally appeared as bosses in Edmund's earlier game, Gish.
  • Distaff Counterpart: To The Cage. They're female and look almost identical to him, except they have heads. They were also supposed to debut in Afterbirth, but were cut and replaced with the pink Champion Cage (which is, of course, two Cages).
  • Dual Boss: Sisters Vis spawns in pairs by default. Can come in as many as eight at once in Greedier Mode.
  • Giant Mook: A pair of giant Vis, although they don't really look like them.
  • Rolling Attack: Just like The Cage.
  • Turns Red: When one Sister is killed, the other will literally turn red and begin moving faster.
  • Wave-Motion Gun: Much like the Vis enemies, their main attack is opening up their stomach and firing blood lasers, although their's is much larger than normal. They usually do it facing towards each other, but if one does it alone (or the other one is dead), they will sweep it left to right.

    Womb, Utero, Scarred Womb 

Debut: The Binding of Isaac
  • Asteroids Monster: As it gets damaged, it splits into smaller blobs. The smallest blob variety leaves behind the Embryo inside when destroyed.
  • Blob Monster: Judging by the name, it's a gigantic, blob-like cell.
  • Bullet Hell: Can happen if too many of them are left onscreen. Since they only fire in a set direction, however, it's pretty tame compared to most other examples in the game.
  • Fake Ultimate Mook: Amusingly enough, the helpless Embryos that spawn as regular enemies on early floors had mini-boss health bars in the original game, as the game counted them as Blastocyst.
  • King Mook: To the Embryos found in early stages.
  • Mega-Microbes: They're cells/developing embryos that are bigger than Isaac.
  • Weaksauce Weakness: Poison. Normally a boss would only take a bit of damage from poison as their health bars reach in the hundreds but if Blastocyst is poisoned when it divides it's instantly killed, ending a long boss fight with in a few minutes.

Debut: The Binding of Isaac
  • Attack Its Weak Point: You can only damage it by hitting it in the very back segment.
  • Fragile Speedster: It has the lowest health of any boss in the game, but it makes up for this with its speed and hard to hit weakpoint. Rebirth gave Scolex a health buff, but it still takes less damage than every other Womb boss.
  • Tactical Suicide Boss: One of its attacks has it poking its vulnerable tail out of the ground for a fairly lengthy period of time before firing three Ipecac shots, giving the player a perfect opportunity to take off a lot of its health.
  • Underground Monkey: It's a much tougher version of Pin, but unlike the Back from the Dead versions of other bosses, Scolex is noticeably different in appearance from its easier version (and was also in the game before Pin).

Daddy Long Legs
Debut: Wrath of the Lamb
  • Easter Egg: There is an item that summons the Daddy Long Legs to stomp enemies in an area the player is standing in without hurting them. Using this against the Daddy Long Legs reskins it as the Triachnid's claw. Using it against Triachnid, however, flat-out doesn't work.
  • Giant Foot of Stomping: Yes, this game has a spider that stomps you. No, it (most likely) does not take place in Soviet Russia.
  • Giant Spider: Bigger than any other spider in the game, taking up more than the screen can show.
  • Heel–Face Turn: The Daddy Long Legs item makes him periodically stomp on your enemies for you.
  • King Mook: A giant spider, same as Widow.

Debut: Wrath of the Lamb
  • The Cameo: Triachnid is a reference to a previous flash game by Edmund McMillen. Furthermore, Triachnid is an alternate of Daddy Long Legs; in his own game, Triachnid was finding a home for his young.
  • Dummied Out: As hinted here, Triachnid was originally cut before the game was released. It wasn't removed entirely, though. Due to a glitch, it originally would replace the Cathedral's True Final Boss. This was eventually corrected, and Triachnid was added in as a normal boss.
  • Giant Foot of Stomping: Shares Daddy Long Legs' stomp attacks, but while Daddy Long Legs has four legs to stomp you with, Triachnid only has three.
  • Underground Monkey: Occasionally replaces Daddy Long Legs once unlocked.

Debut: Wrath of the Lamb
  • The Artifact: With the "Double Trouble" mechanic in Rebirth, Lokii is kind of redundant; the fact that the halves summon Red Boom Flies instead of regular Boom Flies is the only way they're different from a Double Trouble Loki fight, aside from appearing in standard 1x1 boss rooms.
  • Back from the Dead: Loki has been split in two, but both halves live on.
  • Dual Boss: He's the equivalent of fighting two Lokis at once, only with Red Boom Flies.
  • Flunky Boss: Unlike standard Loki, they summon Red Boom Flies. This gives them an advantage because they won't be blasted in the face if their minions die near them.
  • Half the Man He Used to Be: They're Loki after being split in half, and somehow they're completely fine.
  • Teleport Spam: Just like normal Loki.
  • Visual Pun: The last two "i"s of his name have a line crossed through them on the bottom, making them resemble part of the Roman numeral II.

Debut: Wrath of the Lamb
  • Asteroids Monster: The same as Fistula, except now filled with spiders instead of Chargers. The biggest difference between them is that Teratoma's largest form splits into three, whereas Fistula splits into four.
  • Back from the Dead: Kind of. It's the posthumous version of Fistula in mechanics, although given that both are different real-life tumors without any personality or even attack method, it's hard to to say how "posthumous" they can really be.
  • Body Horror: Like Fistula, it's named after a real-life phenomenon in which the body forms a growth containing all three germ layers, one of which can potentially manifest as bone shards and teeth!

Mama Gurdy
Debut: Rebirth
  • Ascended Meme: Apparently a reference to a fan-made animation.
  • Emerging from the Shadows: The boss screen shows her arm doing this. She actually looks like this in-game.
  • Metamorphosis: The fourth form of Gurdy to appear. This one is quite different than her predecessors - instead of a ball of guts with a human face, it's a (probably) humanoid creature that's misshapen and lumpy.
  • Spikes of Doom: She is able to create spikes around the room.
  • Wall Master: She can hide in the walls of the boss room, immune to damage.
  • Weaksauce Weakness: She never creates spikes directly under the player, so standing still during her spike attack will leave you safe and her defenseless.
  • Zombie Puke Attack: One of her moves has her spew orange vomit all over.

Mr. Fred
Debut: Rebirth
  • Flunky Boss: Starts the fight accompanied by four Homunculi whose bonds he can break at will, and spawns Freds throughout the fight.
  • King Mook: A giant boss version of the enemy Fred that appears in Chapter Four.
  • Stationary Boss: Never moves from the centre of the room.

The Matriarch
Debut: Afterbirth†
  • Body Horror: She is a giant maggot wrapped in a chunk of rotting flesh also infested with a bunch of smaller maggots. Is there any more to be said?
  • Composite Character: She's Chub wrapped up in a Fistula, although the boss doesn't actually take any attack patterns from those two.
  • Feed It a Bomb: On second thought, don't. Unlike regular Chub, the Chub that spawns when the Matriarch takes enough damage will spit the bomb back at you.
  • King Mook: She is to the Fistuloid enemies what Chub is to the Chargers.
  • Took a Level in Badass: The boss is Chub character-wise (she turns in to Chub after losing all her health as the Matriarch), but now clad in a Fistula mass of flesh and fought much later in the game.
  • Turns Red: After being damaged enough, the Matriarch fires a wave of Fistulas that quickly break into maggots, and can do this attack at any time after that point.


