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Characters: The Binding of Isaac
A list of characters who appear in The Binding of Isaac. Currently under construction, please contribute!

    open/close all folders 

Playable Characters

    In General 

Isaac/Player Character

A little boy who gets thrown in the basement and must fight for his life against a never-ending assortment of demons and mutants, the alternative being his mother killing him. Beating the game in certain ways or collecting certain items unlocks variations of Isaac with their own unique attributes.

Story-related Tropes:

  • The Antichrist: The definitive true ending of Rebirth shows that Isaac was the anti-Christ, the voice his mother heard really was the voice of God telling her to kill him. And by defeating Mega-Satan, you prove to him that you're worthy to be his champion and Isaac is turned into a demon.
  • Break the Cutie: The entire premise of the game is one for him.
  • Children Forced To Kill: One boss is his own mother trying to murder him. He must do this in self-defense.
  • Create Your Own Villain: Well, antagonist. Isaac would never have been forced to kill his own mother if she hadn't snapped and tried to sacrifice him in the first place. Gains some very interesting implications at the true ending of Rebirth where it's revealed that Isaac becomes a demon or the Anti-Christ inside the Chest. Did Isaac have darkness inside him all along or did he decide Then Let Me Be Evil after the horror that he went through?
  • Dark and Troubled Past: The horrible memories of things that Isaac suffered through are relived in level loading screens. In one ending, the photograph montage of Isaac's past leaves a lot of interpretation as to what happened to his family, namely what happened to his father (who likely left, went missing, or died).
  • Dead All Along: After beating It Lives for the tenth time and unlocking Ending 10, Isaac comes across his corpse stuffed into a chest. At least one interpretation of this involves Isaac having been dead the whole time. The next three endings explore the events leading up to his death in reverse chronological order, first showing him willingly locking himself in the chest, then showing his self-loathing which led to this, and finally showing his tragic backstory through a heartbreaking Photo Montage.
  • Driven to Suicide: Isaac hangs himself upon finding Transcendence (a noose) in Ending 2. This is Played for Drama in the final few endings: After we see that Isaac has possibly been Dead All Along in the tenth ending, we are shown him willingly entering the chest himself due to his self-loathing over his Dark and Troubled Past.
  • Enemy Without: The boss of The Cathedral Isaac seemingly fighting himself and the boss of The Chest is ???, which was strongly implied to be a dead Isaac post-suffocation and cyanotic.
  • Then Let Me Be Evil: It is strongly implied that at the ending of Rebirth, Isaac becomes a demon or the anti-christ in order to deal with all the horror he went through, up to and including his mother.

Gameplay-related tropes:

  • Acrofatic: Several items make your character fatter, and most don't negatively impact speed. Combine these with items that increase your speed and you have this trope.
  • Badass: Badass enough to kill Satan, in both his normal & most powerful forms.
  • Badass Adorable: He's still a child in the end of the day.
  • Blessed with Suck: Guppy's Tail makes you finds golden treasure chests more often. This comes at the expense of keys needed to open those chests, though if you're lucky the chests cough them up. Works wonders with an Skeleton Key or a Flat Penny.
    • Made potentially worse or better with The Left Hand item that changes all chests to Red Chests. They don't require a key to open, but half or more of the things that come out of a red chest is not something you want (including enemies and troll bombs).
  • Body Horror: Most of the powerups mutilate the character in some horrific way.
  • Bullet Hell: It's possible to get a character that shoots a four-way bullet spread at the speed of a machine gun with additional single shots from the other three cardinal directions.
  • Collision Damage: Isaac takes damage from pretty much everything that moves. The player can cause this if they use My Little Unicorn (or the Chariot tarot card) or the Virus powerup. The former is temporary, while the latter is permanent but doesn't prevent damage in return.
  • Cross Dresser: The alternate characters are all Isaac wearing different costumes, meaning that he is this when dressed as Eve or Maggy.
  • Dark Is Not Evil: An Isaac with a lot of Devil items is still just looking to survive.
  • Deal with the Devil: The player can trade heart containers to Satan for demonic items.
  • Detachment Combat:
    • When using The Shears or Transcendence (the latter is permanent), Isaac floats around as a severed head. The former also turns his body into a secondary attacker, but only works for the current room.
    • The Peeper pops out one of your eyes, which bounces around the room, hurting everything it touches.
  • Did You Just Punch Out Cthulhu?: Isaac can tear apart any number of bosses over the course of the game, including Satan.
  • Empowered Badass Normal: No matter which version you choose, you'll inevitably turn him into a supernatural being in the process of beating the game.
  • Eye Scream: Some items cause this.
  • Fantasy Character Classes: The characters are based on archetypal RPG classes (with the exception of ???)
    • The Hero/Balanced: Isaac.
    • The Cleric: Maggie.
    • The Druid: Eve.
    • The Thief: Cain.
    • The Mage: Judas.
    • The Berserker: Samson.
  • Faustian Rebellion: The items Satan sells you at the cost of your maximum health often end up making beating him a lot easier.
  • Flash of Pain
  • Flight: Plenty of items, both permanent and temporary. You can become an angel, a demon, an angelic ghost, a demonic ghost, a floating head, and a cat (which somehow flies). All of these let you pass through rocks and over pits.
    • Becoming possesed by Guppy (the flying cat form) alows you to fly because why couldn't a possibly demonic cat possesion also allow you to fly. Also it's a kitty cat.
  • Full-Frontal Assault: Before the events of the game, his clothes were taken away from him as part of Mom's attempts to remove the evil around him. In most playthroughs, he fights his way through monsters naked.
  • Good Wings, Evil Wings: Both are possible.
  • Hammerspace: It's not specified where all the coins, keys and bombs are stored.
  • He Who Fights Monsters
  • Ironic Name: "Isaac" means "he laughed" or "he who laughs." Not much laughing occurs. Quite the opposite, really. invoked
    • Although it was based off the biblical story. See Meaningful Name below.
  • Item Get: Holds up new items - even in battle. You're not invincible when that happens, either.
  • Kindhearted Cat Lover:
    • Isaac seems to adore Guppy the cat the most out of his (deceased) pets.
    • He seemed to also like Max (Cricket in Rebirth) second most out of the pets, or possibly equally to Guppy, because Max's head makes him cry hardest of all items.
    • There is also Tammy, who although she doesn't evoke as strong a response as as guppy, will still makes Isaac cry more than normal, translating into a 360 shot.
  • Meaningful Name: The name of all of the playable character relate to bible stories, with Isaac's name relating to the Binding of Isaac story the game is based on.
  • No Name Given: His surname is never known.
  • Paper-Thin Disguise: It is strongly implied in-game (and confirmed by Word of God) that all the characters are just Isaac putting on a wig, eyepatch, hat, etc.
  • Secret Character:
    • Collecting three Guppy items (Dead Cat, Guppy's Tail, Guppy's Paw or Guppy's Head) will transform the player character into Isaac's pet cat. Doing so unlocks a new item (the first time), gives you flight, and applies the effect of the Mulligan.
    • In Rebirth, the same is possible with "Lord of the Flies", activated by finding three fly-related items.
  • Swiss Army Tears: As a weapon!
  • Throw Down the Bomblet
  • Took a Level in Badass: Throughout the game, if the right items are acquired. Isaac starts the game as a crying child and can potentially end it as a flying demon that can demolish bosses in seconds with giant lasers.
  • Troubled Fetal Position
  • Urine Trouble:
    • The aptly named Number One upgrade replaces his tears for a urine attack instead.
    • Also Lemon Mishap, which leaves a puddle that damages enemies.
    • Entering a room with half a heart makes the player leave yellow urine stains on the floor (unless playing as Eve, whose stains are red instead).
  • Winged Humanoid: Possible with certain items.

