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Syura: You've gotta be joking... I can't die here. I need the throne, so I can change this boring world!
Lubbock: It isn't like I don't understand what you want.
Syura: Crap, I can't... In a place like this... I was supposed to...
Lubbock: You want to change the world, huh? I understand. Everyone feels that way... But it doesn't give you the right to treat others' lives like toys. You can't just destroy whatever you want! (crushes Syura's heart with Cross Tail, killing him)
Akame ga Kill! Anime

"Impossible. You CAN'T be alive. What is that form? Who are you?"
Ulquiorra Cifer, towards a Hollowfied Ichigo, Bleach

"Absurd! That couldn't possibly be! A mere human cannot surpass me! THAT CAN'T BE!!!"
Sōsuke Aizen, right before Ichigo proves him wrong, Bleach

"My life...?! My life is taken... BY A LOWLY ELEVEN?!? GAAAAAH!!!"
Luciano Bradley as he is microwaved to death inside his Percival by Kallen Kozuki and her Guren S.E.I.T.E.N.; Code Geass

"No! That's absurd!"
Embryo reacting to his Hysterica having been reduced to a smoking wreck by Ange's Villkiss, Salia's Cleopatra, Hilda's Theodra, and Salamandinay's Enryugo; Cross Ange

MaloMyotismon: I'm curious to know why my Mind Illusion was ineffective against you. How can it be that you have no insecurities or unhappinesses for it to feed off of?
Davis: What do I have to worry about? I have my friends, my family, and a Digimon. Plus some guy with a letter opener on his face trying to kill me. I'm happy to say I don't have any problems!
MaloMyotismon: Impossible! There isn't a single child in the world that doesn't have something they're worried about!

"No! This can't be happening! These paltry children can't make me disappear! I won't allow it!"
MaloMyotismon before being finished off by Imperialdramon in Digimon Adventure 02

"A human child defeated me?!"
Cerberumon, about Takuya, who had Spirit Evolved into Agunimon, in Digimon Frontier

"NOOOOOOOO!!!! It's impossible!!!!"
Lucemon upon being destroyed by the Ten Legendary Warriors in Digimon Frontier

Nappa: (about Goku) Vegeta, what does the scouter say about his power level?"
Vegeta: (takes off scouter and crushes it) IT'S OVER 9,000!
Nappa: WHAT?! 9,000?! There's no way that can be right! Can it?

I WAS PERFECT...!
Cell's last words, Dragon Ball Z

"How humiliating! To think I could be outclassed by some filthy, half-evolved Saiyan! I am the mighty Frieza, the most powerful force in the universe! This is a nightmare! Yes, that's the only logical explanation! Why else would this be happening?!"
Frieza as Goku starts handing him his ass, Dragon Ball Z Kai

Cell: (minus an arm thanks to Vegeta's Final Flash) This can't be - it's impossible! My perfect form... I don't believe it! I can't be defeated - not like this! NOT BY A SAIYAAAAN!
Vegeta: HAHAHAHAHAHAHA!
Cell:....No, seriously.
Vegeta: (stops laughing immediately)
Cell: You truly are a fool. Have you forgotten I share Piccolo's powers of regeneration? (regrows his entire arm in seconds as Vegeta's frozen laugh turns into a shocked expression) Well, look at that. Now then, I think I've humored you long enough.

No! This can't... BE!
(Cell begins to disintegrate as Gohan and Goku's Father-Son Kamehameha powers up)
THIS CAN'T BE, I AM PERFECTION!
Cell's last words, Dragon Ball Z Kai

"Impossible...this cannot be..."
Alok, after Natsu destroys Ikusa-Tsunagi, Fairy Tail

"I don't understand! How can this happen when I've absorbed God?! How could a mere human...a meager alchemist... with his bare hands...?!?"
Father's thoughts as he is pummeled by Edward, Fullmetal Alchemist

"Impossible! Nothing should be able to withstand our power!"

"NGAAAAAAAAAAHHHHH! WHAT THE HEEEEEEELL!? IT'S IMPOSSIBLE! I AM THE IMMORTAL DIOOOOO...! I AM DIOOOOOOOOOO!!"
Dio Brando right before he explodes after Star Platinum shatters The World in JoJo's Bizarre Adventure: Stardust Crusaders

"For real...?!"