The Fallen
Debut: The Binding of Isaac
  • Asteroids Monster: After about 75% of his health his gone, he splits into two versions of himself.
  • Bullfight Boss: Does this when he isn't shooting. The charge is stopped by shooting him enough times or when he reaches you, after which he'll shoot blood in every direction.
  • Classic Video Game Screw You: It's uncommon, but this guy can be the boss of any dungeon save ones with predetermined bosses. He's notorious for showing up in the Basement/Cellar, often before you've had a chance to buff your speed and survive his charge.
    • Somewhat downplayed since he gives you a free devil room item note  if you manage to beat him. Because of this, veteran players may actually be happy to find him early on in a run.
  • Degraded Boss: In Sheol. He's later fought at full strength when the Satan fight begins.
  • Early-Bird Boss: He can replace any boss that's not pre-set by the level. If you're unlucky, he can appear on the first or second floor.
  • The Dragon: To Satan. He even acts as the first stage of his master's boss fight!
  • High-Pressure Blood: He shoots Brimstone lasers in all four cardinal directions at once for one of his attacks.
  • Nerf: In Rebirth, The Fallen's health scaling scales based on the floor, making him significantly weaker on early floors. Additionally, he now only appears if you've been inside a Devil Room previously.

Debut: Wrath of the Lamb
  • Bad Santa: Drops a Lump of Coal.
  • Chest Monster: Randomly appears in Devil Rooms. He's more likely to appear if you have already entered a Devil room, even more so if you've made a deal.
  • Classic Video Game Screw You: Krampus can appear in the first Devil Room, potentially invalidating any chance to see further Devil Rooms merely by being there. Also, just by showing up, he invalidates a hard-earned devil deal in favor of an item that may or may not help as much as the stuff you were hoping for... assuming he doesn't just kill you, that is. It doesn't help that Krampus gets buffed with every major update to the game.
    • At least partially subverted if you're targeting Mega Satan. Getting a Krampus item doesn't ruin your chances for Angel rooms in later floors, therefore making it easier to get the Key Pieces.
  • Early-Bird Cameo: He can be fought in Greed mode, even if he hasn't been unlocked yet.
  • High-Pressure Blood: Just like the Fallen, but he'll do it if you pass by him in any direction rather than after a charge. Afterbirth adds in a chance of him rotating his beams, and Afterbirth+ adds in a chance of him firing them off diagonally.
  • The Krampus: It's in the name, after all.
  • Mini-Boss: By virtue of being a weaker version of the Fallen, not to mention he has the same kind of entrance as the Seven Deadly Sins. Though unlike the Sins, he only appears in Devil Rooms and is the only mini-boss that Delirium can turn into.
  • Palette Swap: Of The Fallen, except he doesn't split into two parts and is mildly weaker. He also has no charge attack note , firing off his Brimstone lasers if you stick to any cardinal direction of him for too long instead. He can also fire them diagonally and rotate them around the room. Killing him may drop the Head of Krampus, which lets you use this attack.

Uriel and Gabriel
Debut: Rebirth
Secret bosses in Rebirth, a fight with one of two Angels is initiated by bombing the statue in an angel room at any point throughout the game. Beating one unlocks a piece of a key each time, and beating both and combining the keys allows the player to unlock the true final boss of the game.

  • The Blank: Even when not in statue form, they lack faces.
  • Bolt of Divine Retribution: They shoot coherent beams of holy light, which functionally behave like Brimstone lasers.
  • Color-Coded for Your Convenience: Uriel wears silver or blue, Gabriel wears red.
  • Degraded Boss: Two Fallen Angels attack you as Mega Satan's flunkies, and to get to that point you're almost required to have already killed the normal ones in this run. One interpretation of this is that they kept the pieces of the Golden Key safe, failed when Isaac took the pieces and were subsequently punished for it. Incidentally, the degraded versions are actually stronger than the originals.
  • Dismantled MacGuffin: They each hold a piece of the key required to open the Gold Gate.
  • Dual Boss: Afterbirth+ gave Angel Rooms a chance to contain two angel statues, letting you fight both at once if you are so inclined (or are short on bombs, or used Mama Mega on the same floor). However, fighting both at once will only spawn one Key Piece, making it better to fight them in sequence.
  • Early-Bird Boss: Though Gabriel is the stronger of the two, they spawn in random order, making it possible to fight him rather than Uriel on an early floor.
  • Guide Dang It!: Bomb the angel statue in an Angel Room to provoke it into a fight. Less aggravating than other examples since there are more in-game clues and it is often next to blue fires, which can be bombed for soul hearts, so the player might figure this out by mistake if nothing else.
  • Hidden in Plain Sight: Those statues in the Angel Room aren't just there for decoration. A fight can be initiated at any point in the game, provided you have beaten either ??? or The Lamb and a spare bomb.
  • Our Angels Are Different: They are much larger than Isaac and have no faces. They're also hostile and attack Isaac like every other boss in the game.
  • Palette Swap: Their main distinction is the color of their scarves. Uriel wears a pale blue one, while Gabriel's is red.
  • Personal Space Invader: Unlike Uriel, Gabriel likes to fly directly at Isaac to deal contact damage.
  • Winged Humanoid: Albeit without a face.

    The Harbingers 

In General

The four Horsemen of the Apocalypse, unlocked after beating Mom for the first time. Famine, Pestilence, War, and Death each have the ability of replacing one of the bosses of the Basement, Caves, Depths, and Womb respectively, while the Headless Horseman has the capability to replace any of these bosses, and Conquest was introduced as an alternate boss to Death.

  • Combat Breakdown: Interestingly, most of the Horsemen actually get easier in their second phases, usually due to you destroying parts of them. The main exceptions are Famine, who switches to a Spread Shot that isn't much easier to dodge than his charge and Pooters, and Conquest, who never changes behavior.
    • Pestilence is reduced to spitting Attack Flies after losing his head, whereas his first phase spawns Chargers.
    • War loses all of his existing attacks after his horse is destroyed, at which point all he does is run at you.
    • After jumping off his horse, Death's only attack is to spawn Knights which, more often than not, get run over by said horse. The horse itself also follows a much more predictable pattern than his first phase's scythes and Hourglass.
  • Degraded Boss: In later stages.
  • Horsemen of the Apocalypse: The very same (except the Headless Horseman). Like many portrayals, Pestilence initially took Conquest's place before Conquest himself was added.
  • Offscreen Teleportation: Most of them charge against you through the screen and return from the other side.
  • Quirky Miniboss Squad: Despite being full bosses in their own right and fought one at a time, they still fit the bill. Their item drops, the Cube of Meat and the Ball of Bandages, become more powerful by collecting more Cubes or Balls from multiple Horsemen, they can be summoned by the Book of Revelations, multiple Horsemen will appear at the same time as normal enemies in later levels, and they're easily recognizable.
  • Sequential Boss: With two stages. Except for Conquest and the Headless Horseman, the latter being a Dual Boss.
  • Signature Roar: The Horsemen that charge at you let out a distinctive shout before doing so.
  • Uncatty Resemblance: Each of the Horsemen's horses look similar to their rider.

Debut: The Binding of Isaac
  • Body Horror: Eyeless Face and physical degradation in general. The lack of lips is especially noticeable.
  • Losing Your Head: After taking enough damage, Famine's body explodes, leaving only his floating head.
  • Mook Maker: Creates Pooters.
  • Slasher Smile: Famine has this as his trademark.
  • Warm-Up Boss: As the Horseman of the Basement, Famine has the lowest health and simplest attack pattern out of the Harbingers.

Debut: The Binding of Isaac
  • Body Horror: No eyes, rotting body with swollen parts, filled with explosive, possibly-toxic fluids, and surrounded by maggots and flies.
  • Green Around the Gills: His entire body is sickly green, swollen, and leaking some sort of disease-ridden fluid. So is his horse.
  • Incurable Cough of Death: His hoarse coughs summon flies.
  • Losing Your Head: Only the body (still riding the horse) remains after the first part.
  • Mook Maker: Maggots at first, Flies later.
  • Walking Wasteland: As the personification of disease and toxin, he leaves a trail of creep everywhere he moves.

