- Career Resurrection: Lee Van Cleef hadn't worked in films since How the West Was Won, although he had worked fairly steadily in television. By this stage, he'd fallen on hard times due to his heavy drinking. The film effectively marked a resurgence in his career. note Van Cleef had taken up painting in the interim as a way of making money.
- Deleted Scene: Several scenes were allegedly shot, but it is debatable if they were shown in any version of the film. Stills exist of all the sequences. They include:
Mook: Why let them live?
- Monco looking at the reward poster for Red Cavanaugh, and later taking the poster of El Indio off a wall.
- When Indio has broken out of jail, he baptizes his gun.
- Monco beds the hotel manager's wife, Mary, in El Paso.
- Monco shoots three of Indio's men by a river, transposed into a desert setting instead.
- In Agua Caliente, Indio and his gang relax with some women from the village.
- In 1967, the censor removed Indio's rape of Mortimer's sister and her suicide, but it has been restored for DVD and Blu-ray. Many of the action scenes were also trimmed for television versions, particularly Indio's escape from prison and the shootout in Agua Caliente.
- Early American and British VHS releases and TV broadcasts feature an extended version of the scene where El Indio tortures Mortimer and Manco, including some new dialogue:
El Indio: All things at the right time.
- Hey, It's That Place!: When Colonel Mortimer gets off the train in the beginning, look to the left. La Calahorra Castle can be seen in the distance.
- Hostility on the Set: During filming, Sergio Leone felt that Gian Maria Volontè was sometimes too theatrical as Indio and would often use many takes as a way of trying to tire the actor out. Volonte became so angry with Leone's methods that he eventually stormed off the set. Unable to get a ride across the desert he returned to resume filming but swore he would never make another western again, which he felt was a tired genre. In fact Volonte would make several Westerns after this, notably A Bullet for the General and Face to Face, which incorporated political themes agreeable to Volonte.
- Looping Lines: As all of the film's footage was shot silent, Clint Eastwood and Lee Van Cleef returned to Italy where they dubbed over their dialogue, and sound effects were added.
- Multiple Languages, Same Voice Actor: Although he did not know any English, Gian Maria Volontè did perform his own voice for the English language version. However, he did need a translator to tell him everything word-for-word.
- Playing Against Type: This, any several other spaghettis such as Sabata, is one of the few times, besides, say, Escape from New York, that you'll ever see Lee Van Cleef play a heroic character of any type.
- Underage Casting: Col. Mortimer is said to be almost fifty, yet Lee Van Cleef was forty at the time.
- What Could Have Been: Sergio Leone wanted either Henry Fonda or Lee Marvin for Col. Douglas Mortimer. Fonda was ruled out as being too expensive and Marvin turned it down in favour of Cat Ballou. Charles Bronson turned it down feeling it was the same as the first film. Leone also considered Robert Ryan, one of his favourite actors since The Naked Spur, and Jack Palance.
- You Look Familiar:
- Lee Van Cleef played the Bounty Hunter Colonel Douglas Mortimer, who worked as the protagonist's ally. Van Cleef later plays the villain Angel Eyes in The Good, the Bad and the Ugly.
- El Indio's actor, Gian Volonte, also played Ramon, the villain in A Fistful of Dollars. It can be somewhat jarring if you watch the two movies back to back. It could have been worse: Volonte was originally supposed to play Tuco in The Good, the Bad and the Ugly as well, but Leone later decided he wanted an actor with a natural comical talent, and Volonte wanted to star in A Bullet for the General.
- Also Luigi Pistilli, who played Groggy in this film, played Tuco's brother Pablo in The Good, the Bad and the Ugly.
- Mario Brega as Nino, who played Chico in A Fistful of Dollars and would go onto play Corporal Wallace in The Good, the Bad and the Ugly.
- The actor who played Guy Calloway in the film would later play Blondie/Manco's ill-fated scam partner Shorty Larson in The Good, the Bad and the Ugly.
- The bartender in Tucumcari would later play a similar bartender in a deleted scene of The Good, the Bad and the Ugly.
Trivia / For a Few Dollars More