The GCU Grey Area - AKA Meatfucker - from Iain Banks' The Culture. A sentient spaceship that kills aging despots by making them die repeatedly while they sleep. He also reads your mind, and contains a museum of torture. He doesn't get many visitors..
The pirates of WarMachine's Mercenary faction has Doc Killingsworth. The mere threat of treatment is enough to make the wounded get up and back into the fight.
Ax Crazy troll gang member Shoot-to-Kill from Shadowrun, most notable for winning her boyfriend back by leaving him a love letter, alongside the head of her love rival, in the fridge.
Or any use of the name, really. The Harkonnen Devastator from the Dune games is the biggest, baddest tank around. In Duke Nukem 3D, Devastator is the local BFG.
Decepticons in general. You'd at least figure the world would realize you can't trust one. It's not 'til 25 years after their debut when, in Transformers Animated, someone actually brings up the name thing. (Jazz: "Deceived by a Decepticon. Who knew?")
Though not truly a verb, Rapine Storm of Cthulhu Tech still qualifies as something to run away from. Pity that doing so will probably mean you run into something worse, given the setting.
You should probably run very fast from a weapon the military designates an "Annihilation Platform". Especially when the individual unit's name has a 'mor' in it, being "Moritz-G."
Louis the Pious had three sons, Pepin II, Charles the Bald, and Lothair. Guess which one tried to take over the Holy Roman Empire...
Apparently, a man in Britain named Rob Banks was accused of bank robbery. The court subsequently granted him the right to be tried under a pseudonym on the grounds that his name might, in fact, influence the jury.
Detective Slaughter on Castle is a Cowboy Cop whose nickname is "the Widowmaker". He earned it based on his partners' life expectancy. Not that gangsters fare much better with him around...
Tod Slaughter, known for his roles in film adaptations of Victorian horror melodramas and is particularly known for his portrayal of the original Sweeney Todd from the penny-dreadful "The String of Pearls".
Former Cleveland Browns wide receiver Webster Slaughter.
Baseball Hall of Famer Enos Slaughter, particularly if you were a pitcher in the 1940s.
The Shivans from Freespace. Not only were they named after Shiva, the Hindu God of Destruction, but they were also dubbed as "The Destroyers" by the Ancients.
The final boss of the storyline in Borderlands is named the Destroyer. Amusingly, the mission where you fight it is named "Destroy The Destroyer".