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You are about to enter the final chapter. You won't be able to go back to previous areas. Will you enter now?

Long last, we arrive at the final showdown. No more defibrillators. No more blood transfusions. Now, me and you, we are dancing on the edge of life and death. Four items each. You know the drill.
The Dealer entering the final round, Buckshot Roulette

POINT OF NO RETURN!
Once you start the party, you won't be able to catch Bugsnax or complete quests! Be sure you've done everything you want to before continuing!

"There is no going back beyond this point. Make sure that you have no unfinished business left, such as uncompleted missions."
Crisis Core: Final Fantasy VII Reunion

You've reached the point of no return. When you enter the restaurant, you will be locked out of all unfinished Side Jobs and other activities like Gigs until all your Main Jobs are complete. If you have any unfinished business, settle it before meeting with Hanako.

Do you require anything before we begin our journey to Urdak? You will not be able to return until the mission is complete.
Dr. Samuel Hayden, Doom Eternal

A word of caution... once you cross that threshold, there is no turning back. The great doors must remain barred. I will open them for no one until I have proof that it is safe.
Knight-Commander Greagoir regarding the "Broken Circle" Plot Tunnel; Dragon Age: Origins

So are you ready? It's a long trek. If you have any business you need to wrap up here, you'd better do it now.
Bartrand regarding the expedition into the Deep Roads, Dragon Age II

I'd wrap up any other business before we go. It's already a mess - and could get worse.
Aveline regarding business with the Qunari's Arishok, Dragon Age II

"This [key] is for the attic. Only go in there when you're sure you're ready, okay? There's no turning back once you open that door."
Bill, Dysmorph: A Sinful Story of Change

"Finally, it's complete! The Phase Distorter, version 2, is equipped with two new features. First, it can repair your biological functions. Second, it can save your progress. Don't be afraid, get right in! ...There is just one thing, though... You may not be able to return. So make sure you are optimally outfitted. Are you ready to go?"
Yes
No
Dr. Andonuts, EarthBound (1994)

If you are reading this, you are ready to complete the search for Mr Eaten's Name. Doing so will irrevocably and forever place your character beyond use. This is not a joke, or a trick, and there are no rewards beyond the completion itself. Consider carefully why you have come this far. Consider what it is you are seeking. Discuss it with your friends and enemies. Be ready.
Fallen London, "Final Preparations"

In the southwest seas, the sanctuary of death has arisen. Beyond the reach of mortals, it waits. If it is a path to Pandæmonium you seek, passage thither I shall grant. Yet these words you had best well heed: from nowhere, nothing can return. In case the memory of your life should fade, let now your peace be made.
Claes Celestia Misca Sancest, Final Fantasy Type-0

I should warn you... we're about to pass the point of no return. I trust you're not having any second thoughts?

"You have reached a pivotal moment in the story. If you continue, you will not be able to return. Proceed?"

Alm: Grandfather, what's this door?
Mycen: It leads to the altar beneath Duma Tower. But know that it is a path not easily returned from. Prepare well before you enter.
There is no turning back beyond this point. Are you prepared?

"This decision will drastically change the story."
Fire Emblem: Three Houses on the decision whether to accompany Edelgard to Enbarr and whether to join her after the Black Eagles version of Chapter 11.

Gade: The end is nigh. Are you ready for it?
Kat: The end?! What are you talking about?
Gade: Call it Creator's intuition, but I sense a disturbance in the fabric of reality, as if a great many things were moving toward their conclusion. It may be your last chance to go to the rift planes or to take care of other business. Something big is about to happen.
Kat: Well, if you say so. I suppose it wouldn't hurt to make sure I'm prepared for... whatever you're talking about.

<<Warning>> Things are going to get pretty intense from here on, so if there's anything you want to do, now is the time. It might be a good idea to save your game too, just in case. This is almost the end of the story, so settle in for the climactic finale. It could take awhile, so if you need to sleep, continue at your own discretion. You can save along the way, but once you start, you can't go back, so consider making a separate save.

Careful. This is the last haven you'll find here. Beyond, there is no light to protect you.
Disembodied voice, Kingdom Hearts

Once we go through, there's no turning back. It's victory or oblivion. So, Sora... are you ready?

