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Anime and Manga
- In Fullmetal Alchemist, during their training under Izumi, Ed and Al come across some wild mushrooms and soon regret eating them. Later on, we see them figuring out how to not have that happen again.
- One Piece: After days of starving in the Whole Cake Island arc, when the crew finally manages to catch a giant fish, Luffy digs right in before he can learn from Chopper that the fish's skin is extremely poisonous. Nami manages to cook it into something edible, but Luffy is soon left on the floor in agony. It's at first Played for Laughs as Luffy often puts himself in situations like that due to being an Idiot Hero, yet comes out no worse for the wear later. However, it's soon afterwards Played for Drama when the crew realizes that Luffy's condition is becoming extremely serious. Fortunately, they meet someone who manages to Suck Out the Poison, curing Luffy.
- A bizarre Played for Drama example occurs in Gilbert Hernandez's graphic novel Julio's Day (first serialized in Love and Rockets). Julio's father bites into a bean taco that, although wrapped, has become contaminated with "blueworms" in a mudslide. He immediately bleeds profusely from the eyes and staggers around in delirium, until an eccentric elderly couple saves his life with a folk remedy. The father later has a relapse of the food poisoning and dies from the same symptoms; worse yet, he's inadvertently passed the incurable infection to Julio's brother.
- In Bone, what got the Bone Cousins chased out of Boneville was that at Phoney's disastrous campaign picnic, he served prune tarts he got from a discount prune dealer. After the giant Phoney-baloon went amok, the "Bad prunes kicked in". As Smiley later states, they gave the entire town a case of the 'Fast Sallies, though Fone Bone implies that this was just The Last Straw after many of Phoney's Noodle Incidents.
- A Running Gag in Astérix is the quality (Or lack thereof) of the fish sold by fish-monger Unhygenix, and the fights that start when discussing it. In Asterix and the Great Crossing, Vitalstatistix complains that the fish have made his shield-bearers too sick to carry him. We learn shortly after that instead of doing his own fishing, Unhygenix gets his fish from sellers in Lutentia because they're better quality- even though that even the best quality fish will lose their freshness during a long trip from the city to the village.
- In one Green Lantern story, Hal Jordan found his power ring going haywire and refusing to respond to his commands. He eventually discovers this was due to food poisoning from eating tainted mushrooms (with those who had consumed them being warned 'not to operate heavy machinery').
- Johnny's takeout poisons the firemen in "Leave No Stomach Unchurned''. Chet gets revenge by slipping him fluid extract of ipecac, but it's more potent than syrup of ipecac and makes John very sick.
- In "Good Gravy'' , Chet gets everyone, including himself, sick when he uses mushrooms from his neighbor's yard in the Thanksgiving gravy.
- Monty Python's The Meaning of Life: The dinner party guests. All of them.
- Please Give: It remains ambiguous if the elderly woman dies at the end from drinking tainted juice
- In Bridesmaids there's a really gross food poisoning scene, although the protagonist claims it's a virus, as she's the one who suggested the restaurant.
- Airplane!. Anyone who had fish for their in-flight dinner got a life-threatening case of food poisoning. Guess what the entire flight crew had.
- Living in Oblivion: In one of the sequences, the chief cinematographer is made violently ill from spoiled milk left out on the craft service table.
- Sleeper - Woody Allen is cryogenically frozen and revived 200 years later as a fugitive. He pleads that he never did anything wrong, that he was just an owner of a health food store - "occasionally a customer got botulism, but that was very rare!"
- Aunt Dimity and the Family Tree has her father-in-law's housewarming party disrupted by eleventh-hour food poisoning at the caterer's firm; the narrator enlist help from the community to come up with the food.
- A Billion for Boris: in this sequel to Freaky Friday, the reveal that the kid brother is in possession of a TV that sees 24 hours into the future is based on his knowing that a certain brand of soup has been recalled before anyone else does.
Live Action TV
- Seinfeld: the woman who gets sick when the silica pack gets into the salsa placed out at Putamayo. By a typical turn of events, Jerry's number is on speed dial under "Poison Control".
Jerry: That's even better than #1!
- The mid-70s syndicated kids show Salty had an episode where they had to find someone who had eaten rancid food and didn't know it.
- All in the Family: Archie may or may not have eaten toxic mushrooms after a recall due to botulism. He ends up going to the ER for a painful anti-toxin injection. Afterwards, Edith realizes that they weren't the recalled brand to begin with.
- On the season 6 finale of How I Met Your Mother, Lily gets sick after eating soup and Marshall, who had eaten the same soup, prepares for the inevitable effects to kick in, just as he's interviewing for his dream job. In the end nothing happens to Marshall, and it turns out it wasn't the soup that made Lily sick; she was pregnant.