"AAAAAAAAAAAAAAAHHHHHHHHHH! NOOOOOOOOOOOOOOOOOOOO! THIS CAN'T BE HAPPENIIIIIIIIIIIINNNNNNGGGGGGG!!!"
Escargoon, Kirby: Right Back at Ya!, Episode 55

Emilia Ludowell: (After realizing she was Naked on Revival and covers herself) I-is this your idea of humiliating me you lowly hybrid!?
Anos Voldigoad: "Lowly hybrid," huh? Emilia, do you really still think you're a royal? Peer into the abyss with your Demonic Eyes
Emilia: Hybrid? (Checks herself.) Impossible... No Way... Am I really a hybrid? (Clutches her hair.) No! No! This isn't me at all!

"I'M NOT GOING TO DIE LIKE THIS!"
Muruta Azrael as he realizes his final attack on the Archangel failed and that he's trapped on the Dominion with no possible way to escape; Mobile Suit Gundam SEED (HD Remaster Dub)

"I refuse to die like this! THIS ISN'T HOW I WANNA DIE!"
Nena Trinity as she is at the mercy of a vengeful Louise Halevy and her Regnant Mobile Armor; Mobile Suit Gundam 00

"WHY?! I CAN'T LOSE! IT'S IMPOSSIBLE!!!"
Desil Galette after being defeated by Asemu Asuno and the AGE-2 Gundam, seconds before he dies in his Khronos' explosion; Mobile Suit Gundam AGE

"I can't die in a place like this! It's impossible!"
Iok Kujan as he is crushed to death inside his Mobile Suit by Akihiro Altland and the Gusion Gundam; Mobile Suit Gundam: Iron-Blooded Orphans (English Dub)

"This can't be happening... WHAT THE HELL ARE YOU?!?"
Guel Jeturk as Suletta Mercury and her Aerial Gundam absolutely demolish his Dilanza; Mobile Suit Gundam: The Witch from Mercury (English Dub)

"The quirks I've stolen in the past..their very wills?! Impossible!! Even New Order didn't manage this! They were spurred on by this?! By the efforts of such pushovers?!"
All For One after Jiro's defiance of him causes the vestiges inside of him from the Quirks he's stolen to rebel against him, My Hero Academia

"No! Not yet! Move! It's not over yet!"

Faust VIII: (after seeing Yoh burst out of a huge pile of skeletons, destroying it in the process, with his oversoul) IMPOSSIBLE! He survived the full force of the Boneyard Crush?!
Manta: He's alive...
Yoh: (points his sword at Faust) Now it's time for Faust VIII to become Faust the last!

"How can this be? Where are you drawing all of this power from?"
Anti-Spiral, Tengen Toppa Gurren Lagann English dub

Kaiba: Draw your last pathetic card so I can end this, Yugi!
Dark Yugi: My grandfather's deck has no pathetic cards, Kaiba! But it does contain... The unstoppable Exodia!
Kaiba: AAH! IMPOSSIBLE!
Dark Yugi: I have assembled all five special cards! All five pieces of the puzzle! (Dark Yugi summoned Exodia)
Kaiba: Exodia! I-It's not possible! No-one's ever been able to call him!
Dark Yugi: EXODIA, OBLITERATE!! (Exodia destroys Kaiba's Blue-Eyes White Dragons; dropping Kaiba's Life Points to 0)
Jonouchi: You did it! Yugi, you've won!
Mokuba: This can't be! My brother never loses!
Dark Yugi: You've played only for power, Kaiba. And that is why you've lost. If you've put your heart in the game, there is nothing you can't do.
Kaiba: But... But how!? How could I've lost to him!?
Dark Yugi:' Kaiba, if you truly want to know, OPEN YOUR MIND! (inflicts a Penalty Game on Kaiba) There, Kaiba. Maybe now, you'll begin to see.
Yu-Gi-Oh! Episode 1 Original Dub

Kaiba: Hah! Did you finally lose hope and decide to pull any card?
Dark Yugi: Not quite! I have my hope right here in my hand! The card I pulled... is Exodia the Forbidden One!
Kaiba: AAH! What the–!?
Dark Yugi: I've assembled all the five needed cards! (Dark Yugi summoned Exodia)
Kaiba: NO WAY! IT'S... IT'S EXODIA! YOU'RE SAYING YOU PERFORMED A MIRACLE?!
Dark Yugi: HELLFIRE'S RAGE, EXODO FLAME!! (Exodia destroys Kaiba's Blue-Eyes White Dragons; dropping Kaiba's Life Points to 0)
Jonouchi: You did it! Yugi wins!
Mokuba: No way... My big brother lost...?
Dark Yugi: No matter how strong your cards are, without heart, they're meaningless. When you link your heart to the cards, miracles can happen.
Kaiba: That's... Ridiculous! How could I've lose!?
Dark Yugi: Kaiba, This shall crush the evil within you! MIND CRUSH!! (inflicts a Penalty Game on Kaiba) Now, the evil-playing in your mind has been crushed to bits.
Yu-Gi-Oh! Episode 1 Uncut Dub

"NOOOOOO!! Unbelievable! My... my beloved monsters are... This is a nightmare! Bad dream! No! This can't be real! Ohhhhhh..."
Pegasus, Yu-Gi-Oh!

