- Banned in China: For about two days in Singapore.
- Beam Me Up, Scotty!: Shepard never says "We'll bang, okay?" in-game. That quote originated from a Youtube Poop that mashed together several Shepard lines out of context.
- Canada, Eh?: Believe it or not, both Shepards Voice Actors are Canadian. While Jennifer Hale is fairly good at hiding the accent, Mark Meer tends to fall into saying "Aboot" every once and awhile.
- Cash Cow Franchise: Four novellas, two comics (plus two free mini-comics), and three spinoff iPhone games, so far.
- Celebrity Voice Actor: All over the place. Seth Green, Adam Baldwin, Yvonne Strahovski, Tricia Helfer, Martin Sheen, Claudia Black, Carrie-Anne Moss... the list goes on. In fact, it could be said that the in-development movie could very well be made with many of the characters literally being played by their voices.
- Doing It for the Art: BioWare had an entire animation team just for eyes.
- Inspired by...: Mass Effect's technological aesthetics, particularly of the omni-tools and Alliance armor, were heavily influenced by box office bomb Final Fantasy: The Spirits Within. The game's art director was a big fan of the movie's style.
- Long-Runners: Ten years and counting. The series started in either November 2007 with the release of the first game, or May 2007 with the release of the first novel and lore guide, and it was still receiving new content (in the form of MP DLC) by at least December of 2017, with plans for at least one more main game. Since then the series has had four main games (1, 2, 3, and Andromeda), two more-or-less independent multiplayer modes with their own mechanics and extensive unique content (for 3 and Andromeda), and roughly 25 hours of single-player Downloadable Content missions with their own stories. Other content includes 7 novels, 2 Gaiden Game IOS titles (Infiltrator and Galaxy), 8 comic book miniseries (rather short ones though), and a straight-to-DVD animated film (Paragon Lost).
- Relationship Voice Actor: Almost example, as Mark Meer (MaleShep) is married to Belinda Cornish, who voices Rana Thanoptis, the asari scientist who shows up on Virmire and has a minor role in the next two games. Don't forget that, in the first game, Shep has the option to ''shoot'' Rana. Turns out she was indoctrinated anyway.
- The series also has several Star Trek alumni voicing many characters: Matriarch Benezia is voiced by Marina Sirtis (Counselor Deanna Troi), the salarian councilor is voiced by Armin Shimerman (Quark), Gatatog Uvenk is voiced by Michael Dorn (Worf), Navigator Pressely is voiced by Dwight Schultz (Lieutenant Reginald Barclay), and Legion is voiced by D.C. Douglas (guest starring as Zepht in an episode of Star Trek: Enterprise).
- The Wiki Rule: The Mass Effect Wiki.
- What Could Have Been: At one point, it was going to be possible to save both Kaidan and Ashley. This was removed when the developers realized no one would want to go on to further games with one of them dead if given the option.
- When Drew Karpyshyn was still attached as head writer, the Reapers' motivation was originally linked to the buildup of dark matter in the galaxy from overuse of eezo; hence the strange readings from Haestrom's sun in Mass Effect 2 (see Aborted Arc). Their rationale was going to be that the energy can't accrue if there's nobody in the galaxy advanced enough to make it. When Karpyshyn was re-assigned to Star Wars: The Old Republic after Mass Effect 2, the new writers instead went with the general conflict between organics and synthetics we see in Mass Effect 3.
- Writing by the Seat of Your Pants: Different interviews with writers across the series reveals that many things about the series' overall plot and some bits of lore was more or less constantly in flux and changed around quite a bit as members of the writing team were added or left (most notably the lead writer for the first Mass Effect, Drew Karpyshyn, left around half-way through the production of the second game and was replaced by Mac Walters). According to interviews in the interactive documentary about the third game, Final Hours, the (quite controversial) ending was not decided upon up until a few months before the game's release.
Trivia / Mass Effect