Two funny guys who travel around the world (often in the Hollywood Atlas version), and though often at odds with each other are ultimately inseparable. They take on various odd jobs, Short Cons and capers, often to pay off their debts. They can go flat broke even quicker.
They often will have to compete for the affections of one local girl who assists them in their escapades.
- Ran and Meow from Kazemakase Tsukikage Ran are constantly traveling, and sometimes together. Money is a frequent problem because Ran keeps drinking all of it.
- The Road to ... movies with Bob Hope and Bing Crosby (and Dorothy Lamour as the love interest) are the Trope Codifier.
- Ostap Bender and whoever he is travelling with (Ippolit Matveevich in The Twelve Chairs and the duo Balaganov & Panikovsky in The Little Golden Calf). Subverted in that his buddyships ultimately go sour: Ippolit betrays him out of greed, Panikovsky dies and Balaganov gets arrested.
- Sam and Dean from Supernatural do a lot of traveling. As Dean puts it "Dad wants us to pick up where he left off. Saving people. Hunting things. The family business."
- Doctor Who:
- The First Doctor and Vicki would have this kind of dynamic, especially in their historicals - usually, Ian and Barbara would get into trouble, and the Doctor and Vicki would attempt to resolve that trouble through the Doctor excessively meddling in a Crazy Awesome way, with Vicki helping him out with Stereo Fibbing and the occasional spot of theft. This dynamic proved so popular that later Doctor/companion duos became more common (as opposed to the rotating quartet of Hartnell) and tended to be of the "Doctor and cheery supporter" mold rather than "Doctor and Foil" - notably the Second Doctor and Jamie, the Third Doctor and Jo, the Fourth Doctor and Sarah Jane, the Eighth Doctor and Grace, the Ninth/Tenth Doctor and Rose, and so on.
- Naturally, given that it's styled after the Road to ... movies listed above, The Road to El Dorado had Miguel and Tulio. They have lots of comedic shenanigans traveling to El Dorado and and more places, including competing over Chilo.
- Brian and Stewie on the various "The Road to..." episodes of Family Guy. They're specifically homages of the Crosby/Hope films, played surprisingly straight for Family Guy. They travel the globe to their destination, sticking together through thick and thin (and usually conning their way through various situations).