Harsher in Hindsight:
- "Turban Cowboy" focused on Peter unwittingly joining a terrorist organization that planned on blowing up a bridge. That episode contained a cutaway gag about Peter winning the Boston Marathon by driving through the racers and killing them. That episode aired three weeks before the Boston Marathon Bombing.
- "Road To The Multiverse" ended with Brian's alternate-universe counterpart being hit by a car after returning from his journey. This ends up happening to the real Brian at the end of "Life Of Brian", Killed Off for Real killing him; however, this managed to be stopped later on, possibly erasing two-and-a-half episodes.
- In "Dog Gone", Brian ends up accidentally running over and killing another dog with his car...but his family doesn't care whatsoever. This ultimately happened to Brian himself, but was thankfully prevented
- Any episode where Brian laments his mortality ("Brian Sings and Swings", "Brian and Stewie", etc.) or someone laments it for him ("Wasted Talent", etc.) becomes this after Brian ends up dying in "Life of Brian".
- This particular line, from "Wasted Talent", is gut-wrenchingly prophetic:
Peter: Beer that never goes flat. Do you know what that means, Brian? This beer will still be carbonated long after you die of old age and we buy another dog to help the kids...you know, forget about you.
- In other media, Brian's death can be really uncomfortable to those who know about the popular Dead Bart Creepy Pasta. Why? Because of the story's eerily similar premise to "Life of Brian", both of which feature a typical start to an episode, only for unthinkable to happen when one of the main characters suddenly dies in a horrifying, gruesome manner, followed by the remaining characters grieving at said character's funeral. Though not official, all you can say is at that point is....."Simpsons did it first!" indeed.
Stewie: You know, you're so in-tune with other people's faults, yet so oblivious to your own. Webster's has words for people like that. Asshole!
- Early episodes took a lot of potshots at Ted Turner, particularly "Screwed the Pooch", which paints him as Too Dumb to Live and willing to have sex with a dog. Kinda awkward now, considering that Cartoon Network was instrumental in saving the show from cancellation (the DVD sales helped too, but the reruns on Cartoon Network showed that the show can get big ratings).