Iron Woobie: Despite going through so much psychological trauma and suffering, Robert always gets back on his feet, even if he's fully aware the world will soon smack him back on his knees. He just embraces his predictment instead. Even when he eventually commits a suicide, he does it more out of spite than anything else.
It Was His Sled: Neville committing suicide in the final pages, after learning he is now the stuff from scary legends, not the vampires.
Narm: Neville tearfully begging a mannequin to say hello to him.
One-Scene Wonder: She has about 1 minute and a half of screen time at the beginning of the film (and isn't listed in the credits), but Emma Thompson as Alice Krippin is so delightful you desperately want to know more about the woman who inadvertently created The Virus.
Special Effect Failure: The zombie/vamps are pretty obvious CG. They tried using extras at first, but since it required constant hyperventilation, they were forced to use CG instead.
They Wasted a Perfectly Good Plot: The film's alternate ending comes closer to the message of the novel than the ending that made it into the movie and fills the above-mentioned plot hole, in addition to many others. It did poorly with test audiences, though, so Executive Meddling changed it to an ending that is completely different and misses the point of the entire novel, twisting the message so that it can still fit the title, but in almost the exact opposite way that the original ending fit it.