- Playing Against Type:
- Recycled Script: The game seems to take a lot from the first season of The Super Hero Squad Show: a cosmic object has broken and been scattered, so the heroes, based in the Helicarrier, must collect the pieces before Doctor Doom and his army of villains, all ending in Galactus attacking Earth and the two sides forming an Enemy Mine to stop him.
- Role Reprise: A significant proportion of the voice cast are sourced from earlier Marvel animated series and games.
- From the X-Men Legends series: Steve Blum reprises his role Wolverine, as he always does.
- From The Incredible Hulk: Ultimate Destruction: Fred Tatasciore reprises his role as The Incredible Hulk again, as per usual.
- From Ultimate Avengers in addition to the Hulk: Nolan North reprises his role as Hank Pym/Ant-Man and James Arnold Taylor reprises his role as the Winter Soldier (albeit he was only Bucky in that film).
- From Hulk Vs. in addition to the Hulk and Wolverine: Nolan North reprises his usual role as Deadpool.
- From Wolverine and the X-Men in addition to Wolverine himself and the Hulk: Nolan North reprises his role as Cyclops and Pyro, Kari Wahlgren reprises her role as Emma Frost, Yuri Lowenthal reprises his role as Iceman, Fred Tatasciore reprises his role as Beast, Phil LaMarr reprises his role as Gambit, and Stephen Stanton reprises his role as the Blob.
- From The Avengers: Earth's Mightiest Heroes! in addition to the Hulk and Wolverine, Dee Bradley Baker reprises his role as Reed Richards/Mister Fantastic, Steven Blum reprises his role as Red Skull, Jeffrey Combs reprises his role as the Leader, and JB Blanc reprises his role as Heimdall (who was white in the show and black here).
- From The Super Hero Squad Show in addition to Wolverine: Dave Boat reprises his role as the Thing and Tara Strong reprises her role as H.E.R.B.I.E.
- From Marvel Ultimate Alliance series in addition to Wolverine and the Hulk: James Horan reprises his role as Doctor Strange.
- From Spider-Man: Battle for New York: James Arnold Taylor reprises his role as Spider-Man.
- From Marvel Avengers: Battle for Earth in addition to Spider-Man, Wolverine and Hulk: Roger Craig Smith reprises his role as the Human Torch and Laura Bailey reprises her role as Jean Grey.
- From the Marvel Cinematic Universe: Clark Gregg reprises his role as Phil Coulson.
- From Iron Man: Adrian Pasdar reprises his role as the titular Tony Stark.
- From Avengers, Assemble! in addition to Iron Man and the Hulk: Roger Craig Smith as Captain America, Travis Willingham as Thor, Troy Baker as Hawkeye and Loki, and Laura Bailey as Black Widow.
- What Could Have Been:
- Demos for LEGO Marvel Superheroes showed that the Green Goblin could turn into his Ultimate incarnation. They are instead separate characters in the actual game.
- Lady Deathstrike was originally going to be in the game, but was cut.
- The box art and the mini comic for stage five suggests that Tony was originally meant to upgrade to the Mk. 7. Instead he goes to Mk. 42
- In one interview, the designers said they had considered giving Captain America a gun, but they decided it would be too difficult to add with his other abilities.
Trivia / LEGO Marvel Super Heroes