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- A culprit in an early episode of Detective Conan had a son who died of appendicitis, and tried to kill the surgeon's son as revenge. When this is explained, Mouri immediately asks how it's even possible to die of appendicitis in this day and age, and the surgeon explained he wasn't able to save the kid, because it was too late when the father brought him in.
- Kara no Kyoukai has an excellent example: The main villain of the third movie, Fujino Asagami, has a severe case of appendicitis, which leads her to believe she'd been stabbed. (It's complicated.) By the end of the episode, her condition has worsened to a point where even immediate attention is pointless; she's vomiting blood and barely able to crawl. And that's before we mention the killer chasing her, or the repeated rapes she endured previously. It ends comparably well for her, when Ryougi Shiki (who can literally kill anything) kills the appendicitis inside Fujino with her powers and saves her life.
- In the Nichijou fanfic, Not a Normal Day, Hakase gets appendicitis and has to be rushed to the hospital. Luckily, she comes out of it just fine.
- In Chapter 26 of the Lucky Star fanfic Lucky Star After Story, Yutaka ends up developing appendicitis during her and Minami's senior year in college. After her appendix is removed, her overall health ends up improving greatly.
- In Crystal Rose of Pollux's "Lone Star and Union Jack" collection of Monkees vignettes, a teenaged Davy contracts appendicitis.
- The Phineas and Ferb fanfic Sick Streak.
- In the Kim Possible fanfic Alone, Together, Kim and Shego are stuck in an otherwise unpopulated alternate universe long enough to become friends (and eventually more). When Kim develops appendicitis, Shego has to remove it, guided only by a frantic review of medical texts from the hospital.
- In My Little Unicorn, this is why Fluttershy has a Sick Episode and is nearly killed by a changeling in the hospital, even though ponies don't have appendixes.
- John Gage's appendix ruptures before Roy and the ambulance can get him to Rampart in the Emergency! fic "A Big Deal''
- A few other writers have done this as well, the medical nature of the show makes it an attractive storyline.
- In Kill la Kill AU, we have this with Satsuki in comic 35 and this marks her as an Ill Girl, as stress had done a number on her health to that degree. She turns out okay.
- House of the Scorpion: In El Patron's backstory, one of his siblings died from this, since his family couldn't afford a doctor.
- Madeline had this happen in her first book, and the scene was also included in the movie adaptation, the '50s animated adaptation, and the first animated special. Some of her dolls even include the scar from the surgery.
- Happens in Epic: Eric gets appendicitis and has to drop out of the competition to move up to the next grade level.
- Doc Leroy, one of the characters in J.T. Edson's Floating Outfit series of western novels, once saved the life of a cowhand with a burst appendix by operating on him with a Bowie knife.
- There was a Baby-Sitters Club special where Kristy was stuck in the hospital with appendicitis.
- In Stephen King's The Stand, after the superflu wipes out most of humanity, one of the survivors dies of appendicitis, because there are no doctors left around. Stu tries to remove it, only to have the patient die partway through the operation. Then the guy's wife commits suicide afterward.
- Robert Merle's novel Malevil has a similar situation. The few survivors of a nuclear holocaust lose the protagonist when he eventually dies of appendicitis.
- Teenage Worrier's Worry Files has Letty's brother being rushed to hospital with appendicitis for the drama factor.
- The Hunt for Red October: Due to drunkenness while on duty, a surgeon botched removing an inflamed appendix from the wife of Marko Ramius, the organ bursting because the doctor took too long to try to sober up by breathing pure oxygen.note
- In one of John Bellairs's Lewis Barnavelt novels, while Mrs. Zimmerman and Rose Rita are driving home, Mrs. Zimmerman is overcome with a crippling pain in her stomach. She believes it's her appendix, which leads to Rose Rita remembering how a classmate of hers died after mistaking appendicitis for a bad stomachache and didn't seek treatment until it was too late. When Mrs. Zimmerman gets to the hospital, it's revealed that the pain was too high to have been her appendix. Mrs. Zimmerman tells Rose Rita that she suspects it was actually the effects of a dark magic curse someone used on her.