Debut: The Binding of Isaac
  • Bullfight Boss: After losing his horse.
  • Bull Seeing Red: He's red, and his horse has bull horns and charges.
  • Mad Bomber: One of his attacks drops bombs randomly.
  • Oh, Crap!: After losing his horse, hit him enough times and he'll fall to the ground stunned, with a terrified look on his face.

Debut: The Binding of Isaac
  • Death's Hourglass: A literal example, in that one of his first stage's attacks is to use the Hourglass item on Isaac.
  • Dual Boss: He hops off his ride on his second stage, which goes on ramming aimlessly while he hovers around spawning Knights.
  • The Grim Reaper: The skeletal kind, complete with black cloak and scythes.
  • Mook Maker: Creates Knights.
  • Shout-Out: One of his attacks is very similar to one that a certain other Death you may know of uses.
  • Sinister Scythe: He can summon flying, spinning scythes to attack.
  • Visual Pun: His champion form is black. Reinforced by the enemies summoned by the champion version: the Red Maws summoned by the first form reference the swelling caused by the disease, while the Kamikaze Leeches refer to the use of leeches as a treatment for the blood build-up.

The Headless Horseman
Debut: The Binding of Isaac
  • All Your Powers Combined: The head has Famine's triple shot and War's triple charge, while the body is Pestilence minus spawning enemies. Plus, you fight two bosses at the same time, which is what happens when Death loses half his health.
  • Classic Video Game Screw You: He can replace any horseman. Are you on the Womb/Utero 1, with Book of Revelations and Level 3 Meat Boy or Bandage Girl, hoping to finally get the corresponding achievement for Level 4? Too bad, have a pony instead.
  • Degraded Boss: The head alone can appear in normal rooms once you reach the Depths. The body can as well starting from Sheol/Cathedral.
  • Dual Boss: The boss is split into: his head, that charges and shoots small bullets, and his body, which shoots large bombs and leaves trails of blood.
  • Early-Bird Boss: While the Headless Horseman is manageable with a few items, he can just as easily show up in the Basement and wipe the floor with you due to being much stronger than just about any other Basement boss.
  • Headless Horseman: Well, yeah.

Debut: Wrath of the Lamb
  • Be Careful What You Wish For: Some players complained that War was "too easy" for a boss in the Depths.
  • Bolt of Divine Retribution: One of only two bosses in the game to summon beams of light from on high.
  • Classic Video Game Screw You: Like the Headless Horseman, he can replace other Horsemen (although he will only replace War or Death in vanilla Isaac or just Death in Rebirth), dicking players out of getting the Meat Boy/Bandage Girl achievements countless times.
  • Continuity Nod/Genius Bonus: invoked The secret calls him "A Forgotten Horseman", reflecting the fact that he's been replaced by Pestilence both in the game and in nearly every other version of the Horsemen of the Apocalypse. Also, it was replaced because it was too similar to War. Conquest has improved versions of War's attacks.
  • Doppelgänger Attack: He can charge across the screen alongside five or so clones. In Rebirth, it's upgraded to about a dozen.
  • Eyepatch of Power: A full blindfold in his case.
  • Holy Hand Grenade: His beam attack.
  • Light Is Not Good: As a Horseman of the Apocalypse, this is a given.
  • Missing Secret/Dummied Out: Weird variation. Conquest does not need to be specifically unlocked, but there is an unused picture for unlocking him. Subverted in Rebirth, where taking ten angel room items unlocks him.
  • Shared Life Meter: During Conquest's Doppelgänger Attack, hitting any of his duplicates will cause damage to the main Conquest. If his health drops to zero during this attack, all Conquests will die at the same time.
  • Sixth Ranger: An additional horseman added later. Technically, the original passage from the Book of Revelations likely referred to Conquest, not Pestilence, but the most modern usage of the horsemen ignore Conquest.

    The Seven Deadly Sins 
Debut: The Binding of Isaac
Debut (Super variants and Ultra Pride): Wrath of the Lamb

In General

  • Ambiguously Human: It's not clear if they are humans under the effect of various itemsnote , humanoid monsters from the start, or the actual Sins themselves given physical embodiment. The implication that every character is an alternate Isaac as he only imagined the events of the gameplay just complicates things further.
  • Anthropomorphic Personification: Of their respective sins.
  • Degraded Boss: Like most of the bosses, they can be found in regular rooms towards the end chapters of a run. However, they will still have specific "miniboss rooms" complete with the music and "Vs" text appearing at the top of the screen in chapter 5.
  • King Mook: The "Super" variants introduced in Wrath of the Lamb, as well as Ultra Greed in Afterbirth.
  • Inescapable Ambush: Unless you hold certain items, they won't show up on the map at all until you run into them, and you cannot leave unless you carry a teleportation item. Their rooms also have metal bars around the doors so that you cannot even bomb your way out as you could with normal enemy rooms.
  • Quirky Miniboss Squad: They fight you individually, but in any of the levels following the fourth chapter, you may encounter up to three different Sins to fight in the same room.

Envy/Super Envy
  • Asteroids Monster: When defeated, he splits into two heads, which each split into two smaller heads, which finally each split into two tiny heads. Super Envy splits into threes instead of twos, except for the smallest heads.
  • Damage-Sponge Boss: To make up for the fact that he is easily the least dangerous Sin in either form, he has more aggregate health than the other Sins.

Gluttony/Super Gluttony

Greed/Super Greed
  • Bandit Mook: His shots (and mere contact with him) take away a couple of pennies from you, while making you drop a variable amount on the floor that you can try to retrieve. Just be careful while doing so, if you don't want to be killed in the process. His mook-look-alikes have the same ability as him.
  • Breakout Character: He's the most memorable and ubiquitous of The Seven Deadly Sins mini-bosses, and Wrath of the Lamb cemented his status by adding a quite a few new versions of him. And Afterbirth makes Ultra Greed the final boss of Greed Mode.
  • Character Blog: The Afterbirth Alternate Reality Game gave him a Twitter. On the other hand, most of the entries were made by the players, who completed the ARG by logging into the account and posting tweets.
  • Chest Monster: Replaces shops and secret rooms. He's more likely to appear as you go further in the game.
  • Expy: He shares some traits with Spelunky's Shopkeeper, including his multi-shot ability, potential to turn hostile on the player without previous warning, and overall dickishness.
  • Flunky Boss: Normal Greed summons Hoppers, Super Greed summons Keepers (which are Greed heads).
  • King Mook: Wrath of the Lamb added Super Greed, who is bigger, meaner, scarier, and can spawn Keepers, who are essentially Greed heads. They can also appear in the Depths, the Catacombs, and the Necropolis. Also, the final boss of Afterbirth's Greed Mode is Ultra Greed.
  • Mook Promotion: Inverted. The game's standard version features him as a mini-boss, but the expansion added mook-versions of him that share some of his most aggravating attributes.note 
  • Shopkeeper: When he's not out for your blood, anyway.
  • Money for Nothing: Invoked; he gives a lot of money when defeated, but his battle has a tendency to replace a shop where there would be one. There's also a chance he might appear in Secret Rooms, making for a bit of a subversion.
  • Took a Level in Badass: He's pretty unimpressive as a mini-boss even in his super form, then comes his Ultra Greed form.
  • Wingding Eyes: Super Greed either has cent signs for eyes or actual coins jammed in his eye holes.

