Like Tobey Maguire, Andrew Garfield played a teenager despite being in his late twenties. In fact, Maguire first played him at 27 and Garfield was 29, so he's actually older than he was, even though this Peter actually spends almost all of the movie as a high-school student, not just the first act. It seems to work, though, as Garfield certainly doesn't look that old.
Same applies to Max Charles, the kid who plays Young Peter. He's nine years old but Peter in the beginning is around 4.
An extended scene of Peter storming off into the night and buys a Milk Chug where he bickers with a store clerk over two cents as the Peters after costs. When Peter was leaving the cash register thief steals the money and gives the milk chug to Peter, once the store clerk notice this he yells at Peter for not stopping him. Peter then rest at the bottom of the railroad and checking his phone calls from Uncle Ben, he notice gunshot was fired of miles away.
While walking down the alleyway an old man was laying in the ground which Peter ran across revealing to Uncle Ben, skulking on his dead body. This led to an extended scene of Aunt May and Peter upset on Uncle Ben's death and more on the suspected killer.
Dr. Connors appears at Peters doorstep and offer his sympathy after the death of Uncle Ben. During his conversation with Peter, Connor asks to take the time to look at his three-legged lab mouse, in which hes grow another leg, thanks to Connors serum.
Peter was going to visit Gwen for dinner when he was stopped by a doorman and telling if he was dropping off or picking up which then lead to him wanting whats in the bag, Peter rejects his permission which then lets not take access to the apartment.
Connors goes through a secret metal gate, Peter, then follows him around a corner of the building higher up to see which then leads up to finding out his secret hiding spot in the sewer.
Ratha hacks his way into the Oscorps network, locating Connors on sewer in a GPS which then gave access to his videoblogs.
Peter and Gwen kissing on top of a clock tower building.
The Lizard showing his humanity even as he scales up the evil inside. Having Connors shown to be having a split personality and letting the Lizard take over.
Connors having a moment of his son Billy and explaining to him that hes going away for a while.
The Lizard makes his way to the Midtown Science High School in a toilet cubicle. Finding two girls in the stall, The Lizard then stared at the two petrified teens. The Lizard uses his tongue lolling out near the girls faces and then leaves as the girls proceeded to scream.
Peter searches the campus for Connors finding scratches on the wall and inspects Connors asking him to help him.
Peter follows Connors in his lair and talk about how change something so that everyone would be equal, Connors then injects another dose of the Lizard serum before growling, hissing and turning his now-yellow eyes towards a frightened Peter. Ratha arrived and shoot bullets into former employees with a gun, spraying sedative into Peters face. Ratha talks to Peter about his father and how his wildest dreams had come true as much as now Peter then get up with the help with Ratha but not as long as the Lizard moves Peter and chokes Ratha and swallow his head whole.
A Running Gag about Peter buying eggs, which had gotten Aunt May breaking eggs into a bowl, after talking about responsibility with Peter.
In multiple deleted scenes, Peter was skateboarding in front of his school which he then failed a trick and hurting himself while the other teenagers laugh at him, Peter skates a busy street in Manhattan, and Peter skateboarding in the streets when suddenly a car went by him which then triggers his spider-sense resulting him to land a land-post.
Died During Production: This was the last Spider-Man film to be produced by Laura Ziskin before her death from breast cancer in 2011.
Averted with Rhys Ifans as Dr. Connors, as the character's thick accent indicates he's really British (although this is also a minor example in that he uses a more generic English accent rather than his own Welsh one).
Subverted with Andrew Garfield as Peter Parker/Spider-Man, given that he is British-American and was born in California but grew up in Surrey, England and subsequently has an English accent.
Milestone Celebration: It came out in 2012, Spidey's 50th anniversary (he first appeared in Amazing Fantasy #15 in August 1962) and the tenth anniversary of the first Sam Raimi film (which came out May 3, 2002).
Older Than They Think: Many fans were vocally upset that Uncle Ben never says "With great power comes great responsibility." In truth, the only place Uncle Ben said those exact words was the 2002 film; in the original comics, those lines were part of the ending narration.
Posthumous Credit: Despite succumbing to breast cancer in 2011, Laura Ziskin is still credited as a producer for the film.
Romance on the Set: Between Andrew Garfield and Emma Stone, although they have since broken up.
Spared by the Cut: Dr. Ratha was attacked by the Lizard. However, the scene doesn't fit into the final continuity of the film.
Word of God: The first thing Spider-Man shoots a web at and subsequently proceeds to swing from just so happens to be a helicopter as a nod to the incident in the comics where Spidey swings past the Empire State building on an off-panel web. It is explained in the letters section of a later issue that there just so happened to be a helicopter passing by at that moment.
Milestone Celebration: 2012 marks the fiftieth anniversary of Spider-Man's first appearance. To commemorate this, co-creator Stan Lee is playable in a side mission, and completing unlocks an Easter Egg that honours the occasion; and playing the game in August unlocks the ability to add a "Happy 50th Birthday!" party hat to whichever costume is selected. The Xtreme host even makes fun of this, questioning if Spidey thought he would be around for 50 years.
Role Reprise: Andrew Chaikin, who had previously voiced Spider-Man in Ultimate Spider-Man: Total Mayhem, reprises his role in the iOS version.