Characters / The Binding Of Isaac Final Bosses

The Binding of Isaac Main Character Index
Main Cast | Monsters (Enemies | Bosses | Final Bosses)

Yes, bosses. Your very first playthrough will likely end at Depths II with you killing Mom, but as you beat the game repeatedly, you unlock more chapters, each with a Final Boss bigger and tougher than before.

All spoilers are unmarked on this page. Proceed at your own caution!

Introduced in the base game

Mom

Mom

Voiced by: Patty Allen-Scott (The Binding of Isaac), Carla Kihlstedt (Rebirth onward)

ISAAAAAC!

Debut: The Binding of Isaac

Floor(s): The Depths, Necropolis, Dank Depths, Mausoleum, Gehenna

This entry is about the Mom boss fight. For tropes about Mom's character, see The Binding of Isaac - Main Cast.

At the end of the Depths, Isaac finally confronts his mother. As her foot stomps down on Isaac from above, she looks and sends her hands through the doors of the boss room while spawning enemies. But even if Isaac defeats Mom, it's not the end.

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• Action Mom: A villainous example, considering that she's... well, trying to get rid of Isaac, though it still counts.
• Attack of the 50-Foot Whatever: Becomes a giant version of herself specifically for her boss fight.
• Ax-Crazy: She doesn't sound too upset about having to kill her own child, what with the laughing during the fight and all.
• Battle Theme Music:
  • The original game had "Thine Wrath...", an orchestrated theme that sounds nearly angelic at points while still being dreadful, to symbolize Mom's willingness to kill her own son to appease what she perceives as "God".
  • Rebirth gave her "Matricide", which leans more to heavy rock and an oppressive tone backed up by a choir.
• Body Horror: The way Mom's body parts move throughout the fight (such as both eyes appearing on opposite sides of the room while she tries to stomp on you) suggest an ability to contort herself in downright freakish ways.
• Boss Banter: She occasionally calls out ISAAAAAC! between attacks.
• Climax Boss: While normally a Disc-One Final Boss, she takes this role in a Beast run. You've still got a number of floors and boss fights to go through before you reach the Beast, after all.
• Death by Irony: She can be killed by her own Bible! Yup, you read that right.
• Disc-One Final Boss: Demoted to this on your second playthrough and beyond.
• Evil Is Visceral: Likely the reason her body parts are detailed and somewhat deformed. Isaac's mom is much less disturbing in cutscenes, fitting with her being at least a little more sympathetic outside of Isaac's fantasies.
• Evil Laugh: She belts out a wicked-sounding laugh every time she successfully damages Isaac.
• Evil Matriarch: A monstrous final boss in the form of Isaac's mother.
• Eye Beams: In her Alternate Route battle, she shoots twin brimstone beams out of her eye.
• The Faceless: Her entire face is never shown at any point in the main game (the intro and epilogue don't count, as they're Isaac's cartoon drawings). This is subverted after you beat the Chest in WOTL or Rebirth, but only briefly. In photographs, to be precise.
• Fan Disservice: When Isaac uses the Mom's Bra item, a picture of his mother's shirtless torso flashes on the screen. A very unflattering picture of his mother's less-than-fit shirtless torso.
• Fat Bitch: As shown by her giant leg, the picture that shows up when using Mom's Bra, and cutscenes of her being an abusive monster.
• Final Boss: The last boss Isaac faces in your first playthrough. Becomes a Disc-One Final Boss in all subsequent playthroughs.
• Flunky Boss: She'll summon groups of random enemies to battle Isaac.
• Gameplay and Story Integration: Using the Bible instantly defeats her in her boss fight, just as it did in the game's first ending.
• Giant Foot of Stomping: Her main method of direct attack. Her Red Champion variant takes it up to eleven — her stomping becomes her main attack^note her summoning is replaced by a spread shot and is executed at roughly twice the speed.
• Gonk: The leg shown above ALONE spells out that Mom ain't gonna be winning any beauty pageants anytime soon.
• Gross-Up Close-Up: One of her leg in the boss portrait, and one of her body in the picture that appears when using Mom's Bra.
• Humanoid Abomination: Most of what she does in-game and in a few cutscenes blatantly disregards normal body movements — if not physics. She can step on her own eye, generally alter her size, and her arm can fit in a chest inside her heart inside her womb.
• Kevlard: A textbook Fat Bitch with rather high health.
• Mook Maker: Spawns an array of previous enemies to make her battle harder. She does it from her body fat, which almost pours out of the boss room doors.
• Mother of a Thousand Young: If you go by the theory that the majority of the enemies are her former children.
• One-Word Vocabulary: Her only voice lines, outside of Voice Grunting, is her screaming ISAAC!
• Point of No Return: Destroys all boss doors in her arena on death, meaning there's no way to return to the rest of the floor without a form of teleportation.
• Red Is Violent: A violent Abusive Mom who's trying to kill Isaac, and sports red nail polish and at least one high heel of the same color. She also has a red champion variant, which almost exclusively uses a faster version of her Giant Foot of Stomping.
• Rubber Woman: Somehow, someway, she can poke her eyes and hands through the doors on the walls all the while stomping on you from above, and this means that she can stomp on her own eyes.
• Sadist: If that Evil Laugh played whenever Mom damages Isaac says anything.
• Say My Name: The main thing she says (or rather screams) is her son's name.
• Skippable Boss: Provided you have a fully-charged Bible on you by the time you reach her, you don't have to actually fight Mom at all.
• Small Role, Big Impact: As you unlock more of the game, Mom's role as the Big Bad and Final Boss start to progressively take a backseat in the overall narrative. However, your actions after defeating her still determine the course that your run will take:
  • Taking the Negative means you will head to the Dark Room.
  • Taking the Polaroid means you will head to the Chest.
  • Using the completed Knife to fight Mom's Heart in the Mausoleum means you will head to the Corpse.
  • Teleporting out of Mom's boss room and using either of the photo items to open the Strange Door means you will head Home.
• Tactical Suicide Boss: It's not actually mandatory, but making her stomp herself is possible and deals lots of damage.
• Voice of the Legion: Her dialogue consists of her screaming "Isaac" in a demonic voice.
• Womb Level: After defeating her, you will unlock her womb as a playable level.
• Your Size May Vary: Just how big is she? In the cutscenes, she's a normal-sized human being, but her underwear is the right size to be worn by a child visibly smaller than her, in the boss fight her leg is the length of the screen, and then her womb is big enough to have two entire levels in it, with her heart being larger than Isaac.

Mom's Heart/It Lives!

Mom's Heart/It Lives!

Voiced by: Patty Allen-Scott (The Binding of Isaac), Carla Kihlstedt (Rebirth onward)

Isaac?

Debut: The Binding of Isaac

Floor(s): Womb, Utero, Scarred Womb, Mausoleum, Gehenna

Defeating Mom once unlocks the Womb in subsequent playthroughs. At the end of the Womb lies Mom's Heart, which summons enemies like Mom does. Defeating Mom's Heart reveals a Chest with something special inside. But once it's beaten enough times, it will become "It Lives!", which is Isaac as a fetus for some odd reason.

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• Battle Theme Music:
  • "...Be Done" in the original, completing Mom's theme and serving as a fast-paced theme to match the intensity of the fight.
  • "Ventricide" in Rebirth, echoing Mom's theme in leaning more towards darker guitar and pounding drums with a background choir, sounding far more sinister. The term "ventricide" in itself isn't real, but it would roughly signify "death of the womb", and could be seen as a Pun on "ventricle".
• Body Horror: It Lives! It's an undeveloped fetus growing out of its mother's heart. Quite grotesque.
• Boss Banter: Has the same voice lines as Mom, only muffled.
• Boss Rush: In the Flash versions, It Lives has the ability to spawn Degraded Bosses such as Monstro, Larry Jr., and Chub to fight you alongside the enemies.
  • Mom's Heart can be fought right after Mausoleum Mom if you enter the Mom fight with all two Knife Pieces.
• Bullet Hell: Rebirth's version shoots red tears nearly constantly throughout the whole fight, even when retreating to the back of the room. In Mausoleum and Gehenna, Mom's Heart gains much more intricate bullet patterns, finally achieving true danmaku.
• The Bus Came Back:
  • The original Mom's Heart form, to an extent, in Afterbirth†. While unlocking It Lives used to make it so that you can no longer fight Mom's Heart, Afterbirth† lets you fight Mom's Heart again in the Void, likely so that the Bestiary is completable for those who already unlocked It Lives. It also shows up as a possible boss encounter in the Womb stage of Greed mode.
  • As of Repentance, a special version of Mom's Heart is fought directly after Mom on the alt path, granting access to the Corpse. It gains completely new attack patterns and is actually harder than It Lives.
• Climax Boss: It Lives! is one for a majority of the routes^note aside from the Corpse, the Ascent and the Void (if the portal spawns after Mom), which you already cut yourself off from by progressing to the Womb and variations, as it provides the branching routes that lead to the final levels, all of which are points of no return. In the Mother route, Mom's Heart takes up this role in Mausoleum and Gehenna.
• Damage-Sponge Boss: Its lack of mobility is made up for by a big health bar. Its Eternal version in the Eternal Edition has even more.
• Disc-One Final Boss: Mom's Heart normally appears at the end of the Womb, but shows up two floors earlier in the alt route, immediately after Mom herself, as its regular place is taken by Mother.
• Fetus Terrible: It Lives is not just any embryo, it has been confirmed by Word of God to be Isaac's embryo.
• Flunky Boss: Will summon enemies intermittently. It Lives ups the ante by spawning Degraded Bosses, though only in the Flash versions.
• "Get Back Here!" Boss: Despite not moving, it accomplishes this by occasionally retreating above the screen and leaving you to deal with its flunkies for a while.
• Mook Maker: Hides at the back of the room while it spawns normal enemies to fight you, then jumps back to the centre to spawn more.
• Not Quite Dead: It seems that Mom survived their fight, or at least her heart did.
• Older Hero vs. Younger Villain: Of sorts with It Lives, who's a fetus that's trying to kill Isaac, a five-year-old.
• Red Is Violent: Both of them are red bosses. Justified because of being a heart.
• Skippable Boss: Using the Bible instantly kills it like it did with Mom.
• Stationary Boss:
  • In the main game, all it can do movement-wise is pull itself upwards to hide from attacks, making bombs very useful against it.
  • The Eternal form in the Eternal Edition averts this greatly; it will pursue you relentlessly around the room until it dies, still spawning enemies.
• Tactical Suicide Boss: In Rebirth, it moves to the top of the screen instead of disappearing entirely. Anything that wanders up there, enemies included, takes damage.
• True Final Boss: Is initially this to Mom's Final Boss, then it becomes demoted to just another Disc-One Final Boss, following all the updates.