    Comic Books 
"No! This cannot be! Miranda! Have mercy..."
Nightfall as Miranda and her sons seal him in a new dragon statue in the Grand Finale of the Double Dragon comic from Marvel Comics

"No! Impossible! You can't beat m--"
Air Man, Mega Man (Archie Comics) Issue #11. He gets better.

    Fan Works 
"Rule Ten: one must not rant about the opposition's unworthiness after they have foiled you."

Qine (After being quad-amputeed): No! No! This is impossible! I'm the most powerful person in this country and you(')r(e) nothing more than a filthy demi with a dirty animal.
Neia: Like your opinion matters to me anymore. Oh and I am not a demi-human, I'm a water elf.

This cannot be! There must be other factors!
Snap/Snape, My Immortal

"You - but - how?!” Temrash demanded, wide-eyed and scared shitless".
<My kid brother could kick your ass any day of the week,> I said smugly. <Your chances don’t look good, dude.>

"Wh...What's this?! Ultra Instinct?! In the hands of a mortal like THIS MAN?!"
Vegeta, after causing Shaggy to activate his Ultra Instinct powers by inadvertently saying his Trigger Phrase, in The Silverscale Arena, "Episode 23"

    Films - Animated 
"No! You'll not have me! My power cannot die! CURSE YOU!"
The Horned King, inches away from being sucked into the Artifact of Doom, in The Black Cauldron

Dark Danny: What makes you think you can change my past?
Danny: Because I promised my family!
Dark Danny: [laughs] Oh, you are such a child! You promised?
Danny: Yes! I. PROMISED! [unleashes Ghostly Wail, blasting a shocked Dark Danny back]
Dark Danny: That power! It's not possible! I don't get that power until ten years from now!
Danny: I guess the future isn't as set in stone as you think it is.

Pacha: Okay, demon llama, just take it easy! I mean you no harm!
Kuzco: What are you talking ab...? Oh wait, I know you. You're that whiny peasant!
Pacha: (making a gasp upon realizing who he is) Emperor Kuzco?
Kuzco: Yeah! Who do you think you were talking to?
Pacha: Dah... How did...? Um... You don't... look like the Emperor.
Kuzco: What do you mean "I don't look like the Emperor"?
Pacha: Uh, um... Do this. (his fingers wiggle around)
Kuzco: What is this? Some kind of little game you country folk like to... (upon seeing his hands became hooves) IT CAN'T BE! AAH! (checks his reflection in a fountain) MY FACE! MY BEAUTIFUL, BEAUTIFUL FACE!

Hades: [sees Hercules emerge from the Stix River, glowing brightly] This is—this is impossible! You-you-y-you can't be alive! You'd have to be a-a-a—
Pain & Panic: A god?
Hades: [flaming up] NYAAAARGHAAH!!!!! Hercules, stop! You can't do this to me! You can't[Herc punches him in the face without turning his head] ...Okay, well, I deserved that.

"Mufasa?! No. You're dead."
Scar, mistaking a grown-up Simba for the late Mufasa, The Lion King (1994)

(Captain Hook and his pirate crew, having seemingly killed Peter Pan with a bomb, send Wendy Darling to walk the plank, but there is no splash from landing in the water)
One pirate: No splash, Captain!
Hook: So, you want a splash, Mr. Starkey? I'LL GIVE YOU A SPLASH!
(He grabs him and throws him overboard, making a splash)
Hook: Who's next?
Peter Pan: You're next, Hook! This time, you've gone too far!
(Hook notices that Peter, having escaped the bomb explosion, has saved Wendy from landing in the water and put her in the crow's nest, much to the excitement of all the captive children)
Hook: It can't be!
Mr. Smee: It's his blinkin' ghost what's talkin'!
Peter: (drawing his dagger to fight Hook) Say your prayers, Hook!
Hook: (drawing his sword to fight) I assure you, this ghost has blood in his veins!

"No...IT CANNOT BE! Now, shall you deal with me, O Prince—and all the powers of HELL!!!"''
Maleficent, about to turn into a dragon to battle Prince Phillip, Sleeping Beauty

"Not. Possible."
—- AUTO once he sees EVE and WALL-E have escaped from being Thrown Out the Airlock and are headed to put the plant in the holodeck, WALL-E

    Films - Live Action 
"I don't believe it... *I* got shot!"
Albert Ganz, 48 Hrs.