Lust/Super Lust
  • Abhorrent Admirer: Possibly due to being the personification of Lust and not exactly in the good-looking department, and her only attack is chasing after the player in great speed and causing Collision Damage.
  • Badass Normal: Pride can spawn bombs from nowhere and either has electrical powers or can stretch out tentacles. Greed can sap money away from Isaac through collision or even bullet contact and can spawn monsters. Lust, however, just seems to be a fast girl with a harmful virus. Super Lust averts this by having a trail of harmful blood that doesn't damage her, which is not "normal" by any standard.
  • Bloody Horror: Lust seems to be affected with some sort of blood disease (likely HIV) and her Super variation bleeds from the face and leaves a trail of blood everywhere she goes.
  • Body Horror: Super Lust's horribly deformed face.
  • Bullfight Boss: She does nothing but charge at you. Thankfully, she can't turn on a dime and there are plenty of rocks around to kill her momentum.
  • Fragile Speedster: Not really that tough of a battle compared to the other Deadly Sins since her only gimmick is just running really fast, and she can be brought down rather quickly even with no special tear upgrades. What would make her dangerous though is if you had a very poor speed stat.
  • Pink Means Feminine: Both Lust and her super form are pink, and she's the only Sin who is female.
  • The Smurfette Principle: The only one of the Sins/Super Sins that have been identified as female.

Pride/Super Pride
  • Combat Tentacles: It's either this or Shock and Awe.
  • Mad Bomber: Occasionally, Pride randomly spawns troll bombs in an attempt to catch you in the blast.
  • Palette Swap: In Wrath of the Lamb, Super Pride's appearance was just that of Pride, but larger and pink instead of grey. In Rebirth, the face is slightly different, but he still resembles a giant, pink Pride.
  • Shock and Awe: Both forms of Pride can do this.

Sloth/Super Sloth

Wrath/Super Wrath
  • Cartoon Bomb: His bombs are identical to yours, skull marking and all.
  • Expy: Of Bomberman.
  • Hoist by His Own Petard: Wrath's bombs can be pushed around like player-dropped bombs, allowing you to push them back towards him for a nice chunk of damage. This doesn't work on Super Wrath's troll bombs, though. Even more amusingly, any items that affect bombs will affect the bombs dropped by Wrath/Super Wrath. This can result in hilarious situations where, if you have the Bobby-Bomb collectible, every bomb the boss drops proceeds to walk back toward him.
  • Mad Bomber: Throws bomb after bomb at you. Since he's Wrath, this doubles as a Stealth Pun.
  • Tactical Suicide Boss: Probably the finest example in the game, as he has exactly one attack which can easily blow up in his face. Less so with Super Wrath, as he throws Mega Troll Bombs, which follow the player around and cannot be pushed. However, these can potentially be lured into him.
  • Wrong Genre Savvy: He seems to think he's in a Bomberman game. Which doesn't work out too well for him since Isaac can just push his bombs back at him with tears.

Ultra Pride
  • Creator Cameo: He's a stylized representation of artist Edmund McMillen, while his familiar is one for programmer Florian Himsl. Hence why he's named Ultra Pride.
  • Death by Cameo: You do fight them, after all.
  • Dual Boss: He comes with his familiar, and both have to be defeated.
  • Meaningful Name: The creators are ultra proud of their product. Additionally, putting yourself as a cameo in your own game is a flagrant show of pride.
  • Palette Swap: He's basically Sloth with different moves, while the familiar is a graphically altered Baby with a different shot type.

    Final Bosses 

Yes, bosses. At first, you end the playthrough in Depths II and kill Mom, but as you beat the game repeatedly, you unlock more chapters, each with a Final Boss bigger and tougher than before.

All spoilers are unmarked from here on out. Proceed at your own caution!

Debut: The Binding of Isaac
At the end of the Depths, Isaac finally confronts his mother. As her foot stomps down on Isaac from above, she looks and sends her hands through the doors of the boss room while spawning enemies. But even if Isaac defeats Mom, it's not the end.
  • Attack of the 50-Foot Whatever: Her boss fight.
  • Ax-Crazy: Her goal is to kill her own son, and she doesn't sound too upset about it during the fight, what with the laughing and all.
  • Battle Theme Music:
    • The original game had "Thine Wrath...", an orchestrated theme that sounds nearly angelic at points while still being dreadful, to symbolize Mom's willingness to kill her own son to appease what she perceives as "God".
    • Rebirth gave her "Matricide", which leans more to heavy rock and an oppressive tone backed up by a choir.
  • Body Horror: The way Mom's body parts move throughout the fight (such as both eyes appearing on opposite sides of the room while she tries to stomp on you) suggest an ability to contort herself in rather...impossible ways.
  • Boss Banter: ISAAAAAC!
  • Death by Irony: Crushed by her own bible!
  • Disc-One Final Boss: Demoted to this on your second playthrough and beyond.
  • Evil Is Visceral: Likely the reason her body parts are detailed and somewhat deformed.
  • Evil Laugh: She lets out one every time she successfully damages Isaac.
  • Evil Matriarch: A monstrous final boss in the form of Isaac's mother.
  • The Faceless: Her entire face is never shown at any point in the main game (the intro and epilogue don't count, as they're Isaac's cartoon drawings). This is subverted after you beat the Chest in WOTL or Rebirth, but only briefly. In photographs, to be precise.
  • Fan Disservice: When Isaac uses the Mom's Bra item, a picture of his mother's shirtless torso flashes on the screen. A very unflattering picture of his mother's less-than-fit shirtless torso.
  • Fat Bastard: As shown by her giant leg and the picture that shows up when using Mom's Bra.
  • Final Boss: In your first playthrough. She's nowhere near the True Final Boss, though.
  • Flunky Boss: She'll summon groups of random enemies to battle Isaac.
  • Gameplay and Story Integration: Using the Bible instantly defeats her in her boss fight.
  • Giant Foot of Stomping: Her main method of direct attack.
  • Gonk: See that leg up above? That's all the proof you need.
  • Gross-Up Close-Up: One of her leg in the boss portrait, and one of her body in the picture that appears when using Mom's Bra.
  • Humanoid Abomination: Most of what she does in-game and in a few cutscenes blatantly disregards normal body movements if not physics. She can step on her own eye, generally alter her size, and her arm can fit in a chest inside her heart inside her womb.
  • Mook Maker: Spawns an array of previous enemies to make her battle harder. She does it from her body fat, which almost pours out of the boss room doors.
  • Mother of a Thousand Young: If you go by the theory that the majority of the enemies are her former children.
  • Say My Name: ISAAC!
  • Skippable Boss: Provided you have the Bible on you by the time you reach her, and it's fully charged.
  • Tactical Suicide Boss: It's not actually mandatory, but making her stomp herself is possible and deals lots of damage.
  • Voice of the Legion: Her dialogue consists of her screaming "Isaac" in a demonic voice.
  • Womb Level/Bigger on the Inside: After defeating her, you will unlock her womb as a playable level.
  • Your Size May Vary: Just how big is she? In the cutscenes, she's a normal-sized human being, but her underwear is the right size to be worn by a child visibly smaller than her, in the boss fight her leg is the length of the screen, and then her womb is big enough to have two entire levels in it, with her heart being larger than Isaac.