- Lu Clarke has one in Cherry Ames: Mountaineer Nurse by Julie Tatham. Since she's in a remote valley, she barely makes it to the hospital in time.
- The mother has one in Sydney Taylor's All of a Kind Family Uptown and recovers.
- In George R. Stewart's 1949 novel Earth Abides Isherwood Williams, who has survived a global plague and is one of the few survivors on Earth, makes a list of positive things that may indicate his survival. One of them is the fact that he has already had his appendix out, so he doesn't have to worry about this.
- In one of the Jonathan Cap books by Francois Rivier, the local Plucky Girl Juliette nearly develops this and she's sent to a luxurious private clinic for treatment. It almost happens for real when she, Jonathan, Alex and Nico are investigating the clinic at her request; she tries to help out Jonathan when he's forcibly given sleeping drugs, but she near collapses in pain. Thankfully her appendix remains in one piece and she recovers.
- In Ray Bradbury's The Halloween Tree, the boys who accompany Moundshroud on a Time Travel tour of Halloween's history are offered the chance to give up a year of their own lives to save their friend Pipkin from this trope.
- In one episode, Hawkeye drugged a colonel and made him think he had acute appendicitis, conducting an unnecessary surgery. BJ refused to go along with it.
- In "White Gold," Hawkeye and Trapper both pull this on Colonel Flagg, who wants to make off with the camp's penicillin inventory.
- In "The Long John Flap", Col. Blake is wearing the titular long underwear, and Hawkeye and Trapper threaten him, when suddenly Blake reacts as though punched. Turns out it's his appendix rupturing, and they have to operate immediately. The entire camp is mildly happy to hear that Blake's appendix was successfully and safely removed... but overjoyed at hearing that they didn't have to cut him out of the long underwear to do so, and so the long underwear was intact.
- Major Houlihan is mentioned in one episode to have chronic appendix flare-ups, and that she'll be fine and doesn't need surgery as long as she takes a brief break from performing surgeries until it calms down. She intends to eventually get it removed in the city, but just in case, she requests that Hawkeye be the one to operate if necessary despite Frank Burns usually being the surgeon to perform minor operationsnote . Of course, it becomes necessary to remove the appendix, and while she can't get to Tokyo or even Seoul, Hawkeye removes the appendix with little problem beyond Burns attempting to horn in on the operation.
- A later episode has Hawkeye performing an appendectomy on a singer with a USO troupe. He spends the rest of the two-episode story dissuading the obvious crush she develops on him, thinking a sweet young woman like her deserves a more honorable man in her life than Hawkeye.
- In one episode, Hawkeye drugged a colonel and made him think he had acute appendicitis, conducting an unnecessary surgery. BJ refused to go along with it.
- In the Sweet 16 episode of Life With Derek, Casey comes down with appendicitis. On her sixteenth birthday.
- Doogie Howser, M.D.: 16-year-old Doogie rushes his appendicitis-stricken girlfriend, Wanda to the ER straight from their Drive-In Theater date. He proceeds to diagnose her (via pelvic exam!) and assist in the operation himself. Trouble ensues because he didn't have time to properly ask for the required authorization from her parents (Wanda is 16 and a minor as well), and they're not happy. (Wanda herself is mostly embarrassed that Doogie saw her naked, and she gets better).
- On I Dream of Jeannie, Jeannie blinks Tony into a doctor just as Roger gets wheeled into the hospital for an appendectomy.
- On Lost, Jack, the survivors' team doctor, had to have his appendix removed while on the island.
- Daniel has very little to do in the Stargate SG-1 episode "Nemesis", as he's recovering from an emergency appendectomy. This was because Michael Shanks was recovering from an appendectomy himself.
- Happened on an episode of Laverne & Shirley; Shirley gets appendicitis while in costume rehearsing for their "Alice in Wonderland" play.
- In the final season of All in the Family, 10-year-old Stephanie comes down with appendicitis on her birthday.
- ER did an episode where Dr. Benton had to have his appendix removed, and Carter (much to his delight) was assigned to operate on him.