"I knew you. But you ain't you. You can't be you. We put you through the window. There ain't no coming back. This is the really real world, there ain't no coming back. We killed you dead, there ain't no coming back! There ain't no coming back! There ain't no coming back!"
T-Bird, The Crow (1994)

Yoda: If into the security recordings you go, only pain will you find.
Obi-Wan Kenobi: I must know the truth, Master. (Views holograms of Anakin Skywalker killing Jedi younglings and kneeling before The Emperor) It can't be. It can't be!
Emperor Palpatine: (To Anakin in the holo-recording) You have done well, my new apprentice. Now, Lord Vader, go and bring peace to The Empire.
Obi-Wan: (Turns off the hologram) I can't watch any more.
Star Wars: Episode III — Revenge of the Sith

Darth Vader: Obi-Wan never told you what happened to your father.
Luke Skywalker: He told me enough! He told me you killed him!
Vader: No. I am your father.
Luke: No... No... That's not true! That's impossible!
Vader: Search your feelings. You know it to be true.
Luke: NOOOOOOOOOOOOOOOOOOOOO!!! NOOOOO!

Barbossa: It's not possible!
Captain Jack Sparrow: Not probable!

"I know you. You're dead! We killed you! We killed you!"
Emil Antonowsky to RoboCop, RoboCop (1987)

"Oh, man, this isn't happening. It only thinks it's happening."
Kevin Flynn's reaction to arriving in the Encom Computer Network, TRON

"This isn't happening." (dropship descends) Oh, man, this is happening."
— ...and his son Sam Flynn's reaction to arriving in the Grid, TRON: Legacy

Leezar: You fool! I cannot be destroyed by mortal blade! One must possess the powerful...
Fabious: I know! Blade of Unicorn!
Leezar: It's not possible.

    Literature 
"You dare defy me! You dare resist!"
Visser Three when Tobias refuses to cooperate in the face of torture, Animorphs

And the Grinch, with his Grinch feet ice cold in the snow
Stood puzzling and puzzling "How could it be so?
It came without ribbons. It came without tags.
It came without packages, boxes or bags."

    Live-Action TV 
"You think you can destroy me?! Like hell you will, you puny humans!"

Lord Zedd: (after seeing the Thunderzord assault sled dodge Lipsyncher's attack) Impossible! I can't believe it!
Baboo: I wanna ride that thing.
Squatt: Where d'ya get a ticket?

"I can't be beat! I'm the baddest of the bad!"
Madimot upon receiving the fatal blow from the Tiger Drill Megazord in Power Rangers Samurai

"IMPOSSIBLE! THAT SERPENT WAS INDESTRUCTIBLE!"
General Gut upon having his serpent severed from his groin by the Sharkzord in Power Rangers Samurai

"IMPOSSIBLE! Samurai Rangers, hear me now. You may have won this battle, but our quest to rule you will never end. You may have defeated me... but the Nighlok will rise again!"
Master Xandred, Power Rangers Samurai

"You healed them without my blessing. That's impossible."
Athena after realizing that Xena has mortally wounded her, meaning that the god-killing vessel Eve has been healed by Ares, Xena: Warrior Princess, "Motherhood"

    Manhua 
"Impossible... He's just an NPC..."
Mōnsuto after her character gets impaled on her own scythe moments before fading away, World Of Super Sand Box

    Video Games 
"This is not my destiny!"
Chakravartin, Asura's Wrath

"Impossible... death cannot take me... I am its master..."
Ketheric Thorm, Baldur's Gate III

System: Subject surface solidifying. Now constructing stasis cocoon for subject 12.
Male Scientist: Whoa...this is... Time-space is frozen... A cocoon of time...
Lead Scientist: What's wrong!?
Male Scientist: Tempering is proceeding as planned! The Cauldron appears normal!
Female Scientist: Extremely high seithr concentration detected, directly above this facility! 6000, 8000, 12000...
Lead Scientist: Wh-What!?
System: Concentration levels climbing rapidly! 34,000, 58,000! If they continue to increase at this rate, the seithr concentration is going to reach critical levels!
Lead Scientist: Is it the Library!? Impossible! Not even the Library... could concentrate this much seithr into one place... There's no way! I want the point of concentration! Now!
Female Scientist: Concentration to exceed 100,000!
Lead Scientist: Agh... After coming this far...! Abort the experiment! Cut all power!
Male Scientist: Roger! Cutting all power! S-Sir! We can't cut the power!
Lead Scientist: What!? What the hell is Sector Seven doing!? Get them online! What the hell are they doing at a time like this!?
System: Point of concentration determined: Point A-A-1.
Female Scientist: ...Sir! It's directly above Ikaruga! Altitude 36,000 feet!
Lead Scientist: Impossible!? It's going into orbit!?