- Happy Days: Chachi's mother has Howard & Marain Cunningham over for dinner, and inadvertently includes an ingredient in her pasta sauce that Marian is allergic to. Marian spends the rest of the evening in the bathroom.
- The Stockard Channing Show: Susan's boss at the Consumer Affairs local tv show she works on gets ptomaine poisoning and thinks it's because of a bad fallafel he gets from a fast food joint. It turns out it's from a high priced fine dining restaurant.
- The Adventures of Pete & Pete: Little Pete pretends to get food poisoning from spoiled tapioca so he can play hooky.
- The "Groundhog Day" Loop episode of Supernatural where one of Dean's deaths is from a bad Taco.
- Has happened to Bear Grylls on his show at least once. Not surprising, given all the dodgy stuff he eats.
- A couple from M*A*S*H: In "The Yalu Brick Road", most of the camp gets samonella from some bad Thanksgiving turkeys that Klinger acquired. There is also an episode where Charles and Margaret eat a canned bird (pheasant?) and get ill.
- In the Fawlty Towers episode "Basil the Rat", one of the catastrophes Basil Fawlty must deal with is the possibility that he has just served the health inspector a poisoned veal cutlet.
- In The Nanny episode "Close Shave", C.C. Babcock is attending a cooking class and gets Maxwell Sheffield to try some of her cooking. He reluctantly does so, and ends up going to the hospital with food poisoning. Due to the food poison, he needs an appendectomy, and in preparation for surgery, the surgeon asks Fran Fine, disguised as a candy striper, to shave Maxwell...
- What's Happening!! Rerun thinks he has gotten food poisoning from bad beef at Rob's. Dee explains later that it is actually appendicitis, and that Rerun had to get surgery
- In an episode of Sex and the City ("The Ick Factor"), Charlotte and Harry go out for a romantic dinner, but they both end up sick shortly thereafter. Rather than being played for laughs, the incident is really sweet, as it shows the two of them accepting and comforting each other in their distress.
- The entire Buffalo Bills starting offense (and all but one back-up quarterback) catching a severe case is the main premise of the TNT movie Second String.
- The entire Orlando Breakers team on Coach comes down with food poisoning, just before their game with the Buffalo Bills. Luther obtained free Buffalo chicken wings from "Buffalo Billy's" when the team was visiting. Hayden has to resort to pulling a team from the stands just to satisfy contractual obligations. (The Breakers were slaughtered.) He suspects the food was deliberately poisoned but when Luther asks Buffalo Billy, Billy gives an ambivalent "no."
- In an episode of Murder, She Wrote, someone dies and some other people become ill after eating jelly at a restaurant in Cabot Cove. However, the murderer swapped out the restaurant's jelly for the poisoned one to kill a specific target and the only reason there was another victim was because they ate jelly from the contaminated container.
- Manhattan Love Story had an episode where both its leads were planning on having sex together for the first time following a meal. Unfortunately, they went to a second-rate oyster bar and both came down with severe food poisoning. However, they bonded more over this than they would've if they simply had sex.
- in Emergency!, a guy got himself and his neighbors sick from undercooked bear meat in one episode, and another,"Botulism", is a sort of restaurant outbreak.
- All the adults except Hermes and Ms Selby eat some bad oysters in the "Follow The Leader" episode of Ship To Shore and the children are left in charge of the communications base while they puke their guts out.
- On Law & Order: Criminal Intent a food critic got food poisoning after eating at a new restaurant. The critic is then brutally beaten and the cops initially suspect that the chef who owns the restaurant tried to kill the critic before her review could ruin his restaurant. Goren quickly realizes that the chef is being framed and his ingredients were sabotaged in order to ruin his business.
- In Fruit Mystery, your character is either very stupid or completely insane and goes to a zoo and feeds human foods to the animals, often with darkly humorous results.
- Talking to Isabela near the docks in Dragon Age II results in her warning you never to eat the clams - she did and was sick for a whole week. Hawke can also remark upon being offered a drink by Merrill that s/he wouldn't drink the water. (Considering the technological era of the setting, and that cholera is mentioned to be a problem, that's a wise decision. Though Merrill does boil it. Several times. It wouldn't stop twitching.)
- In Faria, the inhabitants of Ehdo get sick from feasting on poisoned caviar, and the player has to do a Fetch Quest to find the cure for them. This was all deliberately arranged by the Big Bad.
- In Cake Mania 4: Main Street Jill, who's heavily implied to be pregnant, asks Tiny to serve her fugu. When she goes in for some tests later on, he thinks it was because of the fugu and rushes to the hospital.