Tough it out!
Kirby 64: The Crystal Shards' pause menu, replacing the option to leave the level when in Dark Star

Once the operation commences, Machias will become a fixed member of the party and the main story will advance. This is the last time during the story that you will be on board the Courageous. This also means that you will not be able to travel to other towns or use their shops or facilities. All quests and sub-events will disappear, and Trial Chests will become permanently unavailable. While it will eventually be possible to restock, this won't happen for a significant period of time.
>Commence Operation
>Continue Preparing

Rean: (Heimdallr Cathedral... Emma and Gaius said people wish to speak with us. It'll probably take a while, so we should take care of any unfinished business.)
System: The story will progress upon entering the cathedral. All additional challenge elements will end.
>Enter the Cathedral
>Leave

*WARNING* THIS DECISION WILL AFFECT YOUR ENDING

"Please confirm destination, Shepard. The Reaper IFF is online, but there is a chance that the Normandy may not survive the Omega-4 relay. Once we are en route, we are committed."
EDI, Mass Effect 2

"Once we're committed against Cerberus, it won't be long before the Reapers take notice. [...] Once we attack, the Crucible won't stay safe for long. For all intents and purposes, an assault on Cerberus will be the first stage of our attack on Earth."
Admiral Steven Hackett, Mass Effect 3

"We meet again. There's something I've been wanting to show you. But remember... From here, there's no turning back! I'll be waiting for you here. Call me when you're ready."
Aile to Grey, Mega Man ZX Advent

What was once changeable, is now set in stone. Of what was gleaming with possibilities, none remain. We can only move on, and let fate dictate the rest.
Ending of all After Midnight event chains, The New Order: Last Days of Europe

"Pass beyond the Gate of Finis, and never again may you return to this world. Follow us if you so choose. But first, be certain that is truly the path you wish to tread."
Lyblac, Octopath Traveler

"It be too late to alter course, mateys..."
Jolly Roger, Pirates of the Caribbean

Rivet: So, how do we find the Emperor?
Captain Quantum: Before I say, are you sure you're ready? There's no turning back after this.
<<ARE YOU READY?>> The final showdown is at hand! This is your last chance to acquire armor and collectibles before the end of the story. Are you sure you want to continue?

"Might want to take care of any leftover errands before going this way. Be a shame to live the rest of your life wondering 'what if' — am I right?"
The Merchant, Resident Evil 4 (Remake)

The Duke: Mr. Winters, I'm afraid you can't return to your old world any longer. Are you ready?
Ethan: Yeah. I have to be.

Telephone: Are you ready to visit the promised land?
Not yet...
> Let's go!
Telephone: This is it. Are you [ERROR] ready to ascend to the higher plane?
On second thought...
> For sure!
Telephone: The promised land awaits. Are you ready to join something bigger than yourself?
If you put it that way, I'm out.
> OK!
Splatoon 2: Octo Expansion

Agent 2: I think it's pretty clear that we have to get into that rocket somehow. Are you ready to try this?
> Yep!
Hold on...
Agent 1: Oh, hey! Is all your Hero Gear the way you want it?
> Sure is! Let's go!
''Not quite... Hold on a sec.
Agent 2: The captain's saying, "This is the final confirmation. Are you really, super-ultra-mega sure you're ready?"
> For the last time, I AM READY!
You're scaring me! I'll wait!
Splatoon 3: Return of the Mammalians

WARNING
This is your last chance to collect resources to upgrade gear before the end of the story.
X ACCEPT ◎ CANCEL

"There is a feeling of finality in the air, as if beyond this door lies the end of your story..."

"This is the barrier. This is what keeps us all trapped underground. [...] If... If by any chance you have unfinished business, please do what you must."
Continue
Go Back
King Asgore Dreemurr, Undertale

THIS IS YOUR LAST CHANCE TO DO LITERALLY ANYTHING OTHER THAN WHAT YOU'RE ABOUT TO DO
VideoHole: Episode I

Hey, just a head's up. I have this weird feeling in my guts that, if you go further; you might not be able to explore the city again, like maybe this is some sort of Point of No Return. It's just a feeling I have. Do what you will with that information, alright?

"You get the strangest feeling this is your last chance to turn back..."
Go on anyway
Better hold off
The World Ends with You, when the player is about to venture deeper into Shibuya River.

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