Jubei: I reckon it's Kokonoe who's trying to pull you out here... An' if she does, I'd be much obliged if you don't tell about me. I got my reasons.
Hakumen: ...Then you have my word. But what has brought you here? What news do you bring of the outside world?
Jubei: ...Terumi's back.
Hakumen: What!? That can't be! It's impossible!

"What?! You broke my spell?! HOW CAN THIS BEEEEEEEE?!"
Litchi Faye-Ling, Platinum's BlazBlue: Continuum Shift Extend Gag Reel

"H-How could this happen...! How could I have lost to a little girl?! Oh what a world... oh what a world...!"
Litchi Faye-Ling, Platinum's BlazBlue: Continuum Shift Extend Gag Reel

"NOOOOOOOOOO!!!! This can't be happening! THIS CAN'T BE HAPPENING!!!"
Handsome Jack witnessing The Warrior's death, Borderlands 2

"No...I reject this outcome! I REFUSE TO ACCEPT IT"
Hoaxe, after finding out that the Everlasting Sapling has wilted from lack of light, Bug Fables

Noooo! This Cannot Be! Does this mean that I'm not Dracula?!
Graham Jones' final words after being defeated by Soma Cruz with the required souls, Castlevania: Aria of Sorrow

Dmitrii: (upon realizing that his power of dominance is starting to go out of control and therefore suffering a Villainous Breakdown) Th-this cannot be... My dominance should be complete!
Arikado: So that's what's happening...
Soma: Arikado, what's going on?
Arikado: The power of dominance isn't easily contained. He isn't like you. His soul can't withstand a power that intense.
Dmitrii: Liar!! I've heard enough from you! (blasts Arikado away)
Arikado: Gwoh!
Soma: Arikado!
Dmitrii: I am the chosen one! I am the dark lord! I shall not succumb to the power! Wroooooooaaaah! (starts to get worse)
Soma: It's useless. You can't control it.
Dmitrii: Gwroaaah! (falls to the ground as Menace bursts out of his back) GAAAAAAAAAAAAAH!

"No! This Cannot Be! AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH!!!"
Dracula's Final Words after being defeated by Richter Belmont, Castlevania: Symphony of the Night (Original version)

"Impossible! Not this time... GyeaaaAAARGH!!!"
Dracula's Final Words after being defeated by Richter Belmont, Castlevania: Symphony of the Night (Dracula X Chronicles version)

"But this power is... NO! It can't be my-"

"Uka Uka is free? No... It cannot be! Evil great, evil has come..."

"No! It cannot be! Not a prisoner of time again! AAAAAAAAAAUUUUUGH!!!"

"This is impossible! I-I cannot lose!!"
Imperial Psyker, Dawn of War

"No, no! We cannot lose! We cannot die, how can we?! [...] Oohhh, the horrid blossom of Chaos will wither, will die!! [...] This world... is slipping... from our grasssp."
Lord Fireavus Carron on the destruction of his fortress, Dawn of War: Soulstorm

Fallen Angel Ramiel: Impossible!
Lilith: I'll kill you for this! Angels! People! I'll kill you ALL!!
Fallen Angel Gabriel: Me?! Lose to babies like YOU?!
Jaldabaoth: I am truth! I am absolute!
Fallen Angel Raphael: No way... I'm the one who broke?
Asura: My fury and ire are unsated!

"The Big Gete Star enabled me to cheat death! How could this be?!"
Cooler, Dragon Ball Xenoverse 2... many, many times.

"I CANNOT BELIEVE IT!"
A majority of the bosses upon defeat in Dynamite Headdy

"Zu'u unslaad! Zu'u nis oblaan!" (Translated from Draconic: "I am eternal! I cannot die!")
Alduin, The Elder Scrolls V: Skyrim (Turns out he was right.)

"But the Ultima Weapon is all-powerful! Why does my enemy still stand!?"
Gaius van Baelsar, Final Fantasy XIV

King of Shuigang: How did this happen? Our walls are impenetrable!
Lord Brevon: Your floor isn't!

