"As far as I know, Peter Parker doesn't even have a mother; he was merely created spontaneously when Aunt May and Uncle Ben came down with nephewism, a common affliction in fictional characters."So Bob's parents aren't around. What happened to them? You tell me. What happens to Bob? He lives with his aunt/uncle, of course. Sometimes a cousin or two will be thrown into the mix. This trope usually occurs when a character's parents are completely absent (as in, not part of the story in any way), missing, secretly the Big Bad, or established as dead. If this trope happens in an adventure story, expect the aunt/uncle to be keeping secrets about the parents, or who/what their niece/nephew really is. Also, expect them to die fairly early on in the story to get the hero motivated. It's an easy way to graft characters to an already-existing dramatic family, and have your old characters (and hence the viewers) be/get emotionally attached to them. The advantage for the writers might be that it's OK to be more distant from aunts, uncles, nieces and nephews than it is from parents and children. If it's a sitcom, expect the new addition to be a Cousin Oliver. If it's used in a soap-opera setting, expect the niece or nephew to be a Troubled, but Cute teen, who can stir things up without breaking any existing characterizations. This trope can also be used in reverse, to apply to a person besieged with nieces and nephews in their life. In these cases it is often used to allow plots in which canonically single characters fulfill a parental role without significantly changing their character. Strangely enough, nephews in these situations often look and act like clones of their uncles, in defiance of everything we know about heredity. The non-animated cousin of Chaste Toons. Not to be confused with Nepotismnote .
— The Comics Curmudgeon, seemingly forgetting about Mary Parker
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- Froot Loops has a toucan and his three nephews as its mascots.
Anime and Manga
- Majiru Itoshiki, a Adorably Precocious Child/Mouthy Kid is the nephew of the protagonist of Sayonara, Zetsubou-Sensei. Majiru was abandoned by his father and so decided to crash at his uncle's place.
- Aizawa Yuuichi, protagonist of Kanon, starts the story by going to live with his aunt because his parents are leaving home for an extended period of time and would rather have him live with Akiko until graduation than be home by himself.
- In Aishiteruze Baby, Yuzuyu, whom the protagonist Kippei is saddled with raising, is technically his cousin, but given that her mother, Kippei's aunt, is basically the same age as his older sister, it's more of this trope.
- Peter Parker has Aunt May and Uncle Ben; in almost all versions, they're his main role models for as long as he can remember.
- In the comics his parents turned out to have been S.H.I.E.L.D. agents who were killed by the second Red Skull. In the Ultimate universe, they were geneticists killed when Eddie Brock Sr. experimented on himself with the anti-cancer Symbiote the Parkers and Brocks created, becoming the first Venom and crashing the plane they were on. The 1990's animated series had Peter Parker's parents being spies, who were actually not dead (as per the full effect of Never Say "Die" that hit the show), but in Russia.
- The trope also kind of applies to Mary Jane Watson, who for the first two decades of her fictional existence only had her Aunt Anna as a relative. It was then revealed that her mother is dead and that she was very much estranged from her abusive father. (The 1987 wedding ceremony by the way was performed by MJ's Uncle Spencer.)
- Benjamin Grimm a.k.a. the Thing was raised by his Uncle Jacob. It was often implied that he was also raised by Jacob's wife, Ben's Aunt Petunia, until a 1980s John Byrne story revealed that Petunia was an attractive brunette, much younger than her husband, and about Ben's age.
- The only known relative of Hulk supporting character Rick Jones is his aunt.
- Due to Parental Neglect, The Flash Wally West considers his aunt Iris West and his uncle by marriage Barry Allen as his parents more than his biological ones.
- The Duck family: Scrooge McDuck is uncle to Donald Duck, who is uncle to Huey, Dewey, & Louie. Not a parent among 'em. Scrooge's sister Hortense and husband Quackmore Duck are eventually revealed to be the parents of Donald and Della Duck, the mother of Huey, Dewey, and Louie. They were first depicted long after the other characters were, and, in any case, are obscure enough to have made no appearances outside of Disney Comics.
