No! This Cannot Be! AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH!!!
— Dracula's Final Words after being defeated by Richter Belmont, Castlevania: Symphony of the Night
Noooo! This Cannot Be! Does this mean that I'm not Dracula?!
— Graham Jones' final words after being defeated by Soma Cruz with the required souls, Castlevania: Aria of Sorrow
Dmitrii: (upon realizing that his power of dominance is starting to go out of control and therefore suffering a Villainous Breakdown) Th-this cannot be... My dominance should be complete!
Arikado: So that's what's happening...
Soma: Arikado, what's going on?
Arikado: The power of dominance isn't easily contained. He isn't like you. His soul can't withstand a power that intense.
Dmitrii: Liar!! I've heard enough from you! (blasts Arikado away)
Dmitrii: I am the chosen one! I am the dark lord! I shall not succumb to the power! Wroooooooaaaah! (starts to get worse)
Soma: It's useless. You can't control it.
Dmitrii: Gwroaaah! (falls to the ground as Menace bursts out of his back) GAAAAAAAAAAAAAH!
No way! I don't believe it!!
— Wolf O' Donnel, Star Fox 64
"No! This cannot be! I am Number One! SHCMA!"
— Captain Spud of Undergrads, upon losing a high-stakes Quake match
Dhaos: What? What the heck is that?
Morrison: This ends here! INDIGNATION!
Dhaos: It can't be!
This cannot be! There must be other factors!
— Snap/Snape, My Immortal
I CANNOT BELIEVE IT!
— All the Keymasters in Dynamite Headdy
"Gah... this can't be happening...! I cannot lose!"
— Shredder, Teenage Mutant Ninja Turtles
"NO! I am the Shredder! I AM THE SHREDDER! I AM - AAAAARRRRRRGGGGGHHHHHHHHHHH!!!" (gets drilled into oblivion by Donatello's Turtle Tunneler)
Faust VIII: (after seeing Yoh burst out of a huge pile of skeletons, destroying it in the process, with his oversoul) IMPOSSIBLE! He survived the full force of the Boneyard Crush?!
Manta: He's alive...
Yoh: (points his sword at Faust) Now it's time for Faust VIII to become Faust the last!
"How could you defeat me?! This is impossible! Noooooooooooooooooooo!" (explodes)
— M. Bison, Street Fighter Alpha 3 (Gameboy Advance version)
"No!!! It's not possible! I'm a Reploid! I can't be destroyed by you! Why, X?! Why have you done this to us?! Without the humans, my Reploid brothers would have ushered in a New Age..."
— Sigma, Mega Man X
Violen: What?! How could he have overloaded my circuits?!! Arrrggghhh...
Serges: This is impossible! The prophecy must be fulfilled!
Agile: NO!! This Cannot Be!!! Master, avenge me!
"No way... how could a simple peasant like you...? Tch! I'll back off for now!"
— Iris, RosenkreuzStilette
Lord Zedd: (after seeing the Thunderzord assault sled dodge Lipsyncher's attack) Impossible! I can't believe it!
Baboo: I wanna ride that thing.
Squatt: Where d'ya get a ticket?
"I can't be beat! I'm the baddest of the bad!"
— Madimot upon receiving the fatal blow from the Tiger Drill Megazord in Power Rangers Samurai
"IMPOSSIBLE! THAT SERPENT WAS INDESTRUCTIBLE!"
— General Gut upon having his serpent severed from his groin by the Sharkzord in Power Rangers Samurai
"IMPOSSIBLE! Samurai Rangers, hear me now. You may have won this battle, but our quest to rule you will never end. You may have defeated me... but the Nighlok will rise again!"
— Master Xandred, Power Rangers Samurai
Sepulchure: (after Drakath has ripped his heart out) I AM DARKNESS! I AM DOOM... NO FORCE ON THIS WORLD CAN DESTROY WHAT I AM! LONG UN-LIVE THE SHADOWSCYTHE!!!!! (lunges at Drakath, who crushes his heart and therefore destroys him in a massive explosion)
Gravelyn: Father... NOOOO!!!!!!!
