Roger Murtaugh (played by Damon Wayans)
A veteran detective with the LAPD's Robbery Homicide Division. He recently returned to work after suffering a major heart attack during the birth of his youngest child. His desire to reduce his stress levels as much as possible is constantly stymied by Riggs' hard-charging ways.
- Badass Grandpa: Not to Riggs' insane extent, but he still pulls off his fair share of awesome moments. Not to mention he's the one with the idea to jump out of a window with a vest of C-4 in his hands. All of this at age 57.
- Bald of Awesome
- Odd Couple: He's the uptight one in his partnership with Riggs, constantly on edge due to the epic messes Riggs leaves in his wake.
- Papa Wolf: Post a picture of his daughter in a bikini on your Facebook page. Just go ahead.
- Sharp-Dressed Man: He's almost always dressed impeccably (especially in contrast to Riggs) and keeps at least five spare outfits at the office in the event his clothes get dirty while on duty.
Martin Riggs (played by Clayne Crawford)
A former Navy SEAL and El Paso Sheriff's Deputy. He is in deep mourning after the deaths of his wife and unborn child and wishes nothing more than to die and see them again.
- Ambiguously Human: Riggs could well have superpowers, given that he can heal completely from bullet wounds in what appears to be days (and severe bruising in hours), explosions barely faze him, and he can tackle a woman off the top of one building and through the window across the street. Add to that his ability to function as a very competent detective despite near-constant drinking, unbelievable reaction time, and he almost never misses.
- The Alcoholic: Bourbon is never too far from Riggs' grasp. He even swigs from a flask while at work.
- Cowboy Cop: Unquestionably. The man is less a police officer and more a force of nature. He even has a Southern accent and wears cowboy boots for emphasis.
- Death by Adaptation: Surviving the entire film series, because of Clayne Crawford getting McLeaned, Riggs is killed visiting his wife's grave.
- Death Seeker: Just like in the first film, Riggs is nigh-suicidal on the job. To the point where he offers himself as a victim to a bank robber, saying that the death of a cop will give the robbery crew better leverage for negotiation. Of course, Riggs then grabs the gun and quickly shoots all the robbers dead.
- I Cannot Self-Terminate: Riggs assures Murtaugh he's not going to commit suicide. He says doing so would shame his deceased wife. His intent is to die on the job.
- Jabba Table Manners: He is disgusting when he eats. Murtaugh can only stare in shock.
- Made of Iron: Gets knocked back by an explosion, thrown off a car, and shot twice (once in the shoulder and once in the foot) in the first episode alone. None of these injuries stick; by the next episode, he's as fit and capable as ever.
- Odd Couple: He's the messy one in his partnership with Murtaugh, causing mass destruction to Murtaugh's chagrin.
- Porn Stache: Murtaugh's barber unfavorably compares Riggs' look with that of a 70's porn actor.
- Screw the Rules, I Have Connections!: Part of the reason why he's allowed to get away with so much as a detective is that his father-in-law is the City Attorney.
- The Stoner: Riggs likes to toke, although his usage is depicted as being driven more by grief than pleasure.
Dr. Maureen Cahill (played by Jordana Brewster)
A LAPD psychiatrist who's been assigned to monitor Martin Riggs. She's one of the few people who can see through his flippant facade and knows about the deep issues affecting him.
- Brainy Brunette
- The Shrink: Her job is to monitor police officers' mental health and make sure that they are fit to serve the city.
Trish Murtaugh (played by Keesha Sharp)
Roger Murtaugh's wife and a very successful criminal defense attorney who maintains a friendly rivalry with her husband's co-workers. Her immediate acceptance of Riggs is a source of consternation to her husband.
- Adaptational Badass: original movie version was just a housewife; this version is a high-powered attorney.
- Beware the Nice Ones: Trish is kind, upbeat, and reasonable....most of the time. In the courtroom, defending her client, she takes no prisoners. Riggs finds this out the hard way.
- Friendly Rivalry: As a criminal defense attorney, she's constantly going up against the LAPD's desire to lock up every person they arrest. It's normally friendly, though, with both sides sharing good-natured barbs.
- Mama Bear: If her family is threatened or harmed in any way, she becomes so ferocious that Roger meekly steps out of the way for his own safety.
- Pintsized Powerhouse: Nearly a foot shorter than her husband, but so formidable when properly motivated that even Riggs will back off. He remarks that she somehow seems to have gotten taller.
Captain Brooks Avery (played by Kevin Rahm)
Murtaugh's former partner who accepted a prestigious promotion (and hefty pay raise) to run LAPD's Robbery Homicide Division.
- Da Chief: He's constantly at his wit's end with Riggs and Murtaugh's wanton destruction of public property, even keeping track of their ever-increasing tab on a whiteboard in his office.
- Hoist by His Own Petard: He does too good a job of covering for Riggs and Murtaugh's antics and he ends up being the one labeled unstable by the LAPD.
- Punny Name: reversal of Avery Brooks.
- Sharp-Dressed Man: Murtaugh notes that Avery is wearing nicer clothes now that he's a captain.
- Straight Gay: His homosexuality is mentioned in passing.
Scorsese (played by Johnathan Fernandez)
A forensics specialist with LAPD's Scientific Investigation Division. He was saddled with his nickname because he graduated from film school.
Leo Getz (played by Thomas Lennon)
A sleazy ambulance chasing lawyer whose need to stick his nose in other people's business puts him in danger.