Mom's Heart/It Lives!
Debut: The Binding of Isaac
Defeating Mom once unlocks the Womb in subsequent playthroughs. At the end of the Womb lies Mom's Heart, which, summons enemies like Mom does. Defeating Mom's Heart reveals a Chest with something special inside. But once it's beaten enough times, it will become "It Lives!", which is Isaac as a fetus for some odd reason.
  • Battle Theme Music:
    • "...Be Done" in the original, completing Mom's theme and serving as a fast-paced theme to match the intensity of the fight.
    • "Ventricide" in Rebirth, echoing Mom's theme in leaning more towards darker guitar and pounding drums with a background choir, sounding far more sinister. The term "ventricide" in itself isn't real, but it would roughly signify "death of the womb", and could be seen as a Pun on "ventricle".
  • Boss Banter/Say My Name: Has the same voice lines as Mom.
  • Boss Rush: It Lives has the ability to spawn Degraded Bosses such as Monstro, Larry Jr., and Chub to fight you alongside the enemies.
  • Bullet Hell: Rebirth's version shoots red tears nearly constantly throughout the whole fight, even when retreating to the back of the room.
  • The Bus Came Back: The original Mom's Heart form, to an extent, in Afterbirth+. While unlocking It Lives used to make it so that you can no longer fight Mom's Heart, Afterbirth+ lets you fight Mom's Heart again in the Void, likely so that the Bestiary is completable for those who already unlocked It Lives. It also shows up as a possible boss encounter in the Womb stage of Greed mode.
  • Damage-Sponge Boss: Its lack of mobility is made up for by a big health bar. Its Eternal version in the Eternal Edition has even more.
  • Enemy Without/Fetus Terrible: It Lives is not just any embryo, it has been confirmed by Word of God to be Isaac's embryo.
  • Flunky Boss: Will summon enemies intermittently. It Lives ups the ante by spawning Degraded Bosses.
  • "Get Back Here!" Boss: Despite not moving, it accomplishes this by occasionally retreating above the screen and leaving you to deal with its flunkies for a while.
  • Mook Maker: Hides at the back of the room while it spawns normal enemies to fight you, then jumps back to the centre to spawn more.
  • Not Quite Dead: It seems that Mom survived their fight, or at least her heart did.
  • Skippable Boss: Using the Bible instantly kills it like it did with Mom.
  • Stationary Boss:
    • In the main game, all it can do movement-wise is pull itself upwards to hide from attacks, making bombs very useful against it.
    • The Eternal form in the Eternal Edition averts this greatly; it will pursue you relentlessly around the room until it dies, still spawning enemies.
  • Tactical Suicide Boss: In Rebirth, it moves to the top of the screen instead of disappearing entirely. Anything that wanders up there, enemies included, takes damage.
  • True Final Boss: Was initially this to Mom's Final Boss. However, this is subverted by the Halloween update, and further subverted by Wrath of the Lamb and Rebirth, to the point that it's no longer anywhere near the real final boss.

Debut: The Binding of Isaac
The original True Final Boss (although this isn't true as of Wrath of the Lamb and Rebirth), Satan himself is the boss of what was originally the game's secret floor. Despite offering Deals with the Devil throughout the game, he turns on Isaac and tries to kill him. His boss fight is comprised of three phases, detailed below under Sequential Boss.
  • Attack of the 50-Foot Whatever: His final form is him flying far above the screen and stomping on Isaac with giant feet a la the Mom boss fight.
  • Battle Theme Music:
    • "Enmity of the Dark Lord" in Wrath of the Lamb, an epic-sounding theme with techno and bells, along with heavy emphasis on bass.
    • "Hericide" in Rebirth, a theme with heavier guitar and Ominous Latin Chanting, along with a deep voice growling demonically. "Hericide" roughly means "death of the master/teacher/lord".
  • Black Speech: During the fight with him, he sounds somewhat like this. They are actually Mom's quotes, played backwards and in a much lower tone.
  • Deal with the Devil: He offers them throughout the game before you reach Sheol. Possibly even as you reach Sheol or after, if you have a Joker card on hand.
  • Evil Laugh: Since he uses Mom's voice clips, he can do this.
  • Faustian Rebellion: Even if you do a ton of deals with him, you can still kill him (and the power ups from said deals can make it all the easier).
  • Flunky Boss: His first form is spawning the Fallen to fight you instead. His third phase continuously spawns Kamikaze Leeches.
  • Frickin' Laser Beams: His second phase can fire dual Brimstone lasers from his hands (that can curve), or a single one from his mouth.
  • Giant Foot of Stomping: His third phase has him attempting to crush Isaac with his giant hooves. They work like Mom's, but he does it much faster.
  • Living Statue: His second form is a unique boss where the statue of Satan comes to life, grows much larger, and attacks Isaac with tears and lasers.
  • The Man Behind the Man: Implied; after all, he did at the very least string Isaac along through the Deals he makes in the devil rooms earlier on, before turning on Isaac at the last minute.
  • Nerf: Satan's legs in his third phase no longer deal contact damage in Rebirth.
  • No-Sell/Press X to Die: Using the Bible on him, which killed Mom and Mom's Heart instantly, kills you instantly instead. The same applies to later bosses, too.
  • One-Winged Angel/Sequential Boss: Has three forms (see Flunky Boss, Living Statue, and Attack of the 50-Foot Whatever respectively).
  • Satan: It's in his name, and he looks the part as well.
  • Say My Name: Satan's battle cry when you defeat his first phase is Mom's Boss Banter, only lower pitched and in reverse.
  • Sequential Boss: Three phases: first a fight with The Fallen, then a fight with Satan himself on the ground with you, and finally a fight against his giant stomping legs.
  • Tactical Suicide Boss: Those leeches he spawns don't just hurt Isaac.
  • Theme Music Power-Up: When you fight the Fallen, his first phase, the regular boss theme plays. When Satan actually starts fighting, however, Hericide kicks in.
  • True Final Boss: He was the final boss of the game in the Halloween update, but this has been since trumped by Wrath of the Lamb and Rebirth.

Debut: Wrath of the Lamb
After beating It Lives, the Cathedral is unlocked. At the end of the Cathedral resides Isaac himself.

Debut: Wrath of the Lamb
Completing the Cathedral with the Polaroid item allows Isaac to enter The Chest. At the end of this super-secret stage lies...the Blue Baby?
  • Back from the Dead: Is a post-mortem version of Isaac, naturally.
  • Battle Theme Music: While the original version of the fight in Wrath of the Lamb shared "My Innermost Apocalypse" with Isaac, Rebirth gave him a proper, original theme called "Ascension", which has discernible Latin lyrics and an aggressive rock beat with odd, creepy noises in the background at certain points.
  • The Cameo: From Edmund McMillen's flash series Dead Babies.
  • Divergent Character Evolution: In Wrath of the Lamb, ??? was mostly an Isaac clone right down to having the same boss theme, with the only real differences being his ability to spawn flies and periodically shoot homing tears. Rebirth reworked both bosses, and ??? was thus given a more distinctive pattern, most noticeably removing the beams of light in favor of increasing the rate at which he spawns flies, and a unique boss theme. The distinction is most obvious in their reworked final phases: Isaac prefers to fly away from the player at high speed while periodically teleporting away to saturate the room with beams of light, while ??? slowly flies towards the player while spawning flies and Pooters and occasionally teleporting into the player's face.
  • Flunky Boss: One way he varies from the previous boss is that he summons flies in addition to his other attacks.
  • Invincible Minor Minion: In Rebirth, he gets a halo of flies, which block your tears.
  • Orbiting Particle Shield: Rebirth gives him two Eternal Flies to block tears partway through the fight. He also gains the ability to summon Pooters, which orbit him at high speed and can thus serve as shields in addition to attacking the player.
  • Palette Swap: He is very similar to the previous boss, Isaac, so most of the tropes above apply to him too. This resemblance is downplayed in Rebirth by giving him different attack patterns from Isaac.
  • Teleport Spam: Utilized in his third phase in Rebirth, with a tendency to reappear right on top of the player.
  • True Final Boss: Of Wrath of the Lamb, being the boss of the only sixth chapter in the game, and since beating him unlocked the game's real ending. Subverted in Rebirth.
  • Weaponized Teleportation: Tries to teleport into the player during his third phase in Rebirth.

