
Whitford was married to Malcolm in the Middle actress Jane Kaczmarek for 16 years. He is now married to his Transparent costar Amy Landecker.
Selected Filmography:
Live-Action Film
- Revenge of the Nerds II: Nerds in Paradise (1987): Roger Latimer
- Young Guns II (1990): Charles Phalen
- Robocop 3 (1993): Jeffrey Fleck
- Billy Madison (1995): Eric Gordon
- Red Corner (1997): Bob Ghery
- Bicentennial Man (1999): Lloyd Charney
- Kate & Leopold (2001): J.J. Camden
- The Sisterhood of the Traveling Pants (2005): Al Lowell
- Little Manhattan (2005): Adam Burton
- An American Crime (2007): Leroy K. New
- The Cabin in the Woods (2012): Steve Hadley
- Marvel One-Shot: Agent Carter (2013): John Flynn
- Saving Mr. Banks (2013): Don DaGradi
- Get Out (2017): Dean Armitage
- Unicorn Store (2017): Gene
- The Darkest Minds (2018): President Gray
- Destroyer (2018): DiFranco
- Godzilla: King of the Monsters (2019): Rick Stanton
- The Call of the Wild (2020): Judge Miller
Live-Action TV
- The Secret Life Of Men (1998): Phil
- The West Wing (1999-2006): Josh Lyman
- Studio 60 on the Sunset Strip (2006-2007): Danny Tripp
- The Good Guys (2010): Dan Stark
- Trophy Wife (2013-2014): Pete Harrison
- Transparent (2014-2019): Marcy / Magnus Hirschfeld
- Brooklyn Nine-Nine (2015-2017): Roger Peralta
- Happyish (2015): Jonathan Cooke
- The Handmaid's Tale (2018-present): Joseph Lawrence
- Perfect Harmony (2019): Arthur Cochran