The author, Brian Clevinger, has claimed that in his comic, the universe exists to hurt Black Mage. Of course, being among the most evil characters in the comic (so evil, in fact, that the symbolic representation of his sins was himself, nothing else being up to the task), he pretty much has it coming to him 95% of the time.
Onion Kid, who loses his parents, multiple sets of foster parents, and an orphanage in unconnected atrocities committed by Black Mage. He gets even by growing up to be the all-powerful Sarda, possibly becoming the force behind Black Mage's own Chew Toy status.
Ansem Retort: Riku, Riku, RIKU. He's been cut in half too many times to count, is pretty much held together only by duct tape, is blamed for anything and everything, and the only reason he has a girlfriend is that she likes boys who don't have the balls to defend themselves.
Rick in Basic Instructions seems to be the universe's scratching post, insulted by even his best friends. And quite often the butt of the comic's jokes.
An unusual example is Laura from Collar 6, who was actually a CONSENTING chew toy.
The title character of Crushed, The Doomed Kitty is under a curse that causes her to be painfully killed, humiliated, and left naked... over and over again.
Charles' girlfriend from Cyanide and Happiness exists only to be insulted and cuckolded by her boyfriend. She always ends the strip with the same frown on her face.
The Cyantian Chronicles: Khaelis and Marcus, during Campus Safari. Although Marcus does do more to deserve it. Darrik gets gnawed on a little in Akaelae.
In a way, the title character of Dominic Deegan, who often gets hurt for comedic effect, such as when he's punched in the groin by a dwarf who then comments on how the seer didn't see it coming, or when he breaks down in a most humiliating fashion because he lost his candy, and so on.
Robot S13, at least for the first 14 chapters. He begins the story in a box, shut off, disassembled, and missing an arm, and from there it just gets worse: After being reassembled, he gets possessed, impaled on a sword, imprisoned, and reduced to a CPU because his body was melted down into paper clips. That said, his luck seems to have turned around, ever since Antimony rescued him and Kat started building him a new body.
Paz. So far she only once (when teaching Kat to push her vision and not give up) was the focus of a strip without some misfortune befalling her. She's the first victim of Mort's new-and-improved scaring skills; her hopes to see cows are rather cruelly shot down; then she gets kidnapped. Then her Love Interest has a crush and on Chang'e at that. She takes it all rather stoically, however.
And how could one forget the hilarious Boxbots? Tom Siddell seems to have an unnatural hatred for these poor robots, in that their appearance is always accompanied by frustration, or even facepalming, on the part of the people around them. Even the cast list hates them!
Conrad Achenleck from Hanna Is Not a Boy's Name seems to live to be tortured. He is maimed, killed, reborn as a vampire, battered and humiliated time and time again. And we love every minute of it.
In The Kingfisher, Darren seems to only serve the purpose of being humiliated for the audience's amusement. He may be working his way up to Bumbling Sidekick.
Steve the Flamboyant Fairy, a minor character from Lightning Made of Owls, to the point that it's been joked that his defining feature is someone trying to kill him.
A pair of Flumphs (jellyfish-like monsters from first edition Dungeons & Dragons, widely ridiculed among players everywhere due to their uselessness) fill this role. Due to their levitation abilities and soft bodies, their purpose in life seems to be to provide the main characters with safe landings.
In this strip, a character falls to their death; in the next strip, there's a panel of the Flumphs, with one saying "Say, isn't there somewhere we were supposed to be?" (Warning! Major Spoilers!)
Another chew toy is the Paladin O-Chul, who suffers abuse after abuse at the end of the bad guys. First paralyzed by Xykon, then catapulted through the air by a giant explosion, captured and used as a doll by the child-like Monster in the Darkness, and it only gets worse afterwards.
Jeremy from Platinum Grit is this almost all the time, with suffering and embarrassment being the two defining features of his friendship with Nils. And most readers wouldn't want it any other way.
Jacob from Precocious. Pretty much everyone but Max picks on him at some point. It's pretty telling when your Catchphrase is "Augh!"
Robert Lynchs Heroes Inc has Luigi. During the auditions at the start of the comic alone, Donkey Kong throws him through a wall, Link crushes him under a giant block, and gets hit by Samus's Zero Laser.
Kharisma Valleti and Mike Dowden in Something*Positive; while both have been shown in a more sympathetic light lately (especially Kharisma, after she was both disfigured and wrongly jailed for murder), they both pretty much deserve what they've been getting. Mike even realizes this, and lampshades that he's paying off a pretty hefty karmic debt. (His last few appearances suggest he has fallen off the reformed-jerkass wagon, though becoming a "real-life" super-hero has helped him tremendously.)
In Weak Hero, most of Helmet's appearances involve him getting his ass beat, freezing in terror at Gray's presence, or having the other characters mock his weakness. As he's a horrid bully who never learns his lesson, his various misfortunes come off as comedic rather than sympathetic.
Clover spends the first half of Yet Another Fantasy Gamer Comic being kicked around by three-fourths of the cast and ignored by the remainder. She doesn't even have clothes for most of that time. Her fate takes a remarkable upturn after a while, but she's still waiting for the other shoe to drop.
.