The Lamb
Debut: Rebirth
Defeating Satan and completing Sheol with the Negative item allows Isaac to enter The Dark Room, a dark reflection of The Chest. The skeletal demon known as the Lamb is the boss of this stage, and it fights with powerful attacks.
  • All Your Powers Combined / Confusion Fu: The Lamb's volleys of shots mirror those of previous bosses. This, combined with how it switches the type of bullet with each volley, and that all of its bullets are the same colour, make it a very difficult opponent to predict.
    • Shadow Archetype: The Lamb's attacks also resemble combinations that can be used by Isaac — for example, Monstro's Lung plus Homing Tears. Its Detachment Combat is a lot like the Pinking Shears. It even begins the battle in Isaac's crying position!
  • The Anti-Christ: In the Bible, the Lamb was a symbolic reference to Jesus. In this game, however, the Lamb is an undead demonic creature fought after Satan. The implication is that this Lamb is an alternate, demonic interpretation of Jesus.
  • Battle Theme Music: "The Fallen Angel", a dark, creepy, fast-paced song with an ominous choir and wail.
  • Blackout Basement: When the body on his second phase is defeated, the room will darken for a brief time.
  • Creepy Cool Crosses: Specifically, an upside-down one on his forehead.
  • Dem Bones: The Lamb is essentially a demonic skeletal child with curved horns.
  • Detachment Combat: His second form involves his head floating around the room attacking you while his body lies limply on the ground spawning flies and sometimes tossing out Monstro-style shots.
  • Dual Boss: His second form, in which his head floats around the arena and his body stays on the ground to summon Flies and fire off a burst of tears.
  • Flash Step: One of his attacks qualifies as this.
  • Frickin' Laser Beams: His second form gains the ability to shoot four-way Brimstone in the cardinal directions. He can also start rotating the beams like Mom's Heart/It Lives.
  • Horned Humanoid Skull for a Head: He looks like an undead demon.
  • Losing Your Head: During the second phase of the battle.
  • Mythology Gag: His name is a reference to the expansion for the original Isaac, named Wrath of the Lamb. He is also visually similar to Wrath of the Lamb's horned skull logo. Given that Edmund had more planned for the original Isaac, it's possible he was always intended to be the last boss of the expansion, but Flash's limitations meant he couldn't add him in.
  • Nightmare Face: Its skeletal face isn't pleasing to look at, especially in the vs. screen.
  • Off-Model: The Lamb's portrait in the versus screen is dark in colour, but in-game and in the Afterbirth+ trailer, The Lamb is coloured white.
  • Sequential Boss: Has two forms.

Mega Satan
Debut: Rebirth
In Rebirth, a giant golden door appears in the Chest and Dark Room stages. This door can be unlocked with a special item, which leads to Rebirth's ultimate boss battle.
  • Attack of the 50-Foot Whatever: Although the name probably gave it away.
  • Battle Theme Music: Shares "Hericide" with his own original form.
  • Boss Rush: He summons bosses as he takes damage, and more if you don't do enough damage fast enough.
  • Bragging Rights Reward: Besides unlocking the final and definitive ending, there is no reason to fight him other than to boast you did it. The only thing you get out of winning is a new picture for your save file. There are no associated item or character unlocks, not even a mark on the character file to indicate that character beat him. Averted in Afterbirth. He gets both character unlocks and a mark on the sticky note upon beating him, and beating him on hard mode is required for getting the final item (or co-op baby, in the case for everyone except The Lost) for every character.
  • Bullet Hell: What some of his attacks delve into.
  • Cognizant Limbs: His hands.
  • Damage-Sponge Boss: He's just shy of Hush in terms of overall health, and his individual forms have as much or more health than any other boss save Ultra Greed. He could actually be considered to have more health than any boss if you include the health of the mandatory boss fights. However, Mega Satan doesn't have the same damage-scaling property of those two, so he's functionally a whole lot weaker than they are.
  • Final Boss Preview: Regular Satan's third phase can be considered this. In Sheol, you only fight his lower half. In the Chest/Dark Room's secret room, you face the much more difficult upper half.
  • Flunky Boss: Summons The Harbingers, the Super Sins, and fallen versions of the Angels. If you take too long on one of his phases, he starts summoning regular Sins and lesser bosses such as The Hollow and Fistula.
  • Giant Hands of Doom: Accompanied by a giant head. The hands serve mainly to block shots aimed at the head, which is treated as the main boss.
  • Guide Dang It!: The only in-game hint you have to his existence is "The Angels await!" You're supposed to bomb the Angel statues in the Angel Rooms, prompting them to engage you; both will drop a piece of a Golden Key on defeat, and getting both pieces opens a Golden Door in the Chest/Dark Room that leads to Mega Satan.note  Fortunately, completing the key also unlocks "Dad's Key" as a regular item, which can also be used on the Golden Door for future playthroughs note .
  • Interface Screw: The only boss note  who doesn't have a health bar, in either form. Averted if you have the Spider Mod item, which gives him a Spider Mod health bar.
  • Marathon Boss: He has two forms, each of which has as much if not more health than every other boss excluding Hush and Ultra Greed. This is on top of all the other bosses he summons. Winning takes several minutes at least, and that's if you have a good enough run.
  • Red Eyes, Take Warning: Considering he was the True Final Boss of the game before the title was being uplifted by Delirium, you will want to take warning.
  • Sealed Evil in a Can: Heavily implied to be sealed by the beings in the Angel Rooms.
  • Sequential Boss: Including his summons, he has twelve phases.
  • Soundtrack Dissonance: Due to a bug, doing too much damage to any form will cause the calm, somber "boss defeated" music to start playing. This was eventually patched.
  • True Final Boss: The second to last True Final Boss of the game (which is saying something, considering there have been seven other candidates before it), hidden at the final stage and having an extra unlock process required each run. Delirium took over the role in Afterbirth+, but even then it is the final boss of an alternate route that also has a 50% chance of being available from Mega Satan.
  • Turns Red: Has two full health bars, and when you take down one of them, he really cranks up the Bullet Hell.
  • Wave-Motion Gun: If you stand in front of him for too long, he'll charge up a gigantic blood laser for a long time, making his head nigh-impossible to shoot.