- Huey, Dewey, and Louie are a particularly odd case in that, in their first appearance in 1938, they did have a mother, Dumbella, who was Donald's sister, and they were explicitly just visiting. They never left, and by 1942 Donald was shown onscreen listing them as dependents on his tax forms. Some German Donald Duck fans have even up with a theory that in Duckburg it is simply the done thing to have children raised by their uncles (or aunts) instead of their parents, and coined the technical term Veronkelung ("uncling") for it. It certainly runs in the family — although Scrooge's parents didn't die until he was an adult, Carl Barks, Keno Don Rosa, and DuckTales all depict Scrooge leaving Scotland for America at age 13, spending his teenage years being raised, employed, and trained by his own uncle!
- It's a trend — Disney prefers nephews to children. Mickey Mouse also has two nephews, Morty and Ferdy. Daisy Duck meanwhile has three nieces, named April, May, and June. Goofy has an Insufferable Genius nephew in the comics named Gilbert, although he is also the only actual parent; he has a son named Max. In the comics, Gyro Gearloose and Donald's cousin Fethry Duck also have nephews.
- Korky the Cat from The Dandy is often seen with his three nephews.
- One of the most-cited aversions, however, is from The Dandy's sister comic The Beano, where Dennis the Menace's dog Gnasher is the father of his sidekick Gnipper.
- Desperate Dan from The Dandy lives with his Aunt Aggie. Colonel Blink from The Beezer and Our Man from The Numskulls (also from The Beezer) also live with their aunts.
- Inverted by Little Dot, who had such a severe case of Aunt/Uncleism that there was a long-running comic series dedicated to them.
- Subverted in ClanDestine. Aspiring superheros Rory and Pandora Destine were raised by their Uncle Walter and grandmother Florence... who turn out to actually be their (much) older siblings posing as their uncle and grandmother. Until Walter explained what was really going on, they sure looked like an instance of this trope...
- In the Archie Sonic the Hedgehog comics (and the Saturday morning cartoon, but the comics have had more opportunity to really explore it), Sir Charles Hedgehog is better known as Uncle Chuck, erstwhile guardian of Sonic the Hedgehog, famous inventor, and purveyor of the finest chili dogs on the planet Mobius. Early on in the comic it's just accepted as fact that Sonic's parents were casualties of Dr. Robotnik's enslavement program the same as everyone else's parents, and Chuck was for whatever reason the important relative. Later on it explains that Chuck is, in fact, the reason he has Nephewism in the first place; when he was forced to test his roboticizer on his gravely injured brother, he discovered that the machines his patients turned into had no will of their own (which made it rather unviable in its intended purpose of extending the lives of the injured and infirm). This sent him spiraling into depression and he abandoned the project, allowing Robotnik to swoop in and steal it for his takeover scheme.
- This occurs in Werewolf by Night: Jack's mother remarried her late husband's brother, meaning he is his children's stepfather as well as uncle.
- In The Fabulous Furry Freak Brothers Fat Freddy's Cat has a trio of nephews he's raising.
- In Condorito, Condorito has his Nephew named Coné. Coné was actually a Doorstop Baby but why he is called a Nephew is never known, they seem to live together, but in some instances is clear that Condorito lives alone. Also Yayita's nephew Yiyito. Yuyito's parents are never talked about.
- Played with in the Marvel 100th Anniversary Special issue of Guardians of the Galaxy: in this possible future, Rocket Raccoon is accompanied by his "nephews" Uno, Duo and Trey ... except they keep slipping up and calling him "Dad".