- Can happen (and sometimes happens often) in The Sims 3 . Common causes are food and/or drinks that are outright spoiled (if it's green and has flies, it's probably not good to eat, or a yellow drink), a cooking disaster that is "horrifying" quality, the consumption of some herbs or potions in foods or drinks, and a vegetarian sim eating meat. The result is your Sim making a mad dash for the toilet 1-2 game hours afterward and vomiting.
- The Simpsons, "Homer and Apu". Apu marks down some expired ham. Homer eats it and gets sick. Upon Homer's complaint, Apu offers him ten pounds of "frozen" shrimp. Homer eats it and gets sick.
- In another Simpsons everyone thinks Homer has eaten poison sushi and only has 24 hours to live.
- Also inverted by The Simpsons when everyone except Lisa gets food poisoning from eating only vegetables (because their bodies are only used to junk food).
- All the kids on Martin's birthday party get sick from eating oysters except Bart. Lisa is just faking to be ill to have an excuse to leave the party.
- Homer becomes a victim of this trope again when he eats at a 33 cent discount store.
- Then there's the time he brought home some six feet of leftover party sub and continued to eat it for weeks afterward, well past its edible state.
- One episode has the entire town sick after eating vegetarian Krustyburgers made with contaminated barley from nearby Ogdenville. This is just a Lead In for the main plot, about Ogdenvillians migrating into Springfield.
- A similar incident appears in a Halloween episode spoofing 28 Days Later, with "Double Meat" Krustyburgers turning people into "Munchers".
- "Worst Episode Ever" opens with Bart betting Homer he won't eat a box of baking soda that Homer thinks was in the house when they moved in. This leads to Homer having an "antacid trip".
Lisa: I'll call poison control. Hi, Fran, it's me. Just a heads-up.
- In one episode of 6teen, an accidentally unplugged fridge results in a Vomit Chain Reaction that wreaks havoc through the entire shopping mall. The worst puking incident of all happens during a kiss.
- In My Little Pony: Friendship Is Magic, "Applebuck Season", a sleep-deprived Applejack tries to help Pinkie Pie with baking muffins, but gets the ingredients ridiculously wrong, replacing chocolate chips with potato chips, baking soda with soda pop, a cup of flour with "a cup of sour" (lemon juice), and wheat germ with "wheat worms" (earthworms from a mud puddle out back). As a result of the "baked bads", many ponies who tried the free muffins get extremely sick.
- Inverted in an episode of Spongebob Squarepants - the titular sponge is thought to have unknowingly eaten a deadly pie, which will end his life at sunset. Squidward, responsible for bringing a pie-shaped bomb to Spongebob, feels guilty enough to spend the rest of the day doing anything Spongebob wants. It's eventually revealed that Spongebob never ate the bomb-pie, but rather a different pie. He saved the bomb, which he promptly trips and thus throws into Squidward's face, producing a nuclear blast.
- A more straightforward example is when Mr. Krabs sells spoiled Krabby Patties that have turned yellow and spongy as an attempt to cash in on SpongeBob's popularity.
- Then there's "The Nasty Patty", in which Krabs and SpongeBob make the titular patty for what the think is a fake health inspector. Hilarity Ensues when they think the patty killed him.
- A milder example is "Pretty Patties", in which SpongeBob sells colored patties. The people who eat them don't get sick exactly, but they do turn the same color as the patties they ate.
- King of the Hill has an episode where the supply of Alamo Beer delivered to Mexico has been tainted with some cleaning solution. Peggy finds out about it while taking on a temporary job as a call-center operator, and listens to complaints all day about vomiting and diarrhea caused by drinking the beer. Eventually she gets the executives at Alamo to admit their mistake and initiate a recall after sneaking some Mexican-market Alamo into a board meeting.
- One episode of Beavis and Butt-Head had Beavis with a really nasty rash on his crotch, which he scratched frantically even while working at Burger World. Everyone in the resteraunt ends up collapsing, and a news reports states that the virus strain is one they've never seen before.
- One episode of The Fairly Oddparents involved Timmy's classroom getting food poisoning from a cake that Tad and Chad made for the student body presidential election. The only ones unaffected were Timmy himself and Principal Waxelplax, who is frosting intolerant.
- One version of The Pied Piper Of Hamlin subverts all of the magical aspects of the original story with natural explanations, including that the piper hid his anger at being cheated then deliberately gave the village children a mild case of food poisoning which also had a mildly hypnotic effect on them. Dancing helped the children to eliminate the poison faster, and the hypnotic effect meant that the children followed the piper. (The piper collapsed the end of the tunnel after all the children were through, and stated his intention of selling them into indentured servitude elsewhere to get the money he'd been cheated out of).