Debut: Afterbirth
Defeating Mom's Heart or It Lives in under thirty minutes of total play time unlocks a short, hidden areanote . This area only has one enemy: Hush, which appears to be another Palette Swap of the Isaac and ??? bosses. Then he enters his second form, which is soundly described below.
  • Attack of the 50-Foot Whatever: According to Edmund, it's a giant ??? pushing through the floor.
  • Battle Theme Music: Its first phase shares "Ascension" with ??? (because according to Edmund, it is ???), before it transitions to the heavier and oppressive "Morituros" when Hush's true form emerges.
  • Body Horror: Hush represents Isaac suffocating inside the chest; unsurprisingly, its "face" looks like it's being asphyxiated inside a bag.
  • Bonus Boss: Hush is sort of the "Isaac" counterpart to Mega Satan. While beating it does grant you a new ending, it doesn't require you to end the game. Instead, you can opt to go to Sheol/Cathedral once the fight is over. This was later patched out; defeating Hush now plays the ending and ends the run, but only the first time you beat it.
    • Averted as of Afterbirth+; beating Hush is the only guaranteed way to reach the Void and fight Delirium, and is required to actually unlock the Void.
  • Bullet Hell: Its attack patterns during its second form. They even resemble the dense ring-patterns found in danmaku shooters like the Touhou games; fortunately, the projectiles fired by these attacks are some of the slowest in the game.
  • Damage-Sponge Boss: Has the second highest health of all bosses in the game. Furthermore, its defenses scale with your damage output, so no matter what items you have, it'll take a long time to wear down. Combine this with its numerous Bullet Hell attacks and absurd enemy spawns, and you have a brutal boss fight.
  • Eldritch Abomination: As an embodiment of impending death by suffocation that looks like a giant face molded from blue flesh.
  • Flunky Boss: Begins spawning hordes and hordes of minions as the battle goes on.
  • Marathon Boss: Hush has 6666 health and has a damage resistance mechanic which hardcaps how much damage you can do at once. Even an overpowered build will still take ten minutes to kill this thing.
  • Meaningful Name: To hush is "to put at rest", and seeing as this boss represents Isaac slowly suffocating in the Chest, the name is quite appropriate.
  • Number of the Beast: Its base HP is 6666.
  • Ocular Gushers: When low on health, Hush will fire out geyser-like streams of tears from its eyes that track you like a pair of Kill Sat lasers.
  • Sequential Boss: Fights like Isaac and ??? at first, but then it teleports away and its huge face comes out of the floor, firing loads of bullets.
  • Stationary Boss: Mostly. It begins laying on the ground, as a variant of Isaac and ???, then turns into a large bullet-spewing head. The head can move around, but generally, it stays still when attacking.
  • Suspicious Video-Game Generosity: Before the fight, the game gives you two item rooms, four golden chests, and a shop. Needless to say, you will need them.
  • Theme Music Power-Up: The first phase of the fight has Ascension playing in the background. Once the second phase begins, the music changes to Hush's own theme, Morituros.
  • Trick Boss: Shares a boss theme with ??? and fights like him, with a health bar that goes all the way down to zero, so you'd think that's all there is to him. Nope.
  • Wrap Around: It fires shots that go out of the room and then come back from the other side. Notably, these shots actually get faster after the wrap-around.
  • Zerg Rush: Easily spawns more enemies than any other boss in the game, throwing entire floors' worth of flies, Gapers, and Boils at you throughout the fight.

Ultra Greed/Ultra Greedier
Debut: Afterbirth (Ultra Greed)
Afterbirth† (Ultra Greedier)
The final boss of Greed Mode fought in a stage named after him. A giant version of Greed that uses coins to attack, summon minions or heal. And he still makes you drop money when hit.
  • Animation Bump: Ultra Greed moves around a lot, and the animations are extremely smooth and detailed.
  • Attack of the 50-Foot Whatever: A massive variant of Greed.
  • Bandit Mook: Like his smaller versions, his attacks will cause you to drop money. Unlike the others, however, he will actively pick up the money you drop, which heals him slightly.
  • Boss Remix: "Chorus Mortis". It incorporates elements of the shop and arcade themes, the latter of which is, itself, a remix of the title screen.
  • Crippling Overspecialization: Ultra Greedier uses almost nothing but explosive attacks. With Pyromaniac or the Host Hat, he is literally incapable of harming you outside of contact damage and highly telegraphed lasers.
  • Damage-Sponge Boss: His health is slightly higher than that of Mega Satan's first form, making him third overall, and the damage scaling means he'll last a whole lot longer.
  • Defend Command: One of his abilities is to shield himself with his arms, reducing all damage dealt to him, which he usually uses when he has flunkies or bomb coins active.
  • Fan Disservice: Has a large, visible, and well-detailed butt. He's also a massive corpse-like monster that ultimately has a little boy as the base of his design, and might even be an alternate version of a little boy.
  • Final Boss: Of Greed Mode.
  • Flunky Boss: Can spawn Keepers close to himself, call more minions from the arena's doors, and drop a bunch of large coins that will cast buffs on him if they're not destroyed.
  • Frickin' Laser Beams: In his second form, the doors shoot gold Brimstone beams whenever he pounds the ground.
  • The Gambler: His primary attack depends on the outcome of a slot machine. Although it's not that much of a gamble since every outcome is pretty terrible for you. You're just hoping that he gets one of the less terrible ones.
  • King Mook: To Greed and all of his mook counterparts.
  • Mad Bomber: One of his slot machine attacks is to drop giant bomb coins all over the arena. Ultra Greedier gains an explosive effect on all of his attacks.
  • Marathon Boss: His health is about half that of Hush, but he shares the same damage reduction mechanic to prevent you from winning too fast. Furthermore, he has the ability to heal during the fight, though not by much. Greedier Mode is even worse, as there's the second half to his fight.
  • Money to Throw Away: Uses large coins as projectiles. At times, huge ones fall from above. They can explode, heal Ultra Greed, or allow him to summon minions if you don't get rid of them.
  • No Cure for Evil: A notable aversion. He's unique in his ability to heal through heart coins, though it isn't very much. He'll also heal a little if he picks up the coins you drop.
  • Palette Swap: Ultra Greedier, Ultra Greed's gold-colored form.
  • Sequential Boss: In Afterbirth+, he becomes this in Greedier Mode. After beating his first form, his statue (now called Ultra Greedier) will start attacking.
  • Spin Attack: Does spinning lariats when you're close.
  • Stone Wall: His attacks, unlike most other final bosses, don't employ Bullet Hell and are comparatively easy to avoid. He makes up for this by being able to tank attacks that only Hush could withstand, with his damage reduction ensuring that he will always last for a few minutes. The challenge comes not from dodging him, but from outlasting him.
  • Tactical Suicide Boss: Downplayed compared to most examples, but his bomb coins can damage him as well. He uses his Defend Command to block most of the damage. His second form is even worse in this regard since all of his attacks have explosive properties and he no longer defends. Half of the time you won't land the final hit that kills him.
  • Taken for Granite: Ultra Greed turns into a solid gold statue when killed. Midas' Touch (touched enemies temporarily turn into gold) applies a penalty to his damage scaling property, letting you deal greatly increased damage. In Greedier Mode, he keeps attacking as a statue and explodes into a fine gold dust on death.
  • Turns Red: As he loses health, his attacks become faster and he spawns more giant coins, which also take effect more quickly. He also visually becomes redder as an indication of this. He also does this whenever heals via the Heart Coins from his slot machine or by picking up coins; the more he heals, the redder he gets. This is only temporary, however.
  • Your Princess Is in Another Castle!: On your first run through Greedier Mode. So you've beaten Ultra Greed, he's turned to a statue, and you wait for the Greed Machine to spawn... but it doesn't, and after a long pause, Ultra Greed's statue starts attacking you. This new form is appropriately called Ultra Greedier. He doesn't bother with the pretense on subsequent runs and will begin attacking in his statue form almost immediately.

Debut: Afterbirth†

The final boss of an area added in Afterbirth†, the Void. Beating Hush will unlock a floor made up of various different environments from the game, with this as the boss of one of its several boss rooms. It first appears to be a giant, melting skull, but will shift forms to white variations of the previous bosses.