- Parodied in Svenska Serier (a Swedish comic anthology from the 80's and 90's) with Sven, an employed comic character whose schtick was that his employers/creators were constantly trying to make him more popular and marketable with anything they could think up. During a brief 2000 AD-themed story trying to use sex, violence and sci-fi to boost ratings, it was revealed that Sven literally had no genitals, only a metal seal with a tag labeled "prepared for nephews". (And later the same seal was broken through unspecified means, and three nephews started living in his house. None of which he even knew, since he didn't even have any siblings or family.)
- A really wonderful Veronica Mars/House crossover fic posited that Logan was House's nephew, and he went to live with him after his dad was arrested for Lilly's murder. Canonically, he became legally emancipated and started living in a hotel suite.
- This is generally a popular trick in crossover fics, as the Relatively Flimsy Excuse is often the only one that can explains why characters from two different canons should give a damn about one another.
- In If Them's the Rules, Harry invokes this to explain why he took Tom Riddle as his ward. He says that he is a distant uncle of Tom's to explain why a man barely out of his teens is raising a kid by himself.
- In The Fifth Act Cloud Strife poses as an uncle to the younger Cloud Strife of the timeline to explain away the name and the resemblance.
- In Star Wars, Luke was raised by his Uncle Owen and Aunt Beru Lars before they were killed by the Empire. Of course, when Darth Vader is your father, maybe it's for the better.
- Interestingly, the prequel movies reveal Owen to be Anakin's stepbrother whom he only met as an adult (and for all we know, only once). Some early drafts/novelizations actually have Owen as Obi-wan's brother instead.
- Also averted. Neither of the twins were placed with their mother's older sister since that would have been too obvious.
- The film version of The Wizard of Oz doesn't even offer the books' token reference to Dorothy's parents.
- Orphaned Gillie Evans from Tiger Bay lives with her aunt Mrs Phillips.
- Nowhere Boy is the Real Life story of John Lennon as a teenager living with his Aunt Mimi. Re-connecting with his mother and finding out what happened to his father are major plot threads in the movie.
- In Rhymes For Young Ghouls, Aila is raised by her uncle Burner since her mother committed suicide and her father was imprisoned.
- In Johnny Belinda, Belinda was raised by her uncle after her mother died in childbed.
- Dorothy in the Land of Oz series. One of the books does verify that her mother was Uncle Henry's sister; he makes the internal observation that his niece is "a dreamer, as her dead mother was".
- The ever-aunt-afflicted Bertie Wooster is an interesting example, because while his parents are established as dead, their deaths are never used as plot devices. Since this is a comedy series, they could just as easily have been written off as absent. This is exploited in Fan Fiction all the time.
- Also Miss Marple, who has nieces and nephews in plenty. She is even explicitly unmarried ("Miss").
- Bilbo Baggins in The Lord of the Rings adopted his cousin/nephew Frodo (at age 21; before, he'd lived with his other relatives). Justified in that almost all Hobbits seem to be rather closely related.
- King Théoden adopts his nephew Éomer and niece Éowyn after their parents die. They live with their cousin Théodred until he also dies, and Éomer becomes heir to the throne.
- Likewise, Thorin Oakenshield from The Hobbit is the guardian of his nephews Fíli and Kíli, who are also his heirs since he doesn't have any children. Their mother is still alive, though.
- Eragon in Inheritance Cycle.
- Harry Potter is nominally the nephew of the couple he lives with. In practice, he's more the unpaid overworked abused servant with nowhere else to go than a family member. Dumbledore arranged for him to live there so he wouldn't learn about the whole "Boy Who Lived" thing until he could have some perspective - and because he needed Harry to live with a family member as part of a magical protection, and Petunia was the only candidate.
- Subverted in Codex Alera, at first it seems like Tavi's aunt and uncle will play the role of the typical "Aunt Beru and Uncle Owen" and die early on to get Tavi's heroic journey started. Actually They remain major characters and Tavi's aunt turns out to actually be his mother. It's worth noting that unlike most nephewism couples, Tavi's aunt and uncle are brother and sister, rather than husband and wife.