Satan

Satan

Voiced by: Patty Allen-Scott (The Binding of Isaac), Carla Kihlstedt (Rebirth onward)

Better the Devil you know...

Debut: Halloween Update

Floor(s): Sheol

The original True Final Boss, Satan himself is the boss of what was originally the game's secret floor. Despite offering Deals with the Devil throughout the game, he turns on Isaac and tries to kill him. His boss fight is comprised of three phases.

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• Attack of the 50-Foot Whatever: His final form is him flying far above the screen and stomping on Isaac with giant feet a la the Mom boss fight.
• Battle Theme Music:
  • "Enmity of the Dark Lord" in Wrath of the Lamb, an epic-sounding theme with techno and bells, along with heavy emphasis on bass.
  • "Hericide" in Rebirth, a theme with heavier guitar and Ominous Latin Chanting, along with a deep voice growling demonically. "Hericide" roughly means "death of the master/teacher/lord".
  • "Spectrum of Sin" in Antibirth, a theme also with heavier guitar, but trades Ominous Latin Chanting with Harsh Vocals.
• Black Speech: During the fight with him, he sounds somewhat like this. They are actually Mom's quotes, played backwards and in a much lower tone.
• Chekhov's Gun: Satan's and Mom's voices being the same becomes much more important with the appearance of The Beast.
• Dark Is Evil: Satan has tons of black.
• Deal with the Devil: He offers them throughout the game before you reach Sheol. Possibly even as you reach Sheol or after, if you have a Joker card on hand or get lucky with red chests.
• Energy Weapon: His second phase can fire dual Brimstone lasers from his hands (that can curve), or a single one from his mouth.
• Evil Laugh: Since he uses Mom's voice clips, he can do this.
• Fallen Angel: The OG in all of his "glory". Tellingly, he and The Fallen are the only demonic enemies Isaac encounters^note if you don't count Fallen Uriel/Gabriel who have visibly angelic wings.
• Faustian Rebellion: Even if you do a ton of deals with him, you can still kill him (and the power ups from said deals can make it all the easier).
• Flunky Boss: His first form is spawning the Fallen to fight you instead. His third phase continuously spawns Kamikaze Leeches.
• Giant Foot of Stomping: His third phase has him attempting to crush Isaac with his giant hooves. They work like Mom's, but he does it much faster.
• Living Statue: His second form is a unique boss where the statue of Satan comes to life, grows much larger, and attacks Isaac with tears and lasers.
• The Man Behind the Man: Implied; after all, he did at the very least string Isaac along through the Deals he makes in the devil rooms earlier on, before turning on Isaac at the last minute.
• Nerf: Satan's legs in his third phase no longer deal contact damage in Rebirth. Un-nerfed in Repentance.
• Nobody Here but Us Statues: Though it looks like the Devil Deal rooms are just using statues of him as representation, he makes it clear in his boss fight that it is him, and he's simply choosing not to move until now.
• One-Winged Angel: After defeating his first form, he grows to massive size and attempts to stomp on you.
• Press X to Die: Using the Bible on him, which killed Mom and Mom's Heart instantly, kills you instantly instead.
• Red and Black and Evil All Over: He has loads of black, is red-eyed, and is Satan.
• Rock Me, Asmodeus!: Both of his themes — Hericide moreso — feature some kickass metal.
• Satan: It's in his name, and he looks the part too.
• Say My Name: Satan's battle cry when you defeat his first phase is Mom's Boss Banter, only lower pitched and in reverse. This becomes much more important later when Isaac encounters The Beast.
• Sequential Boss: Three phases: first a fight with The Fallen, then a fight with Satan himself on the ground with you, and finally a fight against his giant stomping legs.
• Superpowered Evil Side: Satan is implied to be Mom's dark side, as manifested in Isaac's imagination.
• Tactical Suicide Boss: The exploding leeches that are summoned during the third phase hurt Satan just as much as they do Isaac.
• Theme Music Power-Up: When you fight the Fallen, his first phase, the regular boss theme plays. When Satan actually starts fighting, however, Enmity of the Dark Lord / Hericide kicks in.
• True Final Boss: He originally served this role upon the Halloween update's release, though he inevitably went the way of Mom and It Lives! as more updates for the game were developed.

Introduced in Wrath Of The Lamb

Isaac

Isaac

Who am I?

Debut: Wrath of the Lamb

Floor(s): Cathedral

This entry is about the Isaac boss fight. For tropes about Isaac's personality and the playable character, see The Binding of Isaac - Main Cast.

After beating It Lives, the Cathedral is unlocked. At the end of the Cathedral resides Isaac himself.

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• Ascend to a Higher Plane of Existence: Appears to do this upon his defeat.
• Battle Theme Music:
  • The original game had "My Innermost Apocalypse", a techno-rock theme that involves a sad reprise of the title screen music.
  • Rebirth gave him "Infanticide", which is entirely centered around Ominous Latin Chanting and heavy guitar, with the version in-game adding a One-Woman Wail.
• Beam Spam: One of his attacks in Rebirth has him covering most of the room with beams of light, except for a couple safe spots in the corners. His third phase in old versions of Wrath of the Lamb had no attacks other than rapidly dropping the beams on random spots in the room.
• Bolt of Divine Retribution: Like Conquest, he can summon several pillars of light. The safe spot is in either corner of the room perpendicular to the direction the pillars are spawning.
• Bullet Hell: Fires bullets in all directions, and fires at you every time you hit him. Having a high fire rate can backfire horribly.
• Children Forced to Kill: A subtle example. While it's easy to miss, Isaac doesn't attack at all until he takes damage.
• Counter-Attack: In addition to the projectiles he fires periodically, he also fires at you whenever you damage him. In Rebirth, he constantly fires in your general direction when not using another attack, instead of only doing so when hit.
• Damage-Sponge Boss: Later updates in Wrath of the Lamb made him this. Rebirth instead adds more Bullet Hell, and makes him mobile in his third form.
• Flunky Boss: Spawns Angelic Babies, which is fitting.
• Holy Hand Grenade: He can cover the screen in rays of deadly light.
• Messianic Archetype: His One-Winged Angel.
• Mirror Match: He is Isaac. Note that he's not a Mirror Boss, as he can do things you'll never be able to pull off, and his fighting style is only superficially similar to yours.
• Power Gives You Wings: In his final form. An item called Fate can be unlocked, allowing the player to have those same wings.
  • Dogma also gives the player this effect immediately after beating it, which is very-much needed to fight The Beast.
• Purposefully Overpowered: You know how almost all the items added to Wrath of the Lamb are much more powerful than the ones in the base game? There's a reason for that.
• Sequential Boss: Three phases: one lying in the fetal position, one standing up, and one with wings and teleportation.
• Stationary Boss: For the original game and the first two phases in Rebirth.
• Troubled Fetal Position: The first part of the fight.

???

???

Fate has come!

Debut: Wrath of the Lamb

Floor(s): Chest

This entry is about the ??? boss fight. For tropes about the playable character, see The Binding of Isaac - Main Cast.

The True Final Boss of Wrath of the Lamb, completing the Cathedral with the Polaroid item allows Isaac to enter The Chest. At the end of this super-secret stage lies… the Blue Baby?

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• Amazing Technicolor Population: His skin is blue. It's justified as he's cyanotic and dead, though.
• Back from the Dead: Is a post-mortem version of Isaac, naturally.
• Battle Theme Music: While the original version of the fight in Wrath of the Lamb shared "My Innermost Apocalypse" with Isaac, Rebirth gave him a proper, original theme called "Ascension", which has discernible Latin lyrics and an aggressive rock beat with odd, creepy noises in the background at certain points.
• The Cameo: From Edmund McMillen's flash series Dead Babies.
• Divergent Character Evolution: In Wrath of the Lamb, ??? was mostly an Isaac clone right down to having the same boss theme, with the only real differences being his ability to spawn flies and periodically shoot homing tears. Rebirth reworked both bosses, and ??? was thus given a more distinctive pattern, most noticeably removing the beams of light in favor of increasing the rate at which he spawns flies, and a unique boss theme. The distinction is most obvious in their reworked final phases: Isaac prefers to fly away from the player at high speed while periodically teleporting away to saturate the room with beams of light, while ??? slowly flies towards the player while spawning flies and Pooters and occasionally teleporting into the player's face.
• Flunky Boss: One way he varies from the previous boss is that he summons flies in addition to his other attacks.
• Invincible Minor Minion: In Rebirth, he gets a halo of flies, which block your tears.
• Orbiting Particle Shield: Rebirth gives him two Eternal Flies to block tears partway through the fight. He also gains the ability to summon Pooters, which orbit him at high speed and can thus serve as shields in addition to attacking the player.
• Palette Swap: He is very similar to the previous boss, Isaac, so most of the tropes above apply to him too. This resemblance is downplayed in Rebirth by giving him different attack patterns from Isaac.
• Teleport Spam: Utilized in his third phase in Rebirth, with a tendency to reappear right on top of the player.
• True Final Boss: Of Wrath of the Lamb, being the boss of the only sixth chapter in the game, and since beating him unlocked the game's real ending. Mega Satan takes over this role in Rebirth.
• Weaponized Teleportation: Tries to teleport into the player during his third phase in Rebirth.

