- Adaptation Displacement: The animated series is more well known than the original comic.
- Awesome Art: The animation has aged very gracefully.
- Awesome Music: The opening theme song.
- They also recorded a full three minute version, which has never been released and probably never will be.
- The ending song isn't that bad, either.
- Complete Monster: Dr. Von Reichter is a cruel scientist with two concerns: conquering the city of Meridiana, and exterminating his hated creation Cybersix. Throughout the series, Von Reichter engages in various ploys to achieve his goals, such as: resurrecting Cybersix's little brother Cyber 29 as a panther, only to wipe his mind and use him as a weapon against his sister; sending in the werewolf Elaine, who attacks civilians and transforms them into more of her kind; and making countless attempts on Cybersix's life. In the final episode, Von Reichter grows weary with his failures, and tries to wipe Meridiana and its populace off the face of the Earth with a gigantic living bomb known as the Isle of Doom, so that the rest of the world will take him seriously as a threat. Even when he is thwarted and moments from being blown to kingdom come, Von Reichter still makes one last effort to ensure Cybersix's demise by setting his remaining creations upon her.
- Fandom Rivalry: With Mega Babies, at least with Teletoon viewers. Fans of Cybersix were upset that season 2 wasn't going to happen while Mega Babies, a show that they perceived as low quality, continued to air for four seasons. (This related to both shows airing in the US too; Cyber Six only aired briefly on the Fox Kids block and was Screwed by the Network— as were lots of other shows— in favor of Digimon and Monster Rancher as to compete against Kids' WB! and Pokémon, while Mega Babies aired on FK's sister network Fox Family and, owing to the mess that channel was in, was one of its' highest rated shows, leading to its' aforementioned extra seasons, which not even its' own creators, the Tremblay brothers anticipated.)
- Hilarious in Hindsight: Lori's Anime Hair in the cartoon (bright red mullet, short bangs, with one longer side-bang) makes her unintentionally resemble Noriaki Kakyoin.
- I Am Not Shazam: Sort of. The lead character's name as written on her left arm is 'Cyber 6', and the comic explains that she is the last survivor of a previously-wiped-out 'cyber series' (occasionally referenced in the show). But the title sequence says 'Cybersix', and characters often pronounce it that way, run together as one word.
- The only character who calls her "Cyber Six" is her creator, Von Reichter.
- LGBT Fanbase: Considering it features one of the few nonbinary-coded, possibly genderfluid, protagonists out there along with a possibly bi love interest, absolutely.
- Macekre: Largely averted in the sense that most of the darker elements, such as Von Reichter's being a Nazi, are not censored, but simply glossed over and not overtly mentioned.
- A little bit of the more sexual content was censored, though. For instance, Lori's "valentine" from the first episode was an offer for a quickie in the hall in the original.
- Mexicans Love Speedy Gonzales: While having a character who is a giant Japanese racist stereotype. How does it do this? It takes a guy with extremely squinty eyes, glasses, and buckteeth who knows kung fu and whose Leitmotif is done with a Japanese instrument... and it makes him a brilliant detective with a grappling hook, lots and lots of ingenious technology, and the most insane biking skills in the world. His little sister, sharing the teeth and eyes, drove it even further by being dressed in a kimono the entire time. She was adorable, though, and was able to keep her cool while having been kidnapped, impressive considering that she looked pretty young. In the show's defense, however, this was an episode that was based off a storyline in the original series, and the designs were likely lifted from the comics too.
- And it's pretty clear that his kung fu was just meant to confuse the Fixed Ideas. José eventually waves them aside and tries to perform some kung fu of his own, only to fall on his butt as Yashimoto makes his escape.
- The obvious one, he figures out Cybersix's identity using genuine detective skills and physical agility that allows him to actually keep up with her.
- Also some of the features of them, like the buck teeth, were shared by a number of Caucasian characters as well.
- Plus his voice is anything but stereotypical "Asian." He actually could stand in for Batman if he wanted.
- Squick: The scene where Lori flirts with Jose in "Lori is Missing" becomes less funny when you find out Jose raped her, in the comic.
- Speaking of Lori, most of her moments in the comic is this, considering her creepy infatuation with Adrian (aka Cybersix) and how she attempted to rape him.
- Tear Jerker:
- The ending of the episode, Terra.
- Also, when it appears that Cybersix is blown up in the last episode. Though it is implied she is alive at the end of the episode.
- In the last episode, perhaps it's because of the music playing at the same time, but the deaths of all the mutated creatures created by Von Reichter when his lair is destroyed is surprisingly a little poignant. While they look grotesque, they are shown to be intelligent and not malicious, as the only thing they do once freed is to attack the man responsible of their current condition, not Cybersix. One of them even silently shows Cyber an escape way and smiles at her, as if to say to her that she has to go without them, while the latter clearly looks sad that she has to leave them in order to escape.
- The Woobie: Terra, from his self-titled episode. Poor thing was one of the more sentient Mooks who wanted to understand love as Cyber knew it, but was forced to go after harsh alterations and verbal beatdowns from Jose, until the end when Terra sacrifices himself to rescue Cyber from burning to death.
- Values Resonance: On the plus side, most modern audiences relate to this show and to a lesser extent the comic due to having a protagonist that can be seen as genderfluid and not portraying Lucas as unusual for wanting to spend Valentines with someone he assumes to be a man.
YMMV / Cyber Six