    Isaac 

Isaac

Debut: The Binding of Isaac
Named after the biblical son of Abraham, is playable from the start and has no defining accessories. According to Edmund McMillan, he represents the fighter class of traditional games and begins with no items.

    Magdalene 

Magdalene

Debut: The Binding of Isaac
Named after a friend of Mary, the mother of Jesus, she is distinguished from Isaac by blonde hair and bow. Maggy represents the cleric class from traditional games and starts with the Yum Heart: an activated item that restores one heart upon use.
  • Boring but Practical: Her gimmick is somewhat bland compared to the others, but having 4 red hearts to work with allows for Devil Room deals early on without severe consequences. Additionally, the Yum Heart restores a red heart every 3-4 rooms or so, which keeps her healthy and can be a godsend during the later chapters.
  • Combat Medic: Called "the cleric" in the art booklet.
  • Crossdresser: It is strongly implied that Maggy is just Isaac wearing a wig and makeup.
  • Everyone Calls Him Barkeep: Usually referred to as Maggy.
  • Stone Wall: Starts with low speed and 4 hearts, the highest starting amount possible, and a healing item.
    • Taken Up to Eleven in Rebirth during "The Tank" challenge. Maggy now starts with seven heart containers, the Yum Heart, and the Infamy mask, which blocks (some) damage from the front. Unfortunately, she now runs slower than even some enemies, making dodging difficult, if not impossible.
  • Tertiary Sexual Characteristics

    Cain 

Cain

Debut: The Binding of Isaac
Named after the biblical son of Eve and first murderer, he is distinguished from Isaac by an eyepatch. He represents the Thief class from traditional Role-Playing Games and starts the game with the Luck Foot: a passive item that improves random events in various ways.
  • Bald of Awesome
  • Born Lucky: Cain's starting item gives him increased luck in certain situations.note 
  • The Dev Team Thinks of Everything: For most characters, Technology 2 stacks the beam on top of their tears. Cain's the exception, his tears being shut off due to his eyepatch. Chemical Peel is changed, too; while with other characters every other tear will have increased damage due to one half of the face being scarred, with Cain, every tear has a 50% chance of dealing increased damage.
  • Eyepatch of Power:
  • Fragile Speedster/Glass Cannon: Starts with great speed and attack and an average rate of fire but suffers from low range and health. Outright called "the thief" by the art booklet. Being "the thief" could be considered Fridge Brilliance considering he "stole" his own brother's life in the Biblical story of Cain and Abel.
  • Nerf: His speed and damage got hit with the nerfbat for Rebirth, and the mechanics of Lucky Foot changing also indirectly hurt him.

    Eve 

Eve

Debut: The Binding of Isaac
Named after the first woman and original sinner, Eve is distinguished from Isaac by long dark hair and eyeshadow. Representing the druid class from traditional games, she starts with The Whore of Babylon, which turns her into a demon at low health, and the Dead Bird, which fights for her when she is damaged.

    Judas 

Judas

Debut: The Binding of Isaac
Named after the disciple who betrayed Jesus, he has a fez to distinguish himself from Isaac. He represents the mage class from RPGs and starts the game with the Book of Belial, an activated item that increases attack power for one room. In the original game, he unlocks after beating the Womb for the first time. In Rebirth, he unlocks after beating Chapter 5 for the first time.
  • Bald of Awesome
  • Glass Cannon: More so then Cain. Starts with average rate of fire, range, speed and high attack power, further bolstered by his Book of Belial. In exchange, he starts with only 1 heart.
  • Deal with the Devil: While holding the Book of Belial, the chances of a Devil Room appearing are increased. Unfortunately, Judas' starting 1 heart makes it impossible to make deals unless he gets more heart containers or soul hearts.
  • Difficult but Awesome: Starts off with the most consistent damage of all the playable characters (Eve and Samson's powers are conditional), but with only one starting heart and average speed for dodging, you don't have much leeway to screw up.
  • Nice Hat / Take That: Judas' fez, which doubles as a jab at Phil Fish, who voted against Edward Mcmillen and his comrades at the Independent Games Festival, which made him a Judas (ergo, a traitor).
    • The Take That part is actually subverted. Edmund has stated that he just needed an iconic hat for Judas, and went with the idea of Fish representing Judas because he found it funny.
  • Squishy Wizard: The artbook refers to him as the "mage", fitting in the other RPG archetypes. It fits since Judas has high starting damage (especially with the Book of Belial active) but very low starting HP.

    Samson 

Samson

Debut: Wrath of the Lamb
Introduced in Wrath of the Lamb and named after the biblical strongman, he has long, brown hair and Big Ol' Eyebrows. He also starts with a red headband called Blood Lust, which grants him a temporary but substantial attack-power boost for each enemy he kills in the current room. This is fitting with the fact that he represents the Berserker class.
  • Blood Knight: His trademark power-up is called Blood Lust, after all!
  • Conservation of Ninjutsu: Invoked by his special hair-band. The more enemies you face in a room, the more powerful you'll get! But single target rooms won't trigger any attack-boost.
  • Critical Status Buff: In Rebirth, Bloody Lust makes Samson deal more damage as takes damage, with him reaching near maximum damage for having taken several hits in a row. In this case he literally Turns Red to reflect Bloody Lust activating.
  • Difficult but Awesome: Blood Lust makes Samson powerful... if you manage to survive the hordes of enemies that give him his strength.
  • Glass Cannon: With just 1 starting heart container, he's as fragile as (and under some circumstances, even more than) Judas. However, his special gear makes him extremely effective against large groups of enemies and/or mook makers.
  • Martial Arts Headband
  • Power-Up Letdown: He's probably the most difficult character to unlock (with ??? possibly being more tedious than difficult), as it requires you to pass on 2 free items on a regular run... and it's capacity is dubious to say the least. After months of complaints, Edmund promised a buff to Samson. The buff was starting with a soul heart on top of his single regular heart. He became much more useful in Rebirth, as he now starts with three regular hearts and his buffs from killing enemies and taking damage remain until you leave the floor. On the other hand, he became even more difficult to unlock, as he now requires you to clear two floors in a single run without taking any damage.
  • Took a Level in Badass: In Rebirth, Samson starts with a much more forgiving 3 hearts and gets to keep his buffs until he leaves that floor. This is a major improvement from his previous incarnation.