Introduced in Rebirth

The Lamb

The Lamb

BAD BAD BAD I'M THE DEVIL

Debut: Rebirth

Floor(s): Dark Room

Defeating Satan and completing Sheol with the Negative item allows Isaac to enter The Dark Room, a dark reflection of The Chest. The skeletal demon known as the Lamb is the boss of this stage, and it fights with powerful attacks.

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• All Your Powers Combined: The Lamb's volleys of shots mirror those of previous bosses. This, combined with how it switches the type of bullet with each volley, and that all of its bullets are the same colour, make it a very difficult opponent to predict.
• The Antichrist: In the Bible, the Lamb was a symbolic reference to Jesus. In this game, however, the Lamb is an undead demonic creature fought after Satan. The implication is that this Lamb is an alternate, demonic interpretation of Jesus.
• Battle Theme Music: "The Fallen Angel", a dark, creepy, fast-paced song with an ominous choir and wail.
• Blackout Basement: When the body on his second phase is defeated, the room will darken for a brief time. This could be bad news if the head is still active.
• Bullfight Boss: During its second phase, The Lamb's head can charge at you. However, unlike some examples, it stops charging before hitting the arena's wall.
• Dem Bones: The Lamb is essentially a demonic skeletal child with curved horns.
• Detachment Combat: His second form involves his head floating around the room attacking you while his body lies limply on the ground spawning flies and sometimes tossing out Monstro-style shots.
• Dual Boss: His second form, in which his head floats around the arena and his body stays on the ground to summon Flies and fire off a burst of tears.
• Energy Weapon: His second form gains the ability to shoot four-way Brimstone in the cardinal directions. He can also start rotating the beams like Mom's Heart/It Lives.
• Flash Step: One of his attacks qualifies as this.
• Horned Humanoid: He has a set of curly ram horns.
• Losing Your Head: During the second phase of the battle, The Lamb's head detaches from its body. However, it clearly isn't fatal.
• Meaningful Name: Named after the lamb that was sacrificed in Isaac's stead, in the original story of the Binding of Isaac. Fittingly enough, it's an alternate counterpart to a dead Isaac.
• Mythology Gag: His name is a reference to the expansion for the original Isaac, named Wrath of the Lamb. He is also visually similar to Wrath of the Lamb's horned skull logo. Given that Edmund had more planned for the original Isaac, it's possible he was always intended to be the last boss of the expansion, but Flash's limitations meant he couldn't add him in.
• Nightmare Face: Its skeletal face isn't pleasing to look at, especially in the vs. screen.
• Non-Human Undead: The Lamb appears to be an undead demon, with an upside-down cross embossed on his forehead for good measure.
• Sequential Boss: Has two forms, first as one entity then split into a Dual Boss with its head and body.
• Shadow Archetype: In addition to mirroring other bosses, The Lamb's attacks also resemble combinations that can be used by Isaac — for example, Monstro's Lung plus Homing Tears. Its Detachment Combat is a lot like the Pinking Shears. It even begins the battle in Isaac's crying position!
• You Don't Look Like You: Strangely, the Lamb has a black skeleton on its splash screen, but has a white skeleton with only his horns being black in-game and in the Afterbirth† trailer.

Mega Satan

Mega Satan

...than the one you don't.

Debut: Rebirth

Floor(s): Chest, Dark Room

In Rebirth, a giant golden door appears in the Chest and Dark Room stages. This door can be unlocked with a special item, which leads to Rebirth's True Final Boss.

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• Attack of the 50-Foot Whatever: Although his name, Mega Satan, probably gave it away.
• Battle Theme Music: Shares "Hericide" with his own original form.
• Boss Rush: Beyond just being able to summon the Seven Deadly Sins and The Hollow as regular enemies, Mega Satan will at certain points withdraw and start summoning the Four Harbingers, the Seven Super Deadly Sins and finally Fallen Uriel and Gabriel that need to be defeated before he comes back to fight
• Bragging Rights Reward: Besides unlocking the final and definitive ending, there is no reason to fight him other than to boast you did it. The only thing you get out of winning is a new picture for your save file. There are no associated items or character unlocks, not even a mark on the character file to indicate that character beat him. This has since been averted with Afterbirth, as he now has his own completion mark with unlocks tied to it, in addition to counting towards the co-op baby (or Godhead, in The Lost's case) unlocked by getting all completion marks for a character on hard mode, and beating him once with every character unlocks the Mega Blast item. Afterbirth† adds another with Booster Pack 5, where defeating him once now unlocks Apollyon. Repentance also tied unlockable content behind defeating him with each Tainted character.
• Bullet Hell: What some of his attacks delve into. In his second phase, it's his only form of attack, albeit in several varieties.
• Cognizant Limbs: His hands perform various attacks alongside his head. The hands can be killed, which damages the main body, but respawn shortly afterwards.
• Damage-Sponge Boss: He's just shy of Hush in terms of overall health, and his individual forms have as much or more health than any other boss save Ultra Greed. He could actually be considered to have more health than any boss if you include the health of the mandatory boss fights. However, Mega Satan doesn't have the same damage-scaling property of those two, so he's functionally a whole lot weaker than they are, though Repentance does fix that, bringing him more up-to-speed with them.
• Dem Bones: Transitions from flesh and bone to just bone once he's in his second phase.
• Dishing Out Dirt: His hands can slam down, sending out rocky shockwaves.
• Final Boss Preview: Regular Satan's third phase can be considered this. In Sheol, you only fight his lower half. In the Chest/Dark Room's secret room, you face the much more difficult upper half.
• Flunky Boss: Summons The Harbingers, the Super Sins, and fallen versions of the Angels. If you take too long on one of his phases, he starts summoning regular Sins and The Hollow.
• Giant Hands of Doom: Accompanied by a giant head. The hands serve mainly to block shots aimed at the head, which is treated as the main boss. Destroying the hands will cause a set amount of damage to be dealt to the main head, and the hands disappear once the second phase begins.
• Guide Dang It!: The only in-game hint you have to his existence is "The Angels await!" You're supposed to bomb the Angel statues in the Angel Rooms, prompting them to engage you; both will drop a piece of a Golden Key on defeat, and getting both pieces opens a Golden Door in the Chest/Dark Room that leads to Mega Satan.^note The Golden Door also only appears once you have completed the key for the first time, which is a Guide Dang It! in and of itself. Fortunately, completing the key also unlocks "Dad's Key" as a regular item, which can also be used on the Golden Door for future playthroughs ^note The "Get Out of Jail Free" card, Mr. ME!, Sharp Key, Cracked Orb, and Soul of Cain also work.
• Interface Screw: The only boss ^note besides the Mask Of Infamy in the original, as well as The Ultra Harbingers and The Beast who doesn't have a health bar, in either form. Averted if you have the Spider Mod item, which gives him a Spider Mod health bar.
• Marathon Boss: He has two forms, each of which has as much if not more health than every other boss excluding Hush and Ultra Greed. This is on top of all the other bosses he summons. Winning takes several minutes at least, and that's if you have a good enough run.
• Names to Run Away from Really Fast: Mega Satan. It's so edgy that it would be comedic if he wasn't a legitimate threat.
• Red Eyes, Take Warning: He's evil and red-eyed. Also, considering he was the True Final Boss of the game before the title was being uplifted by Delirium and The Beast, you will want to take warning.
• Sealed Evil in a Can: Heavily implied to be sealed by the beings in the Angel Rooms.
• Sequential Boss: Including his summons, he has twelve phases.
• Shows Damage: While not present in the first phase, cracks will start to form across Mega Satan's skull; starting with a few cracks after some damage has been done and several more appearing once some serious damage has been dealt.
• Soundtrack Dissonance: Due to a bug, doing too much damage to any form will cause the calm, somber "boss defeated" music to start playing. This was eventually patched.
• Superboss: Beating him isn't required to finish a run, since you can always fight ??? or The Lamb instead. It was even worse in Rebirth, where he only had to be beat a single time with any character for completion purposes, with all other wins just being bragging rights.
• True Final Boss: The True Final Boss of Rebirth and Afterbirth, hidden at the final stage and having an extra unlock process required each run. Delirium took over the role in Afterbirth†, but even then it is the final boss of an alternate route that also has a 50% chance of being available from Mega Satan.
• Turns Red: Has two full health bars, and when you take down one of them, he really cranks up the Bullet Hell.
• Wave-Motion Gun: If you stand in front of him for too long, he'll charge up a gigantic blood laser for a long time, making his head nigh-impossible to shoot.

Introduced in Afterbirth

Hush

Hush

The end is nigh!

Debut: Afterbirth

Floor(s): ???