- Also subverted in His Dark Materials, in which the man Lyra has been lead to believe is her uncle turns out to be her father.
- Jupiter Jones in The Three Investigators series lives with his aunt and uncle.
- A common plot in the Goosebumps series was for the protagonist to be palmed off with an aunt and uncle while the parents made a flimsy excuse to disappear - usually just long enough for the protagonist to encounter the ghost/vampire/werewolf/mummy/whatever horror made up the subject of the book. The best (or worst) example is probably Werewolf Skin, where Alex apparently has to live with his aunt and uncle indefinitely because he even starts going to the local school. And we never once hear where his parents are!
- Anthony Horowitz's Alex Rider series, does this... twice. First, when Alex's parents die, he gets sent to live with his Uncle, Ian Rider, and when he dies, he gets to live with Jack Starbright, who isn't actually family, subverting the trope, the second time.
- The Belgariad employs this with Garion being raised by his "Aunt Polgara", in actuality, his great-great-great-etc-aunt, sister to his royal ancestor some 3000 years ago.
- The Finneys of Sharon Creech's novels Walk Two Moons and Absolutely Normal Chaos seem to take in cousins as necessary: in the latter book, Carl Ray is looking for a job, and in the former, Ben's mother is explicitly out of the picture due to being in a mental institution. Where his father is in this isn't made clear.
- In Voyage of the Dawn Treader, Edmund and Lucy are left to live with their aunt, uncle, and cousin Eustace while their parents and elder siblings are traveling.
- Prince Caspian was also raised by his uncle, Miraz, who'd secretly murdered his father to claim the crown. While Caspian's paternal grandfather had presumably died when Caspian's father became king, the absence of his mother or of his maternal grandparents is not explained.
- Tobias lives with various uncaring aunts and uncles for the first few Animorphs books, until he gets stuck in hawk morph.
- Tash and Zak Arranda in Galaxy of Fear. Their parents died on Alderaan, and they were taken in by their uncle-by-marriage, Hoole. While nothing secret is found out about their parents - except that one or both could possibly have been Force Sensitive - Hoole starts out with tons of secrets and a refusal to let the kids get close. Eventually he thaws.
- In Dolphin Island by Arthur C. Clarke, the main character begins his adventure by stowing away on a transcontinental hovership that's made an emergency landing where his home is—this act made guilt-free by the conveniently uncaring (and immediately forgotten) aunt and uncle he lives with.
- In Paris in the Twentieth Century, Michel lives with his aunt, his father's sister. So he is trapped with Monsieur Boutardin, who considers him a shame for his artistic qualities, like his father.
- Sebastian Verlac from The Mortal Instruments was raised by his aunt Elodie after the death of his parents.
- Jane Eyre lives with her maternal uncle's family. Sadly, her maternal uncle was the only one who really loved her, and he died so early that Jane grew up bullied, abused, and constantly maligned. The Reeds constantly remind Jane that she is living on their charity.
- An exaggerated trope: in Circle of Magic Trisana Chandler's parents are alive, but they don't want her because of her frightening and uncontrollable connection with the weather. She's been passed around from one relative to another, usually exploited as free labor before they get frightened of her, too, and shuffle her further along, until finally her parents decide to confine her in a Living Circle school. Tris can count the number of relatives that actually were kind to her on one hand.
- While Carla's mother is alive in The Red And The Rest, she hasn't appeared at all in the story. Instead, her uncle/slash surrogate father Mel tries to reign her in.
Live Action TV
- Jessica Fletcher from Murder, She Wrote has no children, but loads of nieces/nephews. Grady Fletcher is the only real repeater among them, but it's explained in more than one episode that he is actually her adopted son; after his parents died when he was very small, Jessica and her late husband Frank raised Grady essentially as their own.