    Spoiler Character (BOI) 

???

Debut: The Binding of Isaac
Click here for the picture 

Unlocked after defeating Mom's Heart/It Lives ten times, ??? is a shout-out to Edmund McMillen's Newgrounds account (specifically his "Dead Baby Dressup" game). Starts with The Poop, which creates a pile of dung once per room. Whilst his official name is ???, his nickname is "Blue Baby", which is how he signs his death note on the Game Over screen (and how he's listed on the PSN Trophies list for Rebirth).

Despite being a Joke Character gameplay-wise, he is possibly one of the most plot-relevant characters in the game. His reveal indicates that the vignette of Isaac suffocating in the chest is canon, and not only that, but he somehow died of asphyxiation whilst there. At this point it is implied that Isaac has been Dead All Along and Endings 11 and 12 seem to indicate that Isaac actually locked himself in the chest after being Driven to Suicide.

    Lazarus 

Lazarus

Debut: Rebirth
Named after the one that was brought back from the dead. Unlocked in Rebirth by having four or more soul hearts at once.
  • Back from the Dead: Starts play with one extra life.
  • Bloody Murder: After he uses his extra life, he gets the Anemic item, which lets him leave a damaging trail of blood for the duration of the room upon taking damage.
  • Jack of All Stats: Apart from his resurrection ability, he essentially plays like Isaac without a D6.
  • Meaningful Name: Who else but Lazarus would start with the ability to rise from the dead?
  • Not Quite Dead: His gimmick is being able to resurrect instantly, rather than outside the room he died (forcing him to restart it).
  • Power-Up Letdown: His extra life only resurrects you with exactly one heart container, and only gives you a blood trail for the current room if you get hit once. On the other hand, it does resurrect you on the spot (unlike the other extra lives that return you to the previous room), possibly allowing you to finish off whatever killed him.
  • Red-Headed Hero

    Azazel 

Azazel

Debut: Rebirth
A demonic looking character whose name is associated with evil. Unlocked in Rebirth by making three deals with the devil in one run.
  • Action Bomb: He starts with only black hearts, which trigger the Death effect when depleted.
  • Bad Black Barf: His starting attack is a limited-range Brimstone.
  • Big Black Devil
  • Close Range Combatant: The closest thing that Rebirth has to one, since his starting weaponry forces him to get relatively close to enemies. He compensates by possessing above-average speed and flight.
  • Disc One Nuke: His flight and Brimstone are a major advantage in the early game, and flight remains an important bonus throughout.
  • Dungeon Bypass: Possessing flight lets him ignore spikes, rocks, and other terrain right from the start. Rather useful.
  • Fragile Speedster/Glass Cannon: Fast, possess flight, and has high starting damage, but at the cost of poor range that cannot be increased and having to charge Brimstone for attacks. His black hearts damage everything if one gets depleted and he can eventually gain red heart containers through Health Up items, but he is in overall much frailer than characters who can pick up red hearts from the get-go.
  • Hit-and-Run Tactics: Unlike others who depend on kiting with tears, Azazel often has to fly in, blast several enemies with brimstone, then get out of there before the rest retaliate.
  • Horned Humanoid: One of his horns is broken.
  • The Last of These Is Not Like the Others: Azazel is by far the most different from the other playable characters, since he starts with miniature brimstone instead of tears, has evil hearts (but can gain red ones, unlike ???), and has flight (which only The Lost shares). The result is a rather different playstyle, including item selection, since his smaller brimstone makes many items useless/redundant but others extremely powerful.
  • Required Secondary Powers: A melee character would've been an interesting addition to the roster, but an actual melee attack would make multiple rooms Impossible By Design. Azazel being equipped with the piercing brimstone and flight fixes both of these problems.
  • Winged Humanoid: Starts with flight.

    Eden 

Eden

Debut: Rebirth
Named after the biblical garden, Eden's stats are randomly generated every time you play as them. Their gender is undefined, and to play as them requires the use of one "Eden token", earned by beating Mom's Heart. Unlocks in Rebirth after beating the Womb for the first time.

    Spoiler Character (Rebirth) 

The Lost

Click here for the picture 
Debut: Rebirth
A ghost character, and one of the only characters not based off of any sort of religious contextnote , next to ???. It is the secret character of Rebirth, and has a very complicated unlock process.

  • Chekhov's Gunman: Actually, it appears several times prior to being unlockable, albeit so briefly that few players would actually notice. Specifically, it is the ghost that departs from Issac every time he dies.
  • Glass Cannon: And how! It has zero health and can't gain any type of hearts, period. The only upside to this is that it take Devil Room and Angel Room upgrades for free, possibly resulting in a One-Hit-Point Wonder powerhouse early on.
  • Guide Dang It: Unlocking it is a bit...convoluted. First, you need to let yourself get killed by a Mulliboom in the basement as Isaac. Next, you need to blow yourself up with one of your own bombs as Maggie in the caves, then let yourself get killed by Mom's foot as Judas. Finally, you need to let yourself die to Satan on the second phase of his fight as Azazel. And you need to do all of this in a row. Mess up once and you have to start all over again. Not very easy, to say the least, although the at the very least you get (cryptic) hints as to the next step once you've completed one.
  • Joke Character: Starts with the ability to fly, with the downside of having absolutely no HP.
  • Lethal Joke Character: Its lack of HP means that it can take Devil items (some of the most powerful items in the game) for no cost at all. Normally it would cost one or two heart containers for one of those items.
  • One-Hit-Point Wonder: Dies in one hit from anything. Earlier versions had him die from continuing a run.
  • Power Up Letdown: Remember how some thought that Samson and ??? weren't worth the effort it took to unlock them? The Lost is quite possibly even worse in this regard, especially since unlocking it involves a dose of Guide Dang It too.
  • Walking Spoiler: Naturally, being the secret character of Rebirth.