Defeating Mom's Heart or It Lives in under thirty minutes of total play time unlocks a short, hidden area^note displayed as ??? in-game but generally called the Blue Womb or Dead Womb. This area only has one enemy: Hush, which appears to be another Palette Swap of the Isaac and ??? bosses. Then he enters his second form, which is soundly described below.

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• Attack of the 50-Foot Whatever: According to Edmund, it's a giant ??? pushing through the floor.
• Battle Theme Music: Its first phase shares "Ascension" with ??? (because according to Edmund, it is ???), before it transitions to the heavier and oppressive "Morituros" when Hush's true form emerges.
• Body Horror: Hush represents Isaac suffocating inside the chest; unsurprisingly, its "face" looks like it's being asphyxiated inside a bag.
• Bullet Hell: Its attack patterns during its second form. They even resemble the dense ring-patterns found in danmaku shooters like the Touhou Project games; fortunately, the projectiles fired by these attacks are some of the slowest in the game.
• Damage-Sponge Boss: Has the second highest health of all bosses in the game. Furthermore, its defenses scale with your damage output, so no matter what items you have, it'll take a long time to wear down. Combine this with its numerous Bullet Hell attacks and absurd enemy spawns, and you have a brutal boss fight.
• Eldritch Abomination: As an embodiment of impending death by suffocation that looks like a giant face molded from blue flesh.
• Flunky Boss: Begins spawning hordes and hordes of minions as the battle goes on.
• Interface Spoiler: The above portrait is its boss splash screen, so players are likely clued in right away that Hush is way more than just a reskinned ???.
• Marathon Boss: Hush has 6666 health and has a damage resistance mechanic which hardcaps how much damage you can do at once. Even an overpowered build will still take at least a few minutes to kill this thing.
• Meaningful Name: To hush is "to put at rest", and seeing as this boss represents Isaac slowly suffocating in the Chest, the name is quite appropriate.
• Number of the Beast: Its base HP is 6666.
• Ocular Gushers: When low on health, Hush will fire out geyser-like streams of tears from its eyes that track you like a pair of Kill Sat lasers.
• Sequential Boss: Fights like Isaac and ??? at first, but then it teleports away and its huge face comes out of the floor, firing loads of bullets.
• Stationary Boss: Mostly. It begins laying on the ground, as a variant of Isaac and ???, then turns into a large bullet-spewing head. The head can move around, but generally, it stays still when attacking.
• Suspicious Video-Game Generosity: Before the fight, the game gives you two item rooms, four golden chests, and a shop. Needless to say, you will need them.
• Superboss: Hush is sort of the "Isaac" counterpart to Mega Satan. While beating it does grant you a new ending, it doesn't require you to end the game. Instead, you can opt to go to Sheol/Cathedral once the fight is over. This was later patched out; defeating Hush now plays the ending and ends the run, but only the first time you beat it.
  • Averted as of Afterbirth†; beating Hush is the only guaranteed way to reach the Void and fight Delirium, and is required to actually unlock the Void.
  • Further averted in Repentance, where you have to beat Hush 3 times to unlock the alternate floors from Antibirth.
  • It continues to be played straight in Challenges and Daily Runs, though, since Hush can be fought despite never being an end-goal. Daily Runs even encourage the player to fight Hush whenever possible, since beating it and/or the Boss Rush award Rush bonuses, significantly increasing the player's score by the end of the run.
• Theme Music Power-Up: The first phase of the fight has Ascension playing in the background. Once the second phase begins, the music changes to Hush's own theme, Morituros.
• Trick Boss: Shares a boss theme with ??? and fights like him, with a health bar that goes all the way down to zero, so you'd think that's all there is to him. Nope.
• Wrap Around: It fires shots that go out of the room and then come back from the other side. Notably, these shots actually get faster after the wrap-around.
• Zerg Rush: Easily spawns more enemies than any other boss in the game, throwing entire floors' worth of flies, Gapers, and Boils at you throughout the fight.

Ultra Greed/Ultra Greedier

Ultra Greed/Ultra Greedier

I spent it. It's gone! Just get over it!

Debut: Afterbirth (Ultra Greed)
Afterbirth† (Ultra Greedier)

The final boss of Greed Mode, fought in a stage named after him. A giant version of Greed that uses coins to attack, summon minions, or heal. A second variant introduced in Afterbirth†'s "Greedier Mode", Ultra Greedier, resumes the battle after the first phase is dealt with, now using all manner of explosive attacks to damage Isaac.

And he still makes you drop money when hit.

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• Achilles' Heel: Ultra Greedier has one in regards to his attacks. He graduates to using explosive moves almost exclusively. If you lucked out earlier and managed to get Pyromaniac or Host Hat, then you're basically invincible as long as you keep your distance and avoid the lasers coming out of the doors.
• Animation Bump: Ultra Greed moves around a lot, and the animations are extremely smooth and detailed.
• Attack of the 50-Foot Whatever: A massive variant of Greed.
• Bandit Mook: Like his smaller versions, his attacks will cause you to drop money. Unlike the others, however, he will actively pick up the money you drop, which heals him slightly.
• Boss Remix: "Chorus Mortis". It incorporates elements of the shop and arcade themes, the latter of which is, itself, a remix of the title screen.
• Crippling Overspecialization: Ultra Greedier uses almost nothing but explosive attacks. With Pyromaniac or the Host Hat, he is literally incapable of harming you outside of contact damage and highly telegraphed lasers.
• Damage-Sponge Boss: His health is slightly higher than that of Mega Satan's first form, making him third overall, and the damage scaling means he'll last a whole lot longer.
• Defend Command: One of his abilities is to shield himself with his arms, reducing all damage dealt to him, which he usually uses when he has flunkies or bomb coins active.
• Energy Weapon: In his second form, the doors shoot gold Brimstone beams whenever he pounds the ground.
• Fan Disservice: Has a large, visible, and well-detailed butt◊. He's also a massive corpse-like monster that ultimately has a little boy as the base of his design, and might even be an alternate version of a little boy^note if it isn't instead a representation of his father, and that is its own can of worms.
• Final Boss: Of Greed Mode.
• Flunky Boss: Can spawn Keepers close to himself, call more minions from the arena's doors, and drop a bunch of large coins that will cast buffs on him if they're not destroyed.
• The Gambler: His primary attack depends on the outcome of a slot machine. Although it's not that much of a gamble, since every outcome is pretty terrible for you. You're just hoping that he gets one of the less terrible ones. He can summon bombs that explode after a few seconds, keys that summon hordes of enemies if not destroyed, hearts that heal him, or blank coins that deal contact damage and last until destroyed.
• Golden Super Mode: Ultra Greedier. Bonus points for literally being made of gold.
• Healing Boss: One of his gamble attacks summons a bunch of coins with hearts on them, and you'll have a few seconds to destroy as many as you can. Any still standing will fly to Ultra Greed and heal him. Also, he heals himself whenever he steals one of your coins.
• King Mook: To Greed and all of his mook counterparts.
• Living Statue: Ultra Greedier is this, since after turning into a golden effigy, he eventually resumes attacking with different moves.
• Mad Bomber: One of his slot machine attacks is to drop giant bomb coins all over the arena. Ultra Greedier gains an explosive effect on all of his attacks.
• Marathon Boss: His health is about half that of Hush, but he shares the same damage reduction mechanic to prevent you from winning too fast. Furthermore, he has the ability to heal during the fight, though not by much. Greedier Mode is even worse, as there's the second half to his fight.
• Mighty Glacier: Ultra Greed isn't particularly mobile outside of one charging attack, and all of his attacks are well-telegraphed and can be dodged easily. However, they hurt Isaac in more ways than one if they connect, and will always do a full heart of damage if Isaac isn't equipped with the Wafer. On top of that, he's one of the most sturdy bosses in the game thanks to his damage scaling, allowing him to outlast almost every other boss in sustained assault.
• Money Mauling: Uses large coins as projectiles. At times, huge ones fall from above. They can explode, heal Ultra Greed, or allow him to summon minions if you don't get rid of them.
• No Cure for Evil: A notable aversion. He's unique in his ability to heal through heart coins, though it isn't very much. He'll also heal a little if he picks up the coins you drop.
• Noose Necktie: Like all other versions of Greed. The main difference being that you get to see Ultra Greed snap it loose himself.
• Palette Swap: Ultra Greedier, Ultra Greed's gold-colored form. Justified since it's still Ultra Greed to begin with, only powering himself up for a second round.
• Roundhouse Kick: If Isaac maintains close contact with him, Ultra Greed will perform a quick roundhouse to knock him away.
• Sequential Boss: In Afterbirth†, he becomes this in Greedier Mode. After beating his first form, his statue (now called Ultra Greedier) will start attacking.
• Spin Attack: Does spinning lariats when you're close. He also flings big coins around when he does it.
• Stone Wall: His attacks, unlike most other final bosses, don't employ Bullet Hell and are comparatively easy to avoid. He makes up for this by being able to tank attacks that only Hush could withstand, with his damage reduction ensuring that he will always last for a few minutes. The challenge comes not from dodging him, but from outlasting him.
• Tactical Suicide Boss: Downplayed compared to most examples, but his bomb coins can damage him too. He uses his Defend Command to block most of the damage. His second form is even worse in this regard since all of his attacks have explosive properties and he no longer defends. Half of the time, you won't land the final hit that kills him.
• Taken for Granite: Ultra Greed turns into a solid gold statue when killed. Midas' Touch (touched enemies temporarily turn into gold) applies a penalty to his damage scaling property, letting you deal greatly increased damage. In Greedier Mode, he keeps attacking as a statue and explodes into a fine gold dust on death, covering the entire room in gold.
• True Final Boss: Ultra Greedier serves as one for Greedier Mode runs.
• Turns Red: As he loses health, his attacks become faster and he spawns more giant coins, which also take effect more quickly. He also visually becomes redder as an indication of this. He also does this whenever heals via the Heart Coins from his slot machine or by picking up coins; the more he heals, the redder he gets. This is only temporary, however.
• Your Princess Is in Another Castle!: On your first run through Greedier Mode. So you've beaten Ultra Greed, he's turned to a statue, and you wait for the Greed Machine to spawn… but it doesn't, and after a long pause, Ultra Greed's statue starts attacking you. This new form is appropriately called Ultra Greedier. He doesn't bother with the pretense on subsequent runs and will begin attacking in his statue form almost immediately.