"AAAAAAaaaaaaargh! No, it can't be! How can I lose! Nooooooooooooo!"
Deathborn, F-Zero GX

"Guwaaahh!! Impossible... This-this can't be..."
Death Adder, Golden Axe (PC-Engine Version)

"UNACCEPTABLE! UNACCEPTABLE! ABSOLUTELY UNACCEPTABLE! Protocol dictates action! I see now that helping you was wrong! You are a child of my makers, inheritors of all they left behind. You are Forerunner, but this ring... is mine!"
343 Guilty Spark on the plan to destroy Installation 04 and the Ark to eliminate the Flood, Halo 3

"How? The great Calamity Ganon... selected me! This humiliation... cannot be my destiny! It cannot be!"

"This cannot be. I am Emperor Sun. I am a god!"
— The last words of Emperor Sun Hai, Jade Empire

Gol: White Eco! It DOES exist!
Maia: They must not be allowed to get it!

Phosphora: I take back what I said before. You're not cute at all! (dissolves)
Viridi: This can't be happening!
Pit: I'm coming for you next, Viridi!
Hades: This place is going back to the dogs without lovely little Phosphora.
Palutena: Smarm it up while you still can, Hades. We'll be after you soon enough.
Viridi's reaction to Phosphora's defeat in Kid Icarus: Uprising

"Bested by this weakling? This cannot be..."
— Last thoughts of Ou Di Wan Lee, Live A Live

Asimov/Demerzel: IMPOSSIBLE...! I'VE BEEN DEFEATED... AGAIN? ME... LIGHTNING INCARNATE...
Copen: Lightning cannot exist forever in this world. Begone, you curse of the past...
Asimov/Demerzel: NO!! THIS IS... IMPOSSIBLE!!!
— After Asimov/Demerzel is beaten in the Boss Rush for Luminous Avenger iX

"EYARGH! It can't be!! IMPOSSIBLE!! I... no... how could I... And to this filthy little pair! How could I LOSE?!"

"No!!! It's not possible! I'm a Reploid! I can't be destroyed by you! Why, X?! Why have you done this to us?! Without the humans, my Reploid brothers would have ushered in a new age..."
Sigma, Mega Man X

Violen: What?! How could he have overloaded my circuits?!! Arrrggghhh...
Serges: This is impossible! The prophecy must be fulfilled!
Agile: NO!! This cannot be!! Master, avenge me!

"No, this isn't happening! There's no reason for me to go on! What... WHAT AM I FIGHTING FOR?!"
Zero, Mega Man X4

Poler Kamrous: Gh gh gh... I can't believe this. I was beaten by this little bug thing... Bobobohfa...!
Panther Flauclaws: No... No... I can't believe this... Master Harpuia... I'm ashamed... I was not good enough... Guhhha....h!
Phoenix Magnion: Ugh... It can't be... I didn't think my heart could be tricked by them... Foolish...
Herculious Anchus: It can't be!! We were manipulated!!!! Uggggg!!
Tretista Kelvarian: H-how did this happen? Why can't I bit you to chunks? Why do I hurt all over again? Ouch. Ouch. Ouuuuuch!!! Grrauwruurrrr!
Pegasolta Eclair: Wah! How could this happen to me!? You... Beating me?! That's impossible... But...my death, it's so beautiful!
Sol Titanion: W-what? Why...can't I... move? How could I... lose to you? Unbelievable... no, impossible... Kyaaah!
Mino Magnus: Roar!? I...I... lost? How...can this... be...happening!
Noble Mandrago: Nooo! Impossible! I won't be able to witness the descent of Ragnarok... I will try to enjoy this final glimpse of the world before it ends...
Popla Cocapetri: H-how could this be happening!? Why did I have to taste defeat at the hands of someone like you!? Unbelievable! Simply unbelievable!
— Several Mutos Reploid bosses that say this stock phrase when they're defeated in the Mega Man Zero series

Lurerre: Oh my... Oh my... Goodbye cruel world. How could this be?! Done in by a creepy little runt!
Fistleo: How could this happen!? I was transformed into a Pseudoroid... I was supposed to have the power of a god... But I was beaten by a little boy/girl!
Purprill: N-nooo! I'm too powerful to be beaten! I'm an... officer... I should be... unstoppable... Ooook!!!
Protectos: Ugh! No! How could anyone break through my armor! Rrraaagh!!
Rospark: (to Ashe) The nerve! That strength... How!? I'm wilting... wilting! Yeeeargh!
Vulturon: What! This was supposed to be Mega's death concert, not mine! Aaaaagggghh!
Queenbee: What!? You refuse my precious gift of despair!? Aaaaargh!
— Seven of the Pseudoroids that say this phrase when they're defeated in Mega Man ZX and Advent

"It cannot be! Shao Kahn is dead! Yet the future remains unchanged!"