Vath: WHAT?! Impossible. Those useless... filthy... I don't believe you.
Hero: You don't have to, just look down and see for yourself.
(shifts to the dwarves winning the battle against the Drow soldiers, then shifts back to an angry Vath)
Vath: (cue Red Eyes, Take Warning) No matter! You are their beacon of hope, hero. Once I finish with you, I will throw your body down to them and they will SEE what happens to those who oppose my might! (leaps at the hero with his sword raised in the air)
"No! Not like this! It can't end like this! I won't go back to the Yokai world! NOOOOoooooooooooo!" (gets sucked into the rift as the hero then closes it back up)
— Kitsune, AdventureQuest Worlds
"Impossible! All the undead I created for your father are under my control!"
— Noxus, AdventureQuest Worlds
"EYARGH! It can't be!! IMPOSSIBLE!! I... no... how could I... And to this filthy little pair! How could I LOSE?!"
— Bowletta, Mario & Luigi: Superstar Saga
Nappa: (about Goku) Vegeta, what does the scouter say about his power level?
Vegeta: (takes off scouter and crushes it) It's over 9000!
Nappa: WHAT?! 9000?! There's no way that can be right! Can it?
Cell: (having lost an entire arm trying to tank Vegeta's Final Flash) My perfect form! I don't believe it! I can't be defeated - not like this! NOT BY A SAIYAAAAN!
Cell:....No, seriously. You truly are a fool. Have you forgotten I share Piccolo's powers of regeneration? (regrows his entire arm in seconds) Well, look at that. Now then, I think I've humored you long enough.
"I don't understand... how could you have done this? You weren't meant to be so important... and now you think to destroy me? How dare you, insect? How dare you interrupt my ascendance? You are nothing. A wretched bag of flesh... what are you, compared to my magnificence?"
— SHODAN, System Shock 2
"AAAAAAAAAAAAAAAHHHHHHHHHH! NOOOOOOOOOOOOOOOOOOOO! THIS CAN'T BE HAPENIIIIIIIIIIIINNNNNNGGGGGGG!!!"
— Escargoon, Kirby: Right Back at Ya! Episode 55
"I can't believe we were beaten by a freshman."
— Darcy, Winx Club, Episode 9
System: Subject surface solidifying. Now constructing stasis cocoon for subject 12.
Male Scientist: Whoa...this is... Time-space is frozen... A cocoon of time...
Lead Scientist: What's wrong!?
Male Scientist: Tempering is proceeding as planned! The Cauldron appears normal!
Female Scientist: Extremely high seithr concentration detected, directly above this facility! 6000, 8000, 12000...
Lead Scientist: Wh-What!?
System: Concentration levels climbing rapidly! 34,000, 58,000! If they continue to increase at this rate, the seithr concentration is going to reach critical levels!
Lead Scientist: Is it the Library!? Impossible! Not even the Library... could concentrate this much seithr into one place... There's no way! I want the point of concentration! Now!
Female Scientist: Concentration to exceed 100,000!
Lead Scientist: Agh... After coming this far...! Abort the experiment! Cut all power!
Male Scientist: Roger! Cutting all power! S-Sir! We can't cut the power!
Lead Scientist: What!? What the hell is Sector Seven doing!? Get them online! What the hell are they doing at a time like this!?
System: Point of concentration determined: Point A-A-1.
Female Scientist: ...Sir! It's directly above Ikaruga! Altitude 36,000 feet!
Lead Scientist: Impossible!? It's going into orbit!?
Jubei: I reckon it's Kokonoe who's trying to pull you out here... An' if she does, I'd be much obliged if you don't tell about me. I got my reasons.
Hakumen: ...Then you have my word. But what has brought you here? What news do you bring of the outside world?
Jubei: ...Terumi's back.
Hakumen: What!? That can't be! It's impossible!
"What?! You broke my spell?! HOW CAN THIS BEEEEEEEE?!"
— Litchi Faye-Ling, Platinum's Continuum Shift Extend Gag Reel
"H-How could this happen...! How could I have lost to a little girl?! Oh what a world... oh what a world...!"