Introduced in Afterbirth†

Delirium

Delirium

T̶̠̈H̸̨͘Ẹ̸͛ ̵̥͘E̸͎͛N̸̮͒D̷̗͆

Debut: Afterbirth†

Floor(s): The Void

The final boss of Afterbirth†. Beating Hush will unlock The Void, made up of various different environments from the game, with this as the boss of one of its several boss rooms. He first appears to be a giant, melting skull, but will shift forms to white variations of the previous bosses.

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• Ambiguous Gender: Being less of a "person" and more of a manifestation of a mental breakdown that can change into almost any other boss from the game that takes the form of a gigantic skull, it's difficult to tell if Delirium even has a gender in the first place. A Tweet from Edmund McMillen during the promotion of Four Souls refers to Delirium with "him", however.
• Anthropomorphic Personification: Of the mental breakdown that Isaac is going through as he's suffocating in the chest. Delirium can rapidly shift between the forms of bosses previously encountered in the current run, and rarely ever sits still while spraying bullets everywhere. Most of his unlocks on the Tainted characters send their supposedly-unique gimmicks to item pools, blurring the sense of distinction between them in the long run. And during his death animation, the screen gets covered with static as moments from earlier in the run are replayed. All of this represents how Isaac's mind is spiraling inward as he dies within the chest, being a rather extreme take on the My Life Flashed Before My Eyes trope.
• All Your Powers Combined: This is the boss' primary attack method. He'll randomly transform into almost any other boss found throughout the game (including some of the other final bosses!) and take on the transformed boss' attack patterns, all while still firing off its own bullet rings. Once he Turns Red, he'll shift through bosses much faster, and each form attacks far more quickly.
• Art Evolution: In Repentance, many of Delirium's forms got redesigned to reflect the changes of their respective bosses, along with some additional Body Horror. Amusingly, Delirium's base form was left untouched.
• Battle Theme Music: The eponymous track, "Delirium", which perfectly matches the increasingly fast pace of the battle, at one point sounding like it's skipping like a scratched CD.
• Berserk Button: Attempting to use the Chaos Card on him will not only fail, but also make him temporarily turn red and attack much faster.
• Body Horror: It's a Blob Monster whose Shapeshifter Default Form resembles some kind of melting skull that transforms into melty versions of other bosses with rather unusual eye placements.
• Bullet Hell: Despite them being more simple, Delirium's bullet patterns manage to be worse than Hush's because he shifts into random bosses you've encountered in the run to change the pattern around, plus he never sits still. Also, Delirium's own unique bullet patterns being fired from the bosses along with their modified patterns. By the time you've got him down to 1/4 health, he'll be firing off a new pattern before the last one even finishes.
• Chekhov's Gun: Delirium's presence is often hailed by TV static covering the screen. This becomes important in Repentance with TV static being Dogma's bread and butter.
• Contractual Boss Immunity: One of two enemies who aren't harmed at all by the Chaos Card. In fact, all it does is piss Delirium off. Plan C (kill everything then yourself three seconds later) does technically kill Delirium, but its death animation is so long that Isaac will die before Delirium does. There are three ways around it, though: playing as Lazarus thanks to his ability to resurrect in the current room^note Lazarus' Rags on another character will work, but Lazarus still gets the credit, Inner Child^note Also grants the ability to resurrect in the current room (with the bonus of letting any character get the kill credit as long as they have that item), and Soul of Lazarus^note normally kills and revives the character in the same room as themself on use, but is used automatically if they die from anything else. Tainted Lost can also use Plan C with his own Birthright^note An item unique for every character. For Tainted Lost, it grants an extra life that revives him in the same room and deals 200 damage to nearby enemies.
  • Amusingly, if it's in the form of a "ghost" boss (such as The Haunt) and it's at less than half of its health, it is not immune to the One-Hit Kill effect that Vade Retro has on ghost enemies.
  • Eraser^note permanently removes an affected enemy from the run, which includes bosses if their health is low enough can also potentially one-shot it. If you used it to erase a boss prior, Delirium will die instantly if it attempts to turn into that boss.
• Damage-Sponge Boss: Clocks in at a whopping 10,000 HP, though he mercifully doesn't have the same damage scaling that Hush and Ultra Greed do.^note Well, technically, he does, but the scaling resets every time he transforms, so his damage reduction is hardly even noticeable. On top of that, his base form doesn't have any damage reduction at all. Even so, he teleports all over the place, so expect to spend a long time trying to kill this thing.
• Defeat Means Friendship: It's not clear whether or not they're the same entity, but upon defeating Delirium for the first time, the player unlocks Delirious (a 12-charge active item that spawns friendly bosses on their Delirium form to fight for Isaac) and Lil' Delirium (a familiar that shapeshifts every ten seconds into one of a handful of different familiars and gets its effects).
• Dying Dream: This creature, its environment, and the ending you get for defeating him drive home the point that most of what is seen during the game was Isaac's dying hallucinations.
• Eldritch Abomination: A physical manifestation of a complete mental breakdown? Yeah, he qualifies.
• Eyes Do Not Belong There: When transformed into The Husk or Conquest, Delirium will have a single eye or a pair of eyes respectively inside its mouth. Its Teratoma form also has an eye inside.
  • In Repentance, many of the redesigned bosses gain extra eyes in unnatural places (Duke of Flies' mouth, Lokii's brain, Fistula's holes, just to name a few).
• Final-Exam Boss: Taken to its logical conclusion. He outright transforms into bosses you've previously encountered during your run while sprinkling in tons of Teleport Spam (and is very capable of Tele Fragging you) and Bullet Hell for good measure. Fitting, considering he's the boss of The Void.
• Flunky Boss: Can spawn minions depending on what form he's in. Bizarrely, when he becomes the Haunt, he'll often transform into a single Lil' Haunt instead, the only instance of Delirium assuming the form of a regular enemy rather than a boss. A bug also causes his health bar to disappear when this happens, but he can still be damaged in this form.
• "Get Back Here!" Boss: With a 2x2 arena to fight in, you'll spend a fair portion of the fight trying to figure out where he teleported to. This isn't helped by him transforming into wall-hugging bosses like Mama Gurdy or extremely small ones like Isaac. And he'll occasionally teleport right into you just to throw you off.
• Glowing Eyelights of Undeath: Has yellow pinprick eyes. And every form it takes has at least one of these somewhere on its person, often where they definitely don't belong.
• Interface Screw: Will occasionally cause the arena to glitch and shift from one tileset to another, causing static to briefly fill the screen in the transition. This can happen anywhere in the Void, but is far more likely to happen when fighting Delirium. It is a guarantee when Delirium is dying, but by that point, there is little in the room that can harm you.
• Marathon Boss: With his high health, constant teleporting, and shifting into whatever boss he feels like, you'll spend a large amount of time chipping this thing down to nothing.
• Meaningful Name: "Delirium" is a disturbed state of mind. The battle plays out in a deranged and bizarre way, almost like some sort of hallucination.
• Mind Screw: It's a giant, melting skull that turns into the other bosses wildly and at random (many of which are considerably smaller than it), and it's encountered in an area made of all of the past floors and fails to keep a consistent theme. Considering the name, nature, and location of this boss, it's implied that the fight is Isaac's mind breaking down.
• Morphic Resonance: Delirium retains his coloring and often its facial features regardless of what form he takes, allowing you to tell him apart if he happens to spawn another boss monster.
• My Life Flashed Before My Eyes: Delirium is a physical representation of the phenomenon, illustrated by its ability to shapeshift into bosses that you've encountered this run and its death animation, which plays back several moments from the current run.
• Nightmare Face: A melting skull certainly isn't pleasant by any stretch of the imagination. And since his features are retained when it transforms, this can result in similar faces appearing on any boss in the game.
• Ominous Visual Glitch: His level may cloak the screen with static, changing the setting of the room where that happened. After beating Delirium himself, the screen will flash with static and various images from earlier in the run for an extended period of time. In this case, the "ominous" is because it represents Isaac's mind breaking down.
• Oculothorax: He evokes this imagery with some of his forms, like The Husk, Seraphim, and D Infinity.
• Rule of Symbolism: Nearly all of Delirium's unlocks on the Tainted characters except for Isaac ^note covered by the Soul of Isaac after clearing Boss Rush beating Hush, the Lost ^note covered by Sacred Orb after beating the Beast, Eden ^note whos randomization-on-hit gimmick doesn't have a corresponding unlock, and Keeper ^note covered by The Hanged Man? after beating Ultra Greedier are items that allow any other character to use one of their gimmicks. The implication, of course, is that if the game is a Dying Dream, all the possible choices that can be made in a run don't matter, since it's all the same story of Isaac's suicide.
• Shapeshifter: He can shapeshift into any other boss, taking on their attack patterns.
• Shapeshifter Swan Song:
  • The less health he has, the more often he changes forms. At critical health, he can't stand still nor stay in a form for more than a few seconds!
  • Interestingly, the arena suffers this. During Delirium's death animation, the arena glitches and shifts between several different appearances, finally stopping as he dies. Just after beating Delirium^note it changes if one leaves and re-enters the boss room, the end result is always the Chest, as that is closest to the "reality" of where Isaac is at that moment.
• Superboss: In Four Souls, Delirium is the only boss who doesn't grant any souls upon defeat, instead allowing the victor to gain two treasure cards. He is also one of the harder bosses despite being considered a "normal" one, having stats on par with with a Mega Boss (Satan, The Lamb, etc.) and giving other monsters a higher dice roll. Requiem somewhat rectifies this by putting him in said Mega^note now called Epic Boss tier, though he still does not grant souls, but at least he now has Dogma to keep him company in that regard.
• Tele-Frag: Like ???, he likes to teleport either very close to or right on top of you, almost guaranteeing damage unless your reflexes are faster. This is most noticeable when he turns into Mom, as she tends to target the player specifically.
• Teleport Spam: Can teleport around in any of his forms. As he loses health, this becomes more frequent, to the point that Delirium barely spends more than five seconds without doing it.
• The Thing That Would Not Leave: In The Binding Of Isaac: Four Souls, most of the final bosses from the main game are worth 2 souls, but is worth none; instead, he has the gimmick that when he dies, he goes back into the monster deck, four cards down from the top. This means that once Delirium shows up, he'll constantly keep returning, no matter how many times he dies, unless extremely specific measures are taken to bury him deep in the deck again.
• Timed Mission: Played with. If you want to guarantee access to the Void and thus to Delirium, you have to beat Hush, which means you need to beat It Lives before the 30 minute mark (or have Mama Mega! on that floor). However, the portal to the Void has a chance to spawn after beating Mom or any subsequent boss, increasing as you go further. Mega Satan has a 50% chance at best. He's also the only boss for whom completion is tracked even on victory laps, however, so one valid strategy is to take your time gathering items on the first run, defeat The Lamb, and then speedrun through the victory lap with your items to reach Hush.
• True Final Boss: Of Afterbirth†. Defeating it earns you the final ending to the game. Oddly enough, however, you can encounter it way before Mega Satan thanks to how its requirements and the level progression are set up.
  • In Repentance, it supposedly loses this role to Dogma and The Beast^note you actually have to beat Hush 3 times to unlock the alternate path and then have to beat Mother on said alternate path at least once to even unlock the ability to fight the Beast, as opposed to defeating Hush once, though it is possible to defeat both of those bosses before Delirium. However, Delirium's ending is still confirmed to be the canonical one, making it remain the true final challenge battled in the story as a whole.
• Turns Red: The lower his health, the faster he shifts between forms and teleports.
• Weaponized Teleportation: Even more than the ??? boss; Delirium loves to teleport directly onto you.

