This works as follows: playing Dungeons & Dragons strengthens a defensivebarrier around the universe. Since it's popular among young nerds, it gets played a lot by said young nerds, helping to protect the universe. However, some evil, already within the universe, utilises spells from DnD to create DnD Fourth Edition, which weakens and destroys the barrier. In response, Gary Gygax creates the "Book of DnD", a magical artifact with the power to fight back against Fourth Edition. Unfortunately, the evil, discovering the Book, attempts to obtain it for unlimited power. Gary retaliates by sealing all the magical power within the Book, but ends up sealing the evil in with it. And the raw magical energy kills him. The plot got pretty complicated, huh?
Unfortunately for the future of the universe, the Book of DnD ends up being sold on eBay - purchased by a main character by the name of Bob. As soon as Bob reads the Book, he is transported inside it, to discover the Book contains a fully-running game of DnD. He then gets fed up with the comic, and decides to leave. However, he finds he can't, and soon meets his friend Fred and a resident named Jane. They go to a town, and then to a castle, where they meet, believe it or not, Trope-tan and defeat Captain Obvious. And with the help of Plot Holes, they get to the Satellite of Love where time travel happens and that's when it gets sort of complicated.
You can read it here.
The Way of the Metagamer provides examples of:
Aerith and Bob: Most of the characters have normal names - the heroes are named "Bob", "Fred", and "Jane". Then we throw in "Xavius" and "Trope-tan".
All in a Row: The party spends a ridiculous amount of time walking in this manner.
Fang Thpeak: Trope-tan thometimeth getth a lithp, due to her Cute Little Fang. However, she's done a lot of vocal training and thus only lisps when she's distracted by something.
Future Badass: Parodied. Everyone from the future is badass. No matter how far that future is. Even characters from five minutes in the future are incredibly badass.
Infinite Canvas: Although the comics are all approximately the same size (except for double-length specials), characters, speech bubbles, and shoes often breach the borders of the panels. And then there's this comic, in which the characters climb behind the panels.
And again here, along with about 12 panels worth of getting it straight. The actual line is used, too.
This becomes a sort of Running Gag, with several conversations lampshading it. For example:
Trope-tan: So, you spent an entire chapter trying to escape from this comic, to no avail? Bob: Yes, that is exactly what I just said, except rephrased as a question.
Magical Computer: The DnD within the Book actually runs on an "XLPQ-732 Dungeon Master" - a computer powerful enough to run Dungeons & Dragons fully. Although it does have the occasional BSOD.
Bob: I was definitely pointing out how Jane having all those spells prepared made no sense. And I certainly wasn't cursing at her like a complete idiot. Definitely. Yeah.
Theory of Narrative Causality: As the comments here explain, narrativium is a major element - high concentrations of narrativium produce raw plot energy, rendering certain areas more plot-relevant than others. The Plot Hole is dangerous because it takes away narrativium.
The Wise Wizard Guy: You, Detective... you are a tomato. The Detective: Yeah, I know. The Wise Wizard Guy: ... no "oh God, what have I become"? The Detective: Nope.
Trade Snark: As noted above, Technobabble Box™. Other trademarked boxes include the "Exposition Box™" and the "Inventory Box™".