- Used to the point of overdose in Are You Afraid of the Dark?? A large number of the protagonists were either living with aunts, uncles, and grandparents or visiting for the weekend, summer, holiday, etc. Used as a way for the kid to stumble into the episode's inherent weirdness without having people wonder why they had lived beside it for years and not noticed it before.
- Used at least twice on Desperate Housewives, first with Edie's nephew and then with Carlos and Gaby's niece.
- Jess on Gilmore Girls. His mother's inability to deal with him is the reason he was sent to live with Luke in Stars Hollow in the first place. She does eventually show up in town
- The Dukes of Hazzard. There were five regular Duke cousins (three originals, two temporary replacements). None of them were siblings. All of them mentioned being raised by "Uncle Jesse" with no sign of any of their parents around. What happened to Jesse's 5 brothers and/or their wives?
- The writing off of the replacement cousins introduced yet another sibling to Jesse as they leave Hazzard to go help an aunt who is also not a parent to any of the five, either.
- At least one set of parents (Luke's) were killed in a fire.
- Family Affair. Mom and Dad died, leaving Buffy, Jody and Cissy to be raised by Uncle Bill and his manservant, Mr. French.
- Cousin Pam on The Cosby Show.
- Veronica on The George Lopez Show. Her mother died and her father is a no-good con man. She is there to replace Carmen, who "went to college".
- Doctor Who
- Eleventh Doctor companion Amy Pond was raised by her aunt, saying that she "doesn't have a mum and dad." This turns out to be a plot point - her parents were Ret Gone by the space-time anomaly in Amy's house. Though interestingly, even after they were brought back to reality, they were never shown or mentioned again
- Classic series companion Sarah Jane Smith was also raised by her aunt.
- Iron Chef: Chairman Kaga has at least one nephew and, depending on what you consider canon, may have two more.
- The Fresh Prince of Bel-Air, of course. He has a Disappeared Dad while his mom is alive and well in Philadelphia (and comes to visit occasionally); she just sent him to his aunt and uncle to keep him off the streets and out of trouble. His dad did show up, for one of the most emotional episodes of the series. Here's the climax.
- In Bakuryuu Sentai Abaranger, Ryouga has been the adoptive parent figure to his niece Mai for most of her life, since her parents were killed when she was a baby.
- Zyuden Sentai Kyoryuger has Nossan living with his sister and young niece after his brother-in-law's death some time previously. Word of God states that the writer originally envisioned the character as an older man with a wife and daughter, but the executives said no so this trope came into play instead.
- Many Police Procedural episodes in which children's parents wind up murdered or jailed end with the tearful child being placed in the custody of an aunt or uncle.
- The American sitcom Bachelor Father (1957-62) was about bachelor attorney Bentley Gregg who raised his adolescent niece Kelly after her parents died in an automobile accident.
- Merlin's mother is still alive on Merlin, but he lives with his uncle Gaius because of his growing magic and destiny in Camelot.
- Shining Time Station has a lot of its adult protagonists matching this trope: Stacy Jones is aunt to Matt and Dan, Schemer is uncle to Schemee, and Billy Twofeathers is uncle to Kit.
- JB King is also uncle to his bullying nephew Buster in the episode, "Bully for Mr. Conductor".
- Ginny Johnson mentions her nephew and his wife in the episode, "Billy's Party".
- In 1982, Happy Days added K.C. Cunningham, Howard's niece.
- Elena and her younger brother Jeremy from The Vampire Diaries both live with their aunt Jenna. Their parents died in a tragic car accident relatively recently before the events of the show.
- Full House has a mild example in that the girls' Uncle Jesse helps their father raise them after their mother dies. They also have family friend Joey as a father figure and occasionally call him Uncle Joey, even though he isn't blood-related.
- Emergency! : One of the few things we learned about Gage is that he was raised by an aunt for a time.
- Kamen Rider Ryuki: Yui and Shiro Kanzaki are orphans, so Yui lives with their aunt. Shiro had been sent to live with relatives in America thirteen years prior to the start of the show then was killed and replaced by his Mirror World counterpart.