- On Night Court during the story arc where Dan, an Army Reservist, gets activated and sent to Alaska. A local Eskimo woman has to have her appendix removed and since he accidentally caused the local doctor to injure both of his hands, Dan must perform the procedure, with the doctor talking him through it.
- This occurred in an episode of Full House with Uncle Jesse, coincidentally while he was in the hospital while his twins were being born.
- Also occurred in Family Matters, in the episode "Number One With a Bullet" where Steve Urkel collapses in the middle of the Winslows' floor from this.
- In the Quantum Leap episode "Ghost Ship", Sam leaps into a pilot who must safely guide a plane out of the Bermuda Triangle and save one of the passengers from dying of appendicitis. Unusually for this trope, her appendix actually bursts, but Sam is able to use his medical knowledge to provide supportive care until they reach a hospital.
- In the second season of Malcolm in the Middle, Malcolm goes to hospital with what's assumed to be appendicitis. Ultimately turned on its' head as the diagnosis proves to be wrong.
- In the episode of Scrubs entitled "My Day Off" J.D. develops appendicitis and has to experience the hospital from a patient's point of view.
- In the Taiwanese Series Devil Beside You, Ahmon goes onstage after the lead guitarist goes down with appendicitis. He then gets to guitar suggestively in front of his love interest.
- CSI had a variation of this, the serial killer Dr. Jekyll, who implanted a guy with a diseased appendix. Naturally, it killed the guy later.
- In Australian children's TV adaptation of The Saddle Club, Lisa (one of the three central characters) is alone on horseback when she's overcome by the pain of Appendicitis and collapses on the trail.
- In Series 2 of Warehouse 13, the Team Medic (in the persona of the original Bionic Woman) answers Artie's call for a second appendectomy — he claims that being around all the artifacts made it grow back. Turns out he was using P.T. Barnum's spinning-top, which can "grow" multiple arms, legs, etc., to regrow it: he had taken a shine to the woman. She has to make a call somewhere else, and doesn't get around to removing it. When it gets bad, Artie has to go to the town vet.
- In The Big Valley, Audra contracted appendicitis on the titular "last train to the fair."
- In the Land of the Giants episode "The Creed", Barry got appendicitis.
- F Troop: Happens to Chief Wild Eagle in "Miss Parmenter"; the men of F-Troop must operate on him, with Captain Parmenter's sister serving as an assistant.
- Colton Cumbie was removed from Survivor One World with symptoms that mirrored appendicitis. (To which Kat asked where it was) However, during his appearance on Blood vs. Water, Probst reveals that Colton might not have actually had it, and even accused Colton of faking it!
- April quickly develops appendicitis after an embarrassing argument with Luke in Gilmore Girls. Luke has to call Lorelai, who's recently married Chris, for advice when April is clutching her side. Lorelai comes to the hospital afterward, and it's what makes Luke realize exactly how much he screwed up by driving her away.
- The Punky Brewster episode "Ouch" has Punky suffering from appendicitis. The thought of being operated on frightens her to tears, and she hides out in a hospital closet. Betty (Cherie's grandmother) finds her and persuades her to have the operation done.
- A Diff'rent Strokes episode had Arnold develop appendicitis and is too scared to the doctor until he meets a girl who is having a similar operation (her tonsils) and would be sharing a room together in the hospital. But when the girl's father decides against it after finding out Arnold is black, Arnold and the girl run away and the families have to search for them before Arnold's appendix bursts.
- Bright Abbot has this happen in the first season of Everwood, but it's not sudden and immediate; he's shown having stomach pains at the beginning of the episode but goes to his grandmother's birthday party anyway. Andy and Harold realize the appendix is inflamed and it only bursts when Bright tries to get up. Andy ends up removing it himself in his office, and Bright recovers.
- In Retail Cooper suffers one of these. It nearly burst because Cooper refused to see a doctor because he doesn't have health insurance, and the $20,000 bill he receives after the surgery nearly sends him into bankruptcy until he wins a big prize in a fast food joint contest.