Enemies and Bosses

Universal

    Enemies 

Flies

Flies are among the most common enemy type throughout the game.

Black Fly/Attack Fly/Moter

  • Asteroids Monster: Moter.
  • Bulletproof Human Shield: As the Halo Of Flies and Pretty Fly powerups. The Forever Alone and Distant Admiration powerups spawn one capable of dealing good damage.
  • Mascot Mook: The black variety is featured prominently in the artwork, and easily has the most related items.
  • Mook Promotion: If allowed to aproach a pile of poop, a black fly consumes it and turns into a Pooter.

Pooter/Fat Fly

Boom Fly/Red Boom Fly

  • Action Bomb: Black variation.
  • Disaster Dominoes: An efficient way to clear a Boom Fly room is to kill one of them while they're all flying in a cluster.

Sucker/Spit

  • Action Bomb: The green variety.
  • Disaster Dominoes: In a room with several Spits, killing one while standing in the right direction will often cause a chain reaction of vomit bombs that kill the rest of them.
  • Taking You with Me: They release hard to dodge ranged attacks for Suckers or vomit bomb for Spits when killed.

Eternal Fly

  • Invincible Minor Minion: Until the monster or poop they orbit is destroyed, at least.
  • Meaningful Name: As mentioned above the Eternal Fly is, well, eternal, until the poop or monster they orbit is destroyed.

Humanoid

Pacer/Gusher/Gaper/Frowning Gaper/Gurgle/Horfs

Hopper/Fire Hopper/Leaper

  • Bullet Hell: Leapers shoot bullets in all four cardinal directions when they jump. If five end up in a room, be prepared to dodge.
  • Elite Mooks: Fire Hoppers and Leapers, the former being stronger and the latter shooting bullets. It should be noted that fire hoppers cannot spawn by themselves, Hoppers have to touch fire first.
  • Infernal Retaliation: Hoppers move twice as fast, jump twice as far, and inflict more damage when they're on fire.
  • Violation of Common Sense: Not only does every other enemy (or character, even) take damage themselves from fire, but Isaac's main combat strategy is attacking enemies with water. Despite that they seem to have double health.

Maw/Red Maw/Physic Maw/Mr. Maw

  • Detachment Combat: Mr. Maw
  • Elite Mooks: Red Maws, with their lips stitched, can't shoot but chase you pretty fast. They also get knocked away farther when hit, making it difficult to line up multiple shots against them.
    • Psychic Maws also have their eyes stitched. They have a Third Eye which shoots homing tears, and a Eternal Fly circling them.

Mulligan/Mulligoon/Mulliboom/Hive/Swarmer

  • Action Bomb:
    • Normal Mulligans puff up and explode into flies if they survive long enough and get cornered.
    • Mulligoons replace the flies with a 4-way shot plus a troll bomb.
    • Mullibooms come with bombs implanted in them and will charge and blow up on you.
    • The Swarmer spawns a Bomb Fly upon death.
  • Body Horror: The tumor-headed Mulligan grows more decayed as the flies inside it transform it into the Hive. From there, the Hive becomes a Swarmer, a rotten head filled with flies.
  • Incurable Cough of Death: Has a very distinctive-sounding one when it spits up flies to attack you.
  • Mook Maker: Hives occasionally cough up flies and spit them at you, and Swarmers constantly spawn small flies as well as Pooters and Fat Flies when damaged.
  • Taking You with Me: Unlike his cousins, the Mulliboom (the one with a bomb stuck in his head) will rush straight at you and try to suicide-bomb you.

Globin/Gazing Globin

  • Artificial Brilliance: They will move coordinately to trap you. Especially problematic in rooms with obstacles.
  • Elite Mooks: The versions with one eye are faster and have more health. Their meat pile also slides away diagonally a short distance to avoid being hit.
  • Pulling Themselves Together: When killed, they will become a pile of goo and then recover. Luckily, they will take less to kill next time.
  • Punny Name: with "goblin" and "hemoglobin".
  • Why Won't You Die?: Unless you finish off the pile of goo, this will happen. The main problem is attacking the goo while several others are chasing you.

Knights/Selfless Knights

  • Attack Its Weak Point: The front of them is solid bone or petrified flesh. The only way to actually damage it is to hit it in the back of its head, the exposed brain.
  • Elite Mooks: Its second variety chases the player instead of wandering aimlessly. They have a crying Isaac face instead of a brain on their back.
  • Shield-Bearing Mook: As customary, the solution is to flank it where its shield can't protect it.

Vis/Double Vis/Chubber

Baby/Angelic Baby

Dople/Evil Twin

  • Doppelgänger: The Evil Knockoff variety.
  • Elite Mooks: The Evil Twin. Instead of looking like a meat puppet, it looks like a demon that can: fly, shoot a three spread, and do more damage. Good things is that its bullets travel slower, giving you time to dodge and shoot.
  • Enemy Without: They mirror the player's movements, including shooting, but most rooms come with a mechanism with which to destroy them. There are also bombs, and praying that whipped shots will work.
  • Foreshadowing: The appearance of these foreshadows the nature of Isaac the boss.

Fred

Lump

Maggots

Charger

Maggot

Spitty

Spiders

Added with Wrath of the Lamb. A faster alternative to the flies, though they're land-bound.

Spider/B. Spider

  • Asteroids Monster: Big Spiders split into two after death.
  • Demonic Spiders: Literally. Gameplay-wise, they're slightly harder to kill than files thanks to their erratic movements and greater speed. invoked

Trite

  • Shout-Out: One of the types of spider is a head on four legs, with what looks like a heavy-lidded eye (probably a mouth, though) in the center. In other words, a tektite.

Other

Clot/Clotty/I. Blob

Host/Red Host

  • Attack Its Weak Point: Only in the grey variation. To hit them, you must wait for them to expose the flesh under the skull. Moving them over spikes will kill them.
  • The Cameo: From a multiplayer player flash game with the same name.
  • No Sell: Regular Hosts are protected by their skull when they aren't firing. Trying to hit them does nothing. Trying to bomb them just causes them to make a troll face.
  • Shield-Bearing Mook

Brain/MemBrain/Guts/Mama Guts

Poky/Slide

Stone Grimace/Vomit Grimace

Boil/Gut/Sack/Walking Boil/Walking Gut/Walking Sack

  • Elite Mooks: As of Wrath of the Lamb, there is a second version which shoots green bombs, much like Sloth. As well as mobile versions of each.
  • Healing Factor: The non-mobile versions slowly regenerate over time when damaged. However, they spawn with less-than-full HP and can't attack until they've reached their maximum health. Their health is directly proportional to their size.
  • Mook Maker: There's also a version made of spider silk, which spits out spiders. It, too, has a mobile version.