- Grimm: Nick was raised by his Aunt Marie after his parents died in a car accident. Over the course of the first season Aunt Marie dies. This triggers Nick's Grimm Powers. A Wesen Nick encounters mentions an Grimm woman he was engaged to that left him to care for her Nephew after his parents were killed in a car accident. It is implied that the accident was actually a murder, because magical coins Nick's parents were protecting. Which leads to Nick looking into their deaths more. In the season finale, Nick finds out his Mother is alive.
- Game of Thrones: Late in the show's run, it's revealed that Jon Snow, supposedly the bastard son of Lord Eddard Stark, is actually the trueborn son of Eddard's late sister. The Newphewism was kept secret to protect the child from their family's enemies.
- Zipper Harris in Doonesbury, who matriculated to Walden College to fill the empty niche left by the graduation of his uncle, Zonker Harris.
- The title character of the strip Nancy lives with her aunt, Fritzi Ritz, who was actually the original title character of the strip.
- Prof. Cosmo Fishhawk, the lead character of Shoe, is shown raising his nephew Skyler, whose parents have never been mentioned.
- Robin the Frog in The Muppet Show, nephew of Kermit the Frog. Robin's father was referenced once on the shownote ; additionally, one episode of Muppet Babies (in which he appears as a tadpole) established that his mother is Kermit's older sister. So he has parents, somewhere, but they're never seen.
- Andy and Randy Pig, nephews of Miss Piggy in Muppets Tonight.
- Gobo's Uncle Travelling Matt in Fraggle Rock — the only family relationship established between any Fraggles.
- In LazyTown Stephanie's is staying with her uncle Milford Meanswell (who is a puppet while Stephanie is a live actress oddly enough) for the summer. Her parents are never seen, and she seems to have moved in permanently as she has had many episodes taking place during non-summer seasons.
- In Charley's Aunt, Mr. Spettigue has a niece, Amy, and a ward, Kitty. And of course, Dona Lucia has a nephew in Charley.
- Mame Dennis and her nephew, Patrick in Mame, Auntie Mame, and Travels with my Aunt. He's an orphan, so the cause of the nephewism isn't unknown, but Mame still has a case of it. It's hinted that Mame is really Patrick's biological mother.
- In the stage musical How to Succeed in Business Without Really Trying (and the 1967 film adaptation), J.B. Biggley, the president of the World Wide Wicket ("WWW") Company, employs his nephew, Bud Frump, in the mailroom of the company. This is where the protagonist, J. Pierrepont Finch, is sent to work. Frump uses his relationship to Biggley as license to bully the others in the mailroom. This is especially true regarding his treatment of Finch, whom he quickly realizes is a real go-getter whose drive for success may trump his nephewism. Just prior to the end of the play, when WWW's chairman of the board, Wally Womper, threatens to fire everybody in the company — including (especially) Biggley and Frump — Finch sings the show-stopper song "Brotherhood of Man" in an effort to change Womper's mind. (In the lead-in to the song, Finch tells Womper "we're all brothers," to which Biggley adds "some of us are uncles.") Womper relents and retains everybody except Frump, who vows revenge.
- A common trope in Shakespeare, especially in Romeo and Juliet where family ties draw the line between the two opposing camps. To whit: Tybalt is Lady Capulet's nephew (specifically her brother's child) and Lord Montegue addresses Benvolio the same way. Both are implied to have grown up alongside their respective protagonist (Juliet and Romeo, respectively).
- Ashley of Another Code gets raised by her aunt due to her dad's perpetual absence.
- Persona 4's main character (whose canonical name is Yu Narukami) gets sent to live with his uncle for the duration of the game because of his parents travels for their work.
- Sunny from Metal Gear Solid 4 calls her caretakers "uncle." Of course, anyone who's played the second game knows exactly what happened to her mother.