The Maverick: Huff... Huff... Is... Is this real life?
Angel: How? How is this possible!?
Kim: I can't believe we lost...
Vance: Kim... I'm hungry. Can we go now?
OMORI, if you manage to beat the Hooligans without using the Pepper Spray

"This...this can't be! I'm supposed to be immortal! Oh, why... Why do you abandon me? Dark Fo...Aaaargh!"
Zio being vaporized after being defeated, Phantasy Star IV

"WHAT! This can't be!"
Giovanni when you defeat him for the first time in Pokémon Red and Blue

"This... this cannot be! It's not possible that I lose!"
Cyrus when his last Pokemon is down to critical health in Pokémon Diamond and Pearl

"My calculations... No! My careful schemes! The world should be mine!"
Ghetsis, when you defeat him in Pokémon Black and White

"I can't believe it! The Black/White Kyurem I went through all the trouble of preparing! How irritating!"
Ghetsis, after you defeat Black/White Kyurem in Pokémon Black 2 and White 2

"Could it be?! My plans for complete and utter world domination foiled yet again?! No! It mustn't be! I couldn't have been beaten by some random trainer from who knows where!"
"How can this be?! I'm the creator of Team Plasma! I'm perfect! I'm the absolute ruler who will change the world! And I've lost to some unknown trainer, not once, but TWICE?! I can't accept this! This isn't possible! I can't be bested by fools who can't even use Pokemon correctly!"
Ghetsis, when you defeat him in Pokémon Black 2 and White 2

"But why...? How can this be? How could someone like you get in my way? I was the one chosen by the chairman... I was the one who was to defeat the Champion... I’m one of the elite—someone who can shoulder the future of the Galar region!"
Bede upon losing to the player for the third time, Pokémon Sword and Shield

"No…why?! This wasn’t supposed to happen! Urgh! No…no, no, no!"
Kieran, when you defeat him in Pokémon Scarlet and Violet: The Indigo Disk DLC

"N-no! There's no...this can't be happening!"
Nascour, when you defeat him in Pokémon Colosseum

Sabuko: Impossible! Defeated by a pair of schoolgirl deviants... How??
Misako: Just 'cause we're young...
Kyoko: And cute!
Misako: ...don't mean we can't tear down this whole town to get our boyfriends back.

"Impossible...! How could a mere peasant like you...? Tch! It's time for an intermission!"
Iris Sepperin, RosenkreuzStilette Grollschwert

"H-how can this be!? Rosenkreuz was made whole again...! This can't be the extent of his power! No! I won't have this! I'm a goddess! My power should be absolute! This isn't supposed to be possible!!!"
Iris Zeppelin, RosenkreuzStilette Freudenstachel

"No, no, no, no, NO...! I lost...!?"
Iris Zeppelin, RosenkreuzStilette Weißsilber

"Im...impossible! I am the supreme being that rules this universe! I am the immortal life form! I am the ultimate power! Gaaaah!"

"How can this be? You've defied the will of the creators! Your allegiance to that monster will destroy this entire universe!"

"NOOOOOOOOOOOO! You... You wretched TERRAAAAAANS! This cannot be! It WILL NOT BEEEEE! I'll plunge you... and the Sol Cresta... into the SUUUUUUUN! I shall be reborn again! Again, and again, and AGAAAAAAIN!"
Sol Mandler, Sol Cresta

"No way! I can't believe this!"
Dr. Eggman, Sonic Adventure

"Defeated? Impossible! NOOOOOOOOOO!!!"
Dr. Eggman, Sonic Heroes

"Guooooo! Why?! I had it all! I am the ultimate overlord, Metal Sonic! I am the real Sonic!"
Metal Sonic as Metal Overlord, Sonic Heroes

"I can't believe I lost to this scum!"
— The Meteo Crusher Pilot upon defeat; Star Fox 64

"I... can't... LOSE!"
Wolf O'Donnell upon being shot down on Fichina or Bolse; Star Fox 64

"This can't be happening!"
Leon Powalski upon being shot down on Fichina or Bolse (Pigma also says this same line on Venom); Star Fox 64

"No WAY! I don't believe it!!"
Wolf O'Donnell upon being defeated on Venom; Star Fox 64

"NO. WE ARE TRUTH. ONLY US. NO."
The Aparoid Queen being forced into her final phase, realizing she's losing; Star Fox: Assault

"HOOOOOOOW?!!!! (lots of Inelegant Blubbering)"
Pigma Dengar upon being defeated on Venom; Star Fox Zero