Eye/Bloodshot Eye

Leech/Kamikaze Leech/Holy Leech

  • Elite Mooks: A second version that has an eyeball and explodes when killed.
  • Palette Swap: There's an alternate version of that that's angelic white. Not just tinted that way, either, but a separate enemy.

Para-Bite

B. Licker

Mask + Heart

Keeper/Hanger

    The Fallen 

The Fallen

  • Asteroids Monster: After about 75% of his health his gone, he splits into two versions of himself.
  • Bullfight Boss: Does this when he isn't shooting. After his charging sequence, he'll shoot blood in every direction.
  • Classic Video Game Screw You: It's uncommon, but this guy can be the boss of ANY dungeon save ones with predetermined bosses. He's notorious for showing up in the Basement/Cellar, often before you've had a chance to buff your speed and survive his charge.
  • Degraded Boss: In Sheol. He's later fought at full strength when the Satan fight begins.
  • Early Bird Boss: He can replace any boss that's not pre-set by the level. If you're unlucky he can appear on the first or second floor...
  • The Dragon: To Satan. He even acts as the first stage of his master's boss fight!
  • High-Pressure Blood

    Krampus 

Krampus

  • Bad Santa: Drops a Lump of Coal.
  • Chest Monster: Randomly appears in Devil Rooms. He's more likely to appear if you have already entered a Devil room, even more so if you've made a deal.
  • High-Pressure Blood
  • The Krampus
  • Palette Swap: Of The Fallen, except he doesn't split into two parts, and he has a special attack (which can be obtained in Rebirth through one of his drops, the "Head of Krampus").

    Spoiler Character (Rebirth) 

Angel/Fallen Angel

A secret boss in Rebirth, a fight with one of three Angels is initiated by bombing the statue in an angel room at any point throughout the game. Beating the boss twice unlocks a piece of a key each time, and doing so allows the player to unlock the true final boss of the game.

The Harbingers

    In General 
The four Horsemen of the Apocalypse, unlocked after beating Mom for the first time. Famine, Pestilence, War and Death each have the ability of replacing one of the bosses of the Basement, Caves, Depths and Womb respectively, while the Headless Horseman has the capability to replace any of these bosses, and Conquest was introduced as an alternate boss to Death.

    Famine 

Famine

    Pestilence 

Pestilence

    War 

War

  • Bullfight Boss: After losing his horse.
  • Bull Seeing Red: He's red, and his horse has bull horns and charges.
  • Oh, Crap: After losing his horse, hit him enough times and he'll fall to the ground stunned, with a terrified look on his face.

    Death 

Death

    The Headless Horseman 

The Headless Horseman

  • All Your Powers Combined: The head has Famine's triple shot and War's triple charge, while the body is Pestilence minus spawning enemies. Plus, you fight two bosses at the same time, which is what happens when Death loses half his health.
  • Classic Video Game Screw You: He can replace any horseman.
  • Degraded Boss: the head alone can appear in normal rooms in Depths.
  • Dual Boss: The boss is split into: his head, that charges and shoots small bullets, and his body, which shoots large bombs and leaves trails of blood.
  • Headless Horseman: Well, yeah.

    Conquest 

Conquest

The Seven Deadly Sins (Minibosses)

    In General 

The Seven Deadly Sins

  • Anthropomorphic Personification: Of their respective sins.
  • King Mook: The "Super" variants introduced in Wrath of the Lamb.
  • Inescapable Ambush: Unless you hold certain items, they won't show up on the map at all until you run into them, and you cannot leave unless you carry a teleportation item.
  • Quirky Miniboss Squad: They fight you individually, but in the any of the levels following the fourth chapter, you may encounter up to three different Sins to fight in the same room.

    Envy 

Envy/Super Envy

    Gluttony 

Gluttony/Super Gluttony

    Greed 

Greed/Super Greed

  • Bandit Mook: His shots (and mere contact with him!) take away a couple of pennies from you, while making you drop a variable amount on the floor that you can try to retrive... Just be careful while doing so, if you don't want to be killed in the process. Oh! And guess what? His mook-lookalikes have the same ability as him. Yay!
  • Breakout Character: He's the most memorable and ubiquitous of the The Seven Deadly Sins mini-bosses, and Wrath of the Lamb cemented his status by adding a quite a few new versions of him.
  • Chest Monster: Replaces shops and secret rooms. He's more likely to appear as you go further in the game.
  • Expy: He shares some traits with Spelunky's Shopkeeper, including his multi-shot ability, potential to turn hostile on the player without previous warning, and overall dickishness.
  • Flunky Boss
  • King Mook: Wrath of the Lamb added Super Greed, who is bigger, meaner, scarier, and can spawn Greed-heads. Said Greed-heads also appear in the Depths, the Catacombs, and the Necropolis.
  • Mook Promotion: Inverted. The game's standard version features him as a mini-boss, but the expansion added mook-versions of him that share some of his most aggravating attributes.note 
  • The Scrappy: Invoked. Given how he can replace shops and secret rooms, can knock out your money when he hits you, and can be fought multiple times in one run, players usually don't enjoy finding him.
    • He becomes an Ensemble Darkhorse if you have the D20.
    • You'd be hard-pressed to find anything in the game that will make you madder than fighting Greed in the Depths/Necropolis 2 or later and having him drop the Steam Sale.
  • Shop Keeper: When he's not out for your blood anyway.

    Lust 

Lust/Super Lust

  • Body Horror: Super Lust's horribly deformed face.
  • Bullfight Boss: How to fight Lust: get her to run after you in straight lines and kite her with your tears.
  • The Smurfette Principle: The only one of the Sins/Super Sins that has been identified as female.

    Pride 

Pride/Super Pride

    Sloth 

Sloth/Super Sloth

    Wrath 

Wrath/Super Wrath

  • Cartoon Bomb
  • Expy: Of Bomberman.
  • Hoist by His Own Petard: Wrath's bombs can be pushed around like player-dropped bombs, allowing you to push them back towards him for a nice chunk of damage. This doesn't work on Super Wrath's troll bombs, though. Even more amusingly, any items that affect bombs will affect the bombs dropped by Wrath/Super Wrath. This can result in hilarious situations where, if you have the Bobby-Bomb collectible, every bomb the boss drops proceeds to walk back toward him.
  • Mad Bomber: Throws bomb after bomb at you. Since he's Wrath, this doubles as a Stealth Pun.

