The last word of which is not just the only time NPC chat is increased in font size, but also increased in font size to eight times normal size and red.
It was also bugged for a long time, causing some raw code to appear as well, thus taking up far too much space. It rather ruined the dramatic effect of the line in question.
"WHERE?!! IS?!! MY?!! MOTHER?!!" from Tomb Raider: Legend, punctuated by a gunshot between each word. Also a Moment of Awesome, as the target of the murderous rage happens to be both an old friend, and the source of the Eldritch Abomination you just spent the last 5-10 minutes killing. Then you get the answer and pistol whip Amanda before delivering this line:
Lara: From this moment, your every breath is a gift from me.
Garrosh: I sent you to Stonetalon Mountains with an army. Your orders were to secure this land for the Horde. Instead, you laid waste to the land. Murdered innocents, children even... I spent a very long time in Northrend, Krom'gar. I learned much about the Horde at that time. While there, a wise old war hero told me something that I would carry with me forever... "Honor," Krom'gar, "No matter how dire the battle... Never forsake it." Overlord Krom'gar, you have disgraced the Horde. You have brought shame to us as a people. By my right as Warchief, I hereby relieve you of duty... * Garrosh Hellscream grabs Overlord Krom'gar.* YOU ARE DISMISSED! * Garrosh Hellscream throws Overlord Krom'gar off the ledge.*
The trope namer is parodied in the introduction quest to the Twilight Highlands zone, in which the player is asked to escort a (literal) red shirt Horde Negotiator to meet with the fel orc leader of the Dragonmaw clan. When the negotiator meets with the Dragonmaw warchief, the warchief rebukes him, leading to this exchange:
Negotiator: This is madness! Dragonmaw Warchief: Madness? This. Is. DRAGONMAW!!! *kicks the Negotiator into the bonfire behind him*
"I am... Deathwing. The Destroyer. The end of all things. Inevitable! Indomitable! I! AM! THE CATACLYSM!"
Garrosh' right hand man in the True Horde, Malkorok, is fought in two phases. In the first phase, he is ratherhammy. In the second phase, he absorbs the Old God energy floating around the arena, and,well..
Baldur's Gate II gives Minsc the classic line "Evil, meet my sword. SWORD! MEET! EVIIIIIIL!" and a line from the villain Irenicus: "Once my thirst for power was everything, and now I hunger only for revenge. And. I. WILL. HAVE IT!!"
Ghaleon of the Lunar series takes this trope as far as it will go as he tends to enunciate. every. possible. word. His voice actor even comments on it in the making of bonus video for Silver Star Story Complete.
Obey! Conform! Abstain! Ignore! Deny! Refrain! Cease! Appease! Shun! ... Avoid new sensations. Avoid all sensations! Avoid any sensation! Avoid unnecessary pleasantries! Avoid necessary pleasantries! Avoid libation! Avoid fermentation! Avoid all these in combinations. Save often! Floss regularly! Floss meaningfully! Floss athletically! Think happy thoughts! And above all, never forget: who is the boss of you! Me! I. Am. The boss. Of you! I. Am.' The boss. Of you! I. Am. The boss. Of you!
Rikku: Think we need a password? Paine: How about "kick... its... ass"?
Ace Attorney: Do. You. Think. You've. Won? Well!? Do you, Mia Fey?
Heh... Heh... Heh... Heheh... That's. Just. Fine!
While on the topic of Ace Attorney, we have to mention this memorable parody from the third game:
Maya: Umm, would you mind taking a look at this? Basil: I'm sorry. That data is SuPer-Admin Restricted Desktop Access password-protected. Maya: SuPer-Admin Restricted Desktop Access password-protected!? What? This is madness! Phoenix: No, Maya, that is SPARDA.
The courthouse! (whipping) Must be! (whipping) Kept clean! (more whipping)
At the end of Perfect Dark, Elvis is looking for Joanna so they can evacuate the Skedar planet before his buddies come to bomb it. He finds her with one of her feet trapped under rubble, and asks him to lend her his Phoenix handgun.
Joanna: WILL — YOU — JUST... (shoots under the rubble at the unseen Skedar leader, who was holding on to her leg) ...let go?
Super Macho Man of Punch-Out!! fame seems prone to this in the Wii version.
WHY! DON'T YOU! LOVE ME!?! SUPEEEER! MACHOOOO! MAAAAAN!
Sora's response, too. "You're wrong! I know now... without a doubt... Kingdom Hearts! Is LIGHT!"
Sora! Donald! Goofy!
Donald does this when reading the writing on the wall in Ansem's Study, though it's because he's struggling to read the faded text. "Hollow... Main... Security... Tron... Door... to... Door... to... Darkness?" Sora then adds "Ah! D! T! D!"
Blacksmith Ed of Demon's Souls does it if you talk to him, then leave without buying or upgrading anything. "Don't. Waste. My. Time." Not exactly the most cheery fellow, but you need him if you want to get any special upgrades for your weapons.
In Xenoblade Chronicles 2, when the normally hyper-optimistic Rex declares his intent to call it quits and give up trying to reach Elysium after Pyra lets herself be taken by Malos and Jin to keep them from killing her friends, Nia's efforts to snap him out of this eventually involve her doing this while angrily shoving him into a bunch of barrels.