Introduced in Repentance

Mother

Mother

"This is what you think of me? This is what I am to you? A monster?! After all I've done for you… this is how you view me? You think I'm a monster?! Isaac, I'll show you a monster."

Debut: Repentance^note originating from Antibirth as the Witness

Floor(s): Corpse

Defeating Hush 3 times unlocks the alternate path from Antibirth. By beating Mom's Heart in the alternate route, you get access to the Corpse, in which lies Mother. Formerly known as the Witness in the Antibirth mod, she's a huge, grotesque form of Mom.

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• Attack of the 50-Foot Whatever: Not as huge as she was when she was the Witness, but still quite big.
• Adaptation Name Change: In a fashion that also changes the identity of the character. In Antibirth, she was known as the Witness and was implied to be an undead Mama Gurdy attacking Isaac after, well, witnessing him kill his mother. In Repentance, instead she's known as "Mother", and now she is essentially the zombified husk of Mom in the aftermath of Isaac killing her with the assembled Knife^note though this is assuming that Mama Gurdy isn't another form of Mom herself.
• Back from the Dead: It's the rotting corpse of Mom, grey from time.
• Bad Boss: She tosses several enemies at you. Considering some of these enemies are Dead Isaacs and how she appears throughout the game, it's not hard to expect.
• Battle Theme Music: Morticide, an extremely dramatic theme that transitions to a rock track. The "Morti-" prefix means "Death/Dead", which means Morticide means… the death of the dead.
• BFS: One of her attacks has her pull out a knife several times Isaac's size and toss it, causing it to explode into a ton of bullets.
• Body Horror: Oh yes. Not only is she a decayed version of Mom, but when her head detaches, it exposes two more skulls where its shoulders would be. Not to mention the numerous worms and maggots she emits as part of her attacks.
• Bullet Hell: As expected of a Binding of Isaac endboss, but Mother takes this to a whole new level that's only rivaled by Hush. It doesn't help that she has a cramped room with less space than her Antibirth incarnation did.
• Bullfight Boss: One of her attacks in her second phase has her dash at you twice, then Ground Pounding into the center of the arena.
• Cognizant Limbs: In her first phase, she has separate weakpoints on her arms and head. Downplayed in that they all share the same health pool.
• Disc-One Final Boss: Of Repentance. She must be defeated in order to unlock the True Final Boss, but does not transition into said True Final Boss on subsequent runs.
• Et Tu, Brute?: Implied with her voicelines. Though she still yells Isaac's name, it's altered to sound less malicious, and instead it gives a vibe that she's heartbroken and anguished over the fact that her own son killed her, making her lash out in sorrowful rage. It even applies to the real-life context, as "Mother" was a result of the feeling of betrayal that Isaac's mom felt after discovering how her own son felt about her.
• Evil Overlooker: Her boss portrait has her looming over Isaac in this fashion, instead of the "facing Isaac from the side" view of every other boss (even the likes of Delirium and Dogma).
• Hell Is That Noise: She greets you by shouting Isaac's name, much like Mom did, but with an extremely distorted voice.
• Marathon Boss: She has a lot of health, and it isn't helped by the fact that, like Mega Satan, she doesn't have a health bar. Unlike Mega Satan, there's no way to tell how close you are to defeating her apart from her entering her second phase.
• One Bad Mother: Naturally, as comes with being yet another form of Mom, and this one is the hardest and most horrific-looking version seen so far.
• Parental Title Characterization: Considering just how monstrous Mother is, especially if she is meant to be Mom's corpse, Isaac calling her "mother" instead of the more casual "mom" shows how far he has grown from her at this point.
• Tennis Boss: With a melee attack, one can reflect her bouncing Fistula attack to stun her with well-timed spin attacks, a la The Legend of Zelda.
• Turns Red: After you deal enough damage to her, her arms explode, and her head bursts out out of her body to keep attacking.
• Two-Faced: Half of her face has rotted down to the skull.
• Wave-Motion Gun: After you finish her first phase, her head retreats back into the wall before firing a huge laser at you. Can also be a nasty surprise for Antibirth vets, as The Witness didn't do this.
• Woobie, Destroyer of Worlds: Implied with how her voice sounds and the context for her existence. Isaac kills her with the assembled Knife Pieces after finishing her in the Mausoleum/Gehenna, and now as Mother, she's attacking again out of despair and heartbreak over her son actually killing her. She even has a little "heartbreak" icon next to her name in the Versus Character Splash.
• Would Hurt a Child: In this game, it goes without saying, but one of her attacks outright weaponizes this. During it, Mother will retreat to the top of the screen, while a horde of unique Gapers known as "Dead Isaacs" wander up to the top of the screen. Any that reach Mother will be swiftly struck down and launched toward Isaac. This attack ends with Mother smashing every remaining Dead Isaac to bits!

Dogma

Dogma

^{Click here to see its second form}

Debut: Repentance

Floor(s): Home

The LORD is my shepherd. I shall not want. He maketh me to lie down in green pastures. He leadeth me beside the stillwaters. He restoreth my soul. He leadeth me, in the paths of righteousness for His Name's sake. Yea though I walk through the valley of the shadow of death, I will fear no evil. For thou art with me; thy rod and thy staff, they comfort me.

After beating Mother for the first time, a strange door will appear in Depths II that can be opened by giving it The Polaroid or The Negative. It leads to a special version of Mausoleum/Gehenna II, which contains Dad's Note, the Ascent, and eventually Home and the fight against Dogma and The Beast.

Dogma is the first of the two bosses of The Very Definitely Final Dungeon, Home. After a flashback sequence where Isaac recalls the fallout and disintegration of his parents' relationship, he has a nightmare about the televangelist sermons that drove his mother to madness. Approaching the TV brings forth this thing, an angelic fetus made of static, representing the demented fundamentalism that drove Mom into her religious fervor and Isaac into his suicidal guilt.