— Litchi Faye-Ling, Platinum's Continuum Shift Extend Gag Reel
"Feeling the weight of the world on your misformed shoulders? My bipolar amplifier increases the force of gravity on you a thousandfold. (Ben starts getting up anyway) No! It's not possible!"
Barbarossa: I... I am the king! Had I... had I been in my original body, you would never have defeated me! I... graaaaahh!
Wraith: It is i..inconceivable! How could pathetic little... I have fallen....NOOOOO!... RRRAAAAAGH!
Hrist: This is impossible! You creatures are but slaves of the gods! Aaagggghh!
Surt: It can't be! *cough* Evil.. you mean to say evil prospers? I do not accept this.. I do NOT ACCEPT THIS!
Loki: The power of creation!? THIS CANNOT BE!!!
Scar: (seeing Simba return and thinking that Simba is Mufasa back from the dead) Mufasa? No. You're dead.
"My destiny... this isn't how it's supposed to end!"
— Megatron, Transformers Prime
A locked door?! IMPOSSIBLE!! No, wait, that's totally possible, what am I talking about?
— Melvin vs a locked door, Yu-Gi-Oh! The Abridged Series
MaloMyotismon: I'm curious to know why my Mind Illusion was ineffective against you. How can it be that you have no insecurities or unhappinesses for it to feed off of?
Davis: What do I have to worry about? I have my friends, my family, and a Digimon. Plus some guy with a letter opener on his face trying to kill me. I'm happy to say I don't have any problems!
MaloMyotismon: Impossible! There isn't a single child in the world that doesn't have something they're worried about!
— ''Digimon Adventure 02'
"No! This can't be happening! These paltry children can't make me disappear! I won't allow it!"
— MaloMyotismon before being finished off by Imperialdramon in Digimon Adventure 02
"A human child defeated me?!"
— Cerberumon, about Takuya, who had Spirit Evolved into Agunimon, in Digimon Frontier
"NOOOOOOOO!!!! It's impossible!!!!"
— Lucemon upon being destroyed by the Ten Legendary Warriors in Digimon Frontier
"No! Impossible! Dio...Dio cannot die!"
— Dio Brando right before he explodes after Star Platinum shatters The World in Jojos Bizarre Adventure
"This is impossible! I-I cannot lose!!"
— Imperial Psyker, Dawn of War
No, no! We cannot lose! We cannot die, how can we?! [...] Oohhh, the horrid blossom of Chaos will wither, will die!! [...] This world... is slipping... from our grasssp.
"UNACCEPTABLE! UNACCEPTABLE! ABSOLUTELY UNACCEPTABLE! Protocol dictates action! I see now that helping you was wrong! You are a child of my makers, inheritors of all they left behind. You are Forerunner, but this ring... is mine!"
— 343 Guilty Spark on the plan to destroy Installation 04 and the Ark to eliminate the Flood, Halo3.
Zu'u unslaad! Zu'u nis oblaan! (Translated from Draconic: I am eternal! I cannot die!)
— Alduin, The Elder Scrolls V: Skyrim (Turns out he was right.)
Lex Luthor: (a bunch of diplomats enter the Hall of Doom) What poor nations are you from?
Superman: We represent every nation, Luthor, and we're here to regain their freedom! (the Super Friends remove their disguises)
Lex Luthor: Super Friends!? But that's impossible! You are dead!
—Challenge of the Super Friends, "Super Friends Rest In Peace"
Phosphora: I take back what I said before. You're not cute at all! (dissolves)
Viridi: This can't be happening!
Pit: I'm coming for you next, Viridi!
Hades: This place is going back to the dogs without lovely little Phosphora.
Palutena: Smarm it up while you still can, Hades. We'll be after you soon enough.
—Viridi's reaction to Phosphora's defeat in Kid Icarus: Uprising
"GYAAAAAH! It's hard to believe, but you actually got me, Pit. The nerve of you..."
—Hades' last words, Kid Icarus: Uprising
Yugi: I've assembled all five special cards, all five pieces of the puzzle! (he summons Exodia)
Kaiba: No, it's not possible! No one's ever been able to summon him!