WMG / Spider-Gwen

The Lizards are part of a Government Conspiracy to create soldiers who can recover from most any injury.

Capt. Stacy mentions six missing Veterans, and Captain America says that these men are the property of SHIELD. The missing Vets had been at a VA hospital before vanishing. It's not hard to imagine that the government, looking to create stronger, faster, more durable soldiers, turned to already wounded men and told them they might have a way to give them back their missing limbs. Not as prosthesis, but as natural, fully functional limbs.

• Jossed. What Cap meant was that (aside from Dr. Connors) they had been SHIELD veterans who were abducted and experimented on by S.I.L.K.

This universe's version of Norman Osborn will not be a villain

Instead he'll be shown as a Parents as People type character, with growing concerns for his troubled son, Harry. There will also likely be a bit of When You Coming Home, Dad? mixed in, and it will be shown that Norman wants to be there for his son, but his business demands more and more of his time. However, given her experience with other Normans of the multiverse, Gwen will be constantly distrusting and combative with him.

Earth-65's heroes are mostly women—even the traditionally male ones.

Not unlike Arcadia on Battleworld, Earth-65's roster of superheroes appears skewed in favor of women. Gwen became a Spider-Hero instead of Peter Parker, Sam(antha) Wilson became Captain America instead of Steve Rogers, and Peggy Carter seems to have absorbed Nick Fury's role as the director of S.H.I.E.L.D. The only male superhero in this comic's reality (so far) is The Falcon —- and even then, he was cloned from a female superhero himself.

Guesses on who might show up soon?

• Toni Stark (or even Pepper Potts) as Iron Woman.
  • Tony Stark has already been mentioned - but his company is a chain of coffee shops! So this one is Jossed.
  • Jury's still out on Pepper Potts, though!
• Jennifer Walters as The Hulk, not She-Hulk.
  • Jossed — Earth-65's Jennifer Walters is a wrestler who goes by the She-Hulk name.
• Jane Foster, amnesiac daughter of Odin.
• Kate Bishop, Earth-65's (original) Hawkeye
• Petra and Juan Maximoff (gender-switched Maximoffs, because why not?)
• Laura Kinney as a Composite Character of herself and Old Man Logan .
  • Sam 13 seems to have some of her backstory, as a younger, opposite sex clone (of Captain America instead of Wolverine). Plus, the X-Men don't even appear to exist here.
  • Jossed: Logan is still around, although he does not appear to have been part of the X-men.
  • Shadowcat is a combination of Kitty Pryde and Laura, she has both phasing and claws and her hair and clothing looks more like Laura's than Kitty's.
• Kaine Drew Stacy, an Opposite-Sex Clone of Gwen who calls himself The Scarlet Spider.
• Per the events of Spider-Women, Earth-65's Jessica Drew seems to be a man◊.

Gwen will have to leave Earth-65

• She has the device to leap dimensions, and has friends and allies on Earth 616. Her Secret Identity seems to be on the verge of being not so secret much longer. She may have no choice but to bolt from her world.
  • Confirmed. She can't get an education or a job on Earth-65, and during a visit to Earth-616 in which she teams up with Peter Parker, decides to enrol at Empire State University, where Peter is already studying. She still goes home to 65, but will now be studying and superheroing in Earth-616 instead.

Alternately:

Gwen's identity will become public, but at the same time she'll be exonerated of Peter's murder

• She'll become a hero with good publicity, allowing her to operate without the mask, and justifying tons of art, both official and fanart, that show her in costume without the mask.
  • Jossed. She served a year in jail for it.

We'll meet Brother Brit-Man

• Gilles Weill was introduced as the Captain Britain of Earth-65 during the 90s Excaliber run.
  • Or his successor; Gilles appears to be older than Brian Braddock, so he might have retired by now. Bonus points if Sister Brit-Girl is the Earth-65 counterpart of Meggan. Because Meggan as a British hippie would be hilarious.

MJ will become this world's Venom

Exactly What It Says on the Tin

• Whether she does a Heel–Face Turn and becomes a Jerk with a Heart of Gold or pulls a Face–Heel Turn and becomes Gwen's archenemy is anyone's guess
• On an alternative theory, she could also end being this Universe's Scarlet Spider. There's a variant cover with MJ on it in a similar costume that's a cross between Ben Reilly's and Gwen's. In an effort to save Gwen from her Venom form, MJ may be used as the willing or non-willing lab rat. The result is two Spider-Women running around Earth-65.
  • Jossed, at least for the Venom thing. Gwen bonds with the symbiote and eventually stabilizes her relationship to get her powers back permanently.

Jesse Drew will become Venom

• His backstory is that he was bitten by alien moon spiders, and their venom caused his blood to start turning into a black, viscous goo. Now that he is no longer taking the isotope that S.I.L.K. provided him with, it may turn out that even if his condition is no longer life-threatening, it still has side effects.
  • Alternately, he may not become Venom himself, but Cindy Moon or Otto Octavius could use samples of his transmuted blood to create Venom at a later time.
    • Jossed. The Venom symbiote isn't created from Jesse Drew's blood, but from a combination of the isotope that gave him his powers and the Lizard serum.

Gabriel and Sarah will eventually appear, although maybe with a different father

Thanos is a humble farmer and an advocate for sustainable harvest.

Characterization on Earth-65 often goes in a wildly different direction, so Thanos getting a big helping of Adaptational Heroism isn't out of the question.