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• 11th-Hour Superpower: Dogma itself is one. After its defeat, it grants its power to Isaac, giving him flight, damage resistance^note Though only in Normal Mode. It behaves the same as The Wafer, a one-time Holy Mantle effect, a damage upgrade, refilling all of Isaac's red hearts, and giving him soul hearts if his max life is fewer than six. You will need it!
• Angelic Abomination: Its secondary form is an orb with four wings, resembling an ophanim.
• Anthropomorphic Personification: It is one of televangelist sermons, and more specifically, the corrupt and fanatical version of religion used by deranged fundamentalists… like what Mom subscribed to. Tellingly, its first form is literally linked to the television it pops out of, and its second form looks like a Starfish Alien of an angel.
• Ambiguous Gender: It has no defining features of any kind outside of being composed of TV static, so any gender it has, if at all, is unknown. The preacher in the background music is male, but Dogma itself is not necessarily the same person as the preacher.
• As the Good Book Says...: Aside from listing off the Seven Deadly Sins, all of the lyrics to its boss music are direct quotations from the Bible.
• Battle Theme Music: "Living in the Light", a hectic song with the sound of television static in the background. Once the second phase hits, the bombastic voices of fundamentalist preachers chime in to quote scripture.
• Boss Banter: It speaks scripture in a deep voice when it attacks^note Psalm 23:1-4, specifically. It's only truly audible for a split second, though, so you need to open the debug menu during that brief period to properly hear it in full. Once it reaches its second form, the music is accompanied by a bombastic hellfire and brimstone preacher speaking the word of God.
• Boss Bonanza: Thought it was over when you defeated Dogma? Think again. It's only just started.
• Climax Boss: While not the final boss, or even the most difficult, Dogma is the penultimate boss. It is also the one that represents the ultimate source of Isaac's mother's insanity, and his own self-doubts and psychological scars.
• Confusion Fu: When it fires its Brimstone beam in its first phase, the beam will fire in the cardinal direction Isaac is closest to and then curve to hit him. If you move closer to another cardinal direction, the beam will abruptly glitch to that direction in an instant with the same behavior, keeping Isaac pinned between the two directions.
• Contrasting Sequel Antagonist: Every enemy encountered in the series so far had been a gross, disgusting monster or a child's interpretation of something from the Bible. Every demon or angel looked like how a child would likely see them, or just have some slightly funny quirk about them. The same cannot be said, however, for Dogma. Instead of being another faceless angel like Uriel and Gabriel, it resembles how something like an Ophanim would actually look in the Bible, has music that is barely even music and preachers screaming of sin, and the implications of the impact it has on the story means what it represents has done more to cause the story than almost any other boss in the game.
• Dark Reprise: Its boss theme, Living in the Light, twists and corrupts leitmotifs heard in Crusade, the standard boss theme in Rebirth onwards, resulting in an unstable-sounding remix.
• Deliberately Monochrome: Applies to both itself (being made of TV static and all) and its boss arena, where the entire screen, barring you, your familiars (if any), and your attacks, is rendered in greyscale.
• The Dragon: It's implied to be Isaac's interpretation of the Dragon of the Apocalypse, the being who "gave [the Beast] his power, and his seat, and great authority." (Though in this case, the Beast is female.)
• Easter Egg: Hitting Dogma with the magnetism effect of Lodestone will cause its static to become fuzzy, as if the magnet was interfering with the TV's signal.
• Eldritch Abomination: Big time. Its first form is already bad enough, being a fetus... thing made out of television static, but the second form is even worse — becoming a biblically accurate angel, still made out of static.
• Evil Counterpart: Based on Freeze-Frame Bonus below and the fact that it gives you angel wings after killing it, Dogma is thematically meant to be last of the "Isaac" line of final bosses, in contrast to the boss that follows after.
• Evil Sounds Deep: Dogma has a "voice" heard when it uses most of its attacks, separate from the preacher in the background of its battle music. It is a very deep, distorted reading of Psalm 23. It is easiest to hear when the debug console is turned on at the right moment.
• Feather Flechettes: One of its second form's attacks involves assuming a ring-like form and spinning like a top and passing through a wall. Upon impact, a storm of feathers sprays outward towards your character. It can also fire a stationary barrage that hangs in the air for a few seconds.
• Fetus Terrible: Its first form is a fetus monster made of static and having an umbilical cord connected to a TV.
• Freeze-Frame Bonus: In its second form, sometimes its sprite gets very briefly replaced by things that look like a demonic troll face, a photorealistic fly, a skull with a snake inside it, or a large, crying Isaac face.
• The Fundamentalist: It's Isaac's means of personifying this, surrounding itself with manic preachers calling out the sins of mankind and driving his mother to see him as a demon.
• Fusion Dance: Heavily implied to do one with Isaac after its defeat, granting him increased power to take on The Beast.
• Glowing Eyes of Doom: Its first form has eyes that glow ominously with pure white light.
• Greater-Scope Villain: Dogma is the personification of the demented fundamentalism which led to Mom's descent into religious madness. It's essentially the source behind Mom's antagonism and all of the negative influence that Christianity has had on Isaac, meaning that its influence is felt in practically every part of the game. And yet, it does not appear at all in the game until you reach the Home area, and isn't even the Final Boss of its path.
• Hell Is That Noise: A lot of its sound effects include distorted static noises and buzzes that grate on your ears. The unearthly sound of its Brimstone laser is particularly unnerving.
• Large Ham: The preachers that rant in the background during the fight are just as bombastic as real life fundamentalist preachers, if not moreso.
  THE ANGER OF GOOOOOOOD IS COOOOOOOOMING!!!
• Light Is Not Good: Far from it. It's the only boss whose versus splash art has a bright white background, as opposed to the darkness of every other boss; it uses several light-themed attacks and is the only source of light in its arena; and the preacher's ranting about "God's Light" is one of the biggest sources of conflict in Isaac's life.
• Meaningful Name: A "dogma" can be described as "a belief or rule that is held onto deeply and fervently despite the lack of basis in its authority". As a representation of televangelism, it represents the fact that many televangelists speak with a false authority on the meaning of God's words.
• Mind Screw: Probably one of the most mind-screwy of bosses, as it's a being that looks like a fetus connected to a television and made of static, then shifting into an eldritch angel form in its second phase while a preacher rants and raves in the background.
• Ominous Visual Glitch: It's made entirely of white noise, and its first form glitches out any time it faces a new direction.
• One-Winged Angel: After the TV's destroyed, Dogma morphs from a fetus into an angelic monster.
• Our Monsters Are Weird: The majority of the game's bosses and enemies are composed of either Body Horror, Toilet Humor, Nausea Fuel, or some combination. Alternatively they are meant to represent various characters from the Bible, outright demonic creatures, or just thematically appropriate entities based on the area they're in. Dogma… is none of these. Instead, it's a being composed of TV static that looks like a fetus connected to the TV it comes out of, and shifts into an Angelic Abomination form after said TV is destroyed. Certainly one of, if not the most out-there bosses in this game.
• Painting the Medium: Its health bar is not the standard blood red that other bosses have. Instead it's composed of the same static that it has as part of its sprite.
• Pre-Final Boss: The first of the True Final Bosses that Isaac must fight in order to reach the true ending of the game.
• Sinister Minister: It is the Christian broadcasts given a physical form, and judging by what the preachers from said broadcasts are constantly screaming, it's not likely those broadcasts are the healthiest for anybody to watch.
• Small Role, Big Impact: Is only the subject of one relatively short boss fight, but its influence on Isaac's life is far-reaching. In another sense it applies to the fight with the Beast, as the static cross it forms after being killed falls on Isaac and grants him angel wings in order to be on equal footing with the Beast.
• Snowy Screen of Death: A more literal example than most, as it appears to be made of TV static and is trying to murder Isaac.
• Stealth Pun: It looks like a fetus and is the personification of televangelism, which is the main key that kicked off Mom's descent into madness and, therefore, the events of the game. In other words, it is the personification of the birth of Isaac's suffering.
• Superboss: In Four Souls Requiem, it is the only other Epic Boss besides Delirium that does not grant souls upon defeat, instead making way for the Ultra Harbingers and the Beast like it does in Repentace.
• Television Portal: Its intro has it emerge from the TV, although it is somewhat complicated as Dogma may very well be the television itself.
• Third Eye: One of its attacks in its first form has it fire a barrage of Godhead bullets. Indeed, Dogma has a third eye while using this attack, just like Isaac does with Godhead.
• Vocal Dissonance: Its first form resembles a fetus, but its "voice" heard during its attacks is very deep and menacing. If the vocals in the battle theme are also somehow Dogma's voice, then it also has the voice of a grown adult.
• Walking Spoiler: Its whole existence is a Spoiler and just try to talk about this boss without discussing the ending.
• You Kill It, You Bought It: When Isaac kills Dogma it turns into a giant cross that falls on him, giving him temporary static eyes and permanent angel wings. This is actually a hidden item that Isaac gets in-game, appropriately named "Dogma".

The Ultra Harbingers

The Ultra Harbingers

"For the great day of his wrath is come; and who shall be able to stand?"

Debut: Repentance

Floor(s): Home

Minions of the Beast and upgraded forms of the regular Horsemen bosses. Isaac must defeat them first before the Beast will attack. They are fought in the order they do when encountered during the game: Famine, Pestilence, War and Death.

