She currently stars as The Evil Queen/Regina Mills in the ABC series Once Upon a Time, for which she has received critical acclaim.
- Spell My Name with an "S": Her last name is spelled Parrilla, not Parilla.
- Star-Making Role: Her role as Regina Mills.
- 2000-2001 Spin City as Angie Ordonez
- 2002-2003 Boomtown as Teresa Ortiz
- 2004 NYPD Blue as Officer Janet Grafton
- 2005 24 as Sarah Gavin
- 2006 Windfall as Nina Schaefer
- 2006 Lost as Greta
- 2008 Swingtown as Trina Decker
- 2010 Miami Medical as Dr. Eva Zambrano
- 2011present Once Upon a Time as The Evil Queen/Regina Mills