- Also Meryl, until we find out that Campbell is actually her father, not her uncle.
- Emil from Tales of Symphonia: Dawn of the New World.
- Diddy Kong is Donkey Kong's nephew. Either he's adopted, or the sibling of a gorilla can have a monkey for a child.
- Link, in The Legend of Zelda: A Link to the Past, lives with his uncle. As it's eventually explained, they are all that remains of the bloodline of the Hylian Knights. The manga gives a backstory to the absence of Link's parents.
- Dr. Neo Cortex's niece Nina Cortex from the Crash Bandicoot series. Parodied in Crash Twinsanity when Neo first introduces her.
My daught... err... NIECE!
- Dragon Age II has a minor example of this if the game is played using an imported save in which Alistair was made king in the first game. He has a brief cameo alongside Bann Teagan, whom he introduces as "my uncle. Sort of." They're not related - Teagan was actually the uncle of Alistair's deceased half-brother - but Teagan and his brother Eamon are the closest thing Alistair has to actual relatives and they helped to raise him.
- Cassandra Pentaghast was raised by her father's brother Vestalus after her parents were executed due of taking the wrong side in the second attempt to overthrow King Markus Pentaghast. She and her older brother Anthony were supposed to be executed as well but were spared due of their good behavior and they were both children back then.
- Partial subversion in Girl Genius - in flashbacks, Agatha is being raised by her uncle, Barry Heterodyne, because her parents have disappeared, but by the time the story begins, Barry's gone missing too, and she's being raised by her foster parents Adam and Lilith Clay (better known as Punch and Judy, construct sidekicks of the Heterodyne Boys).
- Last Res0rt has the Vaeo family with Vince, his daughter Cypress, and his nephews/ her cousins, Nathaniel and Damien. It's been heavily implied so far that the Vuelos Incedent killed off Cypress's mother and Nathaniel and Damien's real parents.
- Avatar: The Last Airbender: Zuko was essentially raised by his uncle Iroh, as his father is the abusive Big Bad and his mother is mysteriously gone. Iroh took Zuko under his wing when a) his own son died in the war and b) Zuko's mom disappeared, having been banished long before the series started. Eventually, Zuko considers Iroh to be more like a father to him than his actual father ever was.
- Inspector Gadget had his niece, Penny, living with him (and secretly solving his cases). The show's second season implies that both of Penny's parents are dead and the Gadget's her only living relative (or at least her closest living relative).
- In the older series, the Scooby-Doo gang seems to spend more time visiting its various members' extended relatives than living with their real parents.
- Speaking of which, there is Scrappy-Doo. Although later on an episode was made to show Scrappy with his mother, Ruby Doo.
- Averted in Scooby-Doo! Mystery Incorporated, where the parents are accounted for, although they're not very helpful, and some of them (Fred's) are even revealed to be the bad guys.
- Up until The Reveal in the series finale, Hey Arnold! was a case of this, since all you knew for sure was that Arnold was living with his paternal grandparents. We never (canonically) found out the kid's last name for crying out loud!
- Skippy Squirrel does not appear to have any parents, and lives with his Aunt Slappy According to Slappy's creator and voice actress, Skippy's folks are on sabbatical.
- James Bond Jr. is the nephew of James Bond.
- Jackie Chan Adventures has the eponymous grown Jackie living with Uncle, who is shown to have raised him. In the first episode, they are given care of Jackie's niece, Jade (technically his first cousin-once-removed), who, despite having living parents in Hong Kong, spends the rest of the series and after with her uncles. Jade's parents show up exactly once at the end of season two, where they wonder if Uncle is their Uncle as well.
- Popeye has four nephews that appear in several Popeye cartoons: Peepeye, Pupeye, Pipeye and Poopeye.
- The 1960 short "Popeye's Junior Headache" gave Olive Oyl a niece named Deezil.