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• Back for the Finale: The original four Horsemen appear again (and are supersized too).
• Body Horror: Ultra Pestilence looks like a giant, bloated, pus-filled corpse drooling disgusting fluids from his decayed mouth, and he hocks up explosive Ipecac shots and literal balls of maggots. Ultra Famine also gets in on the trope, appearing as his usual emaciated, lipless self, with the additional change that his pinprick eyes are instead now empty, gaping sockets.
• Boss Bonanza: They collectively have a total of 7800 HP^note Ultra War, Ultra Famine, and Ultra Death each have 2,000 HP while Ultra Pestilence has 1,800 HP, which is even more than Hush and Mega Satan. And they're the in-between bosses between Dogma and The Beast. The only reprieves Isaac has are the Ultra Harbingers having significantly weaker boss armor than Hush or Mega Satan, and each fight being treated as a wave (just like Challenge Rooms and the game's own Boss Rush), so any room-clearing effects will proc here.
• Bullet Hell: While Ultra Famine can summon flies, his main attack patterns revolve around spamming bursts of bloody tears in Isaac's vicinity, especially during his second phase.
• Burning with Anger: After his horse is destroyed in the first phase of his fight, Ultra War becomes so enraged that his skin turns to ash and his head lights up with flames.
• Call-Back: All of them except Ultra Death have a second phase where they undergo the same changes as their regular counterparts: Ultra Pestilence still loses his head, Ultra Famine still loses everything but his head, and Ultra War still loses his horse but his body is otherwise left intact.
• Combat Breakdown: Zig-zagged compared to the originals. While they retain the same phases, the second phase isn't always easier with the Ultra versions.
• Defeat Equals Explosion: Besides the usual "burst into gore" death effect that most bosses have, Ultra War explodes more traditionally upon death — which can hurt Isaac if he's too close.
• Evil Is Burning Hot: During one of his attacks in his second phase, Ultra War lights himself aflame.
• Eyeless Face: Unlike the pinprick eyes that normal Famine has, Ultra Famine outright has no eyes.
• Facepalm: Ultra Death facepalms in the background when the three other Harbingers die (or more specifically, when Ultra War dies, who directly precedes Ultra Death).
• Fat Bastard: While Pestilence was always bloated due to being a diseased corpse, his Ultra form has clearly put on a few pounds.
• Funny Background Event: They can be seen far in the background around the Beast, and they all react each time one is beaten. They also cheer if Isaac takes damage.
• Glowing Eyes of Doom: One of Ultra Death's eye sockets gains a small red glow for a brief moment whenever he's about to swing his scythe at Isaac.
• Green and Mean: Along with being one of the Horsemen of the Apocalypse, Ultra Pestilence is green.
• The Grim Reaper: Ultra Death uses a giant scythe to attack instead of just summoning scythe-shaped projectiles (although he still has those too).
• Horsemen of the Apocalypse: The classic four (Famine, Pestilence, War, and Death), bigger and stronger than ever. They come complete with an actual apocalypse this time.
• Losing Your Head: As with his "regular" counterpart, Ultra Pestilence's head explodes once he's low enough on health. Not that this stops him from spewing out projectiles from the gaping hole where his head used to be.
• Playing with Fire: One of Ultra War's new attacks. In his first phase, he can ride through the lava to shoot up balls of fire at Isaac. In the second, his chase sequence starts with lighting himself on fire. Ultra Pestilence also gets in on a downplayed version, as the Ipecac shots he lobs into the lava below splashes some fireballs upwards each time they explode.
• Sequential Boss: All four and the Beast have to be fought in sequence — Famine, Pestilence, War, Death — which is always fixed. On top of that, the first three all have a second phase once they drop under a specific health threshold.
• The Swarm: Ultra Pestilence comes with a constant swarm of flies around him, and constantly coughs up even more.
• Throw Down the Bomblet: Instead of dropping Troll Bombs everywhere, Ultra War now tosses massive Giga Bombs one at a time. Granted, Isaac can actually steal them if he has Safety Scissors.
• Unexpected Shmup Level: Isaac sprouts wings and takes flight to do battle with the Beast and its Horsemen. The fight itself is a side-scroller rather than the top-down perspective of most of the game, with some of the Horsemen's attacks taking advantage of the downwards gravity.
• Variable Mix: Each Horseman gets a variation of the boss theme, "Revelations 13:1".
  • Ultra Famine starts with a brutal-sounding electric guitar that takes center stage, even performing an epic solo in the middle. Throughout the track, vibrating wailing and demonic chanting accompy the melody.
  • Ultra Pestilence brings in droning sirens, vibrating synth and an offbeat melody. The electric guitar is still present, but lower and slower. The end features various noises: slithers, gurgles and what can best be described as an helicopter's rotor.
  • Ultra War drops the electric guitars in favor of bass guitar, horns, guttural chants and oppressive drum beats and percussion.
  • Ultra Death opts for something less percussion heavy, putting more emphasis on the melody with strings, piano notes and singing voices, all reminiscient of Danse Macabre by Saint​-​Saëns. It keeps the tension up with a One-Woman Wail and "Psycho" Strings with violin, and what sounds like animalistic squealing and shrieking near the end.

The Beast

The Beast

Debut: Repentance

Floor(s): Home

And the beast which I saw was like unto a leopard, and his feet were as the feet of a bear, and his mouth as the mouth of a lion: and the dragon gave him his power, and his seat, and great authority.

The Beast of the Apocalypse, the Mother of Harlots, heralded by the Four Horsemen. Repentance's True Final Boss (and by extension the series as a whole), The Beast challenges Isaac after his victory over Dogma.

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• Animation Bump: The Beast and her Ultra Harbingers have very smooth and detailed animation, benefitting their status as the game's cinematic endbosses.
• Anthropomorphic Personification: Heavily implied to be the last (and most primordial) manifestation of Isaac's various traumas that he must destroy before he can move on.
• Attack of the 50-Foot Whatever: Her head alone takes up half the screen, making her the largest boss in the entire game.
• Battle Theme Music: "Revelations 13-1". The boss theme is segmented so that it fits each of the Ultra Harbingers specifically until it reaches the Beast proper, but for all intents and purposes, it's the Beast's proper boss theme. The segment corresponding to her involves a lot more demonic chanting and distorted guitar.
• Beast of the Apocalypse: It's in the name, and she controls the classic Four Horsemen of the Apocalypse.
• Blood from the Mouth: She appears to have blood coming from her mouth.
• Bolt of Divine Retribution: On the receiving end of one after her defeat, serving as the proper killing blow before Isaac begins ascending to Heaven.
• Boss Bonanza: The final boss of the Home sequence.
• Chekhov's Gunman: When importing a save file from Afterbirth+ where all three save files are at 1,000,000%, the 3,000,000% triptych is replaced with one where the skeletons are menaced by three eyes. It's not apparent until the final climax of the game that those eyes belong to the Beast.
• Combat Breakdown: Her last phase consists solely of her charging toward Isaac constantly as bits and pieces of her get chipped away.
• Contractual Boss Immunity: One of two enemies who isn't harmed at all by the Chaos Card. Plan C can kill the Beast before Isaac, but only if he uses it on her specifically (i.e. he must actually fight the Ultra Harbingers first).
• Earn Your Happy Ending: By killing The Beast, Isaac manages to redeem himself, and comes to terms with all of his trauma as he ascends to Heaven.
• Final Boss, New Dimension: While every floor is implied to be an extension of the unknown depths below the house, the Beast's boss fight takes place in a vast fiery cavern that looks like and is implied to be either Hell or the biblical apocalypse.
• Fire and Brimstone Hell: As a stark contrast to Sheol, The Beast's lair is a fiery cavern flooded with lava.
• Five-Second Foreshadowing: During the cutscene that follows Dogma's defeat, the preachers in the background can be heard reciting Revelations 13:2, which describes the appearance of the Beast. Right on cue, she rises from the lake of lava as Isaac looks on in terror.
• Historical Gender Flip: The Beast of the Apocalypse was described as male in the Bible proper (as shown in the above quote), but here said beast is female.
• Marathon Boss: Coming in at 10,000 HP by herself, and being the final boss of the entire Home sequence. She also has boss armor similar to other final bosses, so it will take a while to take the Beast down.
• Mix-and-Match Critters: In a thematic (and possibly even literal sense), the Beast is a fusion between Mom and Satan — note that the Beast wears Mom's dress, but has Mega Satan's giant laser.
• Monster Progenitor: Considering one of her titles is Mother of Harlots, this seems to be implied. She's also the culmination of Isaac's religious trauma, and destroying her allows him to pass peacefully into heaven (or a facsimile thereof).
• One Bad Mother: Described as the "Mother of Harlots," implied to be yet another form of Mom, and is the true True Final Boss.
• Red Eyes, Take Warning: She's red-eyed and is trying to kill Isaac.
• Sequential Boss: Subtler than most, but she has two distinct phases. First she alternates between chasing Isaac and stopping to perform various attacks. Once her health is down to 33%, she drops all other attacks and only moves across the screen.
• Shows Damage: As she takes more and more punishment, she starts bleeding, losing teeth, eyes and her horns. This is especially noticeable during the third and final phase.
• Stalactite Spite: When she chases you, you have to navigate through a maze of stalactites and stalagmites (or alternatively turn around to shoot them). Some stalactites will also fall when Isaac gets under them.
• The Pawns Go First: Isaac must defeat her minions, the Harbingers (sans Headless Horseman and Conquest), before he can take on the Beast herself.
• Red and Black and Evil All Over: She's the True Final Boss with red eyes, appears to have red blood coming from her mouth, and has loads of black.
• Third Eye: She has an extra eye, though doesn't seem to do anything with it.
• True Final Boss: Of Repentance, and as of this writing, the entire game itself.
  • More specifically, where Dogma may serve as the finale of the "Isaac" line of final bosses^note It Lives!, Isaac, ???, the Lamb, and Hush, the Beast serves as the finale of both the "Mom" and "Satan" lines of final bosses^note Mom, Mom's Heart, Mother, Satan, and Mega Satan.
• Unexpected Shmup Level: Continued from the Horsemen fight. This time she actively chases you while taking up half the screen!
• Vacuum Mouth: She does this to draw in fire and try to swallow you, before finishing with a huge laser.
• Variable Mix: The Beast's version of "Revelations 13:1" sounds more brutal and oppressive than the rest, with drawn out notes, heavy drums, harder electric guitar, both demonic and angelic chanting, and a sense of impending doom. The chants are pleas for the Beast's death. The priest from the vocals of Dogma's 2nd phase can even be heard rambling towards the end.
• Wave-Motion Gun: She uses what is probably the largest version of Brimstone in the whole game as one of her attacks; it even outsizes Mega Satan's brimstone laser, requiring you to be at the top of the screen to dodge.

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