The English dub of Demon Slayer: Kimetsu no Yaiba has many characters who share a voice actor:
- Abby Trott voicing Nezuko, Chuntaro, the Hand Demon's deceased brother, and Koto Shinazugawa.
- Allegra Clark voicing the Mother Spider Demon and a child Tanjiro.
- Brandon Winckler voicing Kiyoshi and the Reporting Demon Slayer.
- Brianna Knickerbocker voicing Kanao, Nichika Ubuyashiki, and Teiko Shinazugawa.
- Bridget Hoffman voicing Kanae Kocho and Rui's mother.
- Christopher Corey Smith voices Hantengu's main body as well as the embodiment of his resentment Urami.
- Cristina Valenzuela makes bank during the Swordsmith Village arc, voicing Suyako Kamado, Mrs. Tokito, Hiroshi Shinazugawa, the female Kakushi who accompanied Tanjiro to the swordsmith village, as well as Muichiro and Mitsuri's Kasugai crows: Ginko and Urara.
- Derek Stephen Prince voicing Goto and the Elder Brother Spider Demon.
- Dorothy Elias-Fahn voicing Kie Kamado and Ozaki.
- Erica Lindbeck voicing the Elder Sister Spider Demon before returning two seasons later as Daki.
- Erik Kimerer voicing Iguro Obanai and the boy who entered Zenitsu's spiritual core.
- Griffin Burns voicing Muichiro Tokito, and his deceased twin brother Yuichiro.
- Jeannie Tirado voicing Kotetsu and Shuya Shinazugawa.
- Jessica DiCicco voicing Shigeru Kamado and a human Hand Demon.
- Kimberly Woods voicing Hinaki Ubuyashiki and and Naho Takada.
- Kira Buckland voicing Mitsuri Kanroji and Lower Rank 4 Mukago.
- Kirk Thornton voicing Tanjuro Kamado, the Hand Demon, the cocky Demon Slayer killed by Rui, and the Mugen Train conductor.
- Kyle Hebert voicing Kozo Kanamori, Rui's father, and Muzan's doctor.
- Laura Post voicing Tamayo and Sumi Shinazugawa.
- Lucien Dodge voicing Kazumi and returning to voice Akaza.
- Matthew Mercer voicing Kagaya Ubuyashiki, the fat and long-lounged demon from Tzumi Mansion, and boy who entered Tanjiro's spiritual realm.
- Mela Lee voicing Kanata Ubuyashiki and the girl who entered Rengoku's spiritual realm.
- Ray Chase voicing Tengen Uzui and Lower Rank 2 Rokuro.
- Ryan Bartley voicing Hanako Kamado, Makomo, a young Kyojuro Rengoku, and the Asakusa Demon's wife.
- Suzie Yeung voicing Amane Ubuyashiki and Ruka Rengoku.
- Xanthe Huynh voicing Tokie and Muzan's "daughter."
- Zach Aguilar plays the lead role as Tanjiro, but also voiced the Slasher from episode one of the Mugen Train season.
- Zeno Robinson voicing Genya and the Asakusa Demon.