    Ultra Pride 

Ultra Pride

  • Creator Cameo: He's a stylized representation of artist Edmund McMillen, while his familiar is one for programmer Florian Himsl. Hence why he's named Ultra Pride.
  • Death by Cameo: You do fight them, after all.
  • Dual Boss: He comes with his familiar, and both have to be defeated.
  • Meaningful Name: The creators are ultra proud of their product. Additionally, putting yourself as a cameo in your own game is a flagrant show of pride.
  • Palette Swap: He's basically Sloth with different moves, while the familiar is a graphically altered Baby with a different shot type.

Chapter One: The Basement/The Cellar

    Monstro 

Monstro

Debut: The Binding of Isaac

    The Duke of Flies 

The Duke of Flies

Debut: The Binding of Isaac

    Gemini/Steven 

Gemini/Steven

Debut: The Binding of Isaac
  • Bullfight Boss: The big one can tire out after a few moments of running. If the big one is killed first, then the small one will turn red, give chase, and never tire out. Steven's little version will do that before the big one goes down.
  • The Cameo / Mythology Gag: Steven is from Time Fcuk.
  • Dual Boss: One big version that charges the player and one small version that shoots bullets.
  • Kaizo Trap: Both parts of Steven shoot bullets in all directions when they die.
  • Polar Opposite Twins: The big one is aggressive and chases you; the little one looks calm and makes ranged attacks until you kill the big one, at which point it charges at you.
  • Turns Red: What the small one does when the big one dies. Steven, on the other hand, has it do this at 1/3rd health.

    Larry Jr. 

Larry Jr.

Debut: The Binding of Isaac
  • Asteroids Monster: Not so much as other bosses, but if the middle section is killed first in a 5 body one, it will split into two more versions with just two segments.
  • The Cameo/Mythology Gag: A smaller version of Larrie's Lament.
  • Degraded Boss: The most common boss enemy to find in The Womb.
  • King Mook: As of Wrath of the Lamb, smaller enemies similar to it appear.
  • Warm-Up Boss: Shares this with Monstro, but which boss is the easier of the two if any is up to personal opinion.

    Widow 

Widow

Debut: Wrath of the Lamb
  • Body Horror: She's made out of a head with four eyes, leg bones, and toes.
  • Flunky Boss: Not only does she spawn spiders directly, but she can also spawn Mook Maker spider silk Boils! And that's not even getting into the ones that can spawn bigger Asteroids Monster spiders or other kinds of Boils.
  • Giant Spider
  • Glass Cannon: Relatively low HP for a boss, but it moves unpredictably and is thus harder to beat without taking any damage than most bosses early on.
  • King Mook: To the spiders.
  • Rush Boss
  • Word of God: Edmund has stated that the Widow is a girl.

    Pin 

Pin

Debut: Wrath of the Lamb
  • Back from the Dead: Inverted: Pin was introduced in the Wrath of the Lamb as a weaker, living version of Scolex.
  • Tactical Suicide Boss: Is not immune to its green exploding projectiles, and due to a quirk in hit detection, can actually damage itself with them when it begins to bury underground. The dark grey one averts it, replacing the bombs with bullets.

    Gurdy Jr. 

Gurdy Jr.

Debut: Wrath of the Lamb

    Dingle 

Dingle

Debut: Rebirth

    The Haunt 

The Haunt

Debut: Rebirth
  • Flying Face: That rips itself open to reveal a skull when its minions are dealt with.
  • Flunky Boss: Before actually fighting you, he will always summon three smaller ghosts.
  • Good Bad Bugs: He is vulnerable for a tiny period of time before sending its minions after you. Sufficiently broken characters can kill it in this window!
  • No Fair Cheating: He normally paces from side to side along the top edge of the screen, shooting downwards. If you try to avoid the shots by approaching the top edge of the screen yourself, it dash in an attempt to bump into you.
  • Our Ghosts Are Different

    Gurglings 

Gurglings

Debut: Rebirth
  • Creepy Twins
  • Degraded Boss: They appear as regular enemies as early as the Caves, and don't even get a health bar.
  • Enfant Terrible: They seem to be even younger versions of Gurdy Jr.
  • Expy: The latest version of Gurdy, this time taking the form of two twins.

Chapter Two: The Caves/The Catacombs

    Fistula 

Fistula

Debut: The Binding of Isaac
  • Asteroids Monster
  • Body Horror: It's named for a real life chunk of Body Horror in which organs try to absorb each other.
  • Degraded Boss:
    • Appears as this in later stages. Most of the time, though, it will already be broken down to its second or third stage.
    • In Rebirth, the boss is now a Chapter One boss.

    Gurdy 

Gurdy

Debut: The Binding of Isaac
  • Body Horror
  • Damage-Sponge Boss
  • Degraded Boss: Interestingly, the weaker version attacks very differently, charging and firing circular waves of bullets. Contrast with the other bosses made into minibosses, who are more or less identical to their original version, but weaker. Wrath of the Lamb separates the degraded form into a different boss: Gurdy Jr. But The Very Definitely Final Dungeon DOES feature Gurdy as a normal Degraded Boss.
  • Flunky Boss
  • Stationary Boss
  • Wake-Up Call Boss: When it comes to the pre-Wrath of the Lamb bosses who gave new players trouble, Gurdy is the most infamous.

    Peep 

Peep

Debut: The Binding of Isaac

    Chub/C.H.A.D. 

Chub/C.H.A.D

Debut: The Binding of Isaac

    Blighted Ovum 

Blighted Ovum

Debut: Wrath of the Lamb
  • Back from the Dead: Gemini is now a zombie, and is accompanied by his conjoined brother's ghost. The image appears to be more of a sperm and an egg. That wouldn't discredit this trope, it would just be a different set that came back, because at least the large one is undeniably dead no matter what perspective you look at it from.
  • Body Horror
  • High-Pressure Blood: The ovum fires a blood beam if you stay in front of it for too long.

    The Hollow 

The Hollow

Debut: Wrath of the Lamb

    Carrion Queen 

Carrion Queen

Debut: Wrath of the Lamb
  • Attack Its Weak Point: Can only be hit from behind, except when exploiting its other weak point (see Feed It a Bomb below).
  • Back from the Dead: A mostly-skeletal Chub.
  • Dung Fu: Randomly produces Red Poop that damages if you touch it. Also can bounce off the poop as if a wall.
  • Feed It a Bomb: Same as Chub, though it's much more difficult once she starts moving diagonally.
  • Turns Red: Will bounce aimlessly around the room once her health is down to half.