- Trauma Center: New Blood has the player character racing against time to remove an infected appendix before it bursts.
- Afterwards, they immediately operate on another patient whose appendix had just burst.
- Mega Man Battle Network: In the second game, the player can come across a sick passenger in an airport complaining about his stomach. Later in the game, you can run into him, and he'll mention that he had appendicitis.
- On The Simpsons, Dr. Hibbert performed an emergency appendectomy on the street, then threw the appendix away as if it were a live grenade. It even exploded like a grenade.
- Another when Bart gets a stomach ache after accidentally eating a jagged metal toy from the Krusty cereal. He's sent to the hospital which it turns out to be appendicitis.
- An episode of Garfield and Friends had Jon suffer from appendicitis, though Garfield's obsession with a video game didn't help him at all... but between the antics of Odie and the noise from Garfield playing the video game, they managed to alert the paramedics in time.
- Happened on Rocko's Modern Life in the episode "Tickled Pinky". Before the procedure, Rocko has a dream in which his appendix is a little kid whom he consoles with a trip to the fair (and other, increasingly silly last requests) before he's taken out.
- Near the end of the final season of As Told by Ginger, shortly after her breakup with Darren, Ginger is left feeling as if her "insides exploded". It's discovered that the pain she's been experiencing isn't solely because of the breakup, but is in fact due to acute Appendicitis. She's rushed to the hospital for an emergency Appendectomy.
- In an episode of The Wild Thornberrys that takes place in Australia, Eliza has the misfortune of not only developing Appendicitis on Valentine's Day, but also that the commvee and mini-comm are immobile. It's a possible life or death situation as Nigel overcomes various obstacles to get her to a hospital.
- Happens to Hector on one Ozzy and Drix episode. Here the appendix is depicted as a roadside motel with swelling attributed to an unscrupulous manager trying to get it filled to the brim.
- This trope is Truth in Television – and it's actually quite common that almost everyone has at least heard of appendicitis or an appendix injury.
- Harry Houdini died of a ruptured appendix, which may or may not have been exacerbated by someone punching him in the stomach a few days earlier—one theory is that he may have attributed the early symptoms of appendicitis to pain from the blow, and did not seek help as soon as he would have otherwise.
- Leonid Rogozov, a Russian doctor, got appendicitis. While on an expedition in Antarctica. Where he was the only doctor. So he operated on himself.
- This led to a policy of preemptively removing the appendix of critical staff members (with their consent) before any trip to the base.
- Similar to the Rogozov example above, some jobs and/or activities that involve traveling to remote areas where evacuation is difficult or impossible will also require or at least suggest preemptively removing the appendix. Astronauts are the most well-known example, but others, such as hikers planning to solo-hike remote areas, will also sometimes have this done.
- James Roday from Psych, was hospitalized with appendicitis and had to have it removed just prior to his scheduled appearance on WWE Raw. He recovered and was even able to make a literal phoned in appearance during the episode, albeit highly medicated and somewhat loopy.
- Buck Tick vocalist Atsushi Sakurai developed abdominal peritonitis from a Ruptured Appendix while in Nepal in late 1996, and was diagnosed as potentially terminal. He demanded to be sent home to Japan to die, and somehow, against all odds, recovered once he was back in Japan, becoming one of the very, very few people to survive a ruptured appendix and subsequent peritonitis.
- Masaki Koh, a gay adult video star, developed appendicitis but refused surgery for several reasons (including appearance and that his condition was so advanced that the surgery itself could have ruptured the appendix) and instead chose nonsurgical treatment with antibiotics and the like. Unfortunately, his appendix ruptured, and he would later die from abdominal peritonitis.
- Ringo Starr, drummer of the The Beatles, nearly died at age six from peritonitis; he missed a year of school while recovering and remained sickly for most of his childhood as a result. It was his constant illnesses and inability to catch up academically that played a big role in him turning to music.
- Happened to Lets Player Roahm Mythril around Thanksgiving time. Thankfully, he made it to the hospital quickly and made a full recovery.