- Time Squad: Buck Tuddrussel tries to explain that Otto is his nephew to his ex wife who is of higher rank. She doesn't believe him, knowing that Larry had admitted to her that he was kidnapped/adopted.
- Young Justice starts out with the well-established Kid Flash, who is The Flash's nephew-by-marriage. When the team is formed, they add Miss Martian, the Martian Manhunter's niece in this continuity. Later, Green Arrow brings his niece, Artemis, to the Team. (Which is when Robin lampshades it) Played With because Artemis isn't really Green Arrow's niece; she just doesn't want the Team to know who her real family is.
- King Leonardo and His Short Subjects: King Leonardo has his twin nephews, Duke and Earl.
- Wonderheart Bear on Care Bears: Welcome to Care-a-Lot lives with her uncle Tenderheart. No parents are ever mentioned.
- Duckman has Ajax, Charles, and Mambo's Aunt Bernice and later, their Aunt Beverly stay with the family as a maternal figure.
- My Little Pony: Friendship Is Magic: Princess Cadance and Prince Blueblood are apparently Princesses Celestia and Luna's niece and nephew, respectively. How this works out, since Celestia and Luna are both well over 1,000 years old, is never explained.
- Most fans just say that Cadance is adopted (the canon side-story Twilight Sparkle and the Crystal Heart Spell states that Cadance was an orphan found by some village-folk). The season three finale supports that, as it shows that regular ponies can become princesses without having to be related to the existing royalty.
- In Blueblood's case, most fans claimed that he is indeed a nephew of either Celestia or Luna, but he's so far descended from them that it's easier to just forget all the "great-great-great..." and just call him "nephew". As of "Hearth's Warming Eve" and the revelation that there was a unicorn kingdom in place that preceded Celestia and Luna's rule, it's possible that he's simply a prince because he's a descendant of that line, which isn't related to Celestia and Luna at all.
- In The Ticket Master, Rarity explicitly states that she hopes to meet Celestia's nephew, Prince Blueblood, at the Grand Galloping Gala. It does leave open the great-great-great... possibility, but sets them more solidly as relatives.
- Some fans have speculated that Blueblood is actually Luna's son.
- Gravity Falls: The Pine twins' summer caretaker is their great uncle, Stanley Pines (aka, "Grunkle Stan"). Dipper and Mabel's parents are sometimes mentioned, but as Dipper explained in a voiceover in the pilot episode, their parents sent them to stay with Grunkle Stan for the summer so they could get some "fresh air."
- Huey, Dewey and Louie more or less created this trope. In the cartoons, when they're not living with their Uncle Donald they're living with their Great-Uncle Scrooge.
- It gets more complicated. Scrooge is also Donald's uncle.
- Sarah and James from Fireman Sam were this for the first five seasons, with Sam himself being their only known relative. In season six, their parents, Charlie and Bronwyn, were introduced.
- Many medieval Popes had 'nephews' that they were close to. The thing was, as often as not, said 'nephews' were the pope's unrecognized illegitimate children. Innocent VIII was the first to actually recognize his bastard children. This is where the term nepotism comes from, since Popes frequently appointed their nephews (both actual nephews and "nephews") to high-ranking Church positions, even when said nephews were clearly unqualified, and nepos is Latin for "nephew".
- Most real life custody arrangements do have either grandparents or aunts/uncles assuming custody if the parents die, followed in likelihood by unrelated godparents, whose express purpose is to raise the godchild in the event of the death or incapacitation of the child's parents.
- This trope may have started just after the deadly influenza epidemic of 1918. A LOT of bachelor aunts and uncles suddenly found themselves having to care for their nieces and nephews.
- In some matrilineal cultures, the mother's (eldest) brother plays a much bigger part in the raising of a child than the father. This concept is known as an "Avunculate". Some theorize that this may have roots in evolutionary biology; since a father can never be 100% certain his children are truly his, it makes sense for him to also invest in the children of his sister since they are guaranteed to share some of his DNA through his sister.