The entire Inuzuka clan (the name means "dog soldiers") work with large, wolf-like dogs, at least one of whom can talk. Akamaru, who in Part I is small enough to be carried in Kiba's hood, is as big as a pony by Part II, and carries Kiba on his back.
Kakashi and his eight Ninken, who he mostly summons for tracking rather than battle.
Neo Human Casshern: Casshern travels with his dog partner Friender. Friender was originally the family dog — brave and fierce, who got killed, but was revived as a trusted companion. Friender can become a tank, car, jet, or a submarine, and can breathe fire. He is the inspiration of Rush.
Groo has Rufferto. Writer Mark Evanier once pointed out that Groo couldn't have a human sidekick unless that sidekick was stupider than Groo, but a dog that would always see him as smart and heroic would be ideal.
I Am Legend: The protagonist has a pet dog. Since a viral outbreak nearly eradicated humanity, this dog is the protagonist's only company and pretty much the only thing keeping the crushing desolation from driving him insane.
I Am Legend: The Dog in the original short story is a subversion. The survivor tries to tame a feral dog into his companion. He appears to succeed in getting the dog to take food from him, and then you find out the dog died two weeks later due to illnesses.
Haplo, Anti-Hero of The Death Gate Cycle, has a dog that goes everywhere with him, even when this defies all logic or common sense. It turns out that the dog, unknown to everyone, is actually a magical manifestation of Haplo's soul.
In Pocket in the Sea, Vicky, Lulu's dog, visits him in prison (and it apparently a regular visitor), is brought on board a deployed military submarine and even goes to prison with the crew later on in the book. Despite her adventures, Vicky is very distinctly a dog.
In The Silmarillion story of Beren and Lúthien, the title characters are accompanied on their adventures by the wolfhound Huan.
Oleg Divov's The Dog Master features an entire paramilitary organization where specially-equipped soldiers hunt zombie-like creatures with their dogs. They are led by the titular Dog Master. Neither the dogs nor their masters survive the final battle with the zombies.
In John C. Wright's The Golden Transcedence, Phaethon populates the bridge with mannequins of famous explorers. Including the dog of one such explorer, because it was just not right to have that man without his dog.
In the Walt Longmire series of mysteries by Craig Johnson, from book two onward the old sheriff is accompanied everywhere by an oversized St. Bernard/Shepherd/miscellaneous mix called Dog. (The dog adopted him, and Walt never got around to giving him a name.) Walt not only implicitly trusts Dog's instincts but wryly muses about what Dog has figured out about the latest case and his various other social complications.
In Ted Wood's mystery/action series about Reid Bennett, a Canadian small-town policeman, Bennett's Alsatian police dog Sam is important enough to make them an outright Buddy Cop Show duo.
In Dana Stabenow's mystery series about Alaskan investigator Kate Shugak, Shugak is usually accompanied, and at times rescued, by her faithful husky/wolf cross Mutt.
Played With in Beetle in the Anthill: Lev Abalkin explored the dying planet of Hope with his longtime partner Schyokn-Itrch, a golovan—that is, member of a sentient species evolved from dogs native to another planet recovering from a nuclear war. The golovans are extremely intelligent, fearless, and possess superhuman senses, so in many ways, Abalkin is Schyokn's humanoid companion rather than vice versa.
Arkham Horror has an Ally card for a dog named Duke. He's good for your sanity.
Warhammer 40K: Space Wolves ride Fenrisian Wolves, ginormous wolves that can grow to bigger than a rhinoceros, and are tamed by finding the pack leader and defeating it in single combat (or being raised by them, as has happened twice already). And they really do follow the hero everywhere: strategic briefings involving multiple Chapters involve either telling the nine-foot-tall space Viking in Power Armor and a giant axe to go wait outside, or tolerate the panting, scratching, and roughhousing of half a dozen wolves bigger than the briefing room table.
This is the central mechanic in Haunting Ground, which has Fiona rely on Hewie as both her primary means of defense and to recover items in areas that are inaccessible to her. Together, they must puzzle their way past the castle's dangers in order to escape.
Suikoden II: Kinnison and his dog, Shiro, live in the forest surrounding Ryubei Village. If Raiou puts the baby bird back in its nest and returns a short while later, Kinnison will ask if he was the one who saved it. Answer "yes" and they'll join Raiou's army.
Fallout: Dogmeat, a dog which the player can have join their party, also makes a cameo (and acted as a non-canon bonus character) in Fallout 2 (along with two normally recruitable cybernetic dogs companions: K-9 and Robodog, and a "special encounter" jinxed dog called Pariah) and appears (in 3D for the first time) in Fallout 3 . He's found next to a dead body named Max, a homage to Mad Max 2 and his dog, Dog. Fallout: New Vegas also gives you Rex, a new cyberdog companion, and in the DLC "Old World Blues" you can get Roxie, a female cyberdog (which can actually "mate" with Rex in several endings if certain conditions are attained) Many players have been known to Save Scum should their dog companions die in Fallout. Human companions, meanwhile, are generally considered expendable.