    The Husk 

The Husk

    The Wretched 

The Wretched

Debut: Wrath of the Lamb

    Dark One 

Dark One

Debut: Rebirth

    Mega Fatty 

Mega Fatty

Debut: Rebirth
  • Acrofatic: Normally slow and fat, but it can leap into the air and smash down onto the ground rather quickly.
  • Damage-Sponge Boss: Noticeably soaks up more punishment than most normal bosses.
  • King Mook: Of the regular Fatty enemy.
  • Selective Magnetism: One of his attacks is to magnetise everything in the room to him, mimicking the effect of the item Magneto.
  • Vomit Indiscretion Shot/Waterfall Puke: After the magnetism attack, he vomits up a barrage of projectiles that cover a portion of the screen.

    Mega Maw 

Mega Maw

Debut: Rebirth

    Polycephalus 

Polycephalus

Debut: Rebirth

Chapter Three: The Depths/The Necropolis

    Loki 

Loki

Debut: The Binding of Isaac
  • Breather Boss: One of the least mechanically difficult bosses of the Depths/Necropolis.
  • Hoist by His Own Petard: If you can kill his Boom Flies as soon as they spawn, they will blow up on him.
  • Flunky Boss: Summons Boom Flies periodically.
  • Tactical Suicide Boss: The Boom Flies it spawns will often explode on him, given how powerful you should be by the time you fight him.
  • Teleport Spam: Frequently teleports away during battle.

    Monstro II 

Monstro II

Debut: The Binding of Isaac

    Gish 

Gish

Debut: The Binding of Isaac

    Mask of Infamy 

Mask of Infamy

Debut: Wrath of the Lamb
  • Attack Its Weak Point: The mask is invincible until you destroy its heart. Even after that, you need to hit it from behind.
  • Interface Screw: the only boss without a health bar. The fact that it's not easy to lay a shot in the last stage makes the fight look depressingly long.
  • King Mook: A beefed-up version of a standard enemy also added in Wrath of the Lamb.
  • Shout-Out: Inspired by Carmillia's mask in Castlevania.
  • Word of God: Edmund has stated on his Formspring that the Mask is female, and the thing inside is not alive.

    Daddy Long Legs/Triachnid 

Daddy Long Legs/Triachnid

Debut: Wrath of the Lamb
  • The Cameo/Mythology Gag: Triachnid is a reference to a previous flash game by Edmund McMillen. Furthermore, Triachnid is an alternate of Daddy Long Legs; in his own game, Triachnid was finding a home for his young.
  • Dummied Out: As hinted here, Triachnid was originally was cut before the game was released. It wasn't removed entirely, though. Due to a glitch, it originally would replace the Cathedral's True Final Boss. This was eventually corrected, and Triachnid was added in as a normal boss.
  • Giant Spider
  • King Mook: A giant spider, same as Widow.
  • The Dev Team Thinks of Everything: There is an item that summons the Daddy Long Legs to stomp enemies in an area the player is standing in without hurting them. Using this against the Daddy Long Legs reskins it as the Triachnid's claw. Using it against Triachnid flat out doesn't work.

    The Adversary 

The Adversary

Debut: Rebirth
  • Back from the Dead: He is the post-humous version of the Dark One, covered in bandages and with a shattered horn.
  • Blackout Basement
  • Dishing Out Dirt: He can jump up in the air and slam down, creating a circle of sharp rocks around him.
  • Frickin' Laser Beams: He can now shoot Brimstone in any cardinal direction, but don't think you're safe if you stand at a diagonal, because it curves towards you.

    The Gate 

The Gate

Debut: Rebirth
  • Back from the Dead: He is a post-mortem version of Mega Maw.
  • Meat Puppet: When defeated, something that looks like a small Blastocyst peeks outside a crack before expiring.
  • Frickin' Laser Beams: One of his attacks is to spawn three Hoppers and then fire a Brimstone laser that connects between the three and deals a whole heart of damage.

    The Cage 

The Cage

Debut: Rebirth
  • Back from the Dead: He is a post-mortem version of Mega Fatty.
  • Dishing Out Dirt: His jumping attack now creates sharp rocks like the Adversary's, but he creates lines of them that travel outwards in several directions until they hit a wall.
  • Mega Mook: He's basically been turned into a Vis, making him this.
  • Mook Maker: He can spawn discoloured Vis that fire sickly gray Brimstone lasers.
  • Rolling Attack: He can curl up in a ball and roll around the floor in an attempt to hit Isaac.

    Mom 

Mom

Debut: The Binding of Isaac
Isaac's mother. In a fit of rage/insanity/fanaticism/whatever you think it is, she attempted to use a knife on Isaac, forcing him to flee to the basement.

Story-related tropes:

  • Abusive Parent
  • The Bad Guy Wins: It's revealed that Isaac suffocated to death while inside the chest. She wanted Isaac to die because of an (alleged) order from God, do the math. However, subsequent endings revealed that Isaac locked himself in the Chest before the events of the game, and Rebirth's Ending 15 shows what appears to be her grieving for Isaac, so this is probably a subversion.
  • Big Bad: Ultimately subverted.
  • The Extremist Was Right: She's a religious fanatic that appears to think that she's on a mission from God, which is clearly not the case. At least until the canonical end of Rebirth, strongly implying that Isaac either was or now is a demon. If you subscribe to the "just batshit insane" theory, then she's Right for the Wrong Reasons.
  • The Fundamentalist
  • Hidden Depths: Ending 13 reveals that she used to be completely sane, and the caring and loving mother of a fully-functional family. However, as the family fell apart, so did her sanity.
  • Knife Nut: She's holding her knife in almost every cutscene she appears in, and you can unlock said knife as a usable weapon in-game.
  • No Name Given: Unlike Isaac, even her first name is unknown.
  • Offing the Offspring
  • One Bad Mother

Gameplay-related tropes:

Chapter Four: The Womb/The Utero

    Scolex 

Scolex

Debut: The Binding of Isaac

    Blastocyst 

Blastocyst

Debut: The Binding of Isaac

    The Bloat 

The Bloat

Debut: Wrath of the Lamb

    Teratoma 

Teratoma

Debut: Wrath of the Lamb
  • Asteroids Monster
  • Back from the Dead: The Fistula has shriveled up and now shelters spiders.
  • Body Horror: Like Fistula, it's named after a real life Body Horror phenomenon in which the body forms a growth containing all three germ layers... one of which can potentially manifest as bone shards and teeth!

    Lokii 

Lokii

Debut: Wrath of the Lamb

    Mama Gurdy 

Mama Gurdy

Debut: Rebirth
  • Ascended Meme: Apparantly a reference to a fan-made animation.
  • Expy: The fourth form of Gurdy to appear.
  • Spikes Of Doom: She is able to create spikes around the room.
  • Wall Master: She can hide in the walls of the boss room, immune from damage.