  • Ambiguous Gender: Being less of a "person" and more of a manifestation of a mental breakdown that can change into almost any other boss from the game that takes the form of a gigantic skull, it's difficult to tell if Delirium even has a gender in the first place. A Tweet from Edmund McMillen during the promotion of Four Souls refers to Delirium with "him", however.
  • All Your Powers Combined: This is the boss' primary attack method. It will randomly transform into almost any other boss found throughout the game (including some of the other final bosses!) and take on the transformed boss' attack patterns, all while still firing off its own bullet rings. Once it Turns Red, it will shift through bosses much faster, and each form attacks far more quickly.
  • Battle Theme Music: The eponymous track, "Delirium", which perfectly matches the increasingly fast pace of the battle, at one point sounding like it's skipping like a scratched CD.
  • Berserk Button: Attempting to use the Chaos Card on it will not only fail, but also make it temporarily turn red and attack much faster.
  • Bullet Hell: Despite them being more simple, Delirium's bullet patterns manage to be worse than Hush's because it shifts into random bosses you've encountred in the run to change the pattern around, plus it never sits still. This is on top of Delirium's own unique bullet patterns being fired from the bosses along with their modified patterns. By the time you've got it down to 1/4 health, it'll be firing off a new pattern before the last one even finishes.
  • Contractual Boss Immunity: The single enemy who isn't harmed at all by the Chaos Card. In fact, all it does is piss Delirium off. Plan C (kill everything then yourself three seconds later) does technically kill Delirium, but its death animation is so long that Isaac will die before Delirium does. Lazarus is the only one who can get around this thanks to his ability to resurrect in the current room (Lazarus' Rags on another character will work, but Lazarus still gets the credit).
  • Damage-Sponge Boss: Clocks in at a whopping 10,000 HP, though it mercifully doesn't have the same damage scaling that Hush and Ultra Greed do.note  Even so, it teleports all over the place, so expect to spend a long time trying to kill this thing.
  • Defeat Means Friendship: It's not clear whether or not they're the same entity, but upon defeating Delirium for the first time, the player unlocks Delirious (spawns friendly bosses on their Delirium form to fight for Isaac) and Lil' Delirium (shapeshifts into one of a handful of different familiars and wins its effects).
  • Dying Dream: This creature, its environment, and the ending you get for defeating it drive home the point that most of what is seen during the game was Isaac's dying hallucinations.
  • Eldritch Abomination: A physical manifestation of a complete mental breakdown? Yeah, it qualifies.
  • Eyes Do Not Belong There: When transformed into The Husk or Conquest, Delirium will have a single eye or a pair of eyes respectively inside its mouth. Its Teratoma form also has an eye inside.
  • Final-Exam Boss: It's only able to transform into bosses you've previously encountered during your run; thus, learning how each boss attacks is vital for surviving the fight with Delirium.
  • Flunky Boss: Can spawn minions depending on what form it is in. Bizarrely, when it becomes the Haunt, it will often transform into a single Lil' Haunt instead, the only instance of Delirium assuming the form of a regular enemy rather than a boss. A bug also causes its health bar to disappear when this happens, but he can still be damaged in this form.
  • "Get Back Here!" Boss: With a 2x2 arena to fight in, you'll spend a fair portion of the fight trying to figure out where it teleported to. This isn't helped by it transforming into wall-hugging bosses like Mama Gurdy or extremely small ones like Isaac.
  • Glowing Eyelights of Undeath: Has yellow pinprick eyes.
  • Interface Screw: Will occasionally cause the arena to glitch and shift from one tileset to another, causing static to briefly fill the screen in the transition. This can happen anywhere in the Void, but is far more likely to happen when fighting Delirium. It is a guarantee when Delirium is dying, but by that point, there is little in the room that can harm you.
  • Marathon Boss: With its high health, constant teleporting, and shifting into whatever boss it feels like, you'll spend a large amount of time chipping this thing down to nothing.
  • Meaningful Name: "Delirium" is a disturbed state of mind. The battle plays out in a deranged and bizarre way, almost like some sort of hallucination.
  • Mind Screw: It's a giant, melting skull that turns into the other bosses wildly and at random (many of which are considerably smaller than it), and it's encountered in an area made of all of the past floors and fails to keep a consistent theme. Considering the name, nature, and location of this boss, it's implied that the fight is Isaac's mind breaking down.
  • Morphic Resonance: Delirium retains its coloring and often its facial features regardless of what form it takes, allowing you to tell it apart if it happens to spawn another boss monster.
  • My Life Flashed Before My Eyes: Delirium is a physical representation of the phenomenon, illustrated by its ability to shapeshift into bosses that you've encountered this run and its death animation, which plays back several moments from the current run.
  • Nightmare Face: A melting skull certainly isn't pleasant by any stretch of the imagination. And since its features are retained when it transforms, this can result in similar faces appearing on any boss in the game.
  • Ominous Visual Glitch: Its level may cloak the screen with static, changing the setting of the room where that happened. After beating Delirium itself, the screen will flash with static and various images from earlier in the run for an extended period of time. In this case, the "ominous" is because it represents Isaac's mind breaking down.
  • Shapeshifter: It can shapeshift into any other boss, taking on their attack patterns.
  • Shapeshifter Swan Song:
    • The less health it has, the more often it changes forms. At critical health, it can't stand still nor stay in a form for more than a few seconds!
    • Interestingly, the arena suffers this too. During Delirium's death animation, the arena glitches and shifts between several different appearances, finally stopping as he dies. Just after beating Deliriumnote , the end result is always the Chest, as that is closest to the "reality" of where Isaac is at that moment.
  • Teleport Spam: Can teleport around in any of its forms. As it loses health, this becomes more frequent, to the point that Delirium barely spends more than five seconds without doing it.
  • Timed Mission: Played with. If you want to guarantee access to the Void and thus to Delirium, you have to beat Hush, which means you need to beat It Lives before the 30 minute mark (or have Mama Mega! on that floor). That said, the portal to the Void has a chance to spawn after beating Mom or any subsequent boss, increasing as you go further. Mega Satan has a 50% chance at best. He's also the only boss for whom completion is tracked even on victory laps, however, so one valid strategy is to take your time gathering items on the first run, defeat The Lamb, and then speedrun through the victory lap with your items to reach Hush.
  • True Final Boss: Of Afterbirth+, and as that is the last major update to the game (for now), the game itself. Defeating it earns you the final ending to the game. Oddly enough, however, you can encounter it way before Mega Satan thanks to how its requirements and the level progression are set up.
  • Turns Red: The lower its health, the faster it shifts between forms and teleports.
  • Weaponized Teleportation: Even more than the ??? boss; Delirium loves to teleport directly onto you.

The Legend of Bumbo



  • Bad Boss: He'll stomp across the battlefield, crushing and killing his own mooks without any regard.
  • Flunky Boss: Spawns Dips and Corn Dips.
  • Talking Poo: Well, he doesn't talk, but he's a giant monsterous humanoid poo.
  • Toilet Humor: A poop-themed enemy named Loaf. Definitely something to expect in a Binding of Isaac installment.

The Duke

  • Suspiciously Similar Substitute: He's this game's version of The Duke of Flies, even boiling down to having almost the same name. Although, unlike his predecessor, he shoots out bullets.
  • Flunky Boss: Just like The Duke of Flies, he'll spawn flies between attacks.


  • Eye Scream: His eyes are detatched from his body and you can hit it to make it switch lanes.
  • Expy: He's pretty much a skinny version of The Bloat, whilst also borrowing Peep's name. Although he lacks the brimstone lasers and jump attack, his eyes are always detatched and he shoots out bullets.
  • Red Eyes, Take Warning: If one of his eyes turn red, that means it's about to attack you.

Shy Gals


  • Speed Blitz: He has quite a bit of movement points, starting at the end of the room and being able to move all the way up and attack you in one whole turn. Be prepared to protect (or heal yourself) when fighting him.


  • Blob Monster: A giant cube of green slime containing organs.
  • Dem Bones: Among the organs suspended in its body include some bones and a skull serving as its face.
  • Flunky Boss: Spawns small goo enemies.
  • Sickly Green Glow: It appears to be glowing, although it's most likely light reflecting through it.


  • Dem Bones: A skull and some bones inside some weird rotting purple goop...
  • Flunky Boss: Spawns flies.
  • Mighty Glacier: She only has one movement point, but has high health and can resist certain attacks each turn.


  • Attack Its Weak Point: The red, glowing heart within its ribcage, which has to be exposed in order for you to hurt it.
  • Dem Bones: It's a floating skeleton with a heart.


  • Flaming Skulls: It's one giant flaming skull that glows different colors.
  • Puzzle Boss: You must match tiles based on the color of its fire.



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