In Fable II, the protagonist gets a dog to help fight off enemies and find buried treasure. You get a dog in Fable III as well.
Samurai Shodown: Galford is accompanied in battle by his dog Poppy, who also assists him with some attacks.
The Shinobi sequel Shadow Dancer had Yamato, who you could sick on enemies to prevent them from attacking.
In Dragon Age: Origins, you have an opportunity to get a Mabari hound into your party, unless you're a Human Noble, then you've had one for years. Ferelden loves dogs.
In Dragon Age II, the Black Emporium DLC provides a Suspiciously Similar Substitute for the original Mabari. This time, the dog is treated much like a ranger's summoned animals were in the original, so he no longer takes up a party member slot and can be with you at all times.
Deadly Premonition has Forrest Kaysen's dalmatian Willie, who is exceptionally good at tracking down missing people. According to Word of God, it also relays orders to Kaysen from the Red World.
The Dead to Rights games has Shadow, an insanely vicious husky capable of killing Mooks as well as his Cowboy Cop partner Jack Slate as well as being able to solve puzzles or get various objects needed for Jack to progress.
Minecraft has wolves, the first mob that can be tamed. They'll follow you around and help you fight, whether that means defending you from hostile mobs or hunting down passive mobs that you have targeted.
Played straight with Wolfie in Far Lands Or Bust, but subverted in Mindcrack Ultra Hardcore, where Kurt's wolves have been responsible for his deaths in both seasons 5 and 6.
The Autobiography of Jane Eyre: Mr Rochester travels a lot and apparently he takes Pilot with him. He even tweets as Pilot. Sometimes it's really what a dog might say, but sometimes the tweets are business related.
Various celebrities, mostly females, at one point or another carried a small Chihuahua or similar with them in their handbag as a fashion accessory.
The self-proclaimed "Fashion Czar" Rudolf Mooshammer from Munich, Germany also had one called Daisy that he carried everywhere he went.
Paris Hilton and Tinkerbell.
Queen Elizabeth II is rarely seen out of the company of at least one of her large brood of corgis.
Dogs that work in fire investigation, bomb or drug sniffing, rescue, etc. practically live as a member of their handler's family in order to increase effectiveness via better rapport.
The Texas A&M Corps of Cadets has ReveilleVIII, the latest in a dynasty of purebred Rough Collies. The original Reveille was a stray mutt that some cadets brought home after accidentally hitting her with their car. They brought her back to campus and smuggled her into the dorms, intending to quietly take her to the vet school in the morning. Instead, the dog revealed herself when she reacted about the same way everyone else does to the morning bugle call, Reveille, and howled in protest, thus leading to her name. Quite a bit of tradition surrounds Reveille. She is considered the highest ranking member of the Corps of Cadets, a Cadet Generalnote designated by the US Army as thanks for the number of Texas A&M cadets who were commissioned as officers and served in World War II , and all other cadets are expected to greet her accordingly, and address her as "Miss Reveille, Ma'am." She is to be attended by a cadet at all times, with this duty usually going to a specific cadet in Company E-2, known colloquially as "The Dog Corporal". She eats meals in the same dining hall as the cadets, Duncan Dining Hallnote "because the food there is fit for a dog", and attends classes with the cadets. If she barks during class, it is said that class is dismissed per her authoritynote though this does not mean the professor will stop teaching.. When a Reveille dies, she is buried in front of Kyle Field, facing the scoreboard so she can see how the Aggies are doing, with a full funeral, where thousands of students and cadets attend.
Back in 1953 the University of Tennessee elected Smokey the Bluetick Coonhound to be their mascot. During the halftime of the 1953 game against Mississippi State several coon hounds were introduced to the student body for consideration. "Blue Smokey" was the last in line, and when his name was called he howled loudly. The stadium went nuts and he was basically elected on the spot. The current mascot is Smokey X.
Miley Cyrus owns (or owned) a large assortment of pet dogs over the years, many of them adopted from animal shelters, and pictures of her and her dogs regularly appear on her Twitter account. She dedicated her performance of "Rebel Yell" at her 2012 VH-1 Divas concert on the air to Lila, a pet dog she tragically lost a month before (fans donated to a charity in Lila's honor).
Russian President Vladmir Putin's dog Koni is extremely faithful to her owner, accompanying him to meetings, press conferences, national events, and even visits with foreign dignitaries. Oh, and if an attempt is made to keep her from being beside Putin at any given time, she will escape her captivity and find a way to go to his side. This has caused some comical headaches for the overprotective President, who has urged the press to "please not feed my dog."
A military working dog named Cairo accompanied the U.S. Navy Seals who took part in Operation Neptune Spear, in which Osama Bin Laden was killed.