Tripping The Rift is a computer-animated sci-fi parody created by Chris Moeller and Chuck Austen (of "The Draco" infamy) in 1998 as a short film released on the Internet. The film gained popularity, especially after being shown on the Sci Fi Channel, and was made into a television series in 2004.
Darph Bobo's Clown Troopers are Expy's of the Stormtroopers while the name is a play on clone troopers
Gus is an Expy of C-3PO. To really nail it in, his vacuum cleaner in the opening looks like R2-D2.
The Confederation are Expys of Star Trek, complete with SEVERAL Expys of Captain Kirk at various stages of his career. You can also see Spok at the bar in one episode, failing at doing the Vulcan neck grip.
Flanderization - A little bit with Six, but the biggest example here, is Gus. He went from being a not-exceptionally-masculine bot with some ambiguously gay tendencies to his stereotypically gay characteristics being the sole definition of his character, kinda like the Larry 3000 on Time Squad, only not as toned down, since Tripping The Rift isn't a children's cartoon.
Gag Boobs: Spamela Anderslut, a rather savage parody of Pamela Anderson, from the planet Titius Maximus. Her breasts are so big that she actually needs a specialized device just to carry them around. They even end up leading her downfall: just as she was about to win the "Miss Galaxy 5000" pageant, T'Nuk purposefully kicks her device out of the way, causing Spamela to fall and injure herself under the weight off her own breasts.
And this will give you an idea of the caliber of the crew on this ship: She doubles as the ship's science officer, because she's STILL the most intelligent and best educated member of the crew, INCLUDING the ship's built-in AI.
Or four, if you count the one time they aired the short in Sci Fi and Terry Farrell redubbed Six's lines.
Lampshaded on the interior of the DVD jacket, where Chode mentions that he changes her voice every so often. And by Bob in one of the couch gag openings, saying something along the lines of "Who's voicing Six this season?"
Ugly Guy, Hot Wife: Chode is in an active relationship with Six. Basically, a short, fat, purple, multi-eyed alien, manages to get with an incredibly hot space-babe. Though this could be zigzagged as he seems to be very handsome for his species.