    Mr. Fred 

Mr. Fred

Debut: Rebirth
  • Giant Mook: A giant boss version of the enemy Fred that appears in Chapter Four.

    Spoiler Character (BOI) 

Mom's Heart/It Lives

Click here for the picture The final boss of the fourth chapter, and the initial final boss of the game overall, after traversing the Womb, Isaac is forced to fight his mother's still-beating heart. Beating it is what unlocks Endings 1-10 (or 1-11 in Rebirth). After reaching Ending 9 (11 in Rebirth), Mom's Heart is replaced by a new boss: It Lives, Isaac's fetus.

Chapters Five and Six: Sheol and Dark Room

    Spoiler Character (BOI) 

Satan

Click here for the picture 
Debut: The Binding of Isaac
The original True Final Boss (although this isn't true as of Wrath of the Lamb and Rebirth), Satan himself is the boss of what was originally the game's secret floor. Despite offering Deals with the Devil throughout the game, he turns on Isaac, and tries to kill him. His boss fight is comprised of three phases, detailed below under Sequential Boss.

  • Black Speech: During the fight with him, he sounds somewhat like this. They're actually Mom's quotes, played backwards and in a much lower tone.
  • Deal with the Devil: He offers them throughout the game before you reach Sheol.
  • Attack of the 50-Foot Whatever: His final form is him flying far above the screen and stomping on Isaac with giant feet ala the Mom boss fight.]]
  • Black Speech: During the fight with him, he sounds somewhat like this. They are actually Mom's quotes, played backwards and in a much lower tone.
  • Evil Laugh
  • Flunky Boss: His first form is spawning the Fallen to fight you instead.
  • Leitmotif: Enmity of the Dark Lord in the original, Hericide in Rebirth.
  • Living Statue: His second form is a unique boss where the statue of Satan comes to life, grows much larger and attacks Isaac with tears and lasers.
  • The Man Behind the Man: Implied, after all, he did at the very least string Isaac along through the Deals he makes in the devil rooms earlier on, before turning on Isaac at the last minute.
  • No Sell/Press X to Die: Using the Bible on him, which killed the Mom and Mom's Heart instantly, kills you instantly instead. The same applies to later bosses too.
  • One-Winged Angel/Sequential Boss: Has three forms (see Flunky Boss, Living Statue and Attack of the 50-Foot Whatever respectively).
  • Satan
  • Say My Name: Satan's battle cry when you defeat his first phase is Mom's Boss Banter, only lower pitched and in reverse.
  • Sequential Boss
  • Tactical Suicide Boss: Those exploding enemies he spawns don't just hurt Isaac...
  • Theme Music Power-Up: Villainous example in Rebirth: When you fight the Fallen, his first phase, the regular boss theme plays. When Satan actually starts fighting, however, Hericide kicks in.
  • True Final Boss: He was the final boss of the game in the Halloween update, but this has been since trumped by Wrath of the Lamb and Rebirth.

    Spoiler Character (Rebirth) 

The Lamb

Debut: Rebirth
  • Detachment Combat: His second form involves his head floating around the room attacking you while his body lies limply on the ground spawning flies and sometimes tossing out Monstro-style shots.
  • Dual Boss: His second form.
  • Flash Step: One of his attacks qualifies as this.
  • Frickin' Laser Beams: His second form gains the ability to shoot four-way Brimstone in the cardinal directions. He can also start rotating the beams like Mom's Heart/It Lives.
  • Leitmotif: The Fallen Angel
  • Losing Your Head: During the second phase of the battle.
  • Sequential Boss: Has two forms.
  • True Final Boss: Averted. He was available from the launch of Rebirth, but so was Mega Satan, meaning he never qualified as the True Final Boss.

Alternate Chapters Five and Six: The Cathedral and The Chest

    Spoiler Character (Wrath of the Lamb) 

Isaac

Click here for the picture 
Debut: Wrath of the Lamb
After beating It Lives, the Cathedral is unlocked. At the center of the Cathedral resides Isaac himself... and one of the toughest challenges in the game.

    Spoiler Character (Wrath of the Lamb) 

???

Click here for the picture 
  • The Cameo/Mythology Gag: From Edmund McMillen's flash series Dead Babies.
  • Flunky Boss: One way he varies from the previous boss is that he summons flies in addition to his other attacks.
  • Leitmotif: In Rebirth, in order to further differentiate ??? from the preceding boss, he's given his own track, Ascension.
  • Palette Swap: He is very similar to the previous boss, Isaac, so most of the tropes above apply to him too.
  • Teleport Spam: Utilized in his third phase in Rebirth, with a tendency to reappear right on top of the player.
  • True Final Boss: Of Wrath of the Lamb, being the boss of the only sixth chapter in the game, and since beating him unlocked the game's real ending. Subverted in Rebirth.
  • Weaponized Teleportation: Tries to teleport into the player during his third phase in Rebirth.

The True Final Boss

    Spoiler Character (Rebirth) 

Mega Satan

Debut: Rebirth
  • Bragging Rights Reward: Besides unlocking the final and definitive ending, there is no reason to fight him other than to boast you did it. The only thing you get out of winning is a new picture for your save file. There are no associated item or character unlocks, not even a mark on the character file to indicate that character beat him.
  • Bullet Hell: What some of his attacks delve into.
  • Final Boss Preview: Regular Satan's third phase can be considered this. In Sheol, you only fight his lower half. In the Chest/Dark Room's secret room, you face the much more difficult upper half.
  • Flunky Boss: Summons The Harbingers, the Super Sins, and fallen versions of the Angels.
  • Guide Dang It: The only in-game hint you have to his existence is "The Angels await!." You're supposed to bomb the Angel statues in the Angel Rooms, prompting them to engage you; both will drop a piece of a Golden Key on defeat, and getting both pieces opens a Golden Door in the Chest/Dark Room that leads to Mega Satan.note 
    • Fortunately, completing the key also unlocks "Dad's Key" as a regular item, which can also be used on the Golden Door for future playthroughs.
  • Leitmotif: Hericide
  • Marathon Boss: Compared to the normal 30-60 second boss fight, he takes 4-5 minutes unless you have the Chaos Card, and that's if you have a good enough run.
  • Red Eyes, Take Warning
  • Sealed Evil in a Can: Heavily implied to be sealed by the beings in the Angel Rooms.
  • Sequential Boss: Including his summons, he has twelve phases.
  • Soundtrack Dissonance: Due to a bug, doing too much damage to any form will cause the calm, somber "boss defeated" music to start playing.
  • True Final Boss: The very definitive True Final Boss of the game (which is saying something, considering there have been seven other candidates before it), having an extra unlock process required each run.

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