"How can this be...?!?"
Leon Powalski upon being defeated on Venom; Star Fox Zero

"Bested... by a fox?! Impossible!"
Wolf O'Donnell upon being defeated on Venom; Star Fox Zero

"How could you defeat me?! This is impossible! Noooooooooooooooooooo!" (explodes)
M. Bison, Street Fighter Alpha 3 (Game Boy Advance version)

"NOOOO! My galaxy! My empire! This can't be happening..."
Bowser, Super Mario Galaxy

"I don't understand... how could you have done this? You weren't meant to be so important... and now you think to destroy me? How dare you, insect? How dare you interrupt my ascendance? You are nothing. A wretched bag of flesh... what are you, compared to my magnificence?"
SHODAN, System Shock 2

Dhaos: What? What the heck is that?
Morrison: This ends here! INDIGNATION!
Dhaos: It can't be!

"What...? How can this be? Bested by this... this thing? (Beat) You insignificant FUCK! THIS IS NOT OVER! (Teleports away as the level ends) May your woes be many, and your days few!"
Gabriel to V1 after they beat him for the first time, ULTRAKILL

Barbarossa: I... I am the king! Had I... had I been in my original body, you would never have defeated me! I... graaaaahh!
Wraith: It is i..inconceivable! How could pathetic little... I have fallen....NOOOOO!... RRRAAAAAGH!
Hrist: This is impossible! You creatures are but slaves of the gods! Aaagggghh!
Surt: It can't be! *cough* Evil.. you mean to say evil prospers? I do not accept this.. I do NOT ACCEPT THIS!
Loki: The power of creation!? THIS CANNOT BE!!!

"GH... HOW?! MY CONTROL WAS PERFECT! HOW COULD I LOSE TO HUMAN FILTH!!!?"

"You are dead! I severed your head from your shoulders! I KILLED YOU!!!"
Frau Engel to B.J. Blazkowicz, Wolfenstein II: The New Colossus

"SHENANIGANS! How could you puny humans have possibly defeated me?"
Laambo, The Wonderful 101

(being defeated in battle) "This... this... can't be happening... I DON'T LOSE!!!!!!!!"
(last words) "No! NO! NOT LIKE THIS!!!!"

"Impossible! The Flame Clock cannot be broken! What is this? Who are these people?! The Flame Clock's power utterly lost... No! But how?!"
Moebius K, Xenoblade Chronicles 3

    Web Animation 
Doctor Doom: Impossible!
Lex Luthor: Impossible? Ha! That word has no meaning for someone like me! What about you?!

    Webcomics 
"I am Sarda. And I am older than time. I possess a power beyond mortal imagination. My plans will not be undone by such amateur-hour horseshit as absorbing too much power and exploding. I am Sarda. My will be done."
Sarda, moments before becoming the physical embodiment of chaos, 8-Bit Theater

    Web Video 
"A locked door?! IMPOSSIBLE!! Wait, no, that's totally possible, what am I talking about?"
Melvin vs a locked door, Yu-Gi-Oh! The Abridged Series

    Western Animation 
"This cannot be!! I AM GENERAL YUNAN!!!"
General Yunan after Captain Grime pushes her a into a river from a high cliff, Amphibia

"Feeling the weight of the world on your misformed shoulders? My bipolar amplifier increases the force of gravity on you a thousandfold. (Ben starts getting up anyway) No! It's not possible!"

Avocato: This... This can't be happening!
Biskit: Believe it. It's happening!
— The Team Squad witnessing Bolo's downfall, Final Space, "The Dead Speak"

Lex Luthor: (a bunch of diplomats enter the Hall of Doom) What poor nations are you from?
Superman: We represent every nation, Luthor, and we're here to regain their freedom! (the Super Friends remove their disguises)
Lex Luthor: Super Friends!? But that's impossible! You are dead!
Challenge of the Super Friends, "Super Friends Rest In Peace"

"I don't believe it! He isn't human!"
Mad Scientist, whose death laser is no match for Superman, Superman Theatrical Cartoons

"Gah... this can't be happening...! I cannot lose!"

"No, I am the Shredder! I AM THE SHREDDER! I! AM - AAAAARRRRRRGGGGGHHHHHHHHHHH!!!" (gets drilled into oblivion by Donatello's Turtle Tunneler)

"My destiny... this isn't how it's supposed to end!"
Megatron, Transformers: Prime

"I can't believe we were beaten by a freshman."
Darcy, Winx Club, Episode 9

    Unsorted 
"No! This cannot be! I am Number One! SHCMA!"
Captain Spud of Undergrads, upon losing